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On MRI, PML may sometimes appear similar to primary central nervous system lymphoma (PCNSL) and glioblastoma multiforme (GBM). The purpose of this pilot study was to evaluate the potential of amide proton transfer (APT) imaging for differentiating PML from PCNSL and GBM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with PML (n\u2009=\u20094; two men; mean age 52.3\u2009\u00b1\u20096.1\u00a0years), PCNSL (n\u2009=\u20097; four women; mean age 74.4\u2009\u00b1\u20095.8\u00a0years), or GBM (n\u2009=\u200911; 6 men; mean age 65.0\u2009\u00b1\u200915.2\u00a0years) who underwent APT-CEST MRI between January 2021 and September 2022 were retrospectively evaluated. Magnetization transfer ratio asymmetry (MTR\n                      <jats:sub>asym<\/jats:sub>\n                      ) values were measured on APT imaging using a region of interest within the lesion. Receiver operating characteristics curve analysis was used to determine diagnostic cutoffs for MTR\n                      <jats:sub>asym<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean MTR\n                      <jats:sub>asym<\/jats:sub>\n                      values were 0.005\u2009\u00b1\u20090.005 in the PML group, 0.025\u2009\u00b1\u20090.005 in the PCNSL group, and 0.025\u2009\u00b1\u20090.009 in the GBM group. There were significant differences in MTR\n                      <jats:sub>asym<\/jats:sub>\n                      between PML and PCNSL (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.023), and between PML and GBM (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.015). For differentiating PML from PCNSL, an MTR\n                      <jats:sub>asym<\/jats:sub>\n                      threshold of 0.0165 gave diagnostic sensitivity, specificity, positive predictive value, and negative predictive value of 100% (all). For differentiating PML from GBM, an MTR\n                      <jats:sub>asym<\/jats:sub>\n                      threshold of 0.015 gave diagnostic sensitivity, specificity, positive predictive value, and negative predictive value of 100%, 90.9%, 80.0%, and 100%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      MTR\n                      <jats:sub>asym<\/jats:sub>\n                      values obtained from APT imaging allowed patients with PML to be clearly discriminated from patients with PCNSL or GBM.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12880-022-00959-3","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T09:06:44Z","timestamp":1672045604000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Amide proton transfer MRI differentiates between progressive multifocal leukoencephalopathy and malignant brain tumors: a pilot study"],"prefix":"10.1186","volume":"22","author":[{"given":"Hirofumi","family":"Koike","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ishimaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Ideguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Uetani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Hiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuharu","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"issue":"8","key":"959_CR1","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1001\/archneurol.2009.153","volume":"66","author":"KL Tyler","year":"2009","unstructured":"Tyler KL. 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