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As a new objective, reproducible and contrast-agent free quantification technique, T2 mapping has been applied to a number of diseases, but studies on the evaluation of uterine lesions and the influence of magnetic field strength are few. Therefore, the aim of this study was to systematically investigate and compare the performance of T2 mapping as a nonenhanced imaging tool in discriminating common uterine lesions between 1.5\u00a0T and 3.0\u00a0T MRI systems.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 50 healthy subjects and 126 patients with suspected uterine lesions were enrolled in our study, and routine uterine MRI sequences with additional T2 mapping sequences were performed. T2 maps were calculated by monoexponential fitting using a custom code in MATLAB. T2 values of normal uterine structures in the healthy group and lesions (benign: adenomyosis, myoma, endometrial polyps; malignant: cervical cancer, endometrial carcinoma) in the patient group were collected. The differences in T2 values between 1.5\u00a0T MRI and 3.0\u00a0T MRI in any normal structure or lesion were compared. The comparison of T2 values between benign and malignant lesions was also performed under each magnetic field strength, and the diagnostic efficacies of the T2 value obtained through receiver operating characteristic (ROC) analysis were compared between 1.5\u00a0T and 3.0\u00a0T.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean T2 value of any normal uterine structure or uterine lesion under 3.0\u00a0T MRI was significantly lower than that under 1.5\u00a0T MRI (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). There were significant differences in T2 values between each lesion subgroup under both 1.5\u00a0T and 3.0\u00a0T MRI. Moreover, the T2 values of benign lesions (71.1\u2009\u00b1\u200922.0\u00a0ms at 1.5\u00a0T and 63.4\u2009\u00b1\u200919.1\u00a0ms at 3.0\u00a0T) were also significantly lower than those of malignant lesions (101.1\u2009\u00b1\u20094.5\u00a0ms at 1.5\u00a0T and 93.5\u2009\u00b1\u20095.1\u00a0ms at 3.0\u00a0T) under both field strengths. In the aspect of differentiating benign from malignant lesions, the area under the curve of the T2 value under 3.0\u00a0T (0.94) was significantly higher than that under 1.5\u00a0T MRI (0.90) (<jats:italic>p<\/jats:italic>\u2009=\u20090.02).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>T2 mapping can be a potential tool for quantifying common uterine lesions, and it has better performance in distinguishing benign from malignant lesions under 3.0\u00a0T MRI.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-022-00960-w","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T10:04:17Z","timestamp":1672826657000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Study of T2 mapping in quantifying and discriminating uterine lesions under different magnetic field strengths: 1.5\u00a0T vs. 3.0\u00a0T"],"prefix":"10.1186","volume":"23","author":[{"given":"Liuhong","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Funan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pu-Yeh","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"issue":"1","key":"960_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21654","volume":"71","author":"RL Siegel","year":"2021","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A. 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After carefully reviewing on the whole study process and protocol, unanimous suggestion obtained from all members of the Institutional Ethics Committee of Zhongshan Hospital (Xiamen) Fudan University, and the study was approved with the approval number Y2021-025. The study did not have any impact on the subjects with the additional scanning of T2 mapping sequence (no contrast-agent required), and the final data were anonymized. Written informed consent was obtained from each subject before the examination.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1"}}