{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T05:34:40Z","timestamp":1676352880709},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Zhuhai Health Bureau","award":["No.2220009000081"],"award-info":[{"award-number":["No.2220009000081"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>To investigate the value of preoperative positron emission tomography\/computed tomography (PET\/CT) in differentiating the invasive degree of hypometabolic lung adenocarcinoma.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We retrospectively analyzed the data of patients who underwent PET\/CT examination, high-resolution computed tomography, and surgical resection for low-metabolism lung adenocarcinoma in our hospital between June 2016 and December 2021. We also investigated the relationship between the preoperative PET\/CT findings and the pathological subtype of hypometabolic lung adenocarcinoma.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 128 lesions were found in 113 patients who underwent resection for lung adenocarcinoma, including 20 minimally invasive adenocarcinomas (MIA) and 108 invasive adenocarcinomas (IAC), whose preoperative PET\/CT showed low metabolism. There were significant differences in the largest diameter (Dmax), lesion type, maximum standard uptake value (SUVmax), SUVindex (the ratio of SUVmax of lesion to SUVmax of contralateral normal lung paranchyma), fasting blood glucose, lobulation, spiculation, and pleura indentation between the MIA and IAC groups (p\u2009&lt;\u20090.05). Multivariate logistic regression analysis showed that the Dmax (odds ratio (OR)\u2009=\u20091.413, 95% confidence interval (CI: 1.155\u20131.729, p\u2009=\u20090.001)) and SUVmax (OR\u2009=\u200912.137, 95% CI: 1.068\u2013137.900, p\u2009=\u20090.044) were independent risk factors for predicting the hypometabolic IAC (p\u2009&lt;\u20090.05). Receiver operating characteristic (ROC) curve analysis showed that the Dmax\u2009\u2265\u200910.5\u00a0mm and SUVmax\u2009\u2265\u20090.85 were the cut-off values for differentiating MIA from IAC, with high sensitivity (84.3% and 75.9%, respectively) and specificity (84.5% and 85.0%, respectively), the Combined Diagnosis showed higher sensitivity (91.7%) and specificity (85.0%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The PET\/CT findings correlated with the subtype of hypometabolic lung adenocarcinoma. The parameters Dmax and SUVmax were independent risk factors for predicting IAC, and the sensitivity of Combined Diagnosis prediction is better.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-023-00986-8","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T07:04:26Z","timestamp":1676012666000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The value of preoperative positron emission tomography\/computed tomography in differentiating the invasive degree of hypometabolic lung adenocarcinoma"],"prefix":"10.1186","volume":"23","author":[{"given":"Yuling","family":"Su","sequence":"first","affiliation":[]},{"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[]},{"given":"Wenshan","family":"Huang","sequence":"additional","affiliation":[]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[]},{"given":"Jinyu","family":"Wang","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"issue":"1","key":"986_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21332","volume":"66","author":"RL Siegel","year":"2016","unstructured":"Siegel RL, Miller KD, Jemal A. 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(2) All experimental protocols were approved and consented by the Ethics Committee of Zhuhai People\u2019s Hospital. (3) The need for written informed consent was waived by the Ethics Committee of Zhuhai People\u2019s Hospital due to retrospective nature of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"31"}}