{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T17:39:31Z","timestamp":1773941971169,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100018688","name":"Korea Disease Control and Prevention Agency","doi-asserted-by":"publisher","award":["2022-ER0507-00"],"award-info":[{"award-number":["2022-ER0507-00"]}],"id":[{"id":"10.13039\/100018688","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Research Foundation of Korea (NRF) grant funded by the Korean government","award":["NRF-2021R1A2C1092807"],"award-info":[{"award-number":["NRF-2021R1A2C1092807"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Technetium-99\u00a0m 3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) and technetium-99\u00a0m sodium pyrophosphate (PYP) are the two most commonly used radiotracers for cardiac amyloidosis (CA), but no studies have directly compared them. Therefore, in this study, we directly compared the diagnostic and clinical utility of DPD and PYP scintigraphy in patients with CA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Ten patients with CA were enrolled. Eight clinical variables and 12 scintigraphic parameters were used. Clinical variables were age, sex, estimated glomerular filtration rate (eGFR), N-terminal pro brain natriuretic peptide (NT-proBNP), and the results of electromyography (EMG), a sensory test, electrocardiogram, and echocardiography (EchoCG). Four heart retention ratios (heart\/whole-body profile, heart\/pelvis, heart\/skull, and heart\/contralateral lung) were calculated from the DPD and PYP scans and two visual scoring systems (Perugini and Dorbala systems) were used. Comparative analyses were performed between radiotracers and between visual scoring systems using clinical variables and scintigraphic parameters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Twenty DPD parameters and nine PYP parameters had significant associations with age, eGFR, NT-proBNP, EchoCG, and EMG. DPD parameters had more frequent significant associations with clinical variables than PYP parameters. Compared to visual scores in the DPD scan, the proportion of patients with higher visual scores in the PYP scan was relatively greater than those with lower visual scores, and there were more patients with a visual score of 2 or higher in PYP scans than DPD scans.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>DPD scintigraphy may reflect the disease severity of CA better than PYP scintigraphy, whereas PYP scintigraphy may be a more sensitive imaging modality for identifying CA involvement.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-023-01054-x","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T16:03:22Z","timestamp":1689609802000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Direct comparison of diagnostic and clinical values between Tc-99\u00a0m DPD and Tc-99\u00a0m PYP scintigraphy in patients with cardiac amyloidosis"],"prefix":"10.1186","volume":"23","author":[{"given":"Yong-Jin","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joohee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Oh","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kihyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"issue":"1","key":"1054_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.cpcardiol.2017.04.003","volume":"43","author":"S Bhogal","year":"2018","unstructured":"Bhogal S, Ladia V, Sitwala P, Cook E, Bajaj K, Ramu V, Lavie CJ, Paul TK. Cardiac amyloidosis: an updated review with emphasis on diagnosis and future directions. Curr Probl Cardiol. 2018;43(1):10\u201334.","journal-title":"Curr Probl Cardiol"},{"issue":"7","key":"1054_CR2","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/s41569-020-0334-7","volume":"17","author":"A Martinez-Naharro","year":"2020","unstructured":"Martinez-Naharro A, Baksi AJ, Hawkins PN, Fontana M. Diagnostic imaging of cardiac amyloidosis. Nat Rev Cardiol. 2020;17(7):413\u201326.","journal-title":"Nat Rev Cardiol"},{"issue":"3","key":"1054_CR3","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s11886-019-1097-9","volume":"21","author":"M Pelletier-Galarneau","year":"2019","unstructured":"Pelletier-Galarneau M, Abikhzer G, Giraldeau G, Harel F. Molecular Imaging of Cardiac Amyloidosis. Curr Cardiol Rep. 2019;21(3):12.","journal-title":"Curr Cardiol Rep"},{"key":"1054_CR4","doi-asserted-by":"crossref","unstructured":"Hotta VT, Giorgi MCP, Fernandes F, Abduch MCD, Falc\u00e3o A, Mady C. Cardiac amyloidosis: non-invasive diagnosis. Rev Assoc Med Bras (1992) 2020, 66(3):345\u2013352.","DOI":"10.1590\/1806-9282.66.3.345"},{"issue":"2","key":"1054_CR5","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s13139-020-00681-4","volume":"55","author":"JC Paeng","year":"2021","unstructured":"Paeng JC, Choi JY. Nuclear Imaging for Cardiac Amyloidosis: bone scan, SPECT\/CT, and amyloid-targeting PET. Nucl Med Mol Imaging. 2021;55(2):61\u201370.","journal-title":"Nucl Med Mol Imaging"},{"key":"1054_CR6","doi-asserted-by":"crossref","unstructured":"Li W, Uppal D, Wang YC, Xu X, Kokkinidis DG, Travin MI, Tauras JM. Nuclear Imaging for the diagnosis of Cardiac Amyloidosis in 2021. Diagnostics (Basel) 2021, 11(6).","DOI":"10.3390\/diagnostics11060996"},{"issue":"5","key":"1054_CR7","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.recesp.2011.12.015","volume":"65","author":"FJ de Haro-del Moral","year":"2012","unstructured":"de Haro-del Moral FJ, S\u00e1nchez-Lajusticia A, G\u00f3mez-Bueno M, Garc\u00eda-Pav\u00eda P, Salas-Ant\u00f3n C, Segovia-Cubero J. Role of cardiac scintigraphy with \u00e2\u00b9\u00e2\u00b9mTc-DPD in the differentiation of cardiac amyloidosis subtype. Rev Esp Cardiol (Engl Ed). 2012;65(5):440\u20136.","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"issue":"6","key":"1054_CR8","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1007\/s00259-020-05144-8","volume":"48","author":"V L\u00f6fbacka","year":"2021","unstructured":"L\u00f6fbacka V, Axelsson J, Pilebro B, Suhr OB, Lindqvist P, Sundstr\u00f6m T. Cardiac transthyretin amyloidosis (99m)Tc-DPD SPECT correlates with strain echocardiography and biomarkers. Eur J Nucl Med Mol Imaging. 2021;48(6):1822\u201332.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"1","key":"1054_CR9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40658-020-00342-7","volume":"8","author":"C Ren","year":"2021","unstructured":"Ren C, Ren J, Tian Z, Du Y, Hao Z, Zhang Z, Fang W, Li F, Zhang S, Hsu B, et al. Assessment of cardiac amyloidosis with (99m)Tc-pyrophosphate (PYP) quantitative SPECT. EJNMMI Phys. 2021;8(1):3.","journal-title":"EJNMMI Phys"},{"issue":"1","key":"1054_CR10","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1007\/s12350-019-01643-w","volume":"28","author":"C Gallini","year":"2021","unstructured":"Gallini C, Tutino F, Martone R, Ciaccio A, Costanzo EN, Taborchi G, Morini S, Bartolini S, Farsetti S, Di Mario C, et al. Semi-quantitative indices of cardiac uptake in patients with suspected cardiac amyloidosis undergoing 99mTc-HMDP scintigraphy. J Nucl Cardiol. 2021;28(1):90\u20139.","journal-title":"J Nucl Cardiol"},{"key":"1054_CR11","doi-asserted-by":"crossref","unstructured":"Kessler L, Fragoso Costa P, Kersting D, Jentzen W, Weber M, L\u00fcdike P, Carpinteiro A, Oubari S, Hagenacker T, Thimm A et al. Quantitative (99m)Tc-DPD-SPECT\/CT assessment of cardiac amyloidosis. J Nucl Cardiol 2022.","DOI":"10.1007\/s12350-022-02960-3"},{"issue":"5","key":"1054_CR12","doi-asserted-by":"publisher","first-page":"716","DOI":"10.2967\/jnumed.120.247312","volume":"62","author":"S Dorbala","year":"2021","unstructured":"Dorbala S, Park MA, Cuddy S, Singh V, Sullivan K, Kim S, Falk RH, Taqueti VR, Skali H, Blankstein R, et al. Absolute quantitation of Cardiac (99m)Tc-Pyrophosphate using cadmium-zinc-telluride-based SPECT\/CT. J Nucl Med. 2021;62(5):716\u201322.","journal-title":"J Nucl Med"},{"issue":"1","key":"1054_CR13","doi-asserted-by":"publisher","first-page":"17271","DOI":"10.1038\/s41598-022-21603-8","volume":"12","author":"S Bae","year":"2022","unstructured":"Bae S, Gil J, Paeng JC, Park EA, Lee SP, Choi H, Kang KW, Cheon GJ, Lee DS. Reliability and feasibility of visual grading systems and quantitative indexes on [(99m)tc]Tc-DPD imaging for cardiac amyloidosis. Sci Rep. 2022;12(1):17271.","journal-title":"Sci Rep"},{"issue":"16","key":"1054_CR14","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1093\/eurheartj\/ehab072","volume":"42","author":"P Garcia-Pavia","year":"2021","unstructured":"Garcia-Pavia P, Rapezzi C, Adler Y, Arad M, Basso C, Brucato A, Burazor I, Caforio ALP, Damy T, Eriksson U, et al. Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2021;42(16):1554\u201368.","journal-title":"Eur Heart J"},{"issue":"7","key":"1054_CR15","first-page":"e000029","volume":"14","author":"S Dorbala","year":"2021","unstructured":"Dorbala S, Ando Y, Bokhari S, Dispenzieri A, Falk RH, Ferrari VA, Fontana M, Gheysens O, Gillmore JD, Glaudemans AWJM, et al. Consensus Recommendations for Multimodality Imaging in Cardiac Amyloidosis: part 1 of 2\u2014Evidence base and standardized methods of imaging. Circ Cardiovasc Imaging. 2021;14(7):e000029. ASNC\/AHA\/ASE\/EANM\/HFSA\/ISA\/SCMR\/SNMMI Expert.","journal-title":"Circ Cardiovasc Imaging"},{"issue":"6","key":"1054_CR16","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/j.jacc.2005.05.073","volume":"46","author":"E Perugini","year":"2005","unstructured":"Perugini E, Guidalotti PL, Salvi F, Cooke RM, Pettinato C, Riva L, Leone O, Farsad M, Ciliberti P, Bacchi-Reggiani L, et al. Noninvasive etiologic diagnosis of cardiac amyloidosis using 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy. J Am Coll Cardiol. 2005;46(6):1076\u201384.","journal-title":"J Am Coll Cardiol"},{"issue":"21","key":"1054_CR17","doi-asserted-by":"publisher","first-page":"2638","DOI":"10.1016\/j.jacc.2019.09.056","volume":"74","author":"J Ternacle","year":"2019","unstructured":"Ternacle J, Krapf L, Mohty D, Magne J, Nguyen A, Galat A, Gallet R, Teiger E, C\u00f4t\u00e9 N, Clavel MA, et al. Aortic stenosis and Cardiac Amyloidosis: JACC Review topic of the Week. J Am Coll Cardiol. 2019;74(21):2638\u201351.","journal-title":"J Am Coll Cardiol"},{"key":"1054_CR18","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/1471-2369-13-118","volume":"13","author":"T Kuroda","year":"2012","unstructured":"Kuroda T, Tanabe N, Kobayashi D, Wada Y, Murakami S, Nakano M, Narita I. Significant association between renal function and amyloid-positive area in renal biopsy specimens in AL amyloidosis. BMC Nephrol. 2012;13:118.","journal-title":"BMC Nephrol"},{"issue":"3","key":"1054_CR19","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1080\/13506129.2020.1744553","volume":"27","author":"MC Azevedo Coutinho","year":"2020","unstructured":"Azevedo Coutinho MC, Cortez-Dias N, Cantinho G, Gon\u00e7alves S, Menezes MN, Guimar\u00e3es T, Lima da Silva G, Francisco AR, Agostinho J, Santos L, et al. The sensitivity of DPD scintigraphy to detect transthyretin cardiac amyloidosis in V30M mutation depends on the phenotypic expression of the disease. Amyloid. 2020;27(3):174\u201383.","journal-title":"Amyloid"},{"issue":"1","key":"1054_CR20","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12947-019-0182-y","volume":"17","author":"G Pesk\u00f3","year":"2019","unstructured":"Pesk\u00f3 G, Jenei Z, Varga G, Apor A, V\u00e1g\u00f3 H, Czibor S, Proh\u00e1szka Z, Masszi T, Pozsonyi Z. Coexistence of aortic valve stenosis and cardiac amyloidosis: echocardiographic and clinical significance. Cardiovasc Ultrasound. 2019;17(1):32.","journal-title":"Cardiovasc Ultrasound"},{"key":"1054_CR21","doi-asserted-by":"publisher","first-page":"663929","DOI":"10.3389\/fcvm.2021.663929","volume":"8","author":"M Harapoz","year":"2021","unstructured":"Harapoz M, Evans S, Geenty P, Kwok F, Stewart G, Taylor MS, Farlow D, Thomas L. Correlation between quantitative uptake of (99m)TC-DPD and echocardiographic parameters in Cardiac ATTR: a Novel Follow-Up strategy. Front Cardiovasc Med. 2021;8:663929.","journal-title":"Front Cardiovasc Med"},{"key":"1054_CR22","doi-asserted-by":"crossref","unstructured":"Asif T, Gupta A, Murthi M, Soman P, Singh V, Malhotra S. Echocardiographic indices of left ventricular function and filling pressure are not related to blood pool activity on pyrophosphate scintigraphy. J Nucl Cardiol 2022.","DOI":"10.1007\/s12350-022-02989-4"},{"issue":"1","key":"1054_CR23","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1002\/mus.26723","volume":"61","author":"MV Pinto","year":"2020","unstructured":"Pinto MV, Milone M, Mauermann ML, Dyck PJB, Alhammad R, McPhail ED, Grogan M, Liewluck T. Transthyretin amyloidosis: putting myopathy on the map. Muscle Nerve. 2020;61(1):95\u2013100.","journal-title":"Muscle Nerve"},{"issue":"22","key":"1054_CR24","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1016\/j.jacc.2020.04.022","volume":"75","author":"M Hanna","year":"2020","unstructured":"Hanna M, Ruberg FL, Maurer MS, Dispenzieri A, Dorbala S, Falk RH, Hoffman J, Jaber W, Soman P, Witteles RM, et al. Cardiac Scintigraphy with Technetium-99m-Labeled bone-seeking Tracers for suspected amyloidosis: JACC Review topic of the Week. J Am Coll Cardiol. 2020;75(22):2851\u201362.","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"1054_CR25","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/s12350-020-02328-5","volume":"28","author":"T Asif","year":"2021","unstructured":"Asif T, Gomez J, Singh V, Doukky R, Nedeltcheva A, Malhotra S. Comparison of planar with tomographic pyrophosphate scintigraphy for transthyretin cardiac amyloidosis: perils and pitfalls. J Nucl Cardiol. 2021;28(1):104\u201311.","journal-title":"J Nucl Cardiol"}],"container-title":["BMC Medical Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-023-01054-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12880-023-01054-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-023-01054-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T16:03:54Z","timestamp":1689609834000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedimaging.biomedcentral.com\/articles\/10.1186\/s12880-023-01054-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,17]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["1054"],"URL":"https:\/\/doi.org\/10.1186\/s12880-023-01054-x","relation":{},"ISSN":["1471-2342"],"issn-type":[{"value":"1471-2342","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,17]]},"assertion":[{"value":"7 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Institutional Review Board (IRB) of Samsung Medical Center approved this retrospective study (IRB number: 2022-08-111). Informed consent was waived by IRB of Samsung Medical Center due to the retrospective nature of the study. This study was conducted according to the Declaration of Helsinki 2013 and its later amendments or similar ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"92"}}