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The patients were divided into low and high Ki-67 expression groups. In the training cohort, DWI, T2WI, and contrast enhancement T1WI (CE-T1) sequence radiomics features were extracted from MRI images. Radiomics marker scores and regression coefficient were then calculated for data fitting to construct a radscore model. Subsequently, clinical features with statistical significance were selected to construct a combined model for preoperative individualized prediction of rectal cancer Ki-67 expression. The models were internally and externally validated, and the AUC of each model was calculated. Calibration and decision curves were used to evaluate the clinical practicality of nomograms.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Three models for predicting rectal cancer Ki-67 expression were constructed. The AUC and Delong test results revealed that the combined model had better prediction performance than other models in three chohrts. A decision curve analysis revealed that the nomogram based on the combined model had relatively good clinical performance, which can be an intuitive prediction tool for clinicians.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The multiparametric MRI radiomics model can provide a noninvasive and accurate auxiliary tool for preoperative evaluation of Ki-67 expression in patients with rectal cancer and can support clinical decision-making.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-023-01123-1","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T12:02:39Z","timestamp":1698408159000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A novel radiomics based on multi-parametric magnetic resonance imaging for predicting Ki-67 expression in rectal cancer: a multicenter study"],"prefix":"10.1186","volume":"23","author":[{"given":"Xiuzhen","family":"Yao","sequence":"first","affiliation":[]},{"given":"Weiqun","family":"Ao","sequence":"additional","affiliation":[]},{"given":"Xiandi","family":"Zhu","sequence":"additional","affiliation":[]},{"given":"Shuyuan","family":"Tian","sequence":"additional","affiliation":[]},{"given":"Xiaoyu","family":"Han","sequence":"additional","affiliation":[]},{"given":"Jinwen","family":"Hu","sequence":"additional","affiliation":[]},{"given":"Wenjie","family":"Xu","sequence":"additional","affiliation":[]},{"given":"Guoqun","family":"Mao","sequence":"additional","affiliation":[]},{"given":"Shuitang","family":"Deng","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"issue":"1","key":"1123_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1177\/0846537119885666","volume":"71","author":"W Ao","year":"2020","unstructured":"Ao W, Bao X, Mao G, Yang G, Wang J, Hu J. 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Front Med (Lausanne). 2020;6:270. https:\/\/doi.org\/10.3389\/fmed.2019.00270.","journal-title":"Front Med (Lausanne)"}],"container-title":["BMC Medical Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-023-01123-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12880-023-01123-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-023-01123-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T12:04:28Z","timestamp":1698408268000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedimaging.biomedcentral.com\/articles\/10.1186\/s12880-023-01123-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,27]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["1123"],"URL":"https:\/\/doi.org\/10.1186\/s12880-023-01123-1","relation":{},"ISSN":["1471-2342"],"issn-type":[{"value":"1471-2342","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,27]]},"assertion":[{"value":"12 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental protocols were approved by the ethics committees of Tongde Hospital of Zhejiang Province (Center 1, No.TD2021-96) and Shanghai Putuo District People\u2019s Hospital (Center 2, No.PT2022-2). The need for informed consent was waived by the ethics committees of Tongde Hospital of Zhejiang Province and Shanghai Putuo District People\u2019s Hospital due to this retrospective study design. All of the procedures were performed in accordance with the Declaration of Helsinki and relevant policies in China.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"168"}}