{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:14:45Z","timestamp":1772165685860,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001781"],"award-info":[{"award-number":["82001781"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Foundation of Liaoning Provincial","award":["2020 BS-049"],"award-info":[{"award-number":["2020 BS-049"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prostate cancer (PCa) is one of the most common cancers in men worldwide, and its timely diagnosis and treatment are becoming increasingly important. MRI is in increasing use to diagnose cancer and to distinguish between non-clinically significant and clinically significant PCa, leading to more precise diagnosis and treatment. The purpose of this study is to present a radiomics-based method for determining the Gleason score (GS) for PCa using tumour heterogeneity on multiparametric MRI (mp-MRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-six patients with biopsy-proven PCa were included in this study. The quantitative T2 values, apparent diffusion coefficient (ADC) and signal enhancement rates (\u03b1) were calculated using multi-echo T2 images, diffusion-weighted imaging (DWI) and dynamic contrast-enhanced MRI (DCE-MRI), for the annotated region of interests (ROI). After texture feature analysis, ROI range expansion and feature filtering was performed. Then obtained data were put into support vector machine (SVM), K-Nearest Neighbor (KNN) and other classifiers for binary classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The highest classification accuracy was 73.96% for distinguishing between clinically significant (Gleason 3\u2009+\u20094 and above) and non-significant cancers (Gleason 3\u2009+\u20093) and 83.72% for distinguishing between Gleason 3\u2009+\u20094 from Gleason 4\u2009+\u20093 and above, which was achieved using initial ROIs drawn by the radiologists. The accuracy improved when using expanded ROIs to 80.67% using SVM and 88.42% using Bayesian classification for distinguishing between clinically significant and non-significant cancers and Gleason 3\u2009+\u20094 from Gleason 4\u2009+\u20093 and above, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results indicate the research significance and value of this study for determining the GS for prostate cancer using the expansion of the ROI region.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12880-023-01167-3","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T09:02:36Z","timestamp":1702026156000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A radiomics based method for prediction of prostate cancer Gleason score using enlarged region of interest"],"prefix":"10.1186","volume":"23","author":[{"given":"Haoming","family":"Zhuang","sequence":"first","affiliation":[]},{"given":"Aritrick","family":"Chatterjee","sequence":"additional","affiliation":[]},{"given":"Xiaobing","family":"Fan","sequence":"additional","affiliation":[]},{"given":"Shouliang","family":"Qi","sequence":"additional","affiliation":[]},{"given":"Wei","family":"Qian","sequence":"additional","affiliation":[]},{"given":"Dianning","family":"He","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"issue":"4","key":"1167_CR1","doi-asserted-by":"publisher","first-page":"044501","DOI":"10.1117\/1.JMI.5.4.044501","volume":"5","author":"IIISG Armato","year":"2018","unstructured":"Armato IIISG, Huisman H, Drukker K. 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