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Independent samples t-test (normality) or Mann-Whitney U test (non-normality) was used to compare the differences of R2*-related parameters between the complete response (CR) and the non-CR groups. Diagnostic performance of parameters in predicting response was tested with receiver operating characteristic (ROC) curve analysis. The 3-year overall survival (OS) was evaluated using Kaplan Meier curve, log rank test, and Cox proportional hazards regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The post-R2*, \u2206R2*, and \u2206%R2* in the CR group were significantly higher than those in the non-CR group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002, 0.003, and 0.006, respectively). The R2*-related parameters showed good prediction of tumor response, with AUC ranging from 0.813 to 0.829. The 3-year OS rate in patients with \u2206R2* &gt;-7.54\u00a0s\n                      <jats:sup>\u2212\u20091<\/jats:sup>\n                      or CR were significantly longer than those with \u2206R2* \u2264 -7.54\u00a0s\n                      <jats:sup>\u2212\u20091<\/jats:sup>\n                      (72.37% vs. 0.00%; Hazard ratio, HR\u2009=\u20090.196; 95% confidence interval, 95% CI\u2009=\u20090.047\u20130.807;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.024) or non-CR (76.47% vs. 29.27%; HR\u2009=\u20090.238, 95% CI\u2009=\u20090.059\u20130.963;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.044).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The preliminary results demonstrated that the R2* value might be a useful hypoxia non-invasive biomarker for assessing response and prognosis of ESCC treated with dCRT. BOLD MRI might be used as a potential tool for evaluating tumor oxygenation metabolism, which is routinely applied in clinical practice and beneficial to clinical decision-making. A large sample size was needed for further follow-up studies to confirm the findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12880-024-01193-9","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T08:02:09Z","timestamp":1705046529000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Value of blood oxygenation level-dependent magnetic resonance imaging in early evaluation of the response and prognosis of esophageal squamous cell carcinoma treated with definitive chemoradiotherapy: a preliminary study"],"prefix":"10.1186","volume":"24","author":[{"given":"Huanhuan","family":"Zheng","sequence":"first","affiliation":[]},{"given":"Hailong","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Yan","family":"Zhu","sequence":"additional","affiliation":[]},{"given":"Xiaolei","family":"Wei","sequence":"additional","affiliation":[]},{"given":"Song","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Wei","family":"Ren","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"issue":"3","key":"1193_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. 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