{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:27:43Z","timestamp":1768012063462,"version":"3.49.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To explore the application of contrast-enhanced ultrasound (CEUS) for the diagnosis and grading of bladder urothelial carcinoma (BUC).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The results of a two-dimensional ultrasound, color Doppler ultrasound and CEUS, were analyzed in 173 bladder lesion cases. The ultrasound and surgical pathology results were compared, and their diagnostic efficacy was analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There were statistically significant differences between BUC and benign lesions in terms of color blood flow distribution intensity and CEUS enhancement intensity (both <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The area under the time-intensity curve (AUC), rising slope, and peak intensity of BUC were significantly higher than those of benign lesions (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The H\/T (height H \/ basal width T)value of 0.63 was the critical value for distinguishing high- and low-grade BUC, had a diagnostic sensitivity of 80.0% and a specificity of 60.0%.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The combination of CEUS and TIC can help improve the diagnostic accuracy of BUC. There is a statistically significant difference between high- and low-grade BUC in contrast enhancement intensity (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05); The decrease of H\/T value indicates the possible increase of the BUC grade.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-024-01199-3","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T11:03:43Z","timestamp":1706180623000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Application of contrast-enhanced ultrasound in diagnosis and grading of bladder urothelial carcinoma"],"prefix":"10.1186","volume":"24","author":[{"given":"Hui-ping","family":"Zhang","sequence":"first","affiliation":[]},{"given":"Rong-xi","family":"Liang","sequence":"additional","affiliation":[]},{"given":"Xue-ying","family":"Lin","sequence":"additional","affiliation":[]},{"given":"En-sheng","family":"Xue","sequence":"additional","affiliation":[]},{"given":"Qin","family":"Ye","sequence":"additional","affiliation":[]},{"given":"Yi-fan","family":"Zhu","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"1199_CR1","doi-asserted-by":"crossref","unstructured":"Ferlay J, Colombet M, Soerjomataram I et al. 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All participants were adults and their informed consent was obtained.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Hui-ping Zhang, Rong-xi Liang, Xue-ying Lin, En-sheng Xue, Qin Ye, Yi-fan Zhu declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"26"}}