{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:11:09Z","timestamp":1782310269402,"version":"3.54.5"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The purpose of our study was to differentiate uterine carcinosarcoma (UCS) from endometrioid adenocarcinoma (EAC) by the multiparametric magnetic resonance imaging (MRI) features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively evaluated clinical and MRI findings in 17 patients with UCS and 34 patients with EAC proven by histologically. The following clinical and pathological features were evaluated: post- or pre-menopausal, clinical presentation, invasion depth, FIGO stage, lymphaticmetastasis. The following MRI features were evaluated: tumor dimension, cystic degeneration or necrosis, hemorrhage, signal intensity (SI) on T2-weighted images (T2WI), relative SI of lesion to myometrium on T2WI, T1WI, DWI, ADCmax, ADCmin, ADCmean (RSI-T2, RSI-T1, RSI-DWI, RSI-ADCmax, RSI-ADCmin, RSI-ADCmean), ADCmax, ADCmin, ADCmean, the maximum, minimum and mean relative enhancement (RE) of lesion to myometrium on the arterial and venous phases (REAmax, REAmin, REAmean, REVmax, REVmin, REVmean). Receiver operating characteristic (ROC) analysis and the area under the curve (AUC) were used to evaluate prediction ability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of UCS was higher than EAC. UCS occurred more often in the postmenopausal patients. UCS and EAC did not significantly differ in depth of myometrial invasion, FIGO stage and lymphatic\u00a0metastasis. The anterior-posterior and transverse dimensions were significantly larger in UCS than EAC. Cystic degeneration or necrosis and hemorrhage were more likely occurred in UCS. The SI of tumor on T2WI was more heterogeneous in UCS. The RSI-T2, ADCmax, ADCmean, RSI-ADCmax and RSI-ADCmean of UCS were significantly higher than EAC. The REAmax, REAmin, REAmean, REVmax, REVmin and REVmean of UCS were all higher than EAC. The AUCs were 0.72, 0.71, 0.86, 0.96, 0.89, 0.84, 0.73, 0.97, 0.88, 0.94, 0.91, 0.69 and 0.80 for the anterior-posterior dimension, transverse dimension, RSI-T2, ADCmax, ADCmean, RSI-ADCmax, RSI-ADCmean, REAmax, REAmin, REAmean, REVmax, REVmin and REVmean, respectively. The AUC was 0.997 of the combined of ADCmax, REAmax and REVmax. Our study showed that ADCmax threshold value of 789.05 (10\n                      <jats:sup>\u20133<\/jats:sup>\n                      mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s) can differentiate UCS from EAC with 100% sensitivity, 76.5% specificity, and 0.76 AUC, REAmax threshold value of 0.45 can differentiate UCS from EAC with 88.2% sensitivity, 100% specificity, and 0.88 AUC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Multiparametric MRI features may be utilized as a biomarker to distinguish UCS from EAC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12880-024-01225-4","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T11:03:18Z","timestamp":1708340598000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical and multiparametric MRI features for differentiating uterine carcinosarcoma from endometrioid adenocarcinoma"],"prefix":"10.1186","volume":"24","author":[{"given":"Xiaodan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqing","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dairong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"issue":"6","key":"1225_CR1","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.bpobgyn.2011.05.010","volume":"25","author":"E D'Angelo","year":"2011","unstructured":"D\u2019Angelo E, Prat J. Pathology of mixed M\u00fcllerian tumours. Best Pract Res Clin Obstet Gynaecol. 2011;25(6):705\u201318.","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"11","key":"1225_CR2","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1007\/s00330-002-1405-3","volume":"12","author":"T Ohguri","year":"2002","unstructured":"Ohguri T, Aoki T, Watanabe H, et al. MRI findings including gadolinium-enhanced dynamic studies of malignant, mixed mesodermal tumors of the uterus: differentiation from endometrial carcinomas. Eur Radiol. 2002;12(11):2737\u201342.","journal-title":"Eur Radiol"},{"issue":"2","key":"1225_CR3","doi-asserted-by":"publisher","first-page":"317","DOI":"10.2214\/ajr.153.2.317","volume":"153","author":"LG Shapeero","year":"1989","unstructured":"Shapeero LG, Hricak H. Mixed m\u00fcllerian sarcoma of the uterus: MR imaging findings. AJR Am J Roentgenol. 1989;153(2):317\u20139.","journal-title":"AJR Am J Roentgenol"},{"issue":"1","key":"1225_CR4","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1006\/gyno.1997.4827","volume":"67","author":"E Sartori","year":"1997","unstructured":"Sartori E, Bazzurini L, Gadducci A, et al. Carcinosarcoma of the uterus: a clinicopathological multicenter CTF study. Gynecol Oncol. 1997;67(1):70\u20135.","journal-title":"Gynecol Oncol"},{"issue":"2","key":"1225_CR5","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s00261-012-9919-x","volume":"38","author":"SH Tirumani","year":"2013","unstructured":"Tirumani SH, Ojili V, Shanbhogue AK, et al. Current concepts in the imaging of uterine sarcoma. Abdom Imaging. 2013;38(2):397\u2013411.","journal-title":"Abdom Imaging"},{"issue":"5","key":"1225_CR6","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1097\/CCO.0b013e328349a45b","volume":"23","author":"R Arend","year":"2011","unstructured":"Arend R, Doneza JA, Wright JD. Uterine carcinosarcoma [J]. Curr Opin Oncol. 2011;23(5):531\u20136.","journal-title":"Curr Opin Oncol"},{"issue":"7","key":"1225_CR7","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.crad.2011.02.008","volume":"66","author":"AV Genever","year":"2011","unstructured":"Genever AV, Abdi S. Can MRI predict the diagnosis of endometrial carcinosarcoma? Clin Radiol. 2011;66(7):621\u20134.","journal-title":"Clin Radiol"},{"issue":"2","key":"1225_CR8","doi-asserted-by":"publisher","first-page":"531","DOI":"10.2214\/ajr.169.2.9242770","volume":"169","author":"T Smith","year":"1997","unstructured":"Smith T, Moy L, Runowicz C. M\u00fcllerian mixed tumors: CT characteristics with clinical and pathologic observations. AJR Am J Roentgenol. 1997;169(2):531\u20135.","journal-title":"AJR Am J Roentgenol"},{"issue":"23","key":"1225_CR9","first-page":"5379","volume":"57","author":"H Wada","year":"1997","unstructured":"Wada H, Enomoto T, Fujita M, et al. Molecular evidence that most but not all carcinosarcomas of the uterus are combination tumors. Cancer Res. 1997;57(23):5379\u201385.","journal-title":"Cancer Res"},{"issue":"4","key":"1225_CR10","first-page":"295","volume":"23","author":"A Gadducci","year":"2002","unstructured":"Gadducci A, Sartori E, Landoni F, et al. The prognostic relevance of histological type in uterine sarcomas: a Cooperation Task Force (CTF) multivariate analysis of 249 cases. Eur J Gynaecol Oncol. 2002;23(4):295\u20139.","journal-title":"Eur J Gynaecol Oncol"},{"issue":"6","key":"1225_CR11","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s00404-010-1649-0","volume":"282","author":"G Vorgias","year":"2010","unstructured":"Vorgias G, Fotiou S. The role of lymphadenectomy in uterine carcinosarcomas (malignant mixed mullerian tumours): a critical literature review. Arch Gynecol Obstet. 2010;282(6):659\u201364.","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"1225_CR12","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ygyno.2008.05.016","volume":"111","author":"D Nemani","year":"2008","unstructured":"Nemani D, Mitra N, Guo M, et al. Assessing the effects of lymphadenectomy and radiation therapy in patients with uterine carcinosarcoma: a SEER analysis. Gynecol Oncol. 2008;111(1):82\u20138.","journal-title":"Gynecol Oncol"},{"issue":"9721","key":"1225_CR13","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/S0140-6736(09)62002-X","volume":"375","author":"Y Todo","year":"2010","unstructured":"Todo Y, Kato H, Kaneuchi M, et al. Survival effect of para-aortic lymphadenectomy in endometrial cancer (SEPAL study): a retrospective cohort analysis. Lancet. 2010;375(9721):1165\u201372.","journal-title":"Lancet"},{"issue":"2","key":"1225_CR14","doi-asserted-by":"publisher","first-page":"248","DOI":"10.6004\/jnccn.2014.0025","volume":"12","author":"WJ Koh","year":"2014","unstructured":"Koh WJ, Greer BE, Abu-Rustum NR, et al. Uterine neoplasms, version 1. 2014. J Natl Compr Canc Netw. 2014;12(2):248\u201380.","journal-title":"J Natl Compr Canc Netw"},{"issue":"5","key":"1225_CR15","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1200\/JCO.2006.06.4907","volume":"25","author":"HD Homesley","year":"2007","unstructured":"Homesley HD, Filiaci V, Markman M, et al. Phase III trial of ifosfamide with or without paclitaxel in advanced uterine carcinosarcoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2007;25(5):526\u201331.","journal-title":"J Clin Oncol"},{"issue":"1","key":"1225_CR16","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ygyno.2008.02.026","volume":"110","author":"N Bansal","year":"2008","unstructured":"Bansal N, Herzog TJ, Burke W, et al. The utility of preoperative endometrial sampling for the detection of uterine sarcomas. Gynecol Oncol. 2008;110(1):43\u20138.","journal-title":"Gynecol Oncol"},{"issue":"1","key":"1225_CR17","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1159\/000080283","volume":"67","author":"S Sagae","year":"2004","unstructured":"Sagae S, Yamashita K, Ishioka S, et al. Preoperative diagnosis and treatment results in 106 patients with uterine sarcoma in Hokkaido, Japan. Oncology. 2004;67(1):33\u20139.","journal-title":"Oncology"},{"issue":"3","key":"1225_CR18","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1148\/radiol.12120315","volume":"266","author":"E Sala","year":"2013","unstructured":"Sala E, Rockall AG, Freeman SJ, et al. The added role of MR imaging in treatment stratification of patients with gynecologic malignancies: what the radiologist needs to know. Radiology. 2013;266(3):717\u201340.","journal-title":"Radiology"},{"issue":"10","key":"1225_CR19","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1177\/0284185115626475","volume":"57","author":"M Takeuchi","year":"2016","unstructured":"Takeuchi M, Matsuzaki K, Harada M. Carcinosarcoma of the uterus: MRI findings including diffusion-weighted imaging and MR spectroscopy. Acta Radiol. 2016;57(10):1277\u201384.","journal-title":"Acta Radiol"},{"issue":"9","key":"1225_CR20","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.annonc.2022.05.009","volume":"33","author":"A Oaknin","year":"2022","unstructured":"Oaknin A, Bosse TJ, Creutzberg CL, et al. Endometrial cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol. 2022;33(9):860\u201377.","journal-title":"Ann Oncol"},{"issue":"3","key":"1225_CR21","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.ijgo.2014.06.022","volume":"127","author":"E Katsoulakis","year":"2014","unstructured":"Katsoulakis E, Mattes MD, Rineer JM, et al. Contemporary analysis of pelvic and para-aortic metastasis in endometrial cancer using the SEER registry. Int J Gynaecol Obstet. 2014;127(3):293\u20136.","journal-title":"Int J Gynaecol Obstet"},{"issue":"2","key":"1225_CR22","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.ygyno.2020.04.683","volume":"158","author":"MA Elshaikh","year":"2020","unstructured":"Elshaikh MA, Modh A, Jhingran A, et al. Executive summary of the American Radium Society\u00ae Appropriate Use Criteria for management of uterine carcinosarcoma. Gynecol Oncol. 2020;158(2):460\u20136.","journal-title":"Gynecol Oncol"},{"issue":"2","key":"1225_CR23","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.ygyno.2005.04.027","volume":"98","author":"F Amant","year":"2005","unstructured":"Amant F, Cadron I, Fuso L, et al. Endometrial carcinosarcomas have a different prognosis and pattern of spread compared to high-risk epithelial endometrial cancer. Gynecol Oncol. 2005;98(2):274\u201380.","journal-title":"Gynecol Oncol"},{"issue":"2","key":"1225_CR24","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1002\/jmri.21469","volume":"28","author":"YO Tanaka","year":"2008","unstructured":"Tanaka YO, Tsunoda H, Minami R, et al. Carcinosarcoma of the uterus: MR findings. J Magn Reson Imaging. 2008;28(2):434\u20139.","journal-title":"J Magn Reson Imaging"},{"issue":"1","key":"1225_CR25","doi-asserted-by":"publisher","first-page":"278","DOI":"10.2214\/AJR.07.3281","volume":"191","author":"SY Teo","year":"2008","unstructured":"Teo SY, Babagbemi KT, Peters HE, et al. Primary malignant mixed mullerian tumor of the uterus: findings on sonography, CT, and gadolinium-enhanced MRI. AJR Am J Roentgenol. 2008;191(1):278\u201383.","journal-title":"AJR Am J Roentgenol"},{"issue":"4","key":"1225_CR26","first-page":"275","volume":"22","author":"T Takahara","year":"2004","unstructured":"Takahara T, Imai Y, Yamashita T, et al. Diffusion weighted whole body imaging with background body signal suppression (DWIBS): technical improvement using free breathing, STIR and high resolution 3D display. Radiat Med. 2004;22(4):275\u201382.","journal-title":"Radiat Med"},{"issue":"6","key":"1225_CR27","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1002\/jmri.23947","volume":"37","author":"N Galea","year":"2013","unstructured":"Galea N, Cantisani V, Taouli B. Liver lesion detection and characterization: role of diffusion-weighted imaging. J Magn Reson Imaging. 2013;37(6):1260\u201376.","journal-title":"J Magn Reson Imaging"},{"issue":"8","key":"1225_CR28","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1681\/ASN.2010111143","volume":"22","author":"T Inoue","year":"2011","unstructured":"Inoue T, Kozawa E, Okada H, et al. Noninvasive evaluation of kidney hypoxia and fibrosis using magnetic resonance imaging. J Am Soc Nephrol. 2011;22(8):1429\u201334.","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"1225_CR29","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1148\/radiol.15141212","volume":"276","author":"S Nougaret","year":"2015","unstructured":"Nougaret S, Reinhold C, Alsharif SS, et al. Endometrial Cancer: Combined MR Volumetry and Diffusion-weighted Imaging for Assessment of Myometrial and Lymphovascular Invasion and Tumor Grade. Radiology. 2015;276(3):797\u2013808.","journal-title":"Radiology"},{"issue":"6","key":"1225_CR30","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1007\/s00330-014-3139-4","volume":"24","author":"A Andreano","year":"2014","unstructured":"Andreano A, Rechichi G, Rebora P, et al. MR diffusion imaging for preoperative staging of myometrial invasion in patients with endometrial cancer: a systematic review and meta-analysis. Eur Radiol. 2014;24(6):1327\u201338.","journal-title":"Eur Radiol"},{"issue":"2","key":"1225_CR31","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1007\/s00330-007-0769-9","volume":"18","author":"S Fujii","year":"2008","unstructured":"Fujii S, Matsusue E, Kigawa J, et al. Diagnostic accuracy of the apparent diffusion coefficient in differentiating benign from malignant uterine endometrial cavity lesions: initial results. Eur Radiol. 2008;18(2):384\u20139.","journal-title":"Eur Radiol"},{"issue":"8","key":"1225_CR32","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1007\/s00330-013-2819-9","volume":"23","author":"I Thomassin-Naggara","year":"2013","unstructured":"Thomassin-Naggara I, Dechoux S, Bonneau C, et al. How to differentiate benign from malignant myometrial tumours using MR imaging. Eur Radiol. 2013;23(8):2306\u201314.","journal-title":"Eur Radiol"},{"issue":"10","key":"1225_CR33","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1016\/j.mri.2008.04.003","volume":"26","author":"H Kato","year":"2008","unstructured":"Kato H, Kanematsu M, Furui T, et al. Carcinosarcoma of the uterus: radiologic-pathologic correlations with magnetic resonance imaging including diffusion-weighted imaging. Magn Reson Imag. 2008;26(10):1446\u201350.","journal-title":"Magn Reson Imag"},{"issue":"3","key":"1225_CR34","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.rx.2015.10.003","volume":"58","author":"P Hern\u00e1ndez Mateo","year":"2016","unstructured":"Hern\u00e1ndez Mateo P, M\u00e9ndez Fern\u00e1ndez R, Serrano Tamayo E. Uterine sarcoma vs adenocarcinoma: can MRI distinguish between them? Radiologia. 2016;58(3):199\u2013206.","journal-title":"Radiologia"},{"issue":"6","key":"1225_CR35","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.clinimag.2014.06.004","volume":"38","author":"GF Zhang","year":"2014","unstructured":"Zhang GF, Zhang H, Tian XM, et al. Magnetic resonance and diffusion-weighted imaging in categorization of uterine sarcomas: correlation with pathological findings. Clin Imaging. 2014;38(6):836\u201344.","journal-title":"Clin Imaging"},{"issue":"2","key":"1225_CR36","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1159\/000291840","volume":"43","author":"M Takemori","year":"1997","unstructured":"Takemori M, Nishimura R, Yasuda D, et al. Carcinosarcoma of the uterus: magnetic resonance imaging. Gynecol Obstet Invest. 1997;43(2):139\u201341.","journal-title":"Gynecol Obstet Invest"},{"issue":"7","key":"1225_CR37","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1093\/annonc\/mdw161","volume":"27","author":"K Matsuo","year":"2016","unstructured":"Matsuo K, Takazawa Y, Ross MS, et al. Significance of histologic pattern of carcinoma and sarcoma components on survival outcomes of uterine carcinosarcoma. Ann Oncol. 2016;27(7):1257\u201366.","journal-title":"Ann Oncol"},{"issue":"4","key":"1225_CR38","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.3892\/ol.2014.2345","volume":"8","author":"RA Caruso","year":"2014","unstructured":"Caruso RA, Branca G, Fedele F, et al. Mechanisms of coagulative necrosis in malignant epithelial tumors (Review). Oncol Lett. 2014;8(4):1397\u2013402.","journal-title":"Oncol Lett"},{"issue":"1","key":"1225_CR39","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1023\/A:1025476722493","volume":"81","author":"L Tomes","year":"2003","unstructured":"Tomes L, Emberley E, Niu Y, et al. Necrosis and hypoxia in invasive breast carcinoma. Breast Cancer Res Treat. 2003;81(1):61\u20139.","journal-title":"Breast Cancer Res Treat"},{"issue":"12","key":"1225_CR40","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1038\/nrc2540","volume":"8","author":"JA Bertout","year":"2008","unstructured":"Bertout JA, Patel SA, Simon MC. The impact of O2 availability on human cancer. Nat Rev Cancer. 2008;8(12):967\u201375.","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"1225_CR41","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.ygyno.2006.05.009","volume":"103","author":"AP Vaidya","year":"2006","unstructured":"Vaidya AP, Horowitz NS, Oliva E, et al. Uterine malignant mixed mullerian tumors should not be included in studies of endometrial carcinoma. Gynecol Oncol. 2006;103(2):684\u20137.","journal-title":"Gynecol Oncol"},{"issue":"5","key":"1225_CR42","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.2214\/AJR.10.4419","volume":"195","author":"N Bharwani","year":"2010","unstructured":"Bharwani N, Newland A, Tunariu N, et al. MRI appearances of uterine malignant mixed m\u00fcllerian tumors. AJR Am J Roentgenol. 2010;195(5):1268\u201375.","journal-title":"AJR Am J Roentgenol"},{"issue":"3","key":"1225_CR43","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.ygyno.2004.08.042","volume":"95","author":"M Emoto","year":"2004","unstructured":"Emoto M, Charnock-Jones DS, Licence DR, et al. Localization of the VEGF and angiopoietin genes in uterine carcinosarcoma. Gynecol Oncol. 2004;95(3):474\u201382.","journal-title":"Gynecol Oncol"},{"issue":"8","key":"1225_CR44","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1007\/s11604-017-0655-6","volume":"35","author":"Y Kamishima","year":"2017","unstructured":"Kamishima Y, Takeuchi M, Kawai T, et al. A predictive diagnostic model using multiparametric MRI for differentiating uterine carcinosarcoma from carcinoma of the uterine corpus. Jpn J Radiol. 2017;35(8):472\u201383.","journal-title":"Jpn J Radiol"}],"container-title":["BMC Medical Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-024-01225-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12880-024-01225-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-024-01225-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T11:05:05Z","timestamp":1708340705000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedimaging.biomedcentral.com\/articles\/10.1186\/s12880-024-01225-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,19]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1225"],"URL":"https:\/\/doi.org\/10.1186\/s12880-024-01225-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3099408\/v1","asserted-by":"object"}]},"ISSN":["1471-2342"],"issn-type":[{"value":"1471-2342","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,19]]},"assertion":[{"value":"23 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures in this study involving human participants were in accordance with the ethical guidelines of the Declaration of Helsinki (as revised in 2013). The study was approved by the Medical Ethics Committee of the First Affiliated Hospital of Fujian Medical University. The\u00a0need for written informed consent was waived due to the retrospective nature of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"48"}}