{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:11:35Z","timestamp":1767006695089},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum W\u00fcrzburg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Unenhanced abdominal CT constitutes the diagnostic standard of care in suspected urolithiasis. Aiming to identify potential for radiation dose reduction in this frequent imaging task, this experimental study compares the effect of spectral shaping and tube voltage modulation on image quality.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Using a third-generation dual-source CT, eight cadaveric specimens were scanned with varying tube voltage settings with and without tin filter application (Sn 150, Sn 100, 120, 100, and 80 kVp) at three dose levels (3 mGy: standard; 1 mGy: low; 0.5 mGy: ultralow). Image quality was assessed quantitatively by calculation of signal-to-noise ratios (SNR) for various tissues (spleen, kidney, trabecular bone, fat) and subjectively by three independent radiologists based on a seven-point rating scale (7\u2009=\u2009excellent; 1\u2009=\u2009very poor).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Irrespective of dose level, Sn 100 kVp resulted in the highest SNR of all tube voltage settings. In direct comparison to Sn 150 kVp, superior SNR was ascertained for spleen (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.004) and kidney tissue (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.009). In ultralow-dose scans, subjective image quality of Sn 100 kVp (median score 3; interquartile range 3\u20133) was higher compared with conventional imaging at 120 kVp (2; 2\u20132), 100 kVp (1; 1\u20132), and 80 kVp (1; 1\u20131) (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Indicated by an intraclass correlation coefficient of 0.945 (95% confidence interval: 0.927\u20130.960), interrater reliability was excellent.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In abdominal CT with maximised dose reduction, tin prefiltration at 100 kVp allows for superior image quality over Sn 150 kVp and conventional imaging without spectral shaping.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-024-01228-1","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T15:03:12Z","timestamp":1708700592000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Influence of spectral shaping and tube voltage modulation in ultralow-dose computed tomography of the abdomen"],"prefix":"10.1186","volume":"24","author":[{"given":"Philipp","family":"Feldle","sequence":"first","affiliation":[]},{"given":"Jan-Peter","family":"Grunz","sequence":"additional","affiliation":[]},{"given":"Andreas Steven","family":"Kunz","sequence":"additional","affiliation":[]},{"given":"Pauline","family":"Pannenbecker","sequence":"additional","affiliation":[]},{"given":"Theresa Sophie","family":"Patzer","sequence":"additional","affiliation":[]},{"given":"Svenja","family":"Pichlmeier","sequence":"additional","affiliation":[]},{"given":"Stephanie Tina","family":"Sauer","sequence":"additional","affiliation":[]},{"given":"Robin","family":"Hendel","sequence":"additional","affiliation":[]},{"given":"S\u00fcleyman","family":"Erg\u00fcn","sequence":"additional","affiliation":[]},{"given":"Thorsten Alexander","family":"Bley","sequence":"additional","affiliation":[]},{"given":"Henner","family":"Huflage","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"1228_CR1","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.eururo.2012.03.052","volume":"62","author":"CD Scales","year":"2012","unstructured":"Scales CD, Smith AC, Hanley JM, Saigal CS. 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For the present study, additional specific permission was obtained from the institutional review board of the University of W\u00fcrzburg, Germany (approval number 20210623 01). The need for written informed consent was waived, since body donors had volunteered their corpses for scientific and educational purposes during their lifetime. Medical history and sociodemographic data of body donors were not accessible for our study; therefore all image material was anonymized before analysis. All procedures were carried out in accordance with the ethical standards of the institutional and national research committee and with the 1975 Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Three authors (J.-P.G, A.S.K., T.A.B.) have received speaker honoraria from Siemens Healthineers unrelated to the present investigation within the last three years. The other authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"49"}}