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Based on the tumor pathology and the results of enhanced CT, tumor patients were divided into malignant and benign groups. All subjects were examined using gray-scale ultrasound, conventional contrast-enhanced ultrasound (C-CEUS), and H-CEUS, and their dynamic images were recorded. Two radiologists independently analyzed and recorded the results of ultrasound, C-CEUS, and H-CEUS images and statistically analyzed the features of C-CEUS and H-CEUS images. The independent sample\n t<\/jats:italic>\n -test was used to compare the difference in age and maximum diameter of nodules between the benign and malignant groups. The\n \u03c7<\/jats:italic>\n \n 2<\/jats:italic>\n <\/jats:sup>\n test was used to compare the sex, mode of operation, gray-scale ultrasound characteristics, and enhancement characteristics of the two CEUS modes (enhancement mode, regression mode, enhancement degree, enhancement uniformity, enhancement or not, enhancement direction, post-enhancement boundary and range, and pseudocapsule) between the benign and malignant groups. The difference in vascular morphology of malignant nodules of varying sizes under two angiographic modes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There were significant differences in gender (\n \u03c7<\/jats:italic>\n \n 2<\/jats:italic>\n <\/jats:sup>\n \u2009=\u200910.408,\n P<\/jats:italic>\n \u2009=\u20090.001), mode of operation (\n \u03c7<\/jats:italic>\n \n 2<\/jats:italic>\n <\/jats:sup>\n \u2009=\u200947.089,\n P<\/jats:italic>\n \u2009<\u20090.001), nodule composition (\n \u03c7<\/jats:italic>\n \n 2<\/jats:italic>\n <\/jats:sup>\n \u2009=\u20097.481,\n P<\/jats:italic>\n \u2009=\u20090.003), nodule echo (\n \u03c7<\/jats:italic>\n \n 2<\/jats:italic>\n <\/jats:sup>\n \u2009=\u200920.926,\n P<\/jats:italic>\n \u2009<\u20090.001), necrosis (\n \u03c7<\/jats:italic>\n \n 2<\/jats:italic>\n <\/jats:sup>\n \u2009=\u200931.343,\n P<\/jats:italic>\n \u2009<\u20090.001) and nodule blood flow (\n \u03c7<\/jats:italic>\n \n 2<\/jats:italic>\n <\/jats:sup>\n \u2009=\u20099.006,\n P<\/jats:italic>\n \u2009=\u20090.029) between the benign and malignant groups. There were significant differences in the regression model (\n \u03c7<\/jats:italic>\n \n 2<\/jats:italic>\n <\/jats:sup>\n \u2009=\u20096.782,\n P<\/jats:italic>\n \u2009=\u20090.034) and enhancement direction (\n \u03c7<\/jats:italic>\n \n 2<\/jats:italic>\n <\/jats:sup>\n \u2009=\u200913.771,\n P<\/jats:italic>\n \u2009=\u20090.001) between the two radiographic techniques in the malignant group. There was a significant difference in the enhancement uniformity between the two CEUS techniques in the benign group (\n \u03c7<\/jats:italic>\n \n 2<\/jats:italic>\n <\/jats:sup>\n \u2009=\u20098.264,\n P<\/jats:italic>\n \u2009=\u20090.004). There was a significant difference between the two CEUS techniques in displaying the vascular morphology in the malignant group with the maximum diameter of nodules\u2009\u2264\u20094.0\u00a0cm (\n \u03c7<\/jats:italic>\n \n 2<\/jats:italic>\n <\/jats:sup>\n \u2009=\u200911.421,\n P<\/jats:italic>\n \u2009<\u20090.022). However, there was no significant difference between the two techniques in the malignant group with the maximum diameter of nodules\u2009>\u20094.0\u00a0cm.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Increasing the frame rate of ultrasound images is helpful to accurately display the enhanced features and vascular morphology of renal tumors, especially for malignant tumors with a maximum diameter of \u2264\u20094.0\u00a0cm. Thus, H-CEUS can make up for the limitation of CEUS with regard to the display of vascular morphology.<\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s12880-024-01245-0","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T06:01:45Z","timestamp":1711346505000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Characteristics of high frame frequency contrast-enhanced ultrasound in renal tumors"],"prefix":"10.1186","volume":"24","author":[{"given":"WeiPing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JingLing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"issue":"1","key":"1245_CR1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1148\/radiol.13130161","volume":"271","author":"RG Barr","year":"2014","unstructured":"Barr RG, Peterson C, Hindi A. 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All the human procedures used were in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2013(\n \n ).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"NA.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"71"}}