{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:55:34Z","timestamp":1780084534409,"version":"3.54.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"DOI":"10.1186\/s12880-025-01560-0","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T04:10:10Z","timestamp":1737951010000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Computed tomography enterography-based radiomics nomograms to predict inflammatory activity for ileocolonic Crohn\u2019s disease: a preliminary single-center retrospective study"],"prefix":"10.1186","volume":"25","author":[{"given":"Yuping","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luanxin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bota","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haige","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"issue":"10114","key":"1560_CR1","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","volume":"390","author":"SC Ng","year":"2017","unstructured":"Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JC, Chan FK. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017;390(10114):2769\u201378.","journal-title":"Lancet"},{"issue":"2","key":"1560_CR2","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1093\/ecco-jcc\/jjy113","volume":"13","author":"C Maaser","year":"2019","unstructured":"Maaser C, Sturm A, Vavricka SR, Kucharzik T, Fiorino G, Annese V, Calabrese E, Baumgart DC, Bettenworth D, Borralho Nunes P. ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: initial diagnosis, monitoring of known IBD, detection of complications. J Crohn\u2019s Colitis. 2019;13(2):144\u2013K164.","journal-title":"J Crohn\u2019s Colitis"},{"issue":"3","key":"1560_CR3","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1093\/ecco-jcc\/jjy114","volume":"13","author":"A Sturm","year":"2019","unstructured":"Sturm A, Maaser C, Calabrese E, Annese V, Fiorino G, Kucharzik T, Vavricka SR, Verstockt B, van Rheenen P, Tolan D. ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 2: IBD scores and general principles and technical aspects. J Crohn\u2019s Colitis. 2019;13(3):273\u201384.","journal-title":"J Crohn\u2019s Colitis"},{"issue":"3","key":"1560_CR4","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/j.acra.2023.08.028","volume":"31","author":"L Mao","year":"2024","unstructured":"Mao L, Li Y, Cui B, Lu L, Dou W, Pylypenko D, Zhu J, Li H. Multiparametric MRI for Staging of Bowel Inflammatory Activity in Crohn\u2019s Disease with MUSE-IVIM and DCE-MRI: A Preliminary Study. Acad Radiol. 2024;31(3):880\u20138.","journal-title":"Acad Radiol."},{"issue":"32","key":"1560_CR5","doi-asserted-by":"publisher","first-page":"e7759","DOI":"10.1097\/MD.0000000000007759","volume":"96","author":"J Zhu","year":"2017","unstructured":"Zhu J, Zhang F, Zhou J, Li H. Assessment of therapeutic response in Crohn\u2019s disease using quantitative dynamic contrast enhanced MRI (DCE-MRI) parameters: A preliminary study. Medicine. 2017;96(32):e7759.","journal-title":"Medicine"},{"key":"1560_CR6","doi-asserted-by":"crossref","unstructured":"Zhu J, Zhang F, Luan Y, Cao P, Liu F, He W, Wang D. Can Dynamic Contrast-Enhanced MRI (DCE-MRI) and Diffusion-Weighted MRI (DW-MRI) Evaluate Inflammation Disease: A Preliminary Study of Crohn's Disease. Medicine (Baltimore). 2016;95(14):e3239.","DOI":"10.1097\/MD.0000000000003239"},{"issue":"8","key":"1560_CR7","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1097\/MIB.0000000000001143","volume":"23","author":"SR Fernandes","year":"2017","unstructured":"Fernandes SR, Rodrigues RV, Bernardo S, Cortez-Pinto J, Rosa I, da Silva JP, Gon\u00e7alves AR, Valente A, Baldaia C, Santos PM. Transmural healing is associated with improved long-term outcomes of patients with Crohn\u2019s disease. Inflamm Bowel Dis. 2017;23(8):1403\u20139.","journal-title":"Inflamm Bowel Dis"},{"key":"1560_CR8","doi-asserted-by":"publisher","first-page":"S192","DOI":"10.1016\/j.acra.2021.02.022","volume":"28","author":"M Chavoshi","year":"2021","unstructured":"Chavoshi M, Mirshahvalad SA, Kasaeian A, Djalalinia S, Kolahdoozan S, Radmard AR. Diagnostic accuracy of magnetic resonance enterography in the evaluation of colonic abnormalities in Crohn\u2019s disease: a systematic review and meta-analysis. Acad Radiol. 2021;28:S192-202.","journal-title":"Acad Radiol"},{"issue":"10432","key":"1560_CR9","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1016\/S0140-6736(23)02586-2","volume":"403","author":"M Dolinger","year":"2024","unstructured":"Dolinger M, Torres J, Vermeire S. Crohn\u2019s disease. Lancet. 2024;403(10432):1177\u201391.","journal-title":"Lancet"},{"issue":"4","key":"1560_CR10","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1097\/MOG.0000000000000440","volume":"34","author":"HT de Sousa","year":"2018","unstructured":"de Sousa HT, Brito J, Magro F. New cross-sectional imaging in IBD. Curr Opin Gastroenterol. 2018;34(4):194\u2013207.","journal-title":"Curr Opin Gastroenterol"},{"issue":"11","key":"1560_CR11","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1093\/ibd\/izad285","volume":"30","author":"Y Gao","year":"2024","unstructured":"Gao Y, Zhang B, Zhao D, Li S, Rong C, Sun M, Wu X. Automatic Segmentation and Radiomics for Identification and Activity Assessment of CTE Lesions in Crohn\u2019s Disease. Inflamm Bowel Dis. 2024;30(11):1957\u201364.","journal-title":"Inflamm Bowel Dis."},{"issue":"4","key":"1560_CR12","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.ejca.2011.11.036","volume":"48","author":"P Lambin","year":"2012","unstructured":"Lambin P, Rios-Velazquez E, Leijenaar R, Carvalho S, Van Stiphout RG, Granton P, Zegers CM, Gillies R, Boellard R, Dekker A. Radiomics: extracting more information from medical images using advanced feature analysis. Eur J Cancer. 2012;48(4):441\u20136.","journal-title":"Eur J Cancer"},{"issue":"1","key":"1560_CR13","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s12880-022-00844-z","volume":"22","author":"H Ding","year":"2022","unstructured":"Ding H, Li J, Jiang K, Gao C, Lu L, Zhang H, Chen H, Gao X, Zhou K, Sun Z. Assessing the inflammatory severity of the terminal ileum in Crohn disease using radiomics based on MRI. BMC Med Imaging. 2022;22(1):118.","journal-title":"BMC Med Imaging"},{"issue":"1","key":"1560_CR14","doi-asserted-by":"publisher","first-page":"e2329812","DOI":"10.2214\/AJR.23.29812","volume":"222","author":"RX Liu","year":"2024","unstructured":"Liu RX, Li H, Towbin AJ, Ata NA, Smith EA, Tkach JA, Denson LA, He L, Dillman JR. Machine learning diagnosis of small-bowel Crohn disease using T2-weighted MRI radiomic and clinical data. Am J Roentgenol. 2024;222(1):e2329812.","journal-title":"Am J Roentgenol"},{"key":"1560_CR15","first-page":"95","volume":"56","author":"FC Magalh\u00e3es","year":"2023","unstructured":"Magalh\u00e3es FC, Lima EM, Carpentieri-Primo P, Barreto MM, Rodrigues RS, Parente DB. Crohn\u2019s disease: review and standardization of nomenclature. Radiologia Brasileira. 2023;56:95\u2013101.","journal-title":"Radiologia Brasileira"},{"issue":"10","key":"1560_CR16","doi-asserted-by":"publisher","first-page":"6628","DOI":"10.1007\/s00330-022-08989-9","volume":"32","author":"C Zhu","year":"2022","unstructured":"Zhu C, Hu J, Wang X, Li C, Gao Y, Li J, Ge Y, Wu X. A novel clinical radiomics nomogram at baseline to predict mucosal healing in Crohn\u2019s disease patients treated with infliximab. Eur Radiol. 2022;32(10):6628\u201336.","journal-title":"Eur Radiol"},{"key":"1560_CR17","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.eclinm.2022.101805","volume":"56","author":"X Li","year":"2023","unstructured":"Li X, Zhang N, Hu C, Lin Y, Li J, Li Z, Cui E, Shi L, Zhuang X, Li J. CT-based radiomics signature of visceral adipose tissue for prediction of disease progression in patients with Crohn\u2019s disease: A multicentre cohort study. EClinicalMedicine. 2023;56:56.","journal-title":"EClinicalMedicine"},{"key":"1560_CR18","doi-asserted-by":"publisher","first-page":"S207","DOI":"10.1016\/j.acra.2023.03.023","volume":"30","author":"L Ruiqing","year":"2023","unstructured":"Ruiqing L, Jing Y, Shunli L, Jia K, Zhibo W, Hongping Z, Keyu R, Xiaoming Z, Zhiming W, Weiming Z. A Novel Radiomics Model Integrating Luminal and Mesenteric Features to Predict Mucosal Activity and Surgery Risk in Crohn\u2019s Disease Patients: A Multicenter Study. Academic Radiology. 2023;30:S207-19.","journal-title":"Academic Radiology"},{"key":"1560_CR19","doi-asserted-by":"publisher","first-page":"110766","DOI":"10.1016\/j.ejrad.2023.110766","volume":"162","author":"R-n Zhang","year":"2023","unstructured":"Zhang R-n, Huang S-y, Liu R-y, Meng J-x, Zhou J, Chen Z, Fang J-y, Mao R, Li Z-p. Sun C-h: preoperative computed tomography enterography-based radiomics signature: a potential predictor of postoperative anastomotic recurrence in patients with Crohn\u2019s disease. Eur J Radiol. 2023;162:110766.","journal-title":"Eur J Radiol"},{"issue":"4","key":"1560_CR20","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1002\/(SICI)1097-0258(19970228)16:4<385::AID-SIM380>3.0.CO;2-3","volume":"16","author":"R Tibshirani","year":"1997","unstructured":"Tibshirani R. The lasso method for variable selection in the Cox model. Stat Med. 1997;16(4):385\u201395.","journal-title":"Stat Med"},{"issue":"4","key":"1560_CR21","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S0016-5107(04)01878-4","volume":"60","author":"M Daperno","year":"2004","unstructured":"Daperno M, D\u2019Haens G, Van Assche G, Baert F, Bulois P, Maunoury V, Sostegni R, Rocca R, Pera A, Gevers A. Development and validation of a new, simplified endoscopic activity score for Crohn\u2019s disease: the SES-CD. Gastrointest Endosc. 2004;60(4):505\u201312.","journal-title":"Gastrointest Endosc"},{"issue":"4","key":"1560_CR22","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1097\/MEG.0000000000001065","volume":"30","author":"M Meral","year":"2018","unstructured":"Meral M, Bengi G, Kayahan H, Akarsu M, Soyt\u00fcrk M, Topalak \u00d6, Akpinar H, Sagol \u00d6. Is ileocecal valve intubation essential for routine colonoscopic examination? Eur J Gastroenterol Hepatol. 2018;30(4):432\u20137.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"1560_CR23","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/BF00203365","volume":"20","author":"M Meyers","year":"1995","unstructured":"Meyers M, McGuire P. Spiral CT demonstration of hypervascularity in Crohn disease:vascular jejunization of the ileum or the comb sign. Abdom Imaging. 1995;20:327\u201332.","journal-title":"Abdom Imaging"},{"key":"1560_CR24","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1007\/s00261-011-9808-8","volume":"37","author":"Y-W Wu","year":"2012","unstructured":"Wu Y-W, Tao X-F, Tang Y-H, Hao N-X, Miao F. Quantitative measures of comb sign in Crohn\u2019s disease: correlation with disease activity and laboratory indications. Abdom Imaging. 2012;37:350\u20138.","journal-title":"Abdom Imaging"},{"issue":"1","key":"1560_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12876-022-02389-5","volume":"22","author":"J Tong","year":"2022","unstructured":"Tong J, Feng Q, Zhang C, Xu X, Ran Z. CT enterography for evaluation of disease activity in patients with ileocolonic Crohn\u2019s disease. BMC Gastroenterol. 2022;22(1):1\u201310.","journal-title":"BMC Gastroenterol"},{"key":"1560_CR26","doi-asserted-by":"publisher","first-page":"175628481876907","DOI":"10.1177\/1756284818769075","volume":"11","author":"S Lopes","year":"2018","unstructured":"Lopes S, Andrade P, Afonso J, Cunha R, Rodrigues-Pinto E, Ramos I, Macedo G, Magro F. Monitoring Crohn\u2019s disease activity: endoscopy, fecal markers and computed tomography enterography. Therapeutic Adv Gastroenterol. 2018;11:1756284818769075.","journal-title":"Therapeutic Adv Gastroenterol"},{"issue":"10","key":"1560_CR27","doi-asserted-by":"publisher","first-page":"3406","DOI":"10.1007\/s00261-022-03605-2","volume":"47","author":"B Dane","year":"2022","unstructured":"Dane B, Kernizan A, O\u2019Donnell T, Petrocelli R, Rabbenou W, Bhattacharya S, Chang S, Megibow A. Crohn\u2019s disease active inflammation assessment with iodine density from dual-energy CT enterography: comparison with endoscopy and conventional interpretation. Abdom Radiol. 2022;47(10):3406\u201313.","journal-title":"Abdom Radiol"},{"issue":"1","key":"1560_CR28","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1148\/radiol.2021204405","volume":"301","author":"B Dane","year":"2021","unstructured":"Dane B, Sarkar S, Nazarian M, Galitzer H, O\u2019Donnell T, Remzi F, Chang S, Megibow A. Crohn disease active inflammation assessment with iodine density from dual-energy CT enterography: comparison with histopathologic analysis. Radiology. 2021;301(1):144\u201351.","journal-title":"Radiology"},{"issue":"1","key":"1560_CR29","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.media.2013.10.005","volume":"18","author":"A Depeursinge","year":"2014","unstructured":"Depeursinge A, Foncubierta-Rodriguez A, Van De Ville D, M\u00fcller H. Three-dimensional solid texture analysis in biomedical imaging: review and opportunities. Med Image Anal. 2014;18(1):176\u201396.","journal-title":"Med Image Anal"},{"issue":"10","key":"1560_CR30","doi-asserted-by":"publisher","first-page":"6910","DOI":"10.1007\/s00330-022-08853-w","volume":"32","author":"D Bao","year":"2022","unstructured":"Bao D, Zhao Y, Li L, Lin M, Zhu Z, Yuan M, Zhong H, Xu H, Zhao X, Luo D. A MRI-based radiomics model predicting radiation-induced temporal lobe injury in nasopharyngeal carcinoma. Eur Radiol. 2022;32(10):6910\u201321.","journal-title":"Eur Radiol"},{"issue":"3","key":"1560_CR31","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.acra.2022.08.002","volume":"30","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Liu L, Zhang K, Su R, Jia H, Qian L, Dong J. Nomograms combining clinical and imaging parameters to predict recurrence and disease-free survival after concurrent chemoradiotherapy in patients with locally advanced cervical cancer. Acad Radiol. 2023;30(3):499\u2013508.","journal-title":"Acad Radiol"},{"key":"1560_CR32","doi-asserted-by":"publisher","unstructured":"Zheng R, Zhang X, Liu B, Zhang Y, Shen H, Xie X, Li S, Huang G. Comparison of non-radiomics imaging features and radiomics models based on contrast-enhanced ultrasound and Gd-EOB-DTPA-enhanced MRI for predicting microvascular invasion in hepatocellular carcinoma within 5 cm. Eur Radiol. 2023;33:6462\u201372. https:\/\/doi.org\/10.1007\/s00330-023-09789-5.","DOI":"10.1007\/s00330-023-09789-5"}],"container-title":["BMC Medical Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-025-01560-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12880-025-01560-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-025-01560-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T04:10:14Z","timestamp":1737951014000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedimaging.biomedcentral.com\/articles\/10.1186\/s12880-025-01560-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,27]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1560"],"URL":"https:\/\/doi.org\/10.1186\/s12880-025-01560-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4465032\/v1","asserted-by":"object"}]},"ISSN":["1471-2342"],"issn-type":[{"value":"1471-2342","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,27]]},"assertion":[{"value":"23 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The studies involving human participants were reviewed and approved by the Institutional Review Board and Ethics Committee of the Second Affiliated Hospital of Nanjing Medical University (ethical approval number: 2013KY034). Due to the retrospective nature of the current study, the Ethics Committee of the Second Affiliated Hospital of Nanjing Medical University waived the requirement for written informed consent from each participant. We confirm that all methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"27"}}