{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T17:10:03Z","timestamp":1744218603994,"version":"3.40.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Chongqing medical scientific research project","award":["2022ZDXM026","2023QNXM029"],"award-info":[{"award-number":["2022ZDXM026","2023QNXM029"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"DOI":"10.1186\/s12880-025-01658-5","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T19:52:09Z","timestamp":1744055529000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiomic analysis using T1 mapping in gadoxetic acid disodium-enhanced MRI for liver function assessment"],"prefix":"10.1186","volume":"25","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[]},{"given":"Guangyong","family":"Ai","sequence":"additional","affiliation":[]},{"given":"Xiaofeng","family":"Qiao","sequence":"additional","affiliation":[]},{"given":"Weijuan","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Qianrui","family":"Fan","sequence":"additional","affiliation":[]},{"given":"Yudong","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Xiaojing","family":"He","sequence":"additional","affiliation":[]},{"given":"Tianwu","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Dajing","family":"Guo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1747-569X","authenticated-orcid":false,"given":"YangYang","family":"Liu","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"issue":"10308","key":"1658_CR1","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1016\/s0140-6736(21)01374-x","volume":"398","author":"P Gin\u00e8s","year":"2021","unstructured":"Gin\u00e8s P, Krag A, Abraldes JG, et al. Liver cirrhosis. Lancet (London, England). 2021;398(10308):1359\u201376. https:\/\/doi.org\/10.1016\/s0140-6736(21)01374-x.","journal-title":"Lancet (London England)"},{"issue":"5","key":"1658_CR2","doi-asserted-by":"publisher","first-page":"541","DOI":"10.6004\/jnccn.2021.0022","volume":"19","author":"AB Benson","year":"2021","unstructured":"Benson AB, D\u2019Angelica MI, Abbott DE, et al. Hepatobiliary cancers, version 2.2021, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2021;19(5):541\u201365. https:\/\/doi.org\/10.6004\/jnccn.2021.0022.","journal-title":"J Natl Compr Canc Netw"},{"issue":"2","key":"1658_CR3","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.jhep.2012.01.031","volume":"57","author":"BE Van Beers","year":"2012","unstructured":"Van Beers BE, Pastor CM, Hussain HK. Primovist, Eovist: What to expect? J Hepatol. 2012;57(2):421\u20139. https:\/\/doi.org\/10.1016\/j.jhep.2012.01.031.","journal-title":"J Hepatol"},{"issue":"6","key":"1658_CR4","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1007\/s00117-006-1444-x","volume":"47","author":"K Holzapfel","year":"2007","unstructured":"Holzapfel K, Breitwieser C, Prinz C, et al. Contrast-enhanced magnetic resonance cholangiography using gadolinium-EOB-DTPA. Preliminary experience and clinical applications. Radiologe. 2007;47(6):536\u201344. https:\/\/doi.org\/10.1007\/s00117-006-1444-x.","journal-title":"Radiologe"},{"issue":"2","key":"1658_CR5","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.ejrad.2007.02.035","volume":"62","author":"J Zizka","year":"2007","unstructured":"Zizka J, Klzo L, Ferda J, et al. Dynamic and delayed contrast enhancement in upper abdominal MRI studies: Comparison of gadoxetic acid and gadobutrol. Eur J Radiol. 2007;62(2):186\u201391. https:\/\/doi.org\/10.1016\/j.ejrad.2007.02.035.","journal-title":"Eur J Radiol"},{"issue":"6","key":"1658_CR6","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1159\/000343092","volume":"30","author":"KE Bae","year":"2012","unstructured":"Bae KE, Kim SY, Lee SS, et al. Assessment of hepatic function with Gd-EOB-DTPA-enhanced hepatic MRI. Dig Dis. 2012;30(6):617\u201322. https:\/\/doi.org\/10.1159\/000343092.","journal-title":"Dig Dis"},{"issue":"9","key":"1658_CR7","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.mri.2015.06.013","volume":"33","author":"C Besa","year":"2015","unstructured":"Besa C, Bane O, Jajamovich G, et al. 3D T1 relaxometry pre and post gadoxetic acid injection for the assessment of liver cirrhosis and liver function. Magn Reson Imaging. 2015;33(9):1075\u201382. https:\/\/doi.org\/10.1016\/j.mri.2015.06.013.","journal-title":"Magn Reson Imaging"},{"issue":"2","key":"1658_CR8","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1148\/radiol.2016152800","volume":"282","author":"JH Yoon","year":"2017","unstructured":"Yoon JH, Lee JM, Kim E, et al. Quantitative liver function analysis: Volumetric T1 mapping with fast multisection B1 inhomogeneity correction in hepatocyte-specific contrast-enhanced liver MR imaging. Radiology. 2017;282(2):408\u201317. https:\/\/doi.org\/10.1148\/radiol.2016152800.","journal-title":"Radiology"},{"issue":"7","key":"1658_CR9","doi-asserted-by":"publisher","first-page":"3584","DOI":"10.1007\/s00330-018-5947-4","volume":"29","author":"JE Kim","year":"2019","unstructured":"Kim JE, Kim HO, Bae K, et al. T1 mapping for liver function evaluation in gadoxetic acid-enhanced MR imaging: Comparison of look-locker inversion recovery and B1 inhomogeneity-corrected variable flip angle method. Eur Radiol. 2019;29(7):3584\u201394. https:\/\/doi.org\/10.1007\/s00330-018-5947-4.","journal-title":"Eur Radiol"},{"issue":"1","key":"1658_CR10","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1148\/radiol.2018180753","volume":"290","author":"JH Yoon","year":"2019","unstructured":"Yoon JH, Lee JM, Kang HJ, et al. Quantitative assessment of liver function by using gadoxetic acid-enhanced MRI: Hepatocyte uptake ratio. Radiology. 2019;290(1):125\u201333. https:\/\/doi.org\/10.1148\/radiol.2018180753.","journal-title":"Radiology"},{"key":"1658_CR11","doi-asserted-by":"publisher","first-page":"109779","DOI":"10.1016\/j.ejrad.2021.109779","volume":"141","author":"XJ Bi","year":"2021","unstructured":"Bi XJ, Zhang XQ, Zhang T, et al. Quantitative assessment of liver function with hepatocyte fraction: Comparison with T1 relaxation-based indices. Eur J Radiol. 2021;141:109779. https:\/\/doi.org\/10.1016\/j.ejrad.2021.109779.","journal-title":"Eur J Radiol"},{"issue":"1","key":"1658_CR12","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12880-023-01028-z","volume":"23","author":"B Ma","year":"2023","unstructured":"Ma B, Xu H, Wu X, et al. Evaluation of liver function using Gd-EOB-DTPA-enhanced MRI with T1 mapping. BMC Med Imaging. 2023;23(1):73. https:\/\/doi.org\/10.1186\/s12880-023-01028-z.","journal-title":"BMC Med Imaging"},{"key":"1658_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clinimag.2023.06.018","volume":"102","author":"X Ai","year":"2023","unstructured":"Ai X, Wang H, Yang Y, et al. Four indices on Gd-EOB-DTPA-enhanced MRI can estimate liver functional reserve compared to ICG-R15: A systematic review and meta-analysis. Clin Imaging. 2023;102:1\u20138. https:\/\/doi.org\/10.1016\/j.clinimag.2023.06.018.","journal-title":"Clin Imaging"},{"issue":"4","key":"1658_CR14","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1097\/RLI.0b013e318200f67d","volume":"46","author":"T Katsube","year":"2011","unstructured":"Katsube T, Okada M, Kumano S, et al. Estimation of liver function using T1 mapping on Gd-EOB-DTPA-enhanced magnetic resonance imaging. Invest Radiol. 2011;46(4):277\u201383. https:\/\/doi.org\/10.1097\/RLI.0b013e318200f67d.","journal-title":"Invest Radiol"},{"issue":"18","key":"1658_CR15","doi-asserted-by":"publisher","first-page":"497","DOI":"10.21037\/atm.2019.08.105","volume":"7","author":"Y Ding","year":"2019","unstructured":"Ding Y, Sun Z, You W, et al. Lymphoepithelioma-like intrahepatic cholangiocarcinoma with Epstein-Barr virus infection: Report of a rare case. Annals Translational Med. 2019;7(18):497. https:\/\/doi.org\/10.21037\/atm.2019.08.105.","journal-title":"Annals Translational Med"},{"issue":"12","key":"1658_CR16","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nrclinonc.2017.141","volume":"14","author":"P Lambin","year":"2017","unstructured":"Lambin P, Leijenaar RTH, Deist TM, et al. Radiomics: The bridge between medical imaging and personalized medicine. Nat Rev Clin Oncol. 2017;14(12):749\u201362. https:\/\/doi.org\/10.1038\/nrclinonc.2017.141. Epub 2017 Oct 4.","journal-title":"Nat Rev Clin Oncol"},{"issue":"1","key":"1658_CR17","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s41747-020-00148-3","volume":"4","author":"J Th\u00fcring","year":"2020","unstructured":"Th\u00fcring J, Rippel O, Haarburger C, et al. Multiphase CT-based prediction of Child-Pugh classification: A machine learning approach. Eur Radiol Experimental. 2020;4(1):20. https:\/\/doi.org\/10.1186\/s41747-020-00148-3.","journal-title":"Eur Radiol Experimental"},{"issue":"3","key":"1658_CR18","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1007\/s00330-022-09137-z","volume":"33","author":"D Zhang","year":"2023","unstructured":"Zhang D, Cao Y, Sun Y, et al. Radiomics nomograms based on R2* mapping and clinical biomarkers for staging of liver fibrosis in patients with chronic hepatitis B: A single-center retrospective study. Eur Radiol. 2023;33(3):1653\u201367. https:\/\/doi.org\/10.1007\/s00330-022-09137-z.","journal-title":"Eur Radiol"},{"issue":"2","key":"1658_CR19","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","volume":"15","author":"TK Koo","year":"2016","unstructured":"Koo TK, Li MY. A guideline of selecting and reporting intraclass correlation coefficients for reliability research. J Chiropr Med. 2016;15(2):155\u201363. https:\/\/doi.org\/10.1016\/j.jcm.2016.02.012.","journal-title":"J Chiropr Med"},{"issue":"6","key":"1658_CR20","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1007\/s00330-012-2378-5","volume":"22","author":"T Heye","year":"2012","unstructured":"Heye T, Yang SR, Bock M, et al. MR relaxometry of the liver: Significant elevation of T1 relaxation time in patients with liver cirrhosis. Eur Radiol. 2012;22(6):1224\u201332. https:\/\/doi.org\/10.1007\/s00330-012-2378-5.","journal-title":"Eur Radiol"},{"issue":"12","key":"1658_CR21","doi-asserted-by":"publisher","first-page":"e85658","DOI":"10.1371\/journal.pone.0085658","volume":"8","author":"M Haimerl","year":"2013","unstructured":"Haimerl M, Verloh N, Zeman F, et al. Assessment of clinical signs of liver cirrhosis using T1 mapping on Gd-EOB-DTPA-enhanced 3T MRI. PLoS One. 2013;8(12):e85658. https:\/\/doi.org\/10.1371\/journal.pone.0085658.","journal-title":"PLoS ONE"},{"issue":"7","key":"1658_CR22","doi-asserted-by":"publisher","first-page":"5142","DOI":"10.1007\/s00330-023-09402-9","volume":"33","author":"AL Eiras-Araujo","year":"2023","unstructured":"Eiras-Araujo AL, Parente DB, da Silva AC, et al. Relative enhancement index can be used to quantify liver function in cirrhotic patients that undergo gadoxetic acid-enhanced MRI. Eur Radiol. 2023;33(7):5142\u20139. https:\/\/doi.org\/10.1007\/s00330-023-09402-9.","journal-title":"Eur Radiol"},{"issue":"10","key":"1658_CR23","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1016\/j.dld.2019.04.009","volume":"51","author":"D Ippolito","year":"2019","unstructured":"Ippolito D, Famularo S, Giani A, et al. Estimating liver function in a large cirrhotic cohort: Signal intensity of gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced MRI. Dig Liver Disease: Official J Italian Soc Gastroenterol Italian Association Study Liver. 2019;51(10):1438\u201345. https:\/\/doi.org\/10.1016\/j.dld.2019.04.009.","journal-title":"Dig Liver Disease: Official J Italian Soc Gastroenterol Italian Association Study Liver"},{"issue":"12","key":"1658_CR24","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1016\/j.ejrad.2016.10.010","volume":"85","author":"Y Takatsu","year":"2016","unstructured":"Takatsu Y, Kobayashi S, Miyati T, et al. Hepatobiliary phase images using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced MRI as an imaging surrogate for the albumin\u2013bilirubin grading system. Eur J Radiol. 2016;85(12):2206\u201310. https:\/\/doi.org\/10.1016\/j.ejrad.2016.10.010.","journal-title":"Eur J Radiol"},{"issue":"1","key":"1658_CR25","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1159\/000512028","volume":"10","author":"M Chen","year":"2021","unstructured":"Chen M, Cao J, Hu J, et al. Clinical-Radiomic analysis for pretreatment prediction of objective response to first transarterial chemoembolization in hepatocellular carcinoma. Liver cancer. 2021;10(1):38\u201351. https:\/\/doi.org\/10.1159\/000512028.","journal-title":"Liver cancer"},{"key":"1658_CR26","doi-asserted-by":"publisher","unstructured":"Bi X-J, Zhang X-Q, Zhang T, et al. Quantitative assessment of liver function with hepatocyte fraction: Comparison with T1 relaxation-based indices. Eur J Radiol. 2021;141. https:\/\/doi.org\/10.1016\/j.ejrad.2021.109779","DOI":"10.1016\/j.ejrad.2021.109779"},{"issue":"10","key":"1658_CR27","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1007\/s00261-020-02478-7","volume":"45","author":"MT Liu","year":"2020","unstructured":"Liu MT, Zhang XQ, Lu J, et al. Evaluation of liver function using the hepatocyte enhancement fraction based on gadoxetic acid-enhanced MRI in patients with chronic hepatitis B. Abdom Radiol (NY). 2020;45(10):3129\u201335. https:\/\/doi.org\/10.1007\/s00261-020-02478-7.","journal-title":"Abdom Radiol (NY)"},{"issue":"10","key":"1658_CR28","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1097\/RLI.0000000000000788","volume":"56","author":"MR Makowski","year":"2021","unstructured":"Makowski MR, Bressem KK, Franz L, et al. De Novo radiomics approach using image augmentation and features from T1 mapping to predict Gleason scores in prostate cancer. Invest Radiol. 2021;56(10):661\u20138. https:\/\/doi.org\/10.1097\/RLI.0000000000000788.","journal-title":"Invest Radiol"},{"key":"1658_CR29","doi-asserted-by":"publisher","unstructured":"Vaziri-Bozorg SM, Ghasemi-Esfe AR, Khalilzadeh O, et al. Diffusion-weighted magnetic resonance imaging for diagnosis of liver fibrosis and inflammation in chronic viral hepatitis: The performance of low or high B values and small or large regions of interest. Can Assoc Radiol J. 2012;63(4):304\u201311. https:\/\/doi.org\/10.1016\/j.carj.2011.04.002","DOI":"10.1016\/j.carj.2011.04.002"},{"issue":"6","key":"1658_CR30","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1002\/jmri.27197","volume":"52","author":"J Song","year":"2020","unstructured":"Song J, Yu X, Song W, et al. MRI-Based radiomics models developed with features of the whole liver and right liver lobe: Assessment of hepatic inflammatory activity in chronic hepatic disease. J Magn Reson Imaging: JMRI. 2020;52(6):1668\u201378. https:\/\/doi.org\/10.1002\/jmri.27197.","journal-title":"J Magn Reson Imaging: JMRI"},{"key":"1658_CR31","doi-asserted-by":"publisher","unstructured":"Yeung J, Ganeshan B, Endozo R, et al. Equilibrium CT texture analysis for the evaluation of hepatic fibrosis: Preliminary evaluation against histopathology and extracellular volume fraction. J Personalized Med. 2020;10(2). https:\/\/doi.org\/10.3390\/jpm10020046.","DOI":"10.3390\/jpm10020046"}],"container-title":["BMC Medical Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-025-01658-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12880-025-01658-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-025-01658-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T16:40:29Z","timestamp":1744216829000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedimaging.biomedcentral.com\/articles\/10.1186\/s12880-025-01658-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,7]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1658"],"URL":"https:\/\/doi.org\/10.1186\/s12880-025-01658-5","relation":{},"ISSN":["1471-2342"],"issn-type":[{"type":"electronic","value":"1471-2342"}],"subject":[],"published":{"date-parts":[[2025,4,7]]},"assertion":[{"value":"22 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). This study was approved by the Ethics Committee on Human Research of the Second Affiliated Hospital of Chongqing Medical University (approval number, (2021)121). Informed consent was waived, as the study was retrospective.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human ethics and consent to participate"}},{"value":"NA.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"111"}}