{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:14:48Z","timestamp":1772165688176,"version":"3.50.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"DOI":"10.1186\/s12880-025-01679-0","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T09:13:58Z","timestamp":1748250838000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ultrasonographic differentiation of medullary thyroid carcinoma from papillary thyroid carcinoma: quantitative comparison of morphologic features and different TIRADS risk categorizations"],"prefix":"10.1186","volume":"25","author":[{"given":"Xiaoyu","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiejie","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"1679_CR1","doi-asserted-by":"publisher","unstructured":"Dadu R, Bagheri-Yarmand R, Ringel MD, Grubbs EG, Zafereo M, Cote G, Gagel RF, Robinson BG, Shaw KR, Hu MI. Hereditary endocrine tumours: current state-of-the-art and research opportunities. The state of science in medullary thyroid carcinoma: current challenges and unmet needs. Endocr Relat Cancer. 2020;27(8):T27-T39. https:\/\/doi.org\/10.1530\/ERC-20-0110. PMID: 32580150.","DOI":"10.1530\/ERC-20-0110"},{"issue":"6","key":"1679_CR2","doi-asserted-by":"publisher","first-page":"R241","DOI":"10.1530\/EJE-14-0726","volume":"172","author":"TP Links","year":"2015","unstructured":"Links TP, Verbeek HH, Hofstra RM, Plukker JT. Endocrine tumours: progressive metastatic medullary thyroid carcinoma: first- and second-line strategies. Eur J Endocrinol. 2015;172(6):R241\u201351. https:\/\/doi.org\/10.1530\/EJE-14-0726. Epub 2015 Jan 27. PMID: 25627652.","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"1679_CR3","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1177\/1553350615596638","volume":"23","author":"G Docimo","year":"2016","unstructured":"Docimo G, Tolone S, Conzo G, Limongelli P, Del Genio G, Parmeggiani D, De Palma M, Lupone G, Avenia N, Lucchini R, Monacelli M, Gulotta G, Scerrino G, Pasquali D, Bellastella G, Esposito K, De Bellis A, Pezzolla A, Ruggiero R, Docimo L. (Floseal) in combination with harmonic scalpel is effective in patients undergoing total thyroidectomy: A prospective, multicenter, Single-Blind, randomized controlled trial. Surg Innov. 2016;23(1):23\u20139. https:\/\/doi.org\/10.1177\/1553350615596638. Epub 2015 Aug 3. PMID: 26243629. A Gelatin-Thrombin Matrix Topical Hemostatic Agent.","journal-title":"Surg Innov"},{"issue":"3","key":"1679_CR4","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1148\/radiol.11110206","volume":"260","author":"JY Kwak","year":"2011","unstructured":"Kwak JY, Han KH, Yoon JH, Moon HJ, Son EJ, Park SH, Jung HK, Choi JS, Kim BM, Kim EK. Thyroid imaging reporting and data system for US features of nodules: a step in Establishing better stratification of cancer risk. Radiology. 2011;260(3):892\u20139. https:\/\/doi.org\/10.1148\/radiol.11110206. Epub 2011 Jul 19. PMID: 21771959.","journal-title":"Radiology"},{"issue":"1","key":"1679_CR5","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s12020-020-02442-x","volume":"72","author":"J Zhou","year":"2021","unstructured":"Zhou J, Song Y, Zhan W, Wei X, Zhang S, Zhang R, Gu Y, Chen X, Shi L, Luo X, Yang L, Li Q, Bai B, Ye X, Zhai H, Zhang H, Jia X, Dong Y, Zhang J, Yang Z, Zhang H, Zheng Y, Xu W, Lai L, Yin L, Superficial Organ and Vascular Ultrasound Group of the Society of Ultrasound in Medicine of Chinese Medical Association. Chinese artificial intelligence alliance for thyroid and breast ultrasound. thyroid imaging reporting and data system (TIRADS) for ultrasound features of nodules: multicentric retrospective study in China. Endocrine. 2021;72(1):157\u201370. https:\/\/doi.org\/10.1007\/s12020-020-02442-x. Epub 2020 Aug 27. PMID: 32852733.","journal-title":"Endocrine"},{"key":"1679_CR6","doi-asserted-by":"crossref","unstructured":"Tessler FN, Middleton WD, Grant EG, Hoang JK, Berland LL, Teefey SA, Cronan JJ, Beland MD, Desser TS, Frates MC, Hammers LW, Hamper UM, Langer JE, Reading CC, Scoutt LM, Stavros AT. White paper of the ACR TI-RADS Committee. J Am Coll Radiol. 2017;14(5):587\u201395. Epub 2017 Apr 2. PMID: 28372962. ACR Thyroid Imaging, Reporting and Data System (TI-RADS).","DOI":"10.1016\/j.jacr.2017.01.046"},{"issue":"6","key":"1679_CR7","doi-asserted-by":"publisher","first-page":"791","DOI":"10.2214\/AJR.22.28556","volume":"220","author":"DH Kim","year":"2023","unstructured":"Kim DH, Kim SW, Basurrah MA, Lee J, Hwang SH. Diagnostic performance of six ultrasound risk stratification systems for thyroid nodules: A systematic review and network Meta-Analysis. AJR Am J Roentgenol. 2023;220(6):791\u2013803. Epub 2023 Feb 8. PMID: 36752367.","journal-title":"AJR Am J Roentgenol"},{"issue":"2","key":"1679_CR8","doi-asserted-by":"publisher","first-page":"424","DOI":"10.3390\/cancers15020424","volume":"15","author":"JS Kim","year":"2023","unstructured":"Kim JS, Kim BG, Stybayeva G, Hwang SH. Diagnostic performance of various ultrasound risk stratification systems for benign and malignant thyroid nodules: A meta-analysis. Cancers (Basel). 2023;15(2):424. https:\/\/doi.org\/10.3390\/cancers15020424. PMID: 36672373; PMCID: PMC9857194.","journal-title":"Cancers (Basel)"},{"issue":"2","key":"1679_CR9","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/hed.23878","volume":"38","author":"X Wei","year":"2016","unstructured":"Wei X, Li Y, Zhang S, Gao M. Meta-analysis of thyroid imaging reporting and data system in the ultrasonographic diagnosis of 10,437 thyroid nodules. Head Neck. 2016;38(2):309\u201315. https:\/\/doi.org\/10.1002\/hed.23878. Epub 2015 Jun 16. PMID: 25244250.","journal-title":"Head Neck"},{"issue":"6","key":"1679_CR10","doi-asserted-by":"publisher","first-page":"3776","DOI":"10.21037\/qims-22-968","volume":"13","author":"L Jiang","year":"2023","unstructured":"Jiang L, Zhu HB, Liang ZW, Chen L, Sun XM, Shao YH, Chen LZ. Comparison of the diagnostic performance and clinical role of different ultrasound-based thyroid malignancy risk stratification systems for medullary thyroid carcinoma. Quant Imaging Med Surg. 2023;13(6):3776\u201388. https:\/\/doi.org\/10.21037\/qims-22-968. Epub 2023 May 4. PMID: 37284109; PMCID: PMC10240009.","journal-title":"Quant Imaging Med Surg"},{"key":"1679_CR11","doi-asserted-by":"publisher","unstructured":"Matrone A, Gambale C, Biagini M, Prete A, Vitti P, Elisei R. Ultrasound features and risk stratification systems to identify medullary thyroid carcinoma. Eur J Endocrinol. 2021;185(2):193\u2013200. https:\/\/doi.org\/10.1530\/EJE-21-0313. PMID: 34010144.","DOI":"10.1530\/EJE-21-0313"},{"key":"1679_CR12","doi-asserted-by":"publisher","unstructured":"Koike E, Noguchi S, Yamashita H, Murakami T, Ohshima A, Kawamoto H, Yamashita H. Ultrasonographic characteristics of thyroid nodules: prediction of malignancy. Arch Surg. 2001;136(3):334-7.https:\/\/doi.org\/10.1001\/archsurg.136.3.334. PMID: 11231857.","DOI":"10.1001\/archsurg.136.3.334"},{"key":"1679_CR13","doi-asserted-by":"publisher","unstructured":"Kebebew E, Ituarte PH, Siperstein AE, Duh QY, Clark OH. Medullary thyroid carcinoma: clinical characteristics, treatment, prognostic factors, and a comparison of staging systems. Cancer. 2000Mar 1;88(5):1139-48.https:\/\/doi.org\/10.1002\/(sici)1097-0142(20000301)88:5%3C1139::aid-cncr26%3E3.0.co;2-z. PMID: 10699905.","DOI":"10.1002\/(sici)1097-0142(20000301)88:5%3C1139::aid-cncr26%3E3.0.co;2-z"},{"issue":"7","key":"1679_CR14","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1002\/cam4.2217","volume":"8","author":"J Zhu","year":"2019","unstructured":"Zhu J, Li X, Wei X, Yang X, Zhao J, Zhang S, Guo Z. The application value of modified thyroid imaging report and data system in diagnosing medullary thyroid carcinoma. Cancer Med. 2019;8(7):3389\u2013400. https:\/\/doi.org\/10.1002\/cam4.2217. Epub 2019 May 9. PMID: 31070290; PMCID: PMC6601574.","journal-title":"Cancer Med"},{"key":"1679_CR15","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1258\/ar.2010.100247","volume":"52","author":"N Choi","year":"2011","unstructured":"Choi N, Moon WJ, Lee JH, Baek JH, Kim DW, Park SW. Ultrasonographic findings of medullary thyroid cancer: differences according to tumor size and correlation with fine needle aspiration results. Acta Radiol. 2011;52:312\u20136.","journal-title":"Acta Radiol"},{"key":"1679_CR16","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.2214\/AJR.09.3276","volume":"194","author":"S Lee","year":"2010","unstructured":"Lee S, Shin JH, Han BK, Ko EY. Medullary thyroid carcinoma: comparison with papillary thyroid carcinoma and application of current sonographic criteria. AJR Am J Roentgenol. 2010;194:1090\u20134.","journal-title":"AJR Am J Roentgenol"},{"key":"1679_CR17","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1089\/thy.2009.0110","volume":"19","author":"DS Cooper","year":"2009","unstructured":"Cooper DS, Doherty GM, Haugen BR, et al. Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer: the American thyroid association (ATA) guidelines taskforce on thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19:1167\u2013214.","journal-title":"Thyroid"}],"container-title":["BMC Medical Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-025-01679-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12880-025-01679-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-025-01679-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T09:14:02Z","timestamp":1748250842000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedimaging.biomedcentral.com\/articles\/10.1186\/s12880-025-01679-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,26]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1679"],"URL":"https:\/\/doi.org\/10.1186\/s12880-025-01679-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4819192\/v1","asserted-by":"object"}]},"ISSN":["1471-2342"],"issn-type":[{"value":"1471-2342","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,26]]},"assertion":[{"value":"29 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This retrospective study was approved by the Ruijin Hospital Institutional Review Board, with waiver of informed consent. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"189"}}