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SLD presence or absence was confirmed through ultrasound in all participants. Two radiologists independently measured the CT attenuation values of the liver (CT<jats:sub>L<\/jats:sub>) and spleen (CT<jats:sub>S<\/jats:sub>). The differences (CT<jats:sub>L\u2212S<\/jats:sub>) and ratios (CT<jats:sub>L\/S<\/jats:sub>) between liver and spleens values were calculated. Independent sample t-tests or Mann\u2013Whitney U tests were used to compare CT<jats:sub>S<\/jats:sub>, CT<jats:sub>L<\/jats:sub>, CT<jats:sub>L\u2212S<\/jats:sub>, and CT<jats:sub>L\/S<\/jats:sub> between SLD and control groups. One-way analysis of covariance or Kruskal\u2013Wallis H tests were conducted to compare the parameters across scanning protocols. Receiver operating characteristic (ROC) analysis was performed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The parameters (CT<jats:sub>L<\/jats:sub>, CT<jats:sub>L\u2212S<\/jats:sub>, and CT<jats:sub>L\/S<\/jats:sub>) were significantly lower in the SLD group than in the control group across all scanning protocols (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In the control group, significant differences in CT<jats:sub>S<\/jats:sub> and CT<jats:sub>L<\/jats:sub> were observed among the three scanning protocols (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), while non-statistically significant differences were found for CT<jats:sub>L\u2212S<\/jats:sub> or CT<jats:sub>L\/S<\/jats:sub> across protocols in either group (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). The ROC analysis revealed abdominal CT<jats:sub>L<\/jats:sub> as the most accurate diagnostic marker for SLD (area under the curve [AUC]: 0.894, sensitivity: 90.91%, specificity: 83.33%). CT<jats:sub>L\u2212S<\/jats:sub> maintained stable diagnostic performance across protocols (AUC range: 0.813\u20130.816). The low-dose protocol achieved the best performance for CT<jats:sub>L\/S<\/jats:sub> (AUC: 0.810), demonstrating high specificity (94.34%) despite moderate sensitivity (64.81%).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Both chest CT and low-dose CT-derived parameters demonstrated diagnostic accuracy comparable to that of abdominal CT in assessing SLD, suggesting their potential as viable alternatives in specific clinical scenarios.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12880-025-01791-1","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T10:57:44Z","timestamp":1751367464000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of accuracy of CT parameters across chest, low-dose lung, and abdominal CT in diagnosing steatotic liver disease"],"prefix":"10.1186","volume":"25","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gengyu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixin","family":"Si","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinquan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"issue":"6","key":"1791_CR1","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1097\/HEP.0000000000000520","volume":"78","author":"ME Rinella","year":"2023","unstructured":"Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, Romero D, Abdelmalek MF, Anstee QM, Arab JP, et al. 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