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However, studies evaluating the image quality of DL-HASTE with and without fat saturation (FS) remain limited. This study aimed to prospectively evaluate the technical feasibility and image quality of abdominal DL-HASTE with and without FS at 3 Tesla.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and methods<\/jats:title>\n            <jats:p>DL-HASTE of the upper abdomen was acquired with variable sequence parameters regarding FS, flip angle (FA) and field of view (FOV) in 10 healthy volunteers and 50 patients. DL-HASTE sequences were compared to clinical sequences (HASTE, HASTE-FS and T2-TSE-FS BLADE). Two radiologists independently assessed the sequences regarding scores of overall image quality, delineation of abdominal organs, artifacts and fat saturation using a Likert scale (range: 1\u20135).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Breath-hold time of DL-HASTE and DL-HASTE-FS was 21\u2009\u00b1\u20092\u00a0s with fixed FA and 20\u2009\u00b1\u20092\u00a0s with variable FA (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with no overall image quality difference (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). DL-HASTE required a 10% larger FOV than DL-HASTE-FS to avoid aliasing artifacts from subcutaneous fat. Both DL-HASTE and DL-HASTE-FS had significantly higher overall image quality scores than standard HASTE acquisitions (DL-HASTE vs. HASTE: 4.8\u2009\u00b1\u20090.40 vs. 4.1\u2009\u00b1\u20090.50; DL-HASTE-FS vs. HASTE-FS: 4.6\u2009\u00b1\u20090.50 vs. 3.6\u2009\u00b1\u20090.60; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Compared to the T2-TSE-FS BLADE, DL-HASTE-FS provided higher overall image quality (4.6\u2009\u00b1\u20090.50 vs. 4.3\u2009\u00b1\u20090.63, <jats:italic>p<\/jats:italic>\u2009=\u20090.011). DL-HASTE achieved significant higher image quality (<jats:italic>p<\/jats:italic>\u2009=\u20090.006) and higher sharpness score of organs compared to DL-HASTE-FS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Deep learning-accelerated HASTE with and without fat saturation were both feasible at 3 Tesla and showed improved image quality compared to conventional sequences.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial registration<\/jats:title>\n            <jats:p>Not applicable.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12880-025-01838-3","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T14:27:04Z","timestamp":1758205624000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Optimized deep learning-accelerated single-breath-hold abdominal HASTE with and without fat saturation improves and accelerates abdominal imaging at 3 Tesla"],"prefix":"10.1186","volume":"25","author":[{"given":"Qinxuan","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Kubicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Nickel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Weiland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Hamm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Geisel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thula C.","family":"Walter-Rittel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"issue":"2","key":"1838_CR1","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.ejrad.2007.11.015","volume":"65","author":"M Dujardin","year":"2008","unstructured":"Dujardin M, Vandenbroucke F, Boulet C, Op de Beeck B, de Mey J. 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Written informed consent was obtained from all participants and patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written and informed consent for publication of anonymised data was obtained from all participants and patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Prof. Dr. Bernd Hamm has relationships with the following companies or institutions: Abbott, AbbVie, Ablative Solutions, Accovion, Achaogen Inc. Actelion Pharmaceutical. ADIR. Aesculap. Agios Pharmaceuticals, INC. AGO. AIF Arbeitsgemeinschaft industrieller Forschungsvereinigungen, AIO Arbeitsgemeinschaft Internistische Onkologie, Aktionsb\u00fcndnis Patientensicherheit e.V. Alexion Pharmaceuticals. Amgen. AO Foundation. Arena Pharmaceuticals. ARMO Biosciences, Inc. Art photonics GmbH Berlin. ASAS, Ascelia Pharma AB, Ascendis, ASR Advanced sleep research, Astellas, BARD, Basiliea, Bayer Healthcare, Bayer Vital, Braun, BerGenBioASA, Berlin-Brandenburger Centrum f\u00fcr Regenerative Therapie (BCRT), Berliner Krebsgesellschaft, Biontech Mainz, BioNTech SE, Biotronik, Bioven, BMBF, Boehring Ingelheimer, Boston Biomedical Inc., Boston Scientific Medizintechnik GmbH, BRACCO Broup, Brahms GmbH, Brainsgate, Bristol-Myers Squibb, Calithera Biosciences UK, Cantargia AB, Medicon Village, Cascadian Therapeutics, Inc., Celgene, CELLACT Pharma, Celldex Therapeutics, Cellestia Biontech AG CH, CeloNova BioSciences, Charit\u00e9 research organization GmbH, Chiltern, CLOVIS ONCOLOGY, Inc., Covance, CRO Chrarit\u00e9, CUBIST, CureVac AG, T\u00fcbingen, Curis, Daiichi Sankyo, Dartmouth College, Hanover, NH, USA, DC Devices, Inc. USA, Delcath Systems, Dermira Inc., Deutsche Krebshilfe, Deutsche Rheuma Liga, DZ-Deutsches Diabetes Forschungsgesellschaft e.V., Deutsches Zentrum f\u00fcr Luft- und Raumfahrt e.V., DFG, Dr. Falk Pharma GmbH, DSM Nutritional Products AG, Dt. Stiftung f\u00fcr Herzforschung, Dynavax, Eisai Ltd., European Knowledge Centre, Mosquito Way, Hatfield, Eli Lilly and Conpany Ltd., EORTC, Episurf Medical, Epizyme, Inc., Essex Pharma, EU Programmes, Euroscreen S.A., F20 Biotech GmbH, Ferring Pharmaceuticals A\/S, Fibrex Medical Inc., Focussed Ultrasound Surgery Foundation, Fraunhofer Gesellschaft, Galena Biopharma, Galmed Research and Development Ltd., Ganymed, GBG Forschung BmbH, GE, Gentech, Inc., Genmab A\/S, Genzyme Europe B.V., GETNE (Grupo Espa\u00f1ol de Tumores Neuroendocrinos, Gilead Sciences, Inc., Glaxo Smith Kline, Glycotope GmbH, Berlin, Goethe Uni Frankfurt, Guerbet. Guidant Europe NV, Halozyme, Hans-Bl\u00f6ckler-Stiftung, Hewlett Packard GmbH, Holaira, Inc., Horizon Therapeutics Ireland, ICON (CRO), Idera Pharmaceutics, Inc., Ignyta, Inc., Immunimedics, Inc., Immunocore, Incyte, INC Research, Innate Pharma, InSightec Ltd, Inspiremd, inVentiv Health Clinical UK Ltd., Inventivhealth, IOMEDICO IONIS IPSEN Pharma IQVIA ISA Therapeutics Isis Pharmaceuticals, Inc. ITM Solucin GmbH Jansen-Cilag GmbH Kantar Health GmbH (CRO) Kartos Therapeutics, Inc. Karyopharm Therapeutics, Inc. Kendle\/MorphoSys AG Kite Pharma Kli Fo Berlin Mitte Kura Oncology, Inc. La Roche Land Berlin Lilly GmbH Lion Biontechnology Lombard Medical Loxo Oncology, Inc. LSK BioPartner, USA Lundbeck GmbH LUX Biosciences LYSARC MacroGenics MagForce MedImmune, Inc, Medpace Germany GmbH (CRO) MedPass (CRO) Medronic Medtrave\u00f6 GmbH Merck Merrimack Pharmaceuticals, Inc. MeVis Medical Solutions AG Miltenyi Biomedicine GmbH, Bergisch Gladbach miRagen Boukider Mologen MorphoSysAG MSD Sharp Nektar Therapeutics NeoVacs SA Newlink Genetics Corporation Nexus Oncology NIH NOGGO Berlin, Novartis, Novocure, Nuvisan, Ockham oncology, Odonate Therapeutics San Diago. OHIRC Kanada, Orion Corporation Orion Pharma, OSE Immunitherapeutics, Parexel CRO Service, PentixalPharmGmbH, Perceptive. Pfizer GmbH, PharmaCept GmbH, Pharma Mar, Pharmaceutical Research Associates GmbH (PRA), Pharmacyclines, Inc., Philipps, Philogen s.p.a.Siena, Pliant Therapeutics San Francisco, PIQUR Therapeutics Ltd., Pluristem, PneumRX, Inc., Portola Pharmaceuticals, PPD (CRO), PRAint, Premier-research, Provectus Biopharmaceuticals, Inc., Psi-cro, Pulmonx International S\u00e0rl Quintiles GmbH Radiobotics ApS Regeneron Pharmaceuticals, Inc. Replimune Respicardia Rhythm Pharmaceuticals, Inc., Boston USA Roche Salix Pharmaceuticals, Inc. Samsung Sanofi Sanofis-aventis S.A. Saving Patient\u00b4s Lives Medical B.V. Schumacher GmbH Seattle Genetics Servier (CRO) SGS Life Science Service (CRO) Shire Human Genetic Therapies Siemens Silena Therapeutics SIRTEX Medical Europe GmbH Spectranetics GmbH Spectrum Pharmaceuticals Stiftung Charit\u00e9\/ BIH St. Jude Medical Stiftung Wolfgang Schulze Syneos Health UK, Limited, Symphogen Taiho Oncology, Inc. Taiho Pharmaceutical Co. Target Pharma Solutions, Inc. TauRx Therapeutics Ltd. Terumo Medical Corporation Tesaro Tetec-ag TEVA Theorem Rheradex Theravance Threshold Pharmaceuticals, Inc. TNS Healthcare GmbH Toshiba UCB Pharma Uni Jena Uni M\u00fcnchen Uni T\u00fcbingen Vaccibody A.S. VDI\/VDE, Vertex Pharmaceuticals Incorporated Virtualscopis LLC, Winicker-norimed, Wyeth Pharma, Xcovery Holding Company. Zukunftsfond Berlin (TSB)Dominik Geisel is a section editor for BMC medical imaging and reports speaker honoraria for Siemens Healthineers.Dominik Nickel, Elisabeth Weiland, Qinxuan Tan, Felix-Maximilian Kubicka, Moritz Wagner and Thula C. Walter-Rittel declare no relationships with any companies whose products or services may be related to the subject matter of the article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"369"}}