{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:29:41Z","timestamp":1770989381963,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Changzhou Science and Technology Program"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"DOI":"10.1186\/s12880-026-02167-9","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T03:43:36Z","timestamp":1768967016000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the direct effect of remote ischemic preconditioning on the rabbit\u2019s kidney by R2\u2019 mapping technique: an experimental study"],"prefix":"10.1186","volume":"26","author":[{"given":"Zhangyan","family":"Bi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyu","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longfei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xintian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiule","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"issue":"9","key":"2167_CR1","doi-asserted-by":"publisher","first-page":"F1026","DOI":"10.1152\/ajprenal.00281.2013","volume":"306","author":"A Abdelkader","year":"2014","unstructured":"Abdelkader A, Ho J, Ow CP, Eppel GA, Rajapakse NW, Schlaich MP, Evans RG. Renal oxygenation in acute renal ischemia-reperfusion injury. Am J Physiol Ren Physiol. 2014;306(9):F1026\u201338.","journal-title":"Am J Physiol Ren Physiol"},{"issue":"1","key":"2167_CR2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s10157-011-0495-0","volume":"16","author":"T Wang","year":"2012","unstructured":"Wang T. Renal outer medullary potassium channel knockout models reveal Thick ascending limb function and dysfunction. Clin Exp Nephrol. 2012;16(1):49\u201354.","journal-title":"Clin Exp Nephrol"},{"issue":"6","key":"2167_CR3","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.semnephrol.2019.10.005","volume":"39","author":"C Rosenberger","year":"2019","unstructured":"Rosenberger C, Eckardt KU. Oxygenation of the transplanted kidney. Semin Nephrol. 2019;39(6):554\u201366.","journal-title":"Semin Nephrol"},{"issue":"2","key":"2167_CR4","doi-asserted-by":"publisher","first-page":"110","DOI":"10.28920\/dhm47.2.110-117","volume":"47","author":"A Francis","year":"2017","unstructured":"Francis A, Baynosa R. Ischaemia-reperfusion injury and hyperbaric oxygen pathways: a review of cellular mechanisms. Diving Hyperb Med. 2017;47(2):110\u20137.","journal-title":"Diving Hyperb Med"},{"issue":"9","key":"2167_CR5","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1590\/S0102-86502012000900005","volume":"27","author":"MO Taha","year":"2012","unstructured":"Taha MO, Caricati-Neto A, Ferreira RM, Sim\u00f5es Mde J, Monteiro HP, Fagundes DJ. L-arginine in the ischemic phase protects against liver ischemia-reperfusion injury. Acta Cir Bras. 2012;27(9):616\u201323.","journal-title":"Acta Cir Bras"},{"key":"2167_CR6","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.2147\/DDDT.S223742","volume":"14","author":"Y Zheng","year":"2020","unstructured":"Zheng Y, Lu H, Huang H. Desflurane preconditioning protects against renal Ischemia-Reperfusion injury and inhibits inflammation and oxidative stress in rats through regulating the Nrf2-Keap1-ARE signaling pathway. Drug Des Devel Ther. 2020;14:1351\u201362.","journal-title":"Drug Des Devel Ther"},{"issue":"2","key":"2167_CR7","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3233\/CH-189414","volume":"71","author":"G Varga","year":"2019","unstructured":"Varga G, Ghanem S, Szabo B, Nagy K, Pal N, Tanczos B, Somogyi V, Barath B, Deak A, Peto K, et al. Renal ischemia-reperfusion-induced metabolic and micro-rheological alterations and their modulation by remote organ ischemic preconditioning protocols in the rat. Clin Hemorheol Microcirc. 2019;71(2):225\u201336.","journal-title":"Clin Hemorheol Microcirc"},{"key":"2167_CR8","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.pneurobio.2017.01.001","volume":"157","author":"S Li","year":"2017","unstructured":"Li S, Hafeez A, Noorulla F, Geng X, Shao G, Ren C, Lu G, Zhao H, Ding Y, Ji X. Preconditioning in neuroprotection: from hypoxia to ischemia. Prog Neurobiol. 2017;157:79\u201391.","journal-title":"Prog Neurobiol"},{"issue":"5","key":"2167_CR9","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1249\/MSS.0000000000001882","volume":"51","author":"CC Wiggins","year":"2019","unstructured":"Wiggins CC, Constantini K, Paris HL, Mickleborough TD, Chapman RF, Ischemic Preconditioning. O2 Kinetics, and performance in normoxia and hypoxia. Med Sci Sports Exerc. 2019;51(5):900\u201311.","journal-title":"Med Sci Sports Exerc"},{"issue":"7","key":"2167_CR10","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1111\/j.1432-2277.2012.01481.x","volume":"25","author":"S Kanoria","year":"2012","unstructured":"Kanoria S, Glantzounis G, Quaglia A, Dinesh S, Fusai G, Davidson BR, Seifalian AM. Remote preconditioning improves hepatic oxygenation after ischaemia reperfusion injury. Transpl Int. 2012;25(7):783\u201391.","journal-title":"Transpl Int"},{"issue":"11","key":"2167_CR11","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1161\/CIRCULATIONAHA.119.044998","volume":"142","author":"D Shan","year":"2020","unstructured":"Shan D, Guo S, Wu HK, Lv F, Jin L, Zhang M, Xie P, Wang Y, Song Y, Wu F, et al. Cardiac ischemic preconditioning promotes MG53 secretion through H(2)O(2)-Activated protein kinase C-\u03b4 signaling. Circulation. 2020;142(11):1077\u201391.","journal-title":"Circulation"},{"key":"2167_CR12","doi-asserted-by":"publisher","first-page":"113142","DOI":"10.1016\/j.expneurol.2019.113142","volume":"325","author":"T Yang","year":"2020","unstructured":"Yang T, Sun Y, Li Q, Li S, Shi Y, Leak RK, Chen J, Zhang F. Ischemic preconditioning provides long-lasting neuroprotection against ischemic stroke: the role of Nrf2. Exp Neurol. 2020;325:113142.","journal-title":"Exp Neurol"},{"key":"2167_CR13","doi-asserted-by":"publisher","first-page":"105711","DOI":"10.1016\/j.intimp.2019.105711","volume":"74","author":"T Jiang","year":"2019","unstructured":"Jiang T, Zhan F, Rao Z, Pan X, Zhong W, Sun Y, Wang P, Lu L, Zhou H, Wang X. Combined ischemic and Rapamycin preconditioning alleviated liver ischemia and reperfusion injury by restoring autophagy in aged mice. Int Immunopharmacol. 2019;74:105711.","journal-title":"Int Immunopharmacol"},{"issue":"suppl2","key":"2167_CR14","doi-asserted-by":"publisher","first-page":"ii22","DOI":"10.1093\/ndt\/gfy243","volume":"33","author":"M Pruijm","year":"2018","unstructured":"Pruijm M, Mendichovszky IA, Liss P, Van der Niepen P, Textor SC, Lerman LO, Krediet CTP, Caroli A, Burnier M, Prasad PV. Renal blood oxygenation level-dependent magnetic resonance imaging to measure renal tissue oxygenation: a statement paper and systematic review. Nephrol Dial Transpl. 2018;33(suppl2):ii22\u20138.","journal-title":"Nephrol Dial Transpl"},{"issue":"8","key":"2167_CR15","doi-asserted-by":"publisher","first-page":"e0161408","DOI":"10.1371\/journal.pone.0161408","volume":"11","author":"A Seiler","year":"2016","unstructured":"Seiler A, Deichmann R, Pfeilschifter W, Hattingen E, Singer OC, Wagner M. T2-Imaging to assess cerebral oxygen extraction fraction in carotid occlusive Disease. Influence of cerebral autoregulation and cerebral blood volume. PLoS ONE. 2016;11(8):e0161408.","journal-title":"PLoS ONE"},{"issue":"3","key":"2167_CR16","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1177\/0271678X17732448","volume":"39","author":"A Seiler","year":"2019","unstructured":"Seiler A, Blockley NP, Deichmann R, N\u00f6th U, Singer OC, Chappell MA, Klein JC, Wagner M. The relationship between blood flow impairment and oxygen depletion in acute ischemic stroke imaged with magnetic resonance imaging. J Cereb Blood Flow Metab. 2019;39(3):454\u201365.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2167_CR17","doi-asserted-by":"crossref","unstructured":"Chandrasekharan P, Kuo R, Fung KLB, Saayujya C, Bryan J, Yousuf M, et al. Magnetic Particle Imaging in Vascular Imaging, Immunotherapy, Cell Tracking, and Noninvasive Diagnosis. Mol Imaging. 2023;2023:4131117.","DOI":"10.1155\/2023\/4131117"},{"issue":"2","key":"2167_CR18","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1002\/mrm.28696","volume":"86","author":"J Zhang","year":"2021","unstructured":"Zhang J, Chen J, Chen Q, Chen J, Luo K, Pan L, Zhang Y, Dou W, Xing W. Can R(2) ' mapping evaluate hypoxia in renal ischemia reperfusion injury quantitatively? An experimental study. Magn Reson Med. 2021;86(2):974\u201383.","journal-title":"Magn Reson Med"},{"issue":"5","key":"2167_CR19","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1213\/ANE.0000000000002864","volume":"126","author":"P Schober","year":"2018","unstructured":"Schober P, Boer C, Schwarte LA. Correlation coefficients: appropriate use and interpretation. Anesth Analg. 2018;126(5):1763\u20138.","journal-title":"Anesth Analg"},{"issue":"2","key":"2167_CR20","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jjcc.2022.09.002","volume":"81","author":"T Sato","year":"2023","unstructured":"Sato T, Takeda N. The roles of HIF-1\u03b1 signaling in cardiovascular diseases. J Cardiol. 2023;81(2):202\u20138.","journal-title":"J Cardiol"},{"issue":"6","key":"2167_CR21","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.7150\/ijbs.32004","volume":"15","author":"L Zhang","year":"2019","unstructured":"Zhang L, Liu H, Xu K, Ling Z, Huang Y, Hu Q, Lu K, Liu C, Wang Y, Liu N, et al. Hypoxia preconditioned renal tubular epithelial cell-derived extracellular vesicles alleviate renal ischaemia-reperfusion injury mediated by the HIF-1\u03b1\/Rab22 pathway and potentially affected by MicroRNAs. Int J Biol Sci. 2019;15(6):1161\u201376.","journal-title":"Int J Biol Sci"},{"issue":"1","key":"2167_CR22","first-page":"6","volume":"180","author":"RA Voit","year":"2020","unstructured":"Voit RA, Sankaran VG, Stabilizing. HIF Ameliorate Anemia Cell. 2020;180(1):6.","journal-title":"HIF Ameliorate Anemia Cell"},{"issue":"2","key":"2167_CR23","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41419-022-04505-5","volume":"13","author":"H Wei","year":"2022","unstructured":"Wei H, Xu Z, Chen L, Wei Q, Huang Z, Liu G, Li W, Wang J, Tang Q, Pu J. Long non-coding RNA PAARH promotes hepatocellular carcinoma progression and angiogenesis via upregulating HOTTIP and activating HIF-1\u03b1\/VEGF signaling. Cell Death Dis. 2022;13(2):102.","journal-title":"Cell Death Dis"},{"key":"2167_CR24","doi-asserted-by":"publisher","first-page":"115912","DOI":"10.1016\/j.ejmech.2023.115912","volume":"262","author":"J Wu","year":"2023","unstructured":"Wu J, Jia J, Ji D, Jiao W, Huang Z, Zhang Y. Advances in nitric oxide regulators for the treatment of ischemic stroke. Eur J Med Chem. 2023;262:115912.","journal-title":"Eur J Med Chem"},{"key":"2167_CR25","doi-asserted-by":"crossref","unstructured":"Yang J, Yan M, Wang Z, Zhang C, Guan M, Sun Z. Optical and MRI multimodal tracing of stem cells in vivo. Mol Imaging. 2023;2023:4223485.","DOI":"10.1155\/2023\/4223485"},{"key":"2167_CR26","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/978-1-4899-7678-9_18","volume":"903","author":"CW Pugh","year":"2016","unstructured":"Pugh CW. Modulation of the hypoxic response. Adv Exp Med Biol. 2016;903:259\u201371.","journal-title":"Adv Exp Med Biol"},{"key":"2167_CR27","doi-asserted-by":"publisher","first-page":"1549276","DOI":"10.3389\/fimmu.2025.1549276","volume":"16","author":"S Shi","year":"2025","unstructured":"Shi S, Ou X, Liu C, Wen H, Ke J. Research progress of HIF-1a on immunotherapy outcomes in immune vascular microenvironment. Front Immunol. 2025;16:1549276.","journal-title":"Front Immunol"},{"key":"2167_CR28","doi-asserted-by":"crossref","unstructured":"Siedek F, Persigehl T, Mueller RU, Burst V, Benzing T, Maintz D, Haneder S, Magma. 2018;31(3):367\u201374.","DOI":"10.1007\/s10334-017-0658-4"},{"issue":"1","key":"2167_CR29","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1186\/s12951-024-02683-2","volume":"22","author":"W Bu","year":"2024","unstructured":"Bu W, Shi Y, Huang X, Wu S, Jiang L, Pan C, Li D, Xu Z, Wang H, Chen H, et al. Rescue of nucleus pulposus cells from an oxidative stress microenvironment via glutathione-derived carbon Dots to alleviate intervertebral disc degeneration. J Nanobiotechnol. 2024;22(1):412.","journal-title":"J Nanobiotechnol"},{"issue":"5","key":"2167_CR30","doi-asserted-by":"publisher","first-page":"874","DOI":"10.3390\/antiox11050874","volume":"11","author":"C Tangeten","year":"2022","unstructured":"Tangeten C, Zouaoui Boudjeltia K, Delporte C, Van Antwerpen P, Korpak K. Unexpected role of MPO-Oxidized LDLs in atherosclerosis: in between inflammation and its resolution. Antioxid (Basel). 2022;11(5):874.","journal-title":"Antioxid (Basel)"},{"key":"2167_CR31","doi-asserted-by":"crossref","unstructured":"Kuusik K, Kasepalu T, Zilmer M, Eha J, V\u00e4hi M, Torop LA, Lieberg J, Kals J. The role of RIPC in preventing organ damage, inflammation, and oxidative stress during lower limb DSA. A randomised controlled trial. Oxid Med Cell Longev. 2021;2021:6043550.","DOI":"10.1155\/2021\/6043550"},{"issue":"1","key":"2167_CR32","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13578-023-00999-4","volume":"13","author":"C Gu","year":"2023","unstructured":"Gu C, Kong F, Zeng J, Geng X, Sun Y, Chen X. Remote ischemic preconditioning protects against spinal cord ischemia-reperfusion injury in mice by activating NMDAR\/AMPK\/PGC-1\u03b1\/SIRT3 signaling. Cell Biosci. 2023;13(1):57.","journal-title":"Cell Biosci"},{"issue":"7","key":"2167_CR33","doi-asserted-by":"publisher","first-page":"8887","DOI":"10.1096\/fj.202000274R","volume":"34","author":"R Chen","year":"2020","unstructured":"Chen R, Zeng Z, Zhang YY, Cao C, Liu HM, Li W, Wu Y, Xia ZY, Ma D, Meng QT. Ischemic postconditioning attenuates acute kidney injury following intestinal ischemia-reperfusion through Nrf2-regulated autophagy, anti-oxidation, and anti-inflammation in mice. Faseb J. 2020;34(7):8887\u2013901.","journal-title":"Faseb J"},{"issue":"1","key":"2167_CR34","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1080\/0886022X.2020.1729189","volume":"42","author":"IO Sherif","year":"2020","unstructured":"Sherif IO, Alshaalan AA, Al-Shaalan NH. Renoprotective effect of vildagliptin following hepatic ischemia\/reperfusion injury. Ren Fail. 2020;42(1):208\u201315.","journal-title":"Ren Fail"},{"key":"2167_CR35","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jclinane.2017.05.017","volume":"41","author":"YY Hou","year":"2017","unstructured":"Hou YY, Li Y, He SF, Song J, Yu DX, Wong GTC, Zhang Y. Effects of differential-phase remote ischemic preconditioning intervention in laparoscopic partial nephrectomy: A single blinded, randomized controlled trial in a parallel group design. J Clin Anesth. 2017;41:21\u20138.","journal-title":"J Clin Anesth"},{"issue":"5","key":"2167_CR36","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.bja.2019.07.019","volume":"123","author":"KV Veighey","year":"2019","unstructured":"Veighey KV, Nicholas JM, Clayton T, Knight R, Robertson S, Dalton N, Harber M, Watson CJE, De Fijter JW, Loukogeorgakis S, et al. Early remote ischaemic preconditioning leads to sustained improvement in allograft function after live donor kidney transplantation: long-term outcomes in the renal protection against Ischaemia-Reperfusion in transplantation (REPAIR) randomised trial. Br J Anaesth. 2019;123(5):584\u201391.","journal-title":"Br J Anaesth"}],"container-title":["BMC Medical Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12880-026-02167-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-026-02167-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-026-02167-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:22:54Z","timestamp":1770985374000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12880-026-02167-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2167"],"URL":"https:\/\/doi.org\/10.1186\/s12880-026-02167-9","relation":{},"ISSN":["1471-2342"],"issn-type":[{"value":"1471-2342","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]},"assertion":[{"value":"9 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experimental rabbits used in this study were from Laifu Farm in Pukou District, Nanjing City (Experimental Animal Production License Number: SCXK(Su)2024-0007) and received informed consent from the farm director. This study was approved by the Ethics Committee for Animal Experimentation in the Jiangsu Aniphe Biolaboratory Inc.(JSAB24019M) and adhered to the Guide for the Care and Use of Laboratory Animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"90"}}