{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:30:03Z","timestamp":1773851403629,"version":"3.50.1"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":34,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"DOI":"10.1186\/s12880-026-02223-4","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:55:10Z","timestamp":1770882910000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional connectivity patterns of the cerebellar components of intrinsic connectivity networks in clinically diagnosed probable Alzheimer\u2019s disease"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-5507","authenticated-orcid":false,"given":"Emre","family":"Hari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1849-0055","authenticated-orcid":false,"given":"Cigdem","family":"Ulasoglu-Yildiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1956-575X","authenticated-orcid":false,"given":"Elif","family":"Kurt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9003-5781","authenticated-orcid":false,"given":"Osman","family":"Kahveci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2908-8475","authenticated-orcid":false,"given":"Hakan","family":"Gurvit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6803-734X","authenticated-orcid":false,"given":"Tamer","family":"Demiralp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"2223_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40673-015-0029-8","volume":"2","author":"M Coco","year":"2015","unstructured":"Coco M, Perciavalle V. Where did the motor function of the cerebellum come from? Cerebellum Ataxias. 2015;2:10. https:\/\/doi.org\/10.1186\/s40673-015-0029-8.","journal-title":"Cerebellum Ataxias"},{"key":"2223_CR2","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1001\/archneur.1991.00530230086029","volume":"48","author":"JD Schmahmann","year":"1991","unstructured":"Schmahmann JD. An emerging concept: the cerebellar contribution to higher function. Arch Neurol. 1991;48:1178\u201387. https:\/\/doi.org\/10.1001\/archneur.1991.00530230086029.","journal-title":"Arch Neurol"},{"key":"2223_CR3","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/S1364-6613(98)01218-2","volume":"2","author":"JD Schmahmann","year":"1998","unstructured":"Schmahmann JD. Dysmetria of thought: clinical consequences of cerebellar dysfunction on cognition and affect. Trends Cogn Sci. 1998;2:362\u201371. https:\/\/doi.org\/10.1016\/S1364-6613(98)01218-2.","journal-title":"Trends Cogn Sci"},{"key":"2223_CR4","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1093\/brain\/121.4.561","volume":"121","author":"JD Schmahmann","year":"1998","unstructured":"Schmahmann JD, Sherman JC. The cerebellar cognitive affective syndrome. Brain. 1998;121:561\u201379. https:\/\/doi.org\/10.1093\/brain\/121.4.561.","journal-title":"Brain"},{"key":"2223_CR5","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1176\/jnp.16.3.367","volume":"16","author":"JD Schmahmann","year":"2004","unstructured":"Schmahmann JD. Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. J Neuropsychiatry Clin Neurosci. 2004;16:367\u201378. https:\/\/doi.org\/10.1176\/jnp.16.3.367.","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"2223_CR6","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.neurobiolaging.2019.10.026","volume":"89","author":"G Olivito","year":"2020","unstructured":"Olivito G, Serra L, Marra C, Di Domenico C, Caltagirone C, Toniolo S, et al. Cerebellar dentate nucleus functional connectivity with cerebral cortex in alzheimer\u2019s disease and memory: a seed-based approach. Neurobiol Aging. 2020;89:32\u201340. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2019.10.026.","journal-title":"Neurobiol Aging"},{"key":"2223_CR7","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1016\/j.jpsychires.2007.12.002","volume":"42","author":"PA Thomann","year":"2008","unstructured":"Thomann PA, Schl\u00e4fer C, Seidl U, Dos Santos V, Essig M, Schr\u00f6der J. The cerebellum in mild cognitive impairment and alzheimer\u2019s disease\u2013a structural MRI study. J Psychiatr Res. 2008;42:1198\u2013202. https:\/\/doi.org\/10.1016\/j.jpsychires.2007.12.002.","journal-title":"J Psychiatr Res"},{"key":"2223_CR8","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3389\/fncel.2018.00430","volume":"12","author":"S Toniolo","year":"2018","unstructured":"Toniolo S, Serra L, Olivito G, Marra C, Bozzali M, Cercignani M. Patterns of cerebellar Gray matter atrophy across alzheimer\u2019s disease progression. Front Cell Neurosci. 2018;12:430. https:\/\/doi.org\/10.3389\/fncel.2018.00430.","journal-title":"Front Cell Neurosci"},{"key":"2223_CR9","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s00401-007-0200-2","volume":"113","author":"T Uchihara","year":"2007","unstructured":"Uchihara T. Silver diagnosis in neuropathology: principles, practice and revised interpretation. Acta Neuropathol. 2007;113:483\u201399. https:\/\/doi.org\/10.1007\/s00401-007-0200-2.","journal-title":"Acta Neuropathol"},{"key":"2223_CR10","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0197-4580(95)00021-6","volume":"16","author":"H Braak","year":"1995","unstructured":"Braak H, Braak E. Staging of alzheimer\u2019s disease-related neurofibrillary changes. Neurobiol Aging. 1995;16:271\u201384. https:\/\/doi.org\/10.1016\/0197-4580(95)00021-6.","journal-title":"Neurobiol Aging"},{"key":"2223_CR11","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991;82:239\u201359. https:\/\/doi.org\/10.1007\/BF00308809.","journal-title":"Acta Neuropathol"},{"key":"2223_CR12","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","volume":"58","author":"DR Thal","year":"2002","unstructured":"Thal DR, R\u00fcb U, Orantes M, Braak H. Phases of A\u03b2-deposition in the human brain and its relevance for the development of AD. Neurology. 2002;58:1791\u2013800. https:\/\/doi.org\/10.1212\/WNL.58.12.1791.","journal-title":"Neurology"},{"key":"2223_CR13","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/ana.410280502","volume":"28","author":"M Mesulam","year":"1990","unstructured":"Mesulam M. Large-scale neurocognitive networks and distributed processing for attention, language, and memory. Annals Neurology: Official J Am Neurol Association Child Neurol Soc. 1990;28:597\u2013613. https:\/\/doi.org\/10.1002\/ana.410280502.","journal-title":"Annals Neurology: Official J Am Neurol Association Child Neurol Soc"},{"key":"2223_CR14","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.clinph.2024.06.018","volume":"165","author":"E Hari","year":"2024","unstructured":"Hari E, Ulasoglu-Yildiz C, Kurt E, Bayram A, Gurvit H, Demiralp T. Volumetric and functional connectivity changes of the thalamic nuclei in different stages of alzheimer\u2019s disease. Clin Neurophysiol. 2024;165:127\u201337. https:\/\/doi.org\/10.1016\/j.clinph.2024.06.018.","journal-title":"Clin Neurophysiol"},{"key":"2223_CR15","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1146\/annurev-neuro-071013-014030","volume":"38","author":"ME Raichle","year":"2015","unstructured":"Raichle ME. The brain\u2019s default mode network. Annu Rev Neurosci. 2015;38:433\u201347. https:\/\/doi.org\/10.1146\/annurev-neuro-071013-014030.","journal-title":"Annu Rev Neurosci"},{"key":"2223_CR16","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.dadm.2017.03.007","volume":"8","author":"A Badhwar","year":"2017","unstructured":"Badhwar A, Tam A, Dansereau C, Orban P, Hoffstaedter F, Bellec P. Resting-state network dysfunction in alzheimer\u2019s disease: a systematic review and meta-analysis. Alzheimer\u2019s Dementia: Diagnosis Assess Disease Monit. 2017;8:73\u201385. https:\/\/doi.org\/10.1016\/j.dadm.2017.03.007.","journal-title":"Alzheimer\u2019s Dementia: Diagnosis Assess Disease Monit"},{"key":"2223_CR17","doi-asserted-by":"publisher","unstructured":"Greicius G MD, Srivastava, Reiss AL, Menon V. Default-mode network activity distinguishes alzheimer\u2019s disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci. 2004;101:4637\u201342. https:\/\/doi.org\/10.1073\/pnas.0308627101.","DOI":"10.1073\/pnas.0308627101"},{"key":"2223_CR18","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.biopsych.2009.08.024","volume":"67","author":"YI Sheline","year":"2010","unstructured":"Sheline YI, Raichle ME, Snyder AZ, Morris JC, Head D, Wang S, et al. Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly. Biol Psychiatry. 2010;67:584\u20137. https:\/\/doi.org\/10.1016\/j.biopsych.2009.08.024.","journal-title":"Biol Psychiatry"},{"key":"2223_CR19","doi-asserted-by":"publisher","first-page":"17035","DOI":"10.1523\/JNEUROSCI.3987-10.2010","volume":"30","author":"YI Sheline","year":"2010","unstructured":"Sheline YI, Morris JC, Snyder AZ, Price JL, Yan Z, D\u2019Angelo G, et al. APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF A\u03b242. J Neurosci. 2010;30:17035\u201340. https:\/\/doi.org\/10.1523\/JNEUROSCI.3987-10.2010.","journal-title":"J Neurosci"},{"key":"2223_CR20","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011","author":"BTT Yeo","year":"2011","unstructured":"Yeo BTT, Krienen FM, Sepulcre J, Sabuncu MR, Lashkari D, Hollinshead M, et al. The organization of the human cerebral cortex estimated by intrinsic functional connectivity. J Neurophysiol. 2011. https:\/\/doi.org\/10.1152\/jn.00338.2011.","journal-title":"J Neurophysiol"},{"key":"2223_CR21","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1152\/jn.00339.2011","volume":"106","author":"RL Buckner","year":"2011","unstructured":"Buckner RL, Krienen FM, Castellanos A, Diaz JC, Yeo BTT. The organization of the human cerebellum estimated by intrinsic functional connectivity. J Neurophysiol. 2011;106:2322\u201345. https:\/\/doi.org\/10.1152\/jn.00339.2011.","journal-title":"J Neurophysiol"},{"key":"2223_CR22","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1002\/gps.1610","volume":"21","author":"E Mioshi","year":"2006","unstructured":"Mioshi E, Dawson K, Mitchell J, Arnold R, Hodges JR. The addenbrooke\u2019s cognitive examination revised (ACE-R): a brief cognitive test battery for dementia screening. Int J Geriatr Psychiatry. 2006;21:1078\u201385. https:\/\/doi.org\/10.1002\/gps.1610.","journal-title":"Int J Geriatr Psychiatry"},{"key":"2223_CR23","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1080\/01688638408401233","volume":"6","author":"H Buschke","year":"1984","unstructured":"Buschke H. Cued recall in amnesia. J Clin Neuropsychol. 1984;6:433\u201340. https:\/\/doi.org\/10.1080\/01688638408401233.","journal-title":"J Clin Neuropsychol"},{"key":"2223_CR24","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein MF, Folstein SE, McHugh PR. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189\u201398. https:\/\/doi.org\/10.1016\/0022-3956(75)90026-6.","journal-title":"J Psychiatr Res"},{"key":"2223_CR25","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1080\/01688639708403753","volume":"19","author":"RJ Ivnik","year":"1997","unstructured":"Ivnik RJ, Smith GE, Lucas JA, Tangalos EG, Kokmen E, Petersen RC. Free and cued selective reminding test: MOANS norms. J Clin Exp Neuropsychol. 1997;19:676\u201391. https:\/\/doi.org\/10.1080\/01688639708403753.","journal-title":"J Clin Exp Neuropsychol"},{"key":"2223_CR26","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a","author":"JC Morris","year":"1993","unstructured":"Morris JC. The Clinical Dementia Rating (CDR). Neurology. 1993;43. https:\/\/doi.org\/10.1212\/WNL.43.11.2412-a."},{"key":"2223_CR27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","volume":"17","author":"JA Yesavage","year":"1982","unstructured":"Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1982;17:37\u201349. https:\/\/doi.org\/10.1016\/0022-3956(82)90033-4.","journal-title":"J Psychiatr Res"},{"key":"2223_CR28","first-page":"62","volume":"34","author":"T Ertan","year":"1997","unstructured":"Ertan T, Eker E, \u015ear V. Geriatrik depresyon \u00f6l\u00e7e\u011finin T\u00fcrk ya\u015fl\u0131 n\u00fcfusunda ge\u00e7erlilik ve g\u00fcvenilirli\u011fi. N\u00f6ropsikiyatri ar\u015fivi. 1997;34:62\u201371.","journal-title":"N\u00f6ropsikiyatri ar\u015fivi"},{"key":"2223_CR29","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2214\/ajr.149.2.351","volume":"149","author":"F Fazekas","year":"1987","unstructured":"Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in alzheimer\u2019s dementia and normal aging. Am J Roentgenol. 1987;149:351\u20136. https:\/\/doi.org\/10.2214\/ajr.149.2.351.","journal-title":"Am J Roentgenol"},{"key":"2223_CR30","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/BF00868807","volume":"242","author":"P Scheltens","year":"1995","unstructured":"Scheltens P, Launer LJ, Barkhof F, Weinstein HC, Van Gool WA. Visual assessment of medial Temporal lobe atrophy on magnetic resonance imaging: interobserver reliability. J Neurol. 1995;242:557\u201360. https:\/\/doi.org\/10.1007\/BF00868807.","journal-title":"J Neurol"},{"key":"2223_CR31","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"GM McKhann","year":"2011","unstructured":"McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CRJ, Kawas CH, et al. The diagnosis of dementia due to alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s association workgroups on diagnostic guidelines for alzheimer\u2019s disease. Alzheimers Dement. 2011;7:263\u20139. https:\/\/doi.org\/10.1016\/j.jalz.2011.03.005.","journal-title":"Alzheimers Dement"},{"key":"2223_CR32","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1097\/WAD.0b013e3181cfc78b","volume":"24","author":"E Grober","year":"2010","unstructured":"Grober E, Sanders AE, Hall C, Lipton RB. Free and cued selective reminding identifies very mild dementia in primary care. Alzheimer Dis Assoc Disord. 2010;24:284\u201390. https:\/\/doi.org\/10.1097\/WAD.0b013e3181cfc78b.","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"2223_CR33","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","volume":"256","author":"RC Petersen","year":"2004","unstructured":"Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med. 2004;256:183\u201394. https:\/\/doi.org\/10.1111\/j.1365-2796.2004.01388.x.","journal-title":"J Intern Med"},{"key":"2223_CR34","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jalz.2012.09.017","volume":"10","author":"F Jessen","year":"2014","unstructured":"Jessen F, Wolfsgruber S, Wiese B, Bickel H, M\u00f6sch E, Kaduszkiewicz H, et al. AD dementia risk in late MCI, in early MCI, and in subjective memory impairment. Alzheimers Dement. 2014;10:76\u201383. https:\/\/doi.org\/10.1016\/j.jalz.2012.09.017.","journal-title":"Alzheimers Dement"},{"key":"2223_CR35","doi-asserted-by":"publisher","unstructured":"Nieto-Castanon A. Handbook of functional connectivity magnetic resonance imaging methods in CONN. Hilbert; 2020. https:\/\/doi.org\/10.56441\/hilbertpress.2207.6598.","DOI":"10.56441\/hilbertpress.2207.6598"},{"key":"2223_CR36","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1089\/brain.2012.0073","volume":"2","author":"S Whitfield-Gabrieli","year":"2012","unstructured":"Whitfield-Gabrieli S, Nieto-Castanon A. Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. Brain Connect. 2012;2:125\u201341.","journal-title":"Brain Connect"},{"key":"2223_CR37","doi-asserted-by":"publisher","unstructured":"Penny WD, Friston KJ, Ashburner JT, Kiebel SJ, Nichols TE. Statistical parametric mapping: the analysis of functional brain images. Elsevier; 2011. https:\/\/doi.org\/10.1089\/brain.2012.0073.","DOI":"10.1089\/brain.2012.0073"},{"key":"2223_CR38","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.neuroimage.2007.04.042","volume":"37","author":"Y Behzadi","year":"2007","unstructured":"Behzadi Y, Restom K, Liau J, Liu TT. A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. NeuroImage. 2007;37:90\u2013101. https:\/\/doi.org\/10.1016\/j.neuroimage.2007.04.042.","journal-title":"NeuroImage"},{"key":"2223_CR39","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1002\/hbm.460030303","volume":"3","author":"KJ Friston","year":"1995","unstructured":"Friston KJ, Ashburner J, Frith CD, Poline J, Heather JD, Frackowiak RSJ. Spatial registration and normalization of images. Hum Brain Mapp. 1995;3:165\u201389. https:\/\/doi.org\/10.1002\/hbm.460030303.","journal-title":"Hum Brain Mapp"},{"key":"2223_CR40","volume-title":"Neuroscience","author":"D Purves","year":"2004","unstructured":"Purves D, Augustine GJ, Fitzpatrick D, Hall WC, LaMantia A-S, McNamara JO, et al. Neuroscience. 3rd ed. Sunderland, MA, US: Sinauer Associates; 2004.","edition":"3"},{"key":"2223_CR41","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1136\/jnnp-2017-315607","volume":"88","author":"HM Gellersen","year":"2017","unstructured":"Gellersen HM, Guo CC, O\u2019Callaghan C, Tan RH, Sami S, Hornberger M. Cerebellar atrophy in neurodegeneration\u2014a meta-analysis. J Neurol Neurosurg Psychiatry. 2017;88:780\u20138. https:\/\/doi.org\/10.1136\/jnnp-2017-315607.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2223_CR42","doi-asserted-by":"publisher","first-page":"596221","DOI":"10.3389\/fnsys.2021.596221","volume":"15","author":"Z Zhou","year":"2021","unstructured":"Zhou Z, Zhu R, Shao W, Zhang S, Wang L, Ding X, et al. Changes in resting-state functional connectivity of cerebellum in amnestic mild cognitive impairment and alzheimer\u2019s disease: A case-control study. Front Syst Neurosci. 2021;15:596221. https:\/\/doi.org\/10.3389\/fnsys.2021.596221.","journal-title":"Front Syst Neurosci"},{"key":"2223_CR43","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/s41593-018-0070-z","volume":"21","author":"HIL Jacobs","year":"2018","unstructured":"Jacobs HIL, Hedden T, Schultz AP, Sepulcre J, Perea RD, Amariglio RE, et al. Structural tract alterations predict downstream Tau accumulation in amyloid-positive older individuals. Nat Neurosci. 2018;21:424\u201331. https:\/\/doi.org\/10.1038\/s41593-018-0070-z.","journal-title":"Nat Neurosci"},{"key":"2223_CR44","doi-asserted-by":"publisher","first-page":"e36652","DOI":"10.7554\/eLife.36652","volume":"7","author":"X Guell","year":"2018","unstructured":"Guell X, Schmahmann JD, Gabrieli JDE, Ghosh SS. Functional gradients of the cerebellum. Elife. 2018;7:e36652. https:\/\/doi.org\/10.7554\/eLife.36652.","journal-title":"Elife"},{"key":"2223_CR45","doi-asserted-by":"publisher","first-page":"e0210028","DOI":"10.1371\/journal.pone.0210028","volume":"14","author":"X Guell","year":"2019","unstructured":"Guell X, Goncalves M, Kaczmarzyk JR, Gabrieli JDE, Schmahmann JD, Ghosh SS. LittleBrain: a gradient-based tool for the topographical interpretation of cerebellar neuroimaging findings. PLoS ONE. 2019;14:e0210028. https:\/\/doi.org\/10.1371\/journal.pone.0210028.","journal-title":"PLoS ONE"},{"key":"2223_CR46","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1038\/s41593-019-0436-x","volume":"22","author":"M King","year":"2019","unstructured":"King M, Hernandez-Castillo CR, Poldrack RA, Ivry RB, Diedrichsen J. Functional boundaries in the human cerebellum revealed by a multi-domain task battery. Nat Neurosci. 2019;22:1371\u20138. https:\/\/doi.org\/10.1038\/s41593-019-0436-x.","journal-title":"Nat Neurosci"},{"key":"2223_CR47","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neuron.2009.03.024","volume":"62","author":"WW Seeley","year":"2009","unstructured":"Seeley WW, Crawford RK, Zhou J, Miller BL, Greicius MD. Neurodegenerative diseases target large-scale human brain networks. Neuron. 2009;62:42\u201352. https:\/\/doi.org\/10.1016\/j.neuron.2009.03.024.","journal-title":"Neuron"},{"key":"2223_CR48","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1093\/brain\/aww003","volume":"139","author":"CC Guo","year":"2016","unstructured":"Guo CC, Tan R, Hodges JR, Hu X, Sami S, Hornberger M. Network-selective vulnerability of the human cerebellum to alzheimer\u2019s disease and frontotemporal dementia. Brain. 2016;139:1527\u201338. https:\/\/doi.org\/10.1093\/brain\/aww003.","journal-title":"Brain"},{"key":"2223_CR49","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.neuron.2013.10.044","volume":"80","author":"RL Buckner","year":"2013","unstructured":"Buckner RL. The cerebellum and cognitive function: 25 years of insight from anatomy and neuroimaging. Neuron. 2013;80:807\u201315. https:\/\/doi.org\/10.1016\/j.neuron.2013.10.044.","journal-title":"Neuron"},{"key":"2223_CR50","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.neubiorev.2014.02.011","volume":"42","author":"JA Bernard","year":"2014","unstructured":"Bernard JA, Seidler RD. Moving forward: age effects on the cerebellum underlie cognitive and motor declines. Neurosci Biobehav Rev. 2014;42:193\u2013207. https:\/\/doi.org\/10.1016\/j.neubiorev.2014.02.011.","journal-title":"Neurosci Biobehav Rev"},{"key":"2223_CR51","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.tics.2013.03.003","volume":"17","author":"AC Bostan","year":"2013","unstructured":"Bostan AC, Dum RP, Strick PL. Cerebellar networks with the cerebral cortex and basal ganglia. Trends Cogn Sci. 2013;17:241\u201354. https:\/\/doi.org\/10.1016\/j.tics.2013.03.003.","journal-title":"Trends Cogn Sci"},{"key":"2223_CR52","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.tics.2017.02.005","volume":"21","author":"AA Sokolov","year":"2017","unstructured":"Sokolov AA, Miall RC, Ivry RB. The cerebellum: adaptive prediction for movement and cognition. Trends Cogn Sci. 2017;21:313\u201332. https:\/\/doi.org\/10.1016\/j.tics.2017.02.005.","journal-title":"Trends Cogn Sci"},{"key":"2223_CR53","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1089\/brain.2020.093","volume":"13","author":"V Gupta","year":"2023","unstructured":"Gupta V, Booth S, Ko JH, Initiative ADN. Hypermetabolic cerebellar connectome in alzheimer\u2019s disease. Brain Connect. 2023;13:356\u201366. https:\/\/doi.org\/10.1089\/brain.2020.093.","journal-title":"Brain Connect"},{"key":"2223_CR54","doi-asserted-by":"publisher","first-page":"837","DOI":"10.2967\/jnumed.118.219097","volume":"60","author":"G Blazhenets","year":"2019","unstructured":"Blazhenets G, Ma Y, S\u00f6rensen A, R\u00fccker G, Schiller F, Eidelberg D, et al. Principal components analysis of brain metabolism predicts development of alzheimer dementia. J Nucl Med. 2019;60:837\u201343. https:\/\/doi.org\/10.2967\/jnumed.118.219097.","journal-title":"J Nucl Med"},{"key":"2223_CR55","doi-asserted-by":"publisher","unstructured":"Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL. A default mode of brain function. Proc Natl Acad Sci. 2001;98:676\u201382. https:\/\/doi.org\/10.1073\/pnas.98.2.676.","DOI":"10.1073\/pnas.98.2.676"},{"key":"2223_CR56","doi-asserted-by":"publisher","first-page":"8586","DOI":"10.1523\/JNEUROSCI.1868-09.2009","volume":"29","author":"C Habas","year":"2009","unstructured":"Habas C, Kamdar N, Nguyen D, Prater K, Beckmann CF, Menon V, et al. Distinct cerebellar contributions to intrinsic connectivity networks. J Neurosci. 2009;29:8586\u201394. https:\/\/doi.org\/10.1523\/JNEUROSCI.1868-09.2009.","journal-title":"J Neurosci"},{"key":"2223_CR57","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.neuron.2010.02.005","volume":"65","author":"JR Andrews-Hanna","year":"2010","unstructured":"Andrews-Hanna JR, Reidler JS, Sepulcre J, Poulin R, Buckner RL. Functional-anatomic fractionation of the brain\u2019s default network. Neuron. 2010;65:550\u201362. https:\/\/doi.org\/10.1016\/j.neuron.2010.02.005.","journal-title":"Neuron"},{"key":"2223_CR58","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1162\/netn_a_00385","volume":"8","author":"M Girn","year":"2024","unstructured":"Girn M, Setton R, Turner GR, Spreng RN. The limbic network, comprising orbitofrontal and anterior Temporal cortex, is part of an extended default network: evidence from multi-echo fMRI. Netw Neurosci. 2024;8:860\u201382. https:\/\/doi.org\/10.1162\/netn_a_00385.","journal-title":"Netw Neurosci"},{"key":"2223_CR59","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1093\/brain\/aww064","volume":"139","author":"JD Schmahmann","year":"2016","unstructured":"Schmahmann JD. Cerebellum in alzheimer\u2019s disease and frontotemporal dementia: not a silent bystander. Brain. 2016;139:1314\u20138. https:\/\/doi.org\/10.1093\/brain\/aww064.","journal-title":"Brain"},{"key":"2223_CR60","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1093\/brain\/121.6.1013","volume":"121","author":"M-M Mesulam","year":"1998","unstructured":"Mesulam M-M. From sensation to cognition. Brain. 1998;121:1013\u201352. https:\/\/doi.org\/10.1093\/brain\/121.6.1013.","journal-title":"Brain"},{"key":"2223_CR61","doi-asserted-by":"publisher","first-page":"341","DOI":"10.3390\/jcm8030341","volume":"8","author":"J Hwang","year":"2019","unstructured":"Hwang J, Jeong JH, Yoon SJ, Park KW, Kim E-J, Yoon B, et al. Clinical and biomarker characteristics according to clinical spectrum of alzheimer\u2019s disease (AD) in the validation cohort of Korean brain aging study for the early diagnosis and prediction of AD. J Clin Med. 2019;8:341. https:\/\/doi.org\/10.3390\/jcm8030341.","journal-title":"J Clin Med"},{"key":"2223_CR62","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13195-018-0459-7","volume":"11","author":"L Parnetti","year":"2019","unstructured":"Parnetti L, Chipi E, Salvadori N, D\u2019Andrea K, Eusebi P. Prevalence and risk of progression of preclinical alzheimer\u2019s disease stages: a systematic review and meta-analysis. Alzheimers Res Ther. 2019;11:7. https:\/\/doi.org\/10.1186\/s13195-018-0459-7.","journal-title":"Alzheimers Res Ther"}],"container-title":["BMC Medical Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12880-026-02223-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-026-02223-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-026-02223-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:18:09Z","timestamp":1773829089000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12880-026-02223-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":62,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2223"],"URL":"https:\/\/doi.org\/10.1186\/s12880-026-02223-4","relation":{"references":[{"id-type":"doi","id":"10.1212\/WNL.43.11.2412-a","asserted-by":"subject"}]},"ISSN":["1471-2342"],"issn-type":[{"value":"1471-2342","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]},"assertion":[{"value":"26 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Clinical Research Ethics Committee of Istanbul University, Istanbul Faculty of Medicine (Protocol No: 2025\/521). This study was performed in accordance with the ethical principles of the latest version of the Declaration of Helsinki. Written informed consent was provided by all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"140"}}