{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:47:38Z","timestamp":1785422858656,"version":"3.56.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"DOI":"10.1186\/s12880-026-02226-1","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T09:19:39Z","timestamp":1771060779000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An interpretable machine learning model for preoperative prediction of aldosterone secretion and CYP11B2 status of adrenal gland"],"prefix":"10.1186","volume":"26","author":[{"given":"Sixian","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,14]]},"reference":[{"issue":"16","key":"2226_CR1","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1016\/j.jacc.2020.02.052","volume":"75","author":"Z Xu","year":"2020","unstructured":"Xu Z, Yang J, Hu J, Song Y, He W, Luo T, Cheng Q, Ma L, Luo R, Fuller PJ, et al. Primary aldosteronism in patients in China with recently detected hypertension. J Am Coll Cardiol. 2020;75(16):1913\u201322.","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"2226_CR2","doi-asserted-by":"publisher","first-page":"102791","DOI":"10.1016\/j.cpcardiol.2024.102791","volume":"49","author":"M Huang","year":"2024","unstructured":"Huang M, Li J, Zhao X, Fu R, Li X, Jiang W. Global and regional prevalence and cardiovascular risk of primary aldosteronism: a systematic review and meta-analysis. Curr Probl Cardiol. 2024;49(10):102791.","journal-title":"Curr Probl Cardiol"},{"issue":"10","key":"2226_CR3","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1097\/HJH.0000000000002510","volume":"38","author":"P Mulatero","year":"2020","unstructured":"Mulatero P, Monticone S, Deinum J, Amar L, Prejbisz A, Zennaro MC, Beuschlein F, Rossi GP, Nishikawa T, Morganti A, et al. Genetics, prevalence, screening and confirmation of primary aldosteronism: a position statement and consensus of the working group on endocrine hypertension of the European society of hypertension. J Hypertens. 2020;38(10):1919\u201328.","journal-title":"J Hypertens"},{"issue":"11","key":"2226_CR4","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/s41574-022-00730-2","volume":"18","author":"AF Turcu","year":"2022","unstructured":"Turcu AF, Yang J, Vaidya A. Primary aldosteronism - a multidimensional syndrome. Nat Rev Endocrinol. 2022;18(11):665\u201382.","journal-title":"Nat Rev Endocrinol"},{"issue":"9","key":"2226_CR5","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1161\/HYPERTENSIONAHA.124.22642","volume":"81","author":"GP Rossi","year":"2024","unstructured":"Rossi GP, Rossi FB, Guarnieri C, Rossitto G, Seccia TM. Clinical management of primary aldosteronism: an update. Hypertension. 2024;81(9):1845\u201356.","journal-title":"Hypertension"},{"issue":"9","key":"2226_CR6","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S2213-8587(17)30135-3","volume":"5","author":"TA Williams","year":"2017","unstructured":"Williams TA, Lenders JWM, Mulatero P, Burrello J, Rottenkolber M, Adolf C, Satoh F, Amar L, Quinkler M, Deinum J, et al. Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort. Lancet Diabetes Endocrinol. 2017;5(9):689\u201399.","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"3","key":"2226_CR7","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1161\/HYPERTENSIONAHA.123.21910","volume":"81","author":"AF Turcu","year":"2024","unstructured":"Turcu AF, Tezuka Y, Lim JS, Salman Z, Sehgal K, Liu H, Larose S, Parksook WW, Williams TA, Cohen DL, et al. Multifocal, asymmetric bilateral primary aldosteronism cannot be excluded by strong adrenal vein sampling lateralization: an international retrospective cohort study. Hypertension. 2024;81(3):604\u201313.","journal-title":"Hypertension"},{"issue":"2","key":"2226_CR8","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1177\/1457496918822622","volume":"109","author":"C Volpe","year":"2020","unstructured":"Volpe C, Hamberger B, Zedenius J, Juhlin CC. Impact of immunohistochemistry on the diagnosis and management of primary aldosteronism: an important tool for improved patient follow-up. Scand J Surg. 2020;109(2):133\u201342.","journal-title":"Scand J Surg"},{"issue":"1\u20132","key":"2226_CR9","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.mce.2013.11.022","volume":"383","author":"CE Gomez-Sanchez","year":"2014","unstructured":"Gomez-Sanchez CE, Qi X, Velarde-Miranda C, Plonczynski MW, Parker CR, Rainey W, Satoh F, Maekawa T, Nakamura Y, Sasano H, et al. Development of monoclonal antibodies against human CYP11B1 and CYP11B2. Mol Cell Endocrinol. 2014;383(1\u20132):111\u20137.","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"2226_CR10","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s12022-022-09710-8","volume":"33","author":"O Mete","year":"2022","unstructured":"Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG. Overview of the 2022 WHO classification of adrenal cortical tumors. Endocr Pathol. 2022;33(1):155\u201396.","journal-title":"Endocr Pathol"},{"key":"2226_CR11","doi-asserted-by":"crossref","unstructured":"Viukari M, Leijon H, Vesterinen T, S\u00f6derlund S, H\u00e4m\u00e4l\u00e4inen P, Yliaska I, Rautiainen P, Rintam\u00e4ki R, Soinio M, P\u00f6rsti I et al. Clinical significance of CYP11B2 immunostaining in unilateral primary aldosteronism. Endocr Connect 2024, 13(2).","DOI":"10.1530\/EC-23-0344"},{"issue":"4","key":"2226_CR12","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1161\/HYPERTENSIONAHA.123.22281","volume":"81","author":"M Tetti","year":"2024","unstructured":"Tetti M, Br\u00fcdgam D, Burrello J, Udager AM, Riester A, Kn\u00f6sel T, Beuschlein F, Rainey WE, Reincke M, Williams TA. Unilateral primary aldosteronism: Long-Term disease recurrence after adrenalectomy. Hypertension. 2024;81(4):936\u201345.","journal-title":"Hypertension"},{"issue":"11","key":"2226_CR13","doi-asserted-by":"publisher","first-page":"e4340","DOI":"10.1210\/clinem\/dgab482","volume":"106","author":"GP Rossi","year":"2021","unstructured":"Rossi GP, Crim\u00ec F, Rossitto G, Amar L, Azizi M, Riester A, Reincke M, Degenhart C, Widimsky J, Naruse M, et al. Identification of surgically curable primary aldosteronism by imaging in a Large, multiethnic international study. J Clin Endocrinol Metab. 2021;106(11):e4340\u20139.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2226_CR14","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s12020-022-03122-8","volume":"78","author":"M Araujo-Castro","year":"2022","unstructured":"Araujo-Castro M, Paja Fano M, Gonz\u00e1lez Boillos M, Pla Peris B, Pascual-Corrales E, Garc\u00eda Cano AM, Parra Ram\u00edrez P, Rojas-Marcos PM, Ruiz-Sanchez JG, Vicente Delgado A, et al. Adrenal venous sampling in primary aldosteronism: experience of a Spanish multicentric study (Results from the SPAIN-ALDO Register). Endocrine. 2022;78(2):363\u201372.","journal-title":"Endocrine"},{"issue":"4","key":"2226_CR15","first-page":"1182","volume":"102","author":"Y Yamazaki","year":"2017","unstructured":"Yamazaki Y, Nakamura Y, Omata K, Ise K, Tezuka Y, Ono Y, Morimoto R, Nozawa Y, Gomez-Sanchez CE, Tomlins SA, et al. Histopathological classification of Cross-Sectional Image-Negative hyperaldosteronism. J Clin Endocrinol Metab. 2017;102(4):1182\u201392.","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2226_CR16","doi-asserted-by":"publisher","first-page":"C5","DOI":"10.1530\/EJE-22-0123","volume":"186","author":"M Reincke","year":"2022","unstructured":"Reincke M, Williams TA. True unilateral primary aldosteronism exists, and unilateral adrenalectomy saves lives. Eur J Endocrinol. 2022;186(6):C5\u20137.","journal-title":"Eur J Endocrinol"},{"key":"2226_CR17","doi-asserted-by":"crossref","unstructured":"Tang R, Pu J, Huang Z. Clinical value of CXCR4-targeted PET-CT in primary aldosteronism: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging. 2025.","DOI":"10.1007\/s00259-025-07312-0"},{"issue":"4","key":"2226_CR18","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.ejca.2011.11.036","volume":"48","author":"P Lambin","year":"2012","unstructured":"Lambin P, Rios-Velazquez E, Leijenaar R, Carvalho S, van Stiphout RG, Granton P, Zegers CM, Gillies R, Boellard R, Dekker A, et al. Radiomics: extracting more information from medical images using advanced feature analysis. Eur J Cancer. 2012;48(4):441\u20136.","journal-title":"Eur J Cancer"},{"issue":"5","key":"2226_CR19","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1016\/j.acra.2023.10.015","volume":"31","author":"PT Chen","year":"2024","unstructured":"Chen PT, Li PY, Liu KL, Wu VC, Lin YH, Chueh JS, Chen CM, Chang CC. Machine learning model with computed tomography radiomics and clinicobiochemical characteristics predict the subtypes of patients with primary aldosteronism. Acad Radiol. 2024;31(5):1818\u201327.","journal-title":"Acad Radiol"},{"key":"2226_CR20","doi-asserted-by":"crossref","unstructured":"Yang W, Hao Y, Mu K, Li J, Tao Z, Ma D, Xu A. Application of a radiomics machine learning model for differentiating aldosterone-producing adenoma from non-functioning adrenal adenoma. Bioengineering (Basel). 2023;10(12).","DOI":"10.3390\/bioengineering10121423"},{"issue":"1","key":"2226_CR21","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1210\/clinem\/dgaa484","volume":"106","author":"TA Williams","year":"2021","unstructured":"Williams TA, Gomez-Sanchez CE, Rainey WE, Giordano TJ, Lam AK, Marker A, Mete O, Yamazaki Y, Zerbini MCN, Beuschlein F, et al. International histopathology consensus for unilateral primary aldosteronism. J Clin Endocrinol Metab. 2021;106(1):42\u201354.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2226_CR22","doi-asserted-by":"publisher","first-page":"G1","DOI":"10.1093\/ejendo\/lvad066","volume":"189","author":"M Fassnacht","year":"2023","unstructured":"Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Pelsma I, Marina L, Lorenz K, Bancos I, et al. European society of endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European network for the study of adrenal tumors. Eur J Endocrinol. 2023;189(1):G1\u201342.","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"2226_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v033.i01","volume":"33","author":"J Friedman","year":"2010","unstructured":"Friedman J, Hastie T, Tibshirani R. Regularization paths for generalized linear models via coordinate descent. J Stat Softw. 2010;33(1):1\u201322.","journal-title":"J Stat Softw"},{"issue":"1","key":"2226_CR24","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1161\/HYPERTENSIONAHA.121.18284","volume":"79","author":"GP Rossi","year":"2022","unstructured":"Rossi GP, Crim\u00ec F, Rossitto G, Amar L, Azizi M, Riester A, Reincke M, Degenhart C, Widimsky J, Naruse M, et al. Feasibility of Imaging-Guided adrenalectomy in young patients with primary aldosteronism. Hypertension. 2022;79(1):187\u201395.","journal-title":"Hypertension"},{"issue":"8","key":"2226_CR25","doi-asserted-by":"publisher","first-page":"e1582","DOI":"10.1210\/clinem\/dgad747","volume":"109","author":"CH Ahn","year":"2024","unstructured":"Ahn CH, Lee YB, Kim JH, Oh YL, Kim JH, Jung KC. Correlation of histopathologic subtypes of primary aldosteronism with clinical phenotypes and postsurgical outcomes. J Clin Endocrinol Metab. 2024;109(8):e1582\u201392.","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2226_CR26","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1093\/ajh\/hpac079","volume":"35","author":"A Vaidya","year":"2022","unstructured":"Vaidya A, Hundemer GL, Nanba K, Parksook WW, Brown JM. Primary aldosteronism: State-of-the-Art review. Am J Hypertens. 2022;35(12):967\u201388.","journal-title":"Am J Hypertens"},{"issue":"2","key":"2226_CR27","first-page":"563","volume":"278","author":"RJ Gillies","year":"2016","unstructured":"Gillies RJ, Kinahan PE, Hricak H. Radiomics: images are more than pictures. They Are Data Radiol. 2016;278(2):563\u201377.","journal-title":"They Are Data Radiol"},{"issue":"1","key":"2226_CR28","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3233\/THC-220031","volume":"31","author":"S He","year":"2023","unstructured":"He S, Xiao B, Wei H, Huang S, Chen T. SVM classifier of cervical histopathology images based on texture and morphological features. Technol Health Care. 2023;31(1):69\u201380.","journal-title":"Technol Health Care"},{"issue":"4","key":"2226_CR29","doi-asserted-by":"publisher","first-page":"488","DOI":"10.2967\/jnumed.118.222893","volume":"61","author":"ME Mayerhoefer","year":"2020","unstructured":"Mayerhoefer ME, Materka A, Langs G, H\u00e4ggstr\u00f6m I, Szczypi\u0144ski P, Gibbs P, Cook G. Introduction to radiomics. J Nucl Med. 2020;61(4):488\u201395.","journal-title":"J Nucl Med"},{"issue":"3","key":"2226_CR30","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1210\/jc.2015-3239","volume":"101","author":"K Nanba","year":"2016","unstructured":"Nanba K, Chen AX, Omata K, Vinco M, Giordano TJ, Else T, Hammer GD, Tomlins SA, Rainey WE. Molecular heterogeneity in Aldosterone-Producing adenomas. J Clin Endocrinol Metab. 2016;101(3):999\u20131007.","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2226_CR31","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1161\/HYPERTENSIONAHA.119.14177","volume":"75","author":"K De Sousa","year":"2020","unstructured":"De Sousa K, Boulkroun S, Baron S, Nanba K, Wack M, Rainey WE, Rocha A, Giscos-Douriez I, Meatchi T, Amar L, et al. Genetic, Cellular, and molecular heterogeneity in adrenals with Aldosterone-Producing adenoma. Hypertension. 2020;75(4):1034\u201344.","journal-title":"Hypertension"},{"issue":"10","key":"2226_CR32","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.1210\/jc.2018-01004","volume":"103","author":"K Nanba","year":"2018","unstructured":"Nanba K, Omata K, Else T, Beck PCC, Nanba AT, Turcu AF, Miller BS, Giordano TJ, Tomlins SA, Rainey WE. Targeted molecular characterization of Aldosterone-Producing adenomas in white Americans. J Clin Endocrinol Metab. 2018;103(10):3869\u201376.","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2226_CR33","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1210\/jc.2012-3726","volume":"98","author":"K Nanba","year":"2013","unstructured":"Nanba K, Tsuiki M, Sawai K, Mukai K, Nishimoto K, Usui T, Tagami T, Okuno H, Yamamoto T, Shimatsu A, et al. Histopathological diagnosis of primary aldosteronism using CYP11B2 immunohistochemistry. J Clin Endocrinol Metab. 2013;98(4):1567\u201374.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2226_CR34","doi-asserted-by":"publisher","first-page":"8892","DOI":"10.1038\/s41598-022-12835-9","volume":"12","author":"PT Chen","year":"2022","unstructured":"Chen PT, Chang D, Liu KL, Liao WC, Wang W, Chang CC, Wu VC, Lin YH. Radiomics utilization to differentiate nonfunctional adenoma in essential hypertension and functional adenoma in primary aldosteronism. Sci Rep. 2022;12(1):8892.","journal-title":"Sci Rep"},{"key":"2226_CR35","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.mce.2016.10.014","volume":"441","author":"K Nishimoto","year":"2017","unstructured":"Nishimoto K, Koga M, Seki T, Oki K, Gomez-Sanchez EP, Gomez-Sanchez CE, Naruse M, Sakaguchi T, Morita S, Kosaka T, et al. Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism. Mol Cell Endocrinol. 2017;441:124\u201333.","journal-title":"Mol Cell Endocrinol"},{"key":"2226_CR36","doi-asserted-by":"crossref","unstructured":"Meyer LS, Wang X, Su\u0161nik E, Burrello J, Burrello A, Castellano I, Eisenhofer G, Fallo F, Kline GA, Kn\u00f6sel T et al. Immunohistopathology and steroid profiles associated with biochemical outcomes after adrenalectomy for unilateral primary aldosteronism. Hypertension. 2018;72(3):650\u2013657.","DOI":"10.1161\/HYPERTENSIONAHA.118.11465"},{"issue":"1","key":"2226_CR37","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s12894-022-01099-0","volume":"22","author":"Z Yu","year":"2022","unstructured":"Yu Z, Ding J, Pang H, Fang H, He F, Xu C, Li X, Ren K. A triple-classification for differentiating renal oncocytoma from renal cell carcinoma subtypes and CK7 expression evaluation: a radiomics analysis. BMC Urol. 2022;22(1):147.","journal-title":"BMC Urol"},{"issue":"1","key":"2226_CR38","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1186\/s13244-024-01840-3","volume":"15","author":"Z Wei","year":"2024","unstructured":"Wei Z, Bai X, Xv Y, Chen SH, Yin S, Li Y, Lv F, Xiao M, Xie Y. A radiomics-based interpretable machine learning model to predict the HER2 status in bladder cancer: a multicenter study. Insights Imaging. 2024;15(1):262.","journal-title":"Insights Imaging"},{"issue":"6","key":"2226_CR39","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1093\/ajh\/hpab189","volume":"35","author":"WW Parksook","year":"2022","unstructured":"Parksook WW, Yozamp N, Hundemer GL, Moussa M, Underhill J, Fudim T, Sacks B, Vaidya A. Morphologically Normal-Appearing adrenal glands as a prevalent source of aldosterone production in primary aldosteronism. Am J Hypertens. 2022;35(6):561\u201371.","journal-title":"Am J Hypertens"}],"container-title":["BMC Medical Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12880-026-02226-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-026-02226-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-026-02226-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T16:14:21Z","timestamp":1774282461000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12880-026-02226-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,14]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2226"],"URL":"https:\/\/doi.org\/10.1186\/s12880-026-02226-1","relation":{},"ISSN":["1471-2342"],"issn-type":[{"value":"1471-2342","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,14]]},"assertion":[{"value":"20 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was a retrospective study and was approved by the ethics committee of the Zhejiang Provincial People\u2019s Hospital. Due to the anonymized and retrospective nature of the data, the requirement for informed consent was waived by the ethics committee. All procedures followed were in accordance with the ethical standards of the responsible committee and with the Helsinki Declaration (as revised in 2013).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"146"}}