{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T03:57:12Z","timestamp":1776398232479,"version":"3.51.2"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"2024 Medical and Health Research Fund of the Baoshan District Science and Technology Committee","award":["2024-E-47"],"award-info":[{"award-number":["2024-E-47"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"DOI":"10.1186\/s12880-026-02265-8","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:37:39Z","timestamp":1773221859000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predicting recurrent chest pain in patients with myocardial bridging using explainable machine learning: a multicenter study integrating CT-derived functional and inflammatory imaging biomarkers"],"prefix":"10.1186","volume":"26","author":[{"given":"Jingquan","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuigang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6203-2951","authenticated-orcid":false,"given":"Xiaolong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"issue":"1","key":"2265_CR1","first-page":"e238300","volume":"52","author":"P Angelini","year":"2025","unstructured":"Angelini P, Uribe C, Raghuram A. Coronary myocardial bridge updates: anatomy, pathophysiology, clinical manifestations, diagnosis, and treatment options. Tex Heart Inst J. 2025;52(1):e238300.","journal-title":"Tex Heart Inst J"},{"issue":"2","key":"2265_CR2","first-page":"87","volume":"18","author":"N Cullu","year":"2021","unstructured":"Cullu N, Yeniceri IO, Ozdemir MY, Altun I, Dogan E. Evaluation of the morphological and clinical features of left anterior descending myocardial bridging with multi-detector computed tomography. Kardiochir Torakochirurgia Pol. 2021;18(2):87\u201391.","journal-title":"Kardiochir Torakochirurgia Pol"},{"key":"2265_CR3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ijcard.2018.04.077","volume":"267","author":"AR Sheikh","year":"2018","unstructured":"Sheikh AR, Zeitz CJ, Rajendran S, Di Fiore DP, Tavella R, Beltrame JF. Clinical and coronary haemodynamic determinants of recurrent chest pain in patients without obstructive coronary artery disease - a pilot study. Int J Cardiol. 2018;267:16\u201321.","journal-title":"INT J CARDIOL"},{"issue":"6","key":"2265_CR4","doi-asserted-by":"publisher","first-page":"3848","DOI":"10.1007\/s00330-022-09305-1","volume":"33","author":"S Dai","year":"2023","unstructured":"Dai S, Xiao Z, Chen C, Yao W, Qian J, Yang J. Nomogram to predict recurrent chest pain in patients with myocardial bridging. Eur Radiol. 2023;33(6):3848\u201356.","journal-title":"EUR RADIOL"},{"issue":"10","key":"2265_CR5","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1016\/j.jcmg.2018.12.024","volume":"12","author":"C Antoniades","year":"2019","unstructured":"Antoniades C, Shirodaria C. Detecting Coronary Inflammation With Perivascular Fat Attenuation Imaging: Making Sense From Perivascular Attenuation Maps. JACC Cardiovasc Imaging. 2019;12(10):2011\u20134.","journal-title":"JACC Cardiovasc Imaging"},{"key":"2265_CR6","doi-asserted-by":"publisher","first-page":"755295","DOI":"10.3389\/fcvm.2021.755295","volume":"8","author":"S Ma","year":"2021","unstructured":"Ma S, Chen X, Ma Y, Liu H, Zhang J, Xu L, Wang Y, Liu T, Wang K, Yang J, et al. Lesion-Specific Peri-Coronary Fat Attenuation Index Is Associated With Functional Myocardial Ischemia Defined by Abnormal Fractional Flow Reserve. Front Cardiovasc Med. 2021;8:755295.","journal-title":"Front Cardiovasc Med"},{"issue":"10151","key":"2265_CR7","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/S0140-6736(18)31114-0","volume":"392","author":"EK Oikonomou","year":"2018","unstructured":"Oikonomou EK, Marwan M, Desai MY, Mancio J, Alashi A, Hutt CE, Thomas S, Herdman L, Kotanidis CP, Thomas KE, et al. Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data. Lancet. 2018;392(10151):929\u201339.","journal-title":"Lancet"},{"issue":"6","key":"2265_CR8","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1007\/s00330-018-5811-6","volume":"29","author":"F Zhou","year":"2019","unstructured":"Zhou F, Tang CX, Schoepf UJ, Tesche C, Bauer MJ, Jacobs BE, Zhou CS, Yan J, Lu MJ, Lu GM, et al. Fractional flow reserve derived from CCTA may have a prognostic role in myocardial bridging. Eur Radiol. 2019;29(6):3017\u201326.","journal-title":"EUR RADIOL"},{"issue":"13","key":"2265_CR9","doi-asserted-by":"publisher","first-page":"e20597","DOI":"10.1161\/JAHA.120.020597","volume":"10","author":"SB Aleksandric","year":"2021","unstructured":"Aleksandric SB, Djordjevic-Dikic AD, Dobric MR, Giga VL, Soldatovic IA, Vukcevic V, Tomasevic MV, Stojkovic SM, Orlic DN, Saponjski JD, et al. Functional Assessment of Myocardial Bridging With Conventional and Diastolic Fractional Flow Reserve: Vasodilator Versus Inotropic Provocation. J Am Heart Assoc. 2021;10(13):e20597.","journal-title":"J AM HEART ASSOC"},{"issue":"38","key":"2265_CR10","doi-asserted-by":"publisher","first-page":"5838","DOI":"10.3748\/wjg.v25.i38.5838","volume":"25","author":"WQ Liang","year":"2019","unstructured":"Liang WQ, Zhang KC, Cui JX, Xi HQ, Cai AZ, Li JY, Liu YH, Liu J, Zhang W, Wang PP, et al. Nomogram to predict prolonged postoperative ileus after gastrectomy in gastric cancer. World J Gastroenterol. 2019;25(38):5838\u201349.","journal-title":"World J Gastroenterol"},{"key":"2265_CR11","doi-asserted-by":"crossref","unstructured":"Writing CM, Gulati M, Levy PD, Mukherjee D, Amsterdam E, Bhatt DL, Birtcher KK, Blankstein R, Boyd J, Bullock-Palmer RP, et al. 2021 AHA\/ACC\/ASE\/CHEST\/SAEM\/SCCT\/SCMR guideline for the evaluation and diagnosis of chest pain: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2021;78(22):e187-e285.","DOI":"10.1016\/j.jacc.2021.07.053"},{"key":"2265_CR12","doi-asserted-by":"crossref","unstructured":"Cury RC, Leipsic J, Abbara S, Achenbach S, Berman D, Bittencourt M, Budoff M, Chinnaiyan K, Choi AD, Ghoshhajra B, et al. CAD-RADS? 2.0\u20132022 coronary artery disease - reporting and data system: an expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT), the American College of Cardiology (ACC), the American College of Radiology (ACR) and the North America Society of Cardiovascular Imaging (NASCI). J Am Coll Radiol. 2022;19(11):1185\u2013212.","DOI":"10.1148\/ryct.220183"},{"issue":"3","key":"2265_CR13","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1007\/s00330-022-09175-7","volume":"33","author":"L Yu","year":"2023","unstructured":"Yu L, Chen X, Ling R, Yu Y, Yang W, Sun J, Zhang J. Radiomics features of pericoronary adipose tissue improve CT-FFR performance in predicting hemodynamically significant coronary artery stenosis. Eur Radiol. 2023;33(3):2004\u201314.","journal-title":"EUR RADIOL"},{"key":"2265_CR14","doi-asserted-by":"crossref","unstructured":"Kwaifa IK, Bahari H, Yong YK, Noor SM. Endothelial dysfunction in obesity-induced inflammation: molecular mechanisms and clinical implications. Biomolecules. 2020;10(2).","DOI":"10.3390\/biom10020291"},{"issue":"1","key":"2265_CR15","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1164\/rccm.202404-0721OC","volume":"211","author":"L Harbaum","year":"2024","unstructured":"Harbaum L, Hennigs JK, Pott J, Ostermann J, Sinning CR, Sau A, Sieliwonczyk E, Ng FS, Rhodes CJ, Tello K, et al. Sex-specific Genetic Determinants of Right Ventricular Structure and Function. Am J Respir Crit Care Med. 2024;211(1):113\u201323.","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"2265_CR16","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1148\/radiol.2018171291","volume":"288","author":"C Tesche","year":"2018","unstructured":"Tesche C, De Cecco CN, Baumann S, Renker M, McLaurin TW, Duguay TM, Bayer RN, Steinberg DH, Grant KL, Canstein C, et al. Coronary CT Angiography-derived Fractional Flow Reserve: Machine Learning Algorithm versus Computational Fluid Dynamics Modeling. Radiology. 2018;288(1):64\u201372.","journal-title":"Radiology"},{"issue":"6","key":"2265_CR17","doi-asserted-by":"publisher","first-page":"e7217","DOI":"10.1161\/CIRCIMAGING.117.007217","volume":"11","author":"A Coenen","year":"2018","unstructured":"Coenen A, Kim YH, Kruk M, Tesche C, De Geer J, Kurata A, Lubbers ML, Daemen J, Itu L, Rapaka S, et al. Diagnostic Accuracy of a Machine-Learning Approach to Coronary Computed Tomographic Angiography-Based Fractional Flow Reserve: Result From the MACHINE Consortium. Circ Cardiovasc Imaging. 2018;11(6):e7217.","journal-title":"Circ Cardiovasc Imaging"},{"issue":"6","key":"2265_CR18","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.jcmg.2018.01.023","volume":"12","author":"JM Lee","year":"2019","unstructured":"Lee JM, Choi G, Koo BK, Hwang D, Park J, Zhang J, Kim KJ, Tong Y, Kim HJ, Grady L, et al. Identification of High-Risk Plaques Destined to Cause Acute Coronary Syndrome Using Coronary Computed Tomographic Angiography and Computational Fluid Dynamics. JACC Cardiovasc Imaging. 2019;12(6):1032\u201343.","journal-title":"JACC Cardiovasc Imaging"},{"issue":"2","key":"2265_CR19","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s00330-019-06400-8","volume":"30","author":"M Yu","year":"2020","unstructured":"Yu M, Dai X, Deng J, Lu Z, Shen C, Zhang J. Diagnostic performance of perivascular fat attenuation index to predict hemodynamic significance of coronary stenosis: a preliminary coronary computed tomography angiography study. EUR RADIOL. 2020;30(2):673\u201381.","journal-title":"EUR RADIOL"},{"issue":"41","key":"2265_CR20","doi-asserted-by":"publisher","first-page":"3094","DOI":"10.1093\/eurheartj\/ehx177","volume":"38","author":"M Margaritis","year":"2017","unstructured":"Margaritis M, Sanna F, Lazaros G, Akoumianakis I, Patel S, Antonopoulos AS, Duke C, Herdman L, Psarros C, Oikonomou EK, et al. Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress. EUR HEART J. 2017;38(41):3094\u2013104.","journal-title":"EUR HEART J"},{"issue":"1","key":"2265_CR21","doi-asserted-by":"publisher","first-page":"20","DOI":"10.14797\/mdcj-13-1-20","volume":"13","author":"Y Wu","year":"2017","unstructured":"Wu Y, Zhang A, Hamilton DJ, Deng T. Epicardial Fat in the Maintenance of Cardiovascular Health. Methodist Debakey Cardiovasc J. 2017;13(1):20\u20134.","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"2265_CR22","doi-asserted-by":"publisher","first-page":"720127","DOI":"10.3389\/fcvm.2021.720127","volume":"8","author":"Y Dang","year":"2021","unstructured":"Dang Y, Chen X, Ma S, Ma Y, Ma Q, Zhou K, Liu T, Wang K, Hou Y. Association of Pericoronary Adipose Tissue Quality Determined by Dual-Layer Spectral Detector CT With Severity of Coronary Artery Disease: A Preliminary Study. Front Cardiovasc Med. 2021;8:720127.","journal-title":"Front Cardiovasc Med"},{"key":"2265_CR23","doi-asserted-by":"crossref","unstructured":"Yan H, Zhao N, Geng W, Hou Z, Gao Y, Lu B. The perivascular fat attenuation index improves the diagnostic performance for functional coronary stenosis. J Cardiovasc Dev Dis. 2022;9(5).","DOI":"10.3390\/jcdd9050128"},{"key":"2265_CR24","doi-asserted-by":"publisher","first-page":"822308","DOI":"10.3389\/fcvm.2022.822308","volume":"9","author":"B Qin","year":"2022","unstructured":"Qin B, Li Z, Zhou H, Liu Y, Wu H, Wang Z. The Predictive Value of the Perivascular Adipose Tissue CT Fat Attenuation Index for Coronary In-stent Restenosis. Front Cardiovasc Med. 2022;9:822308.","journal-title":"Front Cardiovasc Med"},{"issue":"6","key":"2265_CR25","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1093\/ehjci\/jez013","volume":"20","author":"M Goeller","year":"2019","unstructured":"Goeller M, Tamarappoo BK, Kwan AC, Cadet S, Commandeur F, Razipour A, Slomka PJ, Gransar H, Chen X, Otaki Y, et al. Relationship between changes in pericoronary adipose tissue attenuation and coronary plaque burden quantified from coronary computed tomography angiography. Eur Heart J Cardiovasc Imaging. 2019;20(6):636\u201343.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"12","key":"2265_CR26","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1016\/j.jacc.2016.11.087","volume":"69","author":"M Namasivayam","year":"2017","unstructured":"Namasivayam M, McCready M, Adji A, O\u2019Rourke MF. The role of heart rate in diastolic coronary perfusion and subclinical myocardial ischemia. J Am Coll CardioL. 2017;69(12):1647.","journal-title":"J AM COLL CARDIOL"},{"issue":"14","key":"2265_CR27","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.4244\/EIJ-D-18-00920","volume":"15","author":"J Sara","year":"2020","unstructured":"Sara J, Corban MT, Prasad M, Prasad A, Gulati R, Lerman LO, Lerman A. Prevalence of myocardial bridging associated with coronary endothelial dysfunction in patients with chest pain and non-obstructive coronary artery disease. Eurointervention. 2020;15(14):1262\u20138.","journal-title":"EUROINTERVENTION"},{"issue":"14","key":"2265_CR28","doi-asserted-by":"publisher","first-page":"e20535","DOI":"10.1161\/JAHA.120.020535","volume":"10","author":"RA Montone","year":"2021","unstructured":"Montone RA, Gurgoglione FL, Del BM, Rinaldi R, Meucci MC, Iannaccone G, La Vecchia G, Camilli M, D\u2019Amario D, Leone AM, et al. Interplay Between Myocardial Bridging and Coronary Spasm in Patients With Myocardial Ischemia and Non-Obstructive Coronary Arteries: Pathogenic and Prognostic Implications. J Am Heart Assoc. 2021;10(14):e20535.","journal-title":"J AM HEART ASSOC"},{"issue":"S1","key":"2265_CR29","first-page":"772","volume":"93","author":"Z Ye","year":"2019","unstructured":"Ye Z, Lai Y, Yao Y, Mintz GS, Liu X. Optical coherence tomography and intravascular ultrasound assessment of the anatomic size and wall thickness of a muscle bridge segment. Catheter Cardiovasc Interv. 2019;93(S1):772\u20138.","journal-title":"Catheter Cardiovasc Interv"},{"issue":"1","key":"2265_CR30","doi-asserted-by":"publisher","first-page":"102874","DOI":"10.1016\/j.cpcardiol.2024.102874","volume":"50","author":"A Alsomali","year":"2025","unstructured":"Alsomali A, Lip G, Akhtar R, Field M, Grillo A, Tidbury N, Leo D, Proietti R. Associations between central and brachial blood pressure in patients with hypertension and aortovascular disease: Implications for clinical practice. Curr Probl Cardiol. 2025;50(1):102874.","journal-title":"Curr Probl Cardiol"},{"issue":"4","key":"2265_CR31","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/s41569-019-0273-3","volume":"17","author":"TM Waterbury","year":"2020","unstructured":"Waterbury TM, Tarantini G, Vogel B, Mehran R, Gersh BJ, Gulati R. Non-atherosclerotic causes of acute coronary syndromes. Nat Rev Cardiol. 2020;17(4):229\u201341.","journal-title":"NAT REV CARDIOL"},{"issue":"3","key":"2265_CR32","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s00380-022-02165-1","volume":"38","author":"JB Kim","year":"2023","unstructured":"Kim JB, Choi BG, Rha SW. Prognostic impact of nitrate therapy in patients with myocardial bridge and coexisting coronary artery spasm. HEART VESSELS. 2023;38(3):291\u20139.","journal-title":"HEART VESSELS"},{"issue":"5","key":"2265_CR33","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.amjmed.2017.11.026","volume":"131","author":"P Pimple","year":"2018","unstructured":"Pimple P, Hammadah M, Wilmot K, Ramadan R, Al MI, Levantsevych O, Sullivan S, Garcia EV, Nye J, Shah AJ, et al. Chest pain and mental stress-induced myocardial ischemia: sex differences. Am J Med. 2018;131(5):540\u20137.","journal-title":"AM J MED"},{"issue":"8","key":"2265_CR34","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1161\/CIRCULATIONAHA.117.030849","volume":"137","author":"V Vaccarino","year":"2018","unstructured":"Vaccarino V, Sullivan S, Hammadah M, Wilmot K, Al MI, Ramadan R, Elon L, Pimple PM, Garcia EV, Nye J, et al. Mental Stress-Induced-Myocardial Ischemia in Young Patients With Recent Myocardial Infarction: Sex Differences and Mechanisms. Circulation. 2018;137(8):794\u2013805.","journal-title":"Circulation"},{"key":"2265_CR35","doi-asserted-by":"publisher","first-page":"106043","DOI":"10.1016\/j.compbiomed.2022.106043","volume":"149","author":"K Rasheed","year":"2022","unstructured":"Rasheed K, Qayyum A, Ghaly M, Al-Fuqaha A, Razi A, Qadir J. Explainable, trustworthy, and ethical machine learning for healthcare: A survey. Comput Biol Med. 2022;149:106043.","journal-title":"COMPUT BIOL MED"},{"issue":"1","key":"2265_CR36","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12876-025-03723-3","volume":"25","author":"M Jiang","year":"2025","unstructured":"Jiang M, Wu XP, Lin XC, Li CL. Explainable machine learning model for predicting acute pancreatitis mortality in the intensive care unit. BMC Gastroenterol. 2025;25(1):131.","journal-title":"BMC GASTROENTEROL"},{"issue":"3","key":"2265_CR37","first-page":"173","volume":"14","author":"HR Reynolds","year":"2025","unstructured":"Reynolds HR, Smilowitz NR. Ischaemia with non-obstructive coronary arteries in the 2024 European Society of Cardiology guidelines for the management of chronic coronary syndromes. Eur Heart J Acute Cardiovasc Care. 2025;14(3):173\u20137.","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"issue":"1","key":"2265_CR38","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1186\/s13256-024-04776-w","volume":"18","author":"M Boumaaz","year":"2024","unstructured":"Boumaaz M, Faraj R, Reggad A, Lakhal Z, Asfalou I. Myocardial infarction with non-obstructive coronary arteries in a young seropositive woman with human immunodeficiency virus: a case report and review of the literature. J Med Case Rep. 2024;18(1):447.","journal-title":"J Med Case Rep"},{"issue":"1","key":"2265_CR39","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1186\/s12872-024-04069-6","volume":"24","author":"Z Qin","year":"2024","unstructured":"Qin Z, Lv H, Ren Z, Li X, Fu C, Fu Q. Myocardial ischemia caused by the synergistic effect of myocardial bridge and moderate stenosis: case report. BMC Cardiovasc Disord. 2024;24(1):412.","journal-title":"BMC Cardiovasc Disord"},{"issue":"1","key":"2265_CR40","doi-asserted-by":"publisher","first-page":"19026","DOI":"10.1038\/s41598-021-97849-5","volume":"11","author":"Y Kanaji","year":"2021","unstructured":"Kanaji Y, Sugiyama T, Hoshino M, Misawa T, Nagamine T, Yasui Y, Nogami K, Ueno H, Hirano H, Hada M, et al. Physiological significance of pericoronary inflammation in epicardial functional stenosis and global coronary flow reserve. Sci Rep-UK. 2021;11(1):19026.","journal-title":"SCI REP-UK"},{"key":"2265_CR41","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.ijcard.2017.06.023","volume":"248","author":"K Nel","year":"2017","unstructured":"Nel K, Nam MCY, Anstey C, Boos CJ, Carlton E, Senior R, Kaski JC, Khattab A, Shamley D, Byrne CD, et al. Myocardial blood flow reserve is impaired in patients with aortic valve calcification and unobstructed epicardial coronary arteries. Int J Cardiol. 2017;248:427\u201332.","journal-title":"INT J CARDIOL"}],"container-title":["BMC Medical Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12880-026-02265-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-026-02265-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-026-02265-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T03:29:09Z","timestamp":1776396549000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12880-026-02265-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,11]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2265"],"URL":"https:\/\/doi.org\/10.1186\/s12880-026-02265-8","relation":{},"ISSN":["1471-2342"],"issn-type":[{"value":"1471-2342","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,11]]},"assertion":[{"value":"31 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This multicenter retrospective study was approved by the institutional ethics committees of all participating centers, including the Ethics Committee of Luodian Hospital, Shanghai University School of Medicine\/ Luodian Hospital of Baoshan District, the Ethics Committee of Tongji Hospital, Tongji University School of Medicine, and the Ethics Committee of Shibei Hospital of Jing\u2019an District, Shanghai, China. Given the retrospective design and the anonymization of all patient data, the requirement for informed consent was waived by the respective ethics committees. The study was conducted in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"196"}}