{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:10:53Z","timestamp":1767175853452,"version":"build-2238731810"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T00:00:00Z","timestamp":1447200000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Inform Decis Mak"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12911-015-0213-z","type":"journal-article","created":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T07:07:03Z","timestamp":1447225623000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Development of a decision analytic model to support decision making and risk communication about thrombolytic treatment"],"prefix":"10.1186","volume":"15","author":[{"given":"Peter","family":"McMeekin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary A.","family":"Ford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Rodgers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"Gray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard G.","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,11,11]]},"reference":[{"key":"213_CR1","doi-asserted-by":"publisher","first-page":"e37066","DOI":"10.1371\/journal.pone.0037066","volume":"7","author":"MJ Murtagh","year":"2012","unstructured":"Murtagh MJ, Watson DLB, Jenkings KN, Lie MLS, Mackintosh JE, Ford GA, et al. Situationally-Sensitive Knowledge Translation and Relational Decision Making in Hyperacute Stroke: A Qualitative Study. PLoS One. 2012;7:e37066.","journal-title":"PLoS One"},{"key":"213_CR2","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/1472-6963-10-157","volume":"10","author":"J Lecouturier","year":"2010","unstructured":"Lecouturier J, Murtagh MJ, Thomson RG, Ford GA, White M, Eccles M, et al. Response to symptoms of stroke in the UK: a systematic review. BMC Health Serv Res. 2010;10:157.","journal-title":"BMC Health Serv Res"},{"key":"213_CR3","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1136\/jnnp.2006.102798","volume":"78","author":"M Dirks","year":"2007","unstructured":"Dirks M, Niessen LW, Koudstaal PJ, Franke CL, van Oostenbrugge RJ, Dippel DW, et al. Delphi panel on indications and contraindications for intravenous thrombolysis in acute ischaemic stroke. Intravenous thrombolysis in acute ischaemic stroke: from trial exclusion criteria to clinical contraindications. An international Delphi study. J Neurol Neurosurg Psychiatry. 2007;78:685\u20139.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"213_CR4","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1093\/ageing\/afh064","volume":"33","author":"J Kwan","year":"2004","unstructured":"Kwan J, Hand P, Sandercock P. A systematic review of barriers to delivery of thrombolysis for acute stroke. Age Ageing. 2004;33:116\u201321.","journal-title":"Age Ageing"},{"key":"213_CR5","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S0140-6736(07)60149-4","volume":"369","author":"N Wahlgren","year":"2007","unstructured":"Wahlgren N, Ahmed N, Davalos A, Ford GA, Grond M, Hacke W, et al. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational Study. Lancet. 2007;369:275\u201382.","journal-title":"Lancet"},{"key":"213_CR6","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.1161\/01.STR.0000109767.11426.17","volume":"35","author":"D Kleindorfer","year":"2004","unstructured":"Kleindorfer D, Kissela B, Schneider A, Woo D, Khoury J, Miller R, et al. Eligibility for recombinant tissue plasminogen activator in acute ischemic stroke: a population-based study. Stroke. 2004;35:e27\u20139.","journal-title":"Stroke"},{"key":"213_CR7","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1161\/STROKEAHA.111.615682","volume":"42","author":"CE Tung","year":"2011","unstructured":"Tung CE, Win SS, Lansberg MG. Cost-effectiveness of tissue-type plasminogen activator in the 3- to 4.5-hour time window for acute ischemic stroke. Stroke. 2011;42:2257\u201362.","journal-title":"Stroke"},{"key":"213_CR8","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1161\/STROKEAHA.108.540138","volume":"40","author":"SR Earnshaw","year":"2009","unstructured":"Earnshaw SR, Jackson D, Farkouh R, Schwamm L. Cost-effectiveness of patient selection using penumbral-based MRI for intravenous thrombolysis. Stroke. 2009;40:1710\u201320.","journal-title":"Stroke"},{"key":"213_CR9","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1111\/j.1524-4733.2009.00531.x","volume":"12","author":"T Kongnakorn","year":"2009","unstructured":"Kongnakorn T, Ward A, Roberts CS, O\u2019Brien JA, Proskorovsky I, Caro JJ. Economic evaluation of atorvastatin for prevention of recurrent stroke based on the SPARCL trial. Value Health. 2009;12:880\u20137.","journal-title":"Value Health"},{"key":"213_CR10","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/S0140-6736(04)17670-8","volume":"365","author":"PM Rothwell","year":"2005","unstructured":"Rothwell PM. External validity of randomised controlled trials: \u201cTo whom do the results of this trial apply?\u201d. Lancet. 2005;365:82\u201393.","journal-title":"Lancet"},{"key":"213_CR11","doi-asserted-by":"crossref","unstructured":"Hunink MM, Weinstein MC, Wittenberg E, Drummond MF, Pliskin JS, Wong JB, et al.\u00a0Decision making in health and medicine: integrating evidence and values,\u00a02nd ed. 2014. Cambridge, UK: Cambridge University Press,.","DOI":"10.1017\/CBO9781139506779"},{"key":"213_CR12","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1161\/01.STR.0000249054.96644.c6","volume":"37","author":"D Kent","year":"2006","unstructured":"Kent D, Selker HP, Ruthazer R, Bluhmki E, Hacke W. The Stroke\u2013Thrombolytic Predictive Instrument: a predictive instrument for intravenous thrombolysis in acute ischemic stroke. Stroke. 2006;37:2957\u201362.","journal-title":"Stroke"},{"key":"213_CR13","doi-asserted-by":"publisher","first-page":"3378","DOI":"10.1161\/STROKEAHA.112.671073","volume":"43","author":"P McMeekin","year":"2012","unstructured":"McMeekin P, Flynn D, Ford GA, Rodgers H, Thomson RG. Validating the Stroke-Thrombolytic Predictive Instrument in a Population in the United Kingdom. Stroke. 2012;43:3378\u201381.","journal-title":"Stroke"},{"key":"213_CR14","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1161\/01.STR.0000177872.87960.61","volume":"36","author":"M Uyttenboogaart","year":"2005","unstructured":"Uyttenboogaart M, Stewart RE, Vroomen PC, De KJ, Luijckx GJ. Optimizing cutoff scores for the Barthel index and the modified Rankin scale for defining outcome in acute stroke trials. Stroke. 2005;36:1984\u20137.","journal-title":"Stroke"},{"key":"213_CR15","doi-asserted-by":"publisher","first-page":"3316","DOI":"10.1161\/STROKEAHA.107.510768","volume":"39","author":"N Wahlgren","year":"2008","unstructured":"Wahlgren N, Ahmed N, Eriksson N, Aichner F, Bluhmki E, Da\u00b4valos A, et al. Multivariable Analysis of Outcome Predictors and Adjustment of Main Outcome Results to Baseline Data Profile in Randomized Controlled Trials Safe Implementation of Thrombolysis in Stroke-Monitoring STudy (SITS-MOST). Stroke. 2008;39:3316\u201322.","journal-title":"Stroke"},{"issue":"9558","key":"213_CR16","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S0140-6736(07)60149-4","volume":"369","author":"N Wahlgren","year":"2007","unstructured":"Wahlgren N, Ahmed N, D\u00e1valos A, Ford GA, Grond M, Hacke W, et al. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet. 2007;369(9558):275\u201382. doi: 10.1016\/S0140-6736(07)60149-4 .","journal-title":"Lancet"},{"key":"213_CR17","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/j.1747-4949.2011.00735.x","volume":"7","author":"M Ali","year":"2012","unstructured":"Ali M, Bath P, Brady M, Davis S, Diener H-C, Donnan G, et al. Development, Expansion and Use of a Stroke Clinical Trials Resource for Novel Exploratory Analyses. Int J Stroke. 2012;7:133\u20138.","journal-title":"Int J Stroke"},{"key":"213_CR18","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1148\/radiology.143.1.7063747","volume":"143","author":"JA Hanley","year":"1982","unstructured":"Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology. 1982;143:29\u201336.","journal-title":"Radiology"},{"key":"213_CR19","doi-asserted-by":"publisher","DOI":"10.1002\/0471722146","volume-title":"Applied Logistic Regression (2nd Edition)","author":"DW Hosmer","year":"2000","unstructured":"Hosmer DW, Lemeshow S. Applied Logistic Regression (2nd Edition). New York: John Wiley & Sons; 2000."},{"key":"213_CR20","doi-asserted-by":"crossref","unstructured":"Cucchiara B, Kasner SE, Tanne D, Levine SR, Demchuk A, Messe SR, Sansing L et al.\u00a0Factors associated with intracerebral hemorrhage after thrombolytic therapy for ischemic stroke: pooled analysis of placebo data from the Stroke-Acute Ischemic NXY Treatment (SAINT)\u00a01 and SAINT II trials. Stroke. 2000;40: 3067\u201372","DOI":"10.1161\/STROKEAHA.109.554386"},{"key":"213_CR21","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1161\/STROKEAHA.111.644815","volume":"43","author":"M Mazya","year":"2012","unstructured":"Mazya M, Egido JA, Ford GA, Lees KR, Mikulik R, Toni D, et al. Predicting the Risk of Symptomatic Intracerebral Hemorrhage in Ischemic Stroke Treated With Intravenous Alteplase: Safe Implementation of Treatments in Stroke (SITS) Symptomatic Intracerebral Hemorrhage Risk Score. Stroke. 2012;43:1524\u201331.","journal-title":"Stroke"},{"issue":"10","key":"213_CR22","doi-asserted-by":"publisher","first-page":"e110189","DOI":"10.1371\/journal.pone.0110189","volume":"9","author":"DD Thompson","year":"2014","unstructured":"Thompson DD, Murray GD, Sudlow CLM, Dennis M, Whiteley WN. Comparison of Statistical and Clinical Predictions of Functional Outcome after Ischemic Stroke. PLoS One. 2014;9(10):e110189. doi: 10.1371\/journal.pone.0110189 .","journal-title":"PLoS One"},{"key":"213_CR23","doi-asserted-by":"crossref","unstructured":"Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E\u00a0et al.Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014. Volume 384 , Issue 9958 , 1929 \u2013 1935","DOI":"10.1016\/S0140-6736(14)60584-5"},{"key":"213_CR24","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1016\/S0140-6736(12)60738-7","volume":"379","author":"JM Wardlaw","year":"2012","unstructured":"Wardlaw JM, Murray V, Berge E, del Zoppo G, Sandercock P, Lindley RL, et al. Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis. Lancet. 2012;379:2364\u201372.","journal-title":"Lancet"},{"key":"213_CR25","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12911-014-0127-1","volume":"15","author":"D Flynn","year":"2015","unstructured":"Flynn D, Nesbitt D, Ford GA, McMeekin P, Rodgers H, Price C, et al. Development of a computerised decision aid for thrombolysis in acute stroke care. BMC Med Inform Decis Mak. 2015;15:6.","journal-title":"BMC Med Inform Decis Mak"}],"updated-by":[{"DOI":"10.1186\/s12911-016-0242-2","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T00:00:00Z","timestamp":1452902400000}}],"container-title":["BMC Medical Informatics and Decision Making"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12911-015-0213-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12911-015-0213-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12911-015-0213-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T08:34:10Z","timestamp":1567326850000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcmedinformdecismak.biomedcentral.com\/articles\/10.1186\/s12911-015-0213-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,11]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["213"],"URL":"https:\/\/doi.org\/10.1186\/s12911-015-0213-z","relation":{},"ISSN":["1472-6947"],"issn-type":[{"value":"1472-6947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,11]]},"article-number":"90"}}