{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T02:18:04Z","timestamp":1775096284413,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"S1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Inform Decis Mak"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1186\/s12911-017-0454-0","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T07:48:53Z","timestamp":1495093733000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Knowledge-driven binning approach for rare variant association analysis: application to neuroimaging biomarkers in Alzheimer\u2019s disease"],"prefix":"10.1186","volume":"17","author":[{"given":"Dokyoon","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna O.","family":"Basile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Bang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emrin","family":"Horgusluoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seunggeun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marylyn D.","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Saykin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwangsik","family":"Nho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,5,18]]},"reference":[{"issue":"1","key":"454_CR1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrg2626","volume":"11","author":"ML Metzker","year":"2010","unstructured":"Metzker ML. Sequencing technologies - the next generation. Nat Rev Genet. 2010;11(1):31\u201346.","journal-title":"Nat Rev Genet"},{"issue":"1","key":"454_CR2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2013.09.006","volume":"155","author":"DC Koboldt","year":"2013","unstructured":"Koboldt DC, Steinberg KM, Larson DE, Wilson RK, Mardis ER. The next-generation sequencing revolution and its impact on genomics. Cell. 2013;155(1):27\u201338.","journal-title":"Cell"},{"key":"454_CR3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/978-1-60327-367-1_12","volume":"628","author":"PC Ng","year":"2010","unstructured":"Ng PC, Kirkness EF. Whole genome sequencing. Methods Mol Biol. 2010;628:215\u201326.","journal-title":"Methods Mol Biol"},{"issue":"6","key":"454_CR4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrg2779","volume":"11","author":"ET Cirulli","year":"2010","unstructured":"Cirulli ET, Goldstein DB. Uncovering the roles of rare variants in common disease through whole-genome sequencing. Nat Rev Genet. 2010;11(6):415\u201325.","journal-title":"Nat Rev Genet"},{"issue":"3","key":"454_CR5","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jalz.2015.02.003","volume":"11","author":"Alzheimer\u2019s A","year":"2015","unstructured":"Alzheimer\u2019s A. 2015 Alzheimer\u2019s disease facts and figures. Alzheimers Dement. 2015;11(3):332\u201384.","journal-title":"Alzheimers Dement"},{"issue":"3","key":"454_CR6","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","volume":"39","author":"S Oddo","year":"2003","unstructured":"Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. Triple-transgenic model of Alzheimer\u2019s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 2003;39(3):409\u201321.","journal-title":"Neuron"},{"issue":"19","key":"454_CR7","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1212\/WNL.0b013e31828726f5","volume":"80","author":"LE Hebert","year":"2013","unstructured":"Hebert LE, Weuve J, Scherr PA, Evans DA. Alzheimer disease in the United States (2010\u20132050) estimated using the 2010 census. Neurology. 2013;80(19):1778\u201383.","journal-title":"Neurology"},{"issue":"9","key":"454_CR8","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.2105\/AJPH.88.9.1337","volume":"88","author":"R Brookmeyer","year":"1998","unstructured":"Brookmeyer R, Gray S, Kawas C. Projections of Alzheimer\u2019s disease in the United States and the public health impact of delaying disease onset. Am J Public Health. 1998;88(9):1337\u201342.","journal-title":"Am J Public Health"},{"issue":"3","key":"454_CR9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1177\/2040622310397636","volume":"2","author":"D Wilson","year":"2011","unstructured":"Wilson D, Peters R, Ritchie K, Ritchie CW. Latest advances on interventions that may prevent, delay or ameliorate dementia. Ther Adv Chronic Dis. 2011;2(3):161\u201373.","journal-title":"Ther Adv Chronic Dis"},{"issue":"2","key":"454_CR10","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1001\/archpsyc.63.2.168","volume":"63","author":"M Gatz","year":"2006","unstructured":"Gatz M, Reynolds CA, Fratiglioni L, Johansson B, Mortimer JA, Berg S, Fiske A, Pedersen NL. Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry. 2006;63(2):168\u201374.","journal-title":"Arch Gen Psychiatry"},{"issue":"10","key":"454_CR11","doi-asserted-by":"crossref","first-page":"a006296","DOI":"10.1101\/cshperspect.a006296","volume":"2","author":"RE Tanzi","year":"2012","unstructured":"Tanzi RE. The genetics of Alzheimer disease. Cold Spring Harb Perspect Med. 2012;2(10):a006296.","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"2","key":"454_CR12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","volume":"368","author":"R Guerreiro","year":"2013","unstructured":"Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, et al. TREM2 variants in Alzheimer\u2019s disease. N Engl J Med. 2013;368(2):117\u201327.","journal-title":"N Engl J Med"},{"issue":"5","key":"454_CR13","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/ng.3246","volume":"47","author":"S Steinberg","year":"2015","unstructured":"Steinberg S, Stefansson H, Jonsson T, Johannsdottir H, Ingason A, Helgason H, Sulem P, Magnusson OT, Gudjonsson SA, Unnsteinsdottir U, et al. Loss-of-function variants in ABCA7 confer risk of Alzheimer\u2019s disease. Nat Genet. 2015;47(5):445\u20137.","journal-title":"Nat Genet"},{"issue":"7484","key":"454_CR14","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nature12825","volume":"505","author":"C Cruchaga","year":"2014","unstructured":"Cruchaga C, Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, Norton J, Budde J, Bertelsen S, et al. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer\u2019s disease. Nature. 2014;505(7484):550\u20134.","journal-title":"Nature"},{"issue":"1","key":"454_CR15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ajhg.2014.06.009","volume":"95","author":"S Lee","year":"2014","unstructured":"Lee S, Abecasis GR, Boehnke M, Lin X. Rare-variant association analysis: study designs and statistical tests. Am J Hum Genet. 2014;95(1):5\u201323.","journal-title":"Am J Hum Genet"},{"issue":"1","key":"454_CR16","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ajhg.2011.05.029","volume":"89","author":"MC Wu","year":"2011","unstructured":"Wu MC, Lee S, Cai T, Li Y, Boehnke M, Lin X. Rare-variant association testing for sequencing data with the sequence kernel association test. Am J Hum Genet. 2011;89(1):82\u201393.","journal-title":"Am J Hum Genet"},{"key":"454_CR17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13040-016-0107-3","volume":"9","author":"CB Moore","year":"2016","unstructured":"Moore CB, Basile AO, Wallace JR, Frase AT, Ritchie MD. A biologically informed method for detecting rare variant associations. BioData Mining. 2016;9:27.","journal-title":"BioData Mining"},{"key":"454_CR18","doi-asserted-by":"crossref","unstructured":"Kim D, Li R, Dudek SM, Wallace JR, Ritchie MD. Binning somatic mutations based on biological knowledge for predicting survival: an application in renal cell carcinoma. Pac Symp Biocomput. 2015:96\u2013107.","DOI":"10.1142\/9789814644730_0011"},{"key":"454_CR19","first-page":"249","volume":"21","author":"AO Basile","year":"2016","unstructured":"Basile AO, Wallace JR, Peissig P, McCarty CA, Brilliant M, Ritchie MD. Knowledge driven binning and phewas analysis in Marshfield personalized medicine research project using biobin. Pac Symp Biocomput. 2016;21:249\u201360.","journal-title":"Pac Symp Biocomput"},{"issue":"Suppl 2","key":"454_CR20","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1755-8794-6-S2-S6","volume":"6","author":"CB Moore","year":"2013","unstructured":"Moore CB, Wallace JR, Frase AT, Pendergrass SA, Ritchie MD. BioBin: a bioinformatics tool for automating the binning of rare variants using publicly available biological knowledge. BMC Med Genomics. 2013;6 Suppl 2:S6.","journal-title":"BMC Med Genomics"},{"key":"454_CR21","doi-asserted-by":"crossref","unstructured":"Moore CB, Wallace JR, Frase AT, Pendergrass SA, Ritchie MD. Using BioBin to explore rare variant population stratification. Pac Symp Biocomput. 2013:332\u2013343.","DOI":"10.1142\/9789814447973_0033"},{"issue":"4","key":"454_CR22","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/biostatistics\/kxs014","volume":"13","author":"S Lee","year":"2012","unstructured":"Lee S, Wu MC, Lin X. Optimal tests for rare variant effects in sequencing association studies. Biostatistics. 2012;13(4):762\u201375.","journal-title":"Biostatistics"},{"issue":"3","key":"454_CR23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jalz.2010.03.013","volume":"6","author":"AJ Saykin","year":"2010","unstructured":"Saykin AJ, Shen L, Foroud TM, Potkin SG, Swaminathan S, Kim S, Risacher SL, Nho K, Huentelman MJ, Craig DW, et al. Alzheimer\u2019s disease neuroimaging initiative biomarkers as quantitative phenotypes: genetics core aims, progress, and plans. Alzheimers Dement. 2010;6(3):265\u201373.","journal-title":"Alzheimers Dement"},{"issue":"Suppl 1","key":"454_CR24","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12920-016-0190-9","volume":"9","author":"K Nho","year":"2016","unstructured":"Nho K, Horgusluoglu E, Kim S, Risacher SL, Kim D, Foroud T, Aisen PS, Petersen RC, Jack Jr CR, Shaw LM, et al. Integration of bioinformatics and imaging informatics for identifying rare PSEN1 variants in Alzheimer\u2019s disease. BMC Med Genomics. 2016;9 Suppl 1:30.","journal-title":"BMC Med Genomics"},{"key":"454_CR25","first-page":"59","volume":"2014","author":"K Nho","year":"2014","unstructured":"Nho K, West JD, Li H, Henschel R, Bharthur A, Tavares MC, Saykin AJ. Comparison of multi-sample variant calling methods for whole genome sequencing. IEEE Int Conf Systems Biol. 2014;2014:59\u201362.","journal-title":"IEEE Int Conf Systems Biol"},{"issue":"4","key":"454_CR26","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/jmri.21049","volume":"27","author":"CR Jack Jr","year":"2008","unstructured":"Jack Jr CR, Bernstein MA, Fox NC, Thompson P, Alexander G, Harvey D, Borowski B, Britson PJ JLW, Ward C, et al. The Alzheimer\u2019s disease neuroimaging initiative (ADNI): MRI methods. J Magn Reson Imaging. 2008;27(4):685\u201391.","journal-title":"J Magn Reson Imaging"},{"issue":"16","key":"454_CR27","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gkq603","volume":"38","author":"K Wang","year":"2010","unstructured":"Wang K, Li M, Hakonarson H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 2010;38(16):e164.","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"454_CR28","doi-asserted-by":"crossref","first-page":"e1000384","DOI":"10.1371\/journal.pgen.1000384","volume":"5","author":"BE Madsen","year":"2009","unstructured":"Madsen BE, Browning SR. A groupwise association test for rare mutations using a weighted sum statistic. PLoS Genet. 2009;5(2):e1000384.","journal-title":"PLoS Genet"},{"issue":"7","key":"454_CR29","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nrg2813","volume":"11","author":"AL Price","year":"2010","unstructured":"Price AL, Zaitlen NA, Reich D, Patterson N. New approaches to population stratification in genome-wide association studies. Nat Rev Genet. 2010;11(7):459\u201363.","journal-title":"Nat Rev Genet"},{"issue":"Web Server issu","key":"454_CR30","doi-asserted-by":"crossref","first-page":"W484","DOI":"10.1093\/nar\/gks458","volume":"40","author":"AK Wong","year":"2012","unstructured":"Wong AK, Park CY, Greene CS, Bongo LA, Guan Y, Troyanskaya OG. IMP: a multi-species functional genomics portal for integration, visualization and prediction of protein functions and networks. Nucleic Acids Res. 2012;40(Web Server issue):W484\u2013490.","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"454_CR31","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3233\/JAD-2012-121408","volume":"33","author":"L Velayudhan","year":"2013","unstructured":"Velayudhan L, Proitsi P, Westman E, Muehlboeck JS, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Spenger C, et al. Entorhinal cortex thickness predicts cognitive decline in Alzheimer\u2019s disease. J Alzheimers Dis. 2013;33(3):755\u201366.","journal-title":"J Alzheimers Dis"},{"issue":"7","key":"454_CR32","doi-asserted-by":"crossref","first-page":"e0159463","DOI":"10.1371\/journal.pone.0159463","volume":"11","author":"H Fu","year":"2016","unstructured":"Fu H, Hussaini SA, Wegmann S, Profaci C, Daniels JD, Herman M, Emrani S, Figueroa HY, Hyman BT, Davies P, et al. 3D visualization of the temporal and spatial spread of tau pathology reveals extensive sites of tau accumulation associated with neuronal loss and recognition memory deficit in aged tau transgenic mice. PLoS One. 2016;11(7):e0159463.","journal-title":"PLoS One"},{"issue":"1","key":"454_CR33","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/00062752-200301000-00011","volume":"10","author":"GC Bagby Jr","year":"2003","unstructured":"Bagby Jr GC. Genetic basis of fanconi anemia. Curr Opin Hematol. 2003;10(1):68\u201376.","journal-title":"Curr Opin Hematol"},{"issue":"42","key":"454_CR34","doi-asserted-by":"crossref","first-page":"43910","DOI":"10.1074\/jbc.M403884200","volume":"279","author":"X Zhang","year":"2004","unstructured":"Zhang X, Li J, Sejas DP, Rathbun KR, Bagby GC, Pang Q. The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR). J Biol Chem. 2004;279(42):43910\u20139.","journal-title":"J Biol Chem"},{"issue":"16","key":"454_CR35","first-page":"3538","volume":"58","author":"J Wang","year":"1998","unstructured":"Wang J, Otsuki T, Youssoufian H, Foe JL, Kim S, Devetten M, Yu J, Li Y, Dunn D, Liu JM. Overexpression of the fanconi anemia group C gene (FAC) protects hematopoietic progenitors from death induced by Fas-mediated apoptosis. Cancer Res. 1998;58(16):3538\u201341.","journal-title":"Cancer Res"},{"issue":"8","key":"454_CR36","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.molmed.2009.06.005","volume":"15","author":"LR Coulthard","year":"2009","unstructured":"Coulthard LR, White DE, Jones DL, McDermott MF, Burchill SA. p38(MAPK): stress responses from molecular mechanisms to therapeutics. Trends Mol Med. 2009;15(8):369\u201379.","journal-title":"Trends Mol Med"},{"key":"454_CR37","doi-asserted-by":"crossref","first-page":"e975","DOI":"10.1038\/cddis.2013.503","volume":"4","author":"B Parajuli","year":"2013","unstructured":"Parajuli B, Sonobe Y, Horiuchi H, Takeuchi H, Mizuno T, Suzumura A. Oligomeric amyloid beta induces IL-1beta processing via production of ROS: implication in Alzheimer\u2019s disease. Cell Death Dis. 2013;4:e975.","journal-title":"Cell Death Dis"},{"issue":"34","key":"454_CR38","doi-asserted-by":"crossref","first-page":"11414","DOI":"10.1523\/JNEUROSCI.2127-10.2010","volume":"30","author":"N Origlia","year":"2010","unstructured":"Origlia N, Bonadonna C, Rosellini A, Leznik E, Arancio O, Yan SS, Domenici L. Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex. J Neurosci. 2010;30(34):11414\u201325.","journal-title":"J Neurosci"},{"issue":"10","key":"454_CR39","doi-asserted-by":"crossref","first-page":"e0140612","DOI":"10.1371\/journal.pone.0140612","volume":"10","author":"A Magron","year":"2015","unstructured":"Magron A, Elowe S, Carreau M. The fanconi anemia C protein binds to and regulates stathmin-1 phosphorylation. PLoS One. 2015;10(10):e0140612.","journal-title":"PLoS One"},{"issue":"9","key":"454_CR40","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/syn.20933","volume":"65","author":"P Saetre","year":"2011","unstructured":"Saetre P, Jazin E, Emilsson L. Age-related changes in gene expression are accelerated in Alzheimer\u2019s disease. Synapse. 2011;65(9):971\u20134.","journal-title":"Synapse"},{"issue":"3","key":"454_CR41","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.neuropharm.2009.11.010","volume":"58","author":"L Munoz","year":"2010","unstructured":"Munoz L, Ammit AJ. Targeting p38 MAPK pathway for the treatment of Alzheimer\u2019s disease. Neuropharmacology. 2010;58(3):561\u20138.","journal-title":"Neuropharmacology"},{"issue":"2","key":"454_CR42","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S0014-4886(03)00180-8","volume":"183","author":"A Sun","year":"2003","unstructured":"Sun A, Liu M, Nguyen XV, Bing G. P38 MAP kinase is activated at early stages in Alzheimer\u2019s disease brain. Exp Neurol. 2003;183(2):394\u2013405.","journal-title":"Exp Neurol"},{"issue":"1","key":"454_CR43","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1128\/MCB.17.1.24","volume":"17","author":"P Juo","year":"1997","unstructured":"Juo P, Kuo CJ, Reynolds SE, Konz RF, Raingeaud J, Davis RJ, Biemann HP, Blenis J. Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE\/CED-3 family proteases. Mol Cell Biol. 1997;17(1):24\u201335.","journal-title":"Mol Cell Biol"},{"issue":"3","key":"454_CR44","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.nbd.2008.05.006","volume":"31","author":"R Betarbet","year":"2008","unstructured":"Betarbet R, Anderson LR, Gearing M, Hodges TR, Fritz JJ, Lah JJ, Levey AI. Fas-associated factor 1 and Parkinson\u2019s disease. Neurobiol Dis. 2008;31(3):309\u201315.","journal-title":"Neurobiol Dis"},{"issue":"12","key":"454_CR45","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1111\/j.1600-0854.2006.00504.x","volume":"7","author":"SW Hicks","year":"2006","unstructured":"Hicks SW, Horn TA, McCaffery JM, Zuckerman DM, Machamer CE. Golgin-160 promotes cell surface expression of the beta-1 adrenergic receptor. Traffic. 2006;7(12):1666\u201377.","journal-title":"Traffic"},{"key":"454_CR46","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.mod.2014.02.001","volume":"132","author":"Z Manojlovic","year":"2014","unstructured":"Manojlovic Z, Earwood R, Kato A, Stefanovic B, Kato Y. RFX7 is required for the formation of cilia in the neural tube. Mech Dev. 2014;132:28\u201337.","journal-title":"Mech Dev"},{"key":"454_CR47","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/1471-2148-8-226","volume":"8","author":"S Aftab","year":"2008","unstructured":"Aftab S, Semenec L, Chu JS, Chen N. Identification and characterization of novel human tissue-specific RFX transcription factors. BMC Evol Biol. 2008;8:226.","journal-title":"BMC Evol Biol"}],"container-title":["BMC Medical Informatics and Decision Making"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12911-017-0454-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T17:50:10Z","timestamp":1750269010000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcmedinformdecismak.biomedcentral.com\/articles\/10.1186\/s12911-017-0454-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":47,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["454"],"URL":"https:\/\/doi.org\/10.1186\/s12911-017-0454-0","relation":{},"ISSN":["1472-6947"],"issn-type":[{"value":"1472-6947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5]]},"article-number":"61"}}