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To give you more description, first of all we have not used any of patients\u2019 data. The data described in the Methods section are metadata, which is data about data including data \u2018specifications\u2019 and \u2018definitions\u2019. We have had no chance of using patients\u2019 private and\/or personal information at all in writing the manuscript. We believe that it is not necessary to take an IRB review for using metadata as long as we do not use any of patients\u2019 data. Secondly, the authors themselves have developed and been in charge of operating the CHMR. Again CHMR is a metadata registry that does not contain any of patients\u2019 real data but list of descriptions and definitions of common data elements (CDEs) conforming the ISO\/IEC 11179 standard for metadata description and registry. According to the standard, metadata has such things as \u2018the minimum value of patient\u2019s age is set to be zero\u2019, \u2018the gender of a patient has a permissible value of \u2018M\u2019 for male, \u2018F\u2019 for female, etc. without having any of real \u2018data\u2019. The metadata used in this paper is freely available in the CHMR.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not Applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"None of the authors has conflicts of interest with other persons or organizations that could inappropriately influence their work.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"166"}}