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Roudebush Veterans Affairs Medical Center","award":["CIN 13-416"],"award-info":[{"award-number":["CIN 13-416"]}]},{"DOI":"10.13039\/100007217","name":"HSR&D","doi-asserted-by":"crossref","award":["HFP 04-148"],"award-info":[{"award-number":["HFP 04-148"]}],"id":[{"id":"10.13039\/100007217","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Inform Decis Mak"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A pharmacogenomic clinical decision support tool (PGx-CDS) for thiopurine medications can help physicians incorporate pharmacogenomic results into prescribing decisions by providing up-to-date, real-time decision support. However, the PGx-CDS user interface may introduce errors and promote alert fatigue. The objective of this study was to develop and evaluate a prototype of a PGx-CDS user interface for thiopurine medications with user-centered design methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study had two phases: In phase I, we conducted qualitative interviews to assess providers\u2019 information needs. Interview transcripts were analyzed through a combination of inductive and deductive qualitative analysis to develop design requirements for a PGx-CDS user interface. Using these requirements, we developed a user interface prototype and evaluated its usability (phase II).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 14 providers participated: 10 were interviewed in phase I, and seven providers completed usability testing in phase II (3 providers participated in both phases). Most (90%) participants were interested in PGx-CDS systems to help improve medication efficacy and patient safety. Interviews yielded 11 themes sorted into two main categories: 1) health care providers\u2019 views on PGx-CDS and 2) important design features for PGx-CDS. We organized these findings into guidance for PGx-CDS content and display. Usability testing of the PGx-CDS prototype showed high provider satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is one of the first studies to utilize a user-centered design approach to develop and assess a PGx-CDS interface prototype for Thiopurine Methyltransferase (TPMT). This study provides guidance for the development of a PGx-CDS, and particularly for biomarkers such as TPMT.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12911-019-0919-4","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T14:59:24Z","timestamp":1571324364000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Utilizing a user-centered approach to develop and assess pharmacogenomic clinical decision support for thiopurine methyltransferase"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6518-8655","authenticated-orcid":false,"given":"Khoa A.","family":"Nguyen","sequence":"first","affiliation":[]},{"given":"Himalaya","family":"Patel","sequence":"additional","affiliation":[]},{"given":"David A.","family":"Haggstrom","sequence":"additional","affiliation":[]},{"given":"Alan J.","family":"Zillich","sequence":"additional","affiliation":[]},{"given":"Thomas F.","family":"Imperiale","sequence":"additional","affiliation":[]},{"given":"Alissa L.","family":"Russ","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,10,17]]},"reference":[{"key":"919_CR1","volume-title":"What is pharmacogenomics","author":"NIH","year":"2018","unstructured":"NIH. 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