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First, a morphological filter operator is applied to remove structures undergoing the respiratory motion from the original image sequence. Second, an inter-frame constrained robust principal component analysis (RPCA) is utilized to remove the quasi-static structures from the image sequence. Third, an intra-frame constrained RPCA is employed to smooth the final extracted vascular sequence. Fourth, a multi-feature fusion is designed to improve the vascular contrast and the final vascular segmentation is realized by thresholding-based method.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Experiments are conducted on 22 clinical X-ray angiographic image sequences. The global and local contrast-to-noise ratio of the proposed method are 6.6344 and 4.2882, respectively. And the precision, sensitivity and F1 value are 0.7378, 0.7960 and 0.7658, respectively. It demonstrates that our method is effective and robust for vascular segmentation from image sequence.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The proposed method is effective to remove non-vascular structures, reduce motion artefacts and other non-uniform illumination caused noises. Also, the proposed method is online which can just process one image per time without re-optimizing the model.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12911-019-0966-x","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T09:04:20Z","timestamp":1576746260000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Inter\/intra-frame constrained vascular segmentation in X-ray angiographic image sequence"],"prefix":"10.1186","volume":"19","author":[{"given":"Shuang","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenbing","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danni","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongtian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,19]]},"reference":[{"key":"966_CR1","first-page":"13","volume":"34","author":"D Cavaye","year":"1993","unstructured":"Cavaye D, White R. 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Informed consent to participate in the study was obtained from all participants. Data access was granted in the context of project National Key R&D Program of China (2017YFC0112000) and the National Science Foundation Program of China (81627803, 61501030, 61672099), where the authors\u2019 institutions participate.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"270"}}