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In the present study, we aimed to evaluate the efficacy and stability of an information and communication technology (ICT)-based centralized monitoring system for increasing medication adherence among Korean KTRs.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>In this prospective, multicenter, randomized controlled study, enrolled KTRs were randomized to either the ICT-based centralized monitoring group or control group. The ICT-based centralized monitoring system alerted both patients and medical staff with texts and pill box alarms if there was a missed dose or a dosage\/time error. We compared the two groups in terms of medication adherence and transplant outcomes over 6\u2009months, and evaluated patient satisfaction with the ICT-based monitoring system.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Among 114 enrolled KTRs, 57 were assigned to the ICT-based centralized monitoring group and 57 to the control group. The two groups did not significantly differ in mean adherence at each follow-up visit. The intrapatient variability of tacrolimus and mycophenolic acid levels, renal function, and adverse transplant outcomes did not differ between the intervention and control groups, or between the intervention group with feedback generation and the intervention group without feedback generation. Patients showed high overall satisfaction with the ICT-based centralized monitoring system, which significantly improved across the study period (<jats:italic>p<\/jats:italic>\u2009=\u20090.012).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Due to high baseline adherence, the ICT-based centralized monitoring system did not maximize medication adherence or enhance transplant outcomes among Korean KTRs. However, patients were highly satisfied with the system. Our results suggest that the ICT-based centralized monitoring system could be successfully applied in clinical trials.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Trial registration<\/jats:title>\n<jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03136588\">NCT03136588<\/jats:ext-link>. Registered 20 April 2017 - Retrospectively registered.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12911-020-01146-6","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T09:03:03Z","timestamp":1591779783000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["ICT-based adherence monitoring in kidney transplant recipients: a randomized controlled trial"],"prefix":"10.1186","volume":"20","author":[{"given":"Hee-Yeon","family":"Jung","sequence":"first","affiliation":[]},{"given":"Yena","family":"Jeon","sequence":"additional","affiliation":[]},{"given":"Sook Jin","family":"Seong","sequence":"additional","affiliation":[]},{"given":"Jung Ju","family":"Seo","sequence":"additional","affiliation":[]},{"given":"Ji-Young","family":"Choi","sequence":"additional","affiliation":[]},{"given":"Jang-Hee","family":"Cho","sequence":"additional","affiliation":[]},{"given":"Sun-Hee","family":"Park","sequence":"additional","affiliation":[]},{"given":"Chan-Duck","family":"Kim","sequence":"additional","affiliation":[]},{"given":"Young-Ran","family":"Yoon","sequence":"additional","affiliation":[]},{"given":"Se-Hee","family":"Yoon","sequence":"additional","affiliation":[]},{"given":"Jong Soo","family":"Lee","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1344-3455","authenticated-orcid":false,"given":"Yong-Lim","family":"Kim","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"issue":"2","key":"1146_CR1","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/j.1600-6143.2011.03840.x","volume":"12","author":"J Sellares","year":"2012","unstructured":"Sellares J, de Freitas DG, Mengel M, Reeve J, Einecke G, Sis B, Hidalgo LG, Famulski K, Matas A, Halloran PF. 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When enrolling participants under the age of 16\u2009years, written informed consent was provided by the parent or guardian. All clinical investigations were conducted in accordance with the guidelines of the Declaration of Helsinki and the Good Clinical Practice guidelines. The present study adheres to CONSORT guidelines.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"105"}}