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Current non-invasive detection methods like serum biomarker are unsatisfactory. Biomarkers with high accuracy for diagnostic of prostate cancer are urgently needed. Many lipid species have been found related to various cancers. The purpose of our study is to explore the diagnostic value of lipids for prostate cancer.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Using triple quadruple liquid chromatography electrospray ionization tandem mass spectrometry, we performed lipidomics profiling of 367 lipids on a total 114 plasma samples from 30 patients with prostate cancer, 38 patients with benign prostatic hyperplasia (BPH), and 46 male healthy controls to evaluate the lipids as potential biomarkers in the diagnosis of prostate cancer. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database was used to construct the potential mechanism pathway. After statistical analysis, five lipids were identified as a panel of potential biomarkers for the detection of prostate cancer between prostate cancer group and the BPH group; the sensitivity, specificity, and area under curve (AUC) of the combination of these five lipids were 73.3, 81.6%, and 0.800, respectively. We also identified another panel of five lipids in distinguishing between prostate cancer group and the control group with predictive values of sensitivity at 76.7%, specificity at 80.4%, and AUC at 0.836, respectively. The glycerophospholipid metabolism pathway of the selected lipids was considered as the target pathway.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our study indicated that the identified plasma lipid biomarkers have potential in the diagnosis of prostate cancer.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12911-020-01242-7","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T01:21:02Z","timestamp":1600910462000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Identification of plasma lipid species as promising diagnostic markers for prostate cancer"],"prefix":"10.1186","volume":"20","author":[{"given":"Xiaoli","family":"Chen","sequence":"first","affiliation":[]},{"given":"Yong","family":"Zhu","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1596-856X","authenticated-orcid":false,"given":"Mayumi","family":"Jijiwa","sequence":"additional","affiliation":[]},{"given":"Masaki","family":"Nasu","sequence":"additional","affiliation":[]},{"given":"Junmei","family":"Ai","sequence":"additional","affiliation":[]},{"given":"Shengming","family":"Dai","sequence":"additional","affiliation":[]},{"given":"Bin","family":"Jiang","sequence":"additional","affiliation":[]},{"given":"Jicai","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Gang","family":"Huang","sequence":"additional","affiliation":[]},{"given":"Youping","family":"Deng","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"issue":"2","key":"1242_CR1","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.3390\/cancers2021125","volume":"2","author":"RA Clarke","year":"2010","unstructured":"Clarke RA, Schirra HJ, Catto JW, Lavin MF, Gardiner RA. 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The Institutional Review Board (IRB) of Rush University Medical Center approved our study. Before collecting plasma samples, written informed consents were obtained from patients and control individuals.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"223"}}