{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T16:02:49Z","timestamp":1775577769116,"version":"3.50.1"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["676265"],"award-info":[{"award-number":["676265"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Inform Decis Mak"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The growing number of older people and, with it, the increase of neurological impairments such as dementia has led to the implementation of the use of computer programs for cognitive rehabilitation in people with dementia. For 20\u00a0years, we have been developing the GRADIOR cognitive rehabilitation program and conducted several studies associated with its usability and effectiveness. This paper describes the development of the latest version of the GRADIOR computer-based cognitive rehabilitation program for people with different neurological etiologies, especially mild cognitive impairment and mild dementia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>GRADIOR is a program that allows cognitive evaluation and rehabilitation of people affected by cognitive impairment. The new version of GRADIOR is characterized by a structure that is dynamic and flexible for both user and therapist, consisting of: Clinical Manager, Clinical History Manager, Treatment Manager and Report Manager. As a structure based on specific requirements, GRADIOR includes a series of modalities and sub-modalities, each modality comprising a series of exercises with different difficulty levels.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>Previous studies associated with earlier versions of GRADIOR have allowed the development of a new version of GRADIOR. Taking into account aspects associated with user experience, usability and effectiveness. Aspects that have made it possible to achieve a program that can meet the needs of older people with dementia.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12911-020-01293-w","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T13:03:03Z","timestamp":1603371783000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Computer-based cognitive rehabilitation program GRADIOR for mild dementia and mild cognitive impairment: new features"],"prefix":"10.1186","volume":"20","author":[{"given":"Manuel A.","family":"Franco-Mart\u00edn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0815-4480","authenticated-orcid":false,"given":"Angie A.","family":"Diaz-Baquero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Bueno-Aguado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda T.","family":"Cid-Bartolom\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Parra Vidales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda V.","family":"Perea Bartolom\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"de la Torre D\u00edez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri\u00ebtte G.","family":"van der Roest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"key":"1293_CR1","unstructured":"Eurostat.European-Comission. Eurostat publications and databases. Eurostat, 2016 9282869342."},{"issue":"11","key":"1293_CR2","doi-asserted-by":"publisher","first-page":"e0142388","DOI":"10.1371\/journal.pone.0142388","volume":"10","author":"PS Sachdev","year":"2015","unstructured":"Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Thalamuthu A, Andrews G, et al. The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: the COSMIC Collaboration. PLoS ONE. 2015;10(11):e0142388.","journal-title":"PLoS ONE"},{"issue":"4","key":"1293_CR3","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.cger.2013.07.003","volume":"29","author":"R Roberts","year":"2013","unstructured":"Roberts R, Knopman DS. Classification and epidemiology of MCI. Clin Geriatr Med. 2013;29(4):753\u201372.","journal-title":"Clin Geriatr Med"},{"issue":"1","key":"1293_CR4","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jalz.2012.11.007","volume":"9","author":"M Prince","year":"2013","unstructured":"Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement. 2013;9(1):63\u201375.","journal-title":"Alzheimers Dement"},{"key":"1293_CR5","unstructured":"Europe A. Prevalence of dementia in Europe. Alzheimer Europe. https:\/\/www.alzheimer-europe.org\/EN\/Research\/European-Collaboration-on-Dementia\/Prevalence-of-dementia\/Prevalence-of-dementia-in-Europe; 2013."},{"key":"1293_CR6","unstructured":"Galeotti F, Giusti A, Meduri F, Raschetti R, Scardetta P, Vanacore N. Epidemiological Data on Dementia: Synthesis Report. ALzheimer COoperation Valuation in Europe (ALCOVE). https:\/\/webgate.ec.europa.eu\/chafea_pdb\/assets\/files\/pdb\/20102201\/20102201_d4-00_en_ps.pdf; 2013."},{"key":"1293_CR7","unstructured":"Ageing Working Group. The 2015 Ageing Report-Economic and budgetary projections for the 28 EU Member States (2013\u20132060). European Economy. 2015."},{"key":"1293_CR8","unstructured":"European-Social-Network. Services for older people in Europe. Facts and figures about long term care services in Europe.2008."},{"key":"1293_CR9","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.mam.2015.06.003","volume":"43\u201344","author":"J Rodakowski","year":"2015","unstructured":"Rodakowski J, Saghafi E, Butters MA, Skidmore ER. Non-pharmacological interventions for adults with mild cognitive impairment and early stage dementia: an updated scoping review. Mol Aspects Med. 2015;43\u201344:38\u201353.","journal-title":"Mol Aspects Med"},{"key":"1293_CR10","first-page":"Cd003260","volume":"6","author":"L Clare","year":"2013","unstructured":"Clare L, Woods B. Cognitive training and cognitive rehabilitation for mild to moderate Alzheimer\u2019s disease and vascular dementia. Cochrane Database Syst Rev. 2013;6:Cd003260.","journal-title":"Cochrane Database Syst Rev"},{"key":"1293_CR11","first-page":"1","volume":"4","author":"L Clare","year":"2003","unstructured":"Clare L, Woods RT, Moniz Cook ED, Orrell M, Spector A. Cognitive rehabilitation and cognitive training for early-stage Alzheimer\u2019s disease and vascular dementia. Cochrane Database of Syst Rev. 2003;4:1\u201339.","journal-title":"Cochrane Database of Syst Rev"},{"issue":"1","key":"1293_CR12","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s11065-013-9230-9","volume":"23","author":"M Huckans","year":"2013","unstructured":"Huckans M, Hutson L, Twamley E, Jak A, Kaye J, Storzbach D. Efficacy of cognitive rehabilitation therapies for mild cognitive impairment (MCI) in older adults: working toward a theoretical model and evidence-based interventions. Neuropsychol Rev. 2013;23(1):63\u201380.","journal-title":"Neuropsychol Rev"},{"issue":"1","key":"1293_CR13","first-page":"166","volume":"13","author":"G Winocur","year":"2007","unstructured":"Winocur G, Craik FI, Levine B, Robertson IH, Binns MA, Alexander M, et al. Cognitive rehabilitation in the elderly: overview and future directions. J Int Neuropsychol Soc. 2007;13(1):166\u201371.","journal-title":"J Int Neuropsychol Soc"},{"issue":"2","key":"1293_CR14","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1159\/000316119","volume":"30","author":"J Olazar\u00e1n","year":"2010","unstructured":"Olazar\u00e1n J, Reisberg B, Clare L, Cruz I, Pe\u00f1a-Casanova J, del Ser T, et al. Nonpharmacological therapies in Alzheimer\u2019s disease: a systematic review of efficacy. Dement Geriatr Cogn Disord. 2010;30(2):161\u201378.","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"6","key":"1293_CR15","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1080\/13607863.2014.954527","volume":"19","author":"A Marshall","year":"2015","unstructured":"Marshall A, Spreadbury J, Cheston R, Coleman P, Ballinger C, Mullee M, et al. A pilot randomised controlled trial to compare changes in quality of life for participants with early diagnosis dementia who attend a \u201cLiving Well with Dementia\u201d group compared to waiting-list control. Aging Mental health. 2015;19(6):526\u201335.","journal-title":"Aging Mental health"},{"key":"1293_CR16","unstructured":"Terr\u00f3n C, Casanova JP. Problem\u00e1tica social del paciente con demencia y el neur\u00f3logo. Aspectos familiares y sociales del paciente con demencia. 2004:83\u201390."},{"issue":"3","key":"1293_CR17","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","volume":"7","author":"RA Sperling","year":"2011","unstructured":"Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, et al. Toward defining the preclinical stages of Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimer\u2019s Dement. 2011;7(3):280\u201392.","journal-title":"Alzheimer's Dement"},{"issue":"2","key":"1293_CR18","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.jalz.2013.01.015","volume":"10","author":"DS Geldmacher","year":"2014","unstructured":"Geldmacher DS, Kirson NY, Birnbaum HG, Eapen S, Kantor E, Cummings AK, et al. Implications of early treatment among medicaid patients with Alzheimer\u2019s disease. Alzheimers Dement. 2014;10(2):214\u201324.","journal-title":"Alzheimers Dement"},{"issue":"1","key":"1293_CR19","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1186\/s12913-017-2456-0","volume":"17","author":"A Broda","year":"2017","unstructured":"Broda A, Bieber A, Meyer G, Hopper L, Joyce R, Irving K, et al. Perspectives of policy and political decision makers on access to formal dementia care: expert interviews in eight European countries. BMC Health Serv Res. 2017;17(1):518.","journal-title":"BMC Health Serv Res"},{"issue":"6","key":"1293_CR20","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1177\/1471301214563551","volume":"15","author":"S Koehn","year":"2016","unstructured":"Koehn S, Badger M, Cohen C, McCleary L, Drummond N. Negotiating access to a diagnosis of dementia: implications for policies in health and social care. Dementia (London). 2016;15(6):1436\u201356.","journal-title":"Dementia (London)"},{"issue":"1","key":"1293_CR21","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1186\/s12913-016-1672-3","volume":"16","author":"L Kerpershoek","year":"2016","unstructured":"Kerpershoek L, de Vugt M, Wolfs C, Jelley H, Orrell M, Woods B, et al. Access to timely formal dementia care in Europe: protocol of the Actifcare (ACcess to Timely Formal Care) study. BMC Health Serv Res. 2016;16(1):423.","journal-title":"BMC Health Serv Res"},{"key":"1293_CR22","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/1471-2377-14-101","volume":"14","author":"JH Barnett","year":"2014","unstructured":"Barnett JH, Lewis L, Blackwell AD, Taylor M. Early intervention in Alzheimer\u2019s disease: a health economic study of the effects of diagnostic timing. BMC Neurol. 2014;14:101.","journal-title":"BMC Neurol"},{"issue":"5","key":"1293_CR23","first-page":"1","volume":"25","author":"JA Garc\u00eda-Casal","year":"2016","unstructured":"Garc\u00eda-Casal JA, Loizeau A, Csipke E, Franco-Mart\u00edn M, Perea-Bartolom\u00e9 MV, Orrell M. Computer-based cognitive interventions for people living with dementia: a systematic literature review and meta-analysis. Aging Mental Health. 2016;25(5):1\u201314.","journal-title":"Aging Mental Health"},{"issue":"1","key":"1293_CR24","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.2196\/rehab.6376","volume":"4","author":"F Meiland","year":"2017","unstructured":"Meiland F, Innes A, Mountain G, Robinson L, van der Roest H, Garcia-Casal JA, et al. Technologies to support community-dwelling persons with dementia: a position paper on issues regarding development, usability, effectiveness and cost-effectiveness, deployment, and ethics. JMIR Rehabil Assist Technol. 2017;4(1):e1.","journal-title":"JMIR Rehabil Assist Technol"},{"key":"1293_CR25","unstructured":"Franco Martin MA, Orihuela Villameriel T, Bueno Aguado Y, Conde Diez R, Alonso Jimenez M. Programa GRADIOR rehabilitaci\u00f3n cognitiva por ordenador. Fundaci\u00f3n INTRAS. 2013:1\u20133."},{"key":"1293_CR26","unstructured":"Franco Mart\u00edn MA, Criado del Valle CH. Intervenci\u00f3n psicoterap\u00e9utica en afectados de enfermedad de Alzheimer con deterioro leve. Madrid 2002."},{"issue":"3","key":"1293_CR27","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein MF, Folstein SE, McHugh PR. \u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189\u201398.","journal-title":"J Psychiatr Res"},{"key":"1293_CR28","first-page":"61","volume":"14","author":"FI Mahoney","year":"1965","unstructured":"Mahoney FI, Barthel DW. Functional evaluation: the Barthel Index. Md State Med J. 1965;14:61\u20135.","journal-title":"Md State Med J"},{"issue":"1","key":"1293_CR29","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","volume":"17","author":"JA Yesavage","year":"1982","unstructured":"Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1982;17(1):37\u201349.","journal-title":"J Psychiatr Res"},{"issue":"3","key":"1293_CR30","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","volume":"9","author":"MP Lawton","year":"1969","unstructured":"Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9(3):179\u201386.","journal-title":"Gerontologist"},{"key":"1293_CR31","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1192\/bjp.149.6.698","volume":"149","author":"M Roth","year":"1986","unstructured":"Roth M, Tym E, Mountjoy CQ, Huppert FA, Hendrie H, Verma S. CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br J Psychiatry. 1986;149:698\u2013709.","journal-title":"Br J Psychiatry"},{"key":"1293_CR32","unstructured":"Thalmann B, Mansch AU, Ermini-Fiinsfchilling D. Improved screening for dementia: combining the clock drawing test and the Mini-Mental State Examination. In: The 4th international Nice\/Springfield alzheimer symposium; 10\u201314 April.1996."},{"key":"1293_CR33","first-page":"9","volume":"1","author":"JE Partington","year":"1949","unstructured":"Partington JE, Leiter RG. Partington\u2019s pathway test. Psychol Serv Center Bull. 1949;1:9\u201320.","journal-title":"Psychol Serv Center Bull"},{"key":"1293_CR34","unstructured":"Fumero Vargas G, Franco Mart\u00edn MA, Perea Bartolom\u00e9 MV. Puesta en marcha y estudio de usabilidad de un programa de rehabilitaci\u00f3n cognitiva por ordenador \"GRADIOR\" en el tratamiento de d\u00e9ficits Neurocognitivo [Doctoral]: Universidad de Salamanca 2009."},{"key":"1293_CR35","unstructured":"Fumero Vargas G, Franco Mar\u00edn MA, Perea Bartolom\u00e9 MV. Usabilidad de un programa de rehabilitaci\u00f3n Neuropsicol\u00f3gica por ordenador \"GRADIOR\" en personas con enfermedad mental grave y prolongada [Doctoral]: Universidad de Salamanca; 2015."},{"key":"1293_CR36","unstructured":"Franco &., Bueno. Uso de las nuevas tecnolog\u00edas como instrumentos de intervenci\u00f3n en programas de psicoestimulaci\u00f3n. In: Ag\u00fcera L, Mart\u00edn M, Cervilla J, editors. Psiquiatr\u00eda Geri\u00e1trica. Barcelona: Mansson2002. p. 665\u201377."},{"key":"1293_CR37","doi-asserted-by":"crossref","unstructured":"Toribio-Guzm\u00e1n JM, Parra Vidales E, Vi\u00f1as Rodr\u00edguez MJ, Bueno Aguado Y, Cid Bartolom\u00e9 MT, Franco-Mart\u00edn MA. Rehabilitaci\u00f3n cognitiva por ordenador en personas mayores: Pragrama Gradior Ediciones Universidad de Salamanca. 2019;Aula(24):61\u201375.","DOI":"10.14201\/aula2018246175"},{"key":"1293_CR38","unstructured":"Diaz Baquero AA. Technology design focused on the characteristics of the population provides usability [3.1.3.6]. 2019. In: Best Practice Guidance: Human Interaction with Technology in Dementia Recommendations based on the research conducted in the Marie Sklodowska Curie International Training Network INDUCT [Internet]. https:\/\/www.dementiainduct.eu\/guidance\/."},{"issue":"1","key":"1293_CR39","doi-asserted-by":"publisher","first-page":"e12192","DOI":"10.2196\/12192","volume":"2","author":"E Guisado-Fern\u00e1ndez","year":"2019","unstructured":"Guisado-Fern\u00e1ndez E, Giunti G, Mackey LM, Blake C, Caulfield BM. Factors influencing the adoption of smart health technologies for people with dementia and their informal caregivers: scoping review and design framework. JMIR Aging. 2019;2(1):e12192.","journal-title":"JMIR Aging"},{"key":"1293_CR40","doi-asserted-by":"crossref","unstructured":"G\u00f3ngora Alonso S, Fumero Vargas G, Mor\u00f3n L, Mor\u00f3n L, Sainz de Abajo B, de la Torre D\u00edez I, et al. Usability Analysis of a System for Cognitive Rehabilitation \u201cGradior\u201d in a Spanish Region. Telemedicine and e-Health. 2019;Online ahead of print.","DOI":"10.1089\/tmj.2019.0084"},{"key":"1293_CR41","doi-asserted-by":"publisher","first-page":"e6","DOI":"10.1016\/j.neulet.2011.05.079","volume":"500","author":"MF Franco-Mart\u00edn","year":"2011","unstructured":"Franco-Mart\u00edn MF, Gonz\u00e1lez Palau F, Ruiz Y, Vargas E, Solis A, Mellado J, et al. Usability of a cognitive (Gradior) and physical training program based in new software technologies in patients with mild dementia, mild cognitive impairment and healthy elderly people: long lasting memories preliminary findings. Neurosci Lett. 2011;500:e6.","journal-title":"Neurosci Lett"},{"key":"1293_CR42","unstructured":"Toribio Guzm\u00e1n JM. Long Lasting Memories, una plataforma TIC integrada contra el deterioro cognitivo relacionado con la edad: estudio de usabilidad [Tesis Doctoral]: Universidad de Salamanca; 2016."},{"issue":"2","key":"1293_CR43","first-page":"119","volume":"11","author":"F Gonz\u00e1lez-Palau","year":"2013","unstructured":"Gonz\u00e1lez-Palau F, Franco Mar\u00edn MA, Toribio Guzm\u00e1n JM, Losada R, Parra E, Bamidis P. Designing a computer-based rehabilitation solution for older adults: the importance of testing usability. PsychNol J. 2013;11(2):119\u201336.","journal-title":"PsychNol J"},{"key":"1293_CR44","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1177\/1460458219889501","volume":"26","author":"S G\u00f3ngoraAlonso","year":"2019","unstructured":"G\u00f3ngoraAlonso S, ToribioGuzm\u00e1n JM, SainzdeAbajo B, Mu\u00f1ozS\u00e1nchez JL, FrancoMart\u00edn MA, de la TorreD\u00edez I. Usability evaluation of the eHealth Long Lasting Memories program in Spanish elderly people. Health Inform J. 2019;26:1728\u201341.","journal-title":"Health Inform J."},{"issue":"3","key":"1293_CR45","first-page":"269","volume":"9","author":"M Franco-Martin","year":"2013","unstructured":"Franco-Martin M, Bueno Aguado Y, Diaz Bravo E, Lorience GM. New technologies applied to psychosocial intervention in elderly people. Intervenci\u00f3n Psicosocial. 2013;9(3):269\u201382.","journal-title":"Intervenci\u00f3n Psicosocial"},{"issue":"1","key":"1293_CR46","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/s11065-016-9338-9","volume":"27","author":"TM Shah","year":"2017","unstructured":"Shah TM, Weinborn M, Verdile G, Sohrabi HR, Martins RN. Enhancing cognitive functioning in healthly older adults: a systematic review of the clinical significance of commercially available computerized cognitive training in preventing cognitive decline. Neuropsychol Rev. 2017;27(1):62\u201380.","journal-title":"Neuropsychol Rev"},{"issue":"4","key":"1293_CR47","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.jagp.2014.04.009","volume":"23","author":"H Coyle","year":"2015","unstructured":"Coyle H, Traynor V, Solowij N. Computerized and virtual reality cognitive training for individuals at high risk of cognitive decline: systematic review of the literature. Am J Geriatr Psychiatry. 2015;23(4):335\u201359.","journal-title":"Am J Geriatr Psychiatry"},{"issue":"2","key":"1293_CR48","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1159\/000323950","volume":"36","author":"C Peretz","year":"2011","unstructured":"Peretz C, Korczyn AD, Shatil E, Aharonson V, Birnboim S, Giladi N. Computer-based, personalized cognitive training versus classical computer games: a randomized double-blind prospective trial of cognitive stimulation. Neuroepidemiology. 2011;36(2):91\u20139.","journal-title":"Neuroepidemiology"},{"issue":"9","key":"1293_CR49","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1589\/jpts.27.2921","volume":"27","author":"JH Hwang","year":"2015","unstructured":"Hwang JH, Cha HG, Cho YS, Kim TS, Cho HS. The effects of computer-assisted cognitive rehabilitation on Alzheimer\u2019s dementia patients memories. J Phys Ther Sci. 2015;27(9):2921\u20133.","journal-title":"J Phys Ther Sci"},{"issue":"8","key":"1293_CR50","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1016\/j.neuropsychologia.2012.04.012","volume":"50","author":"C Herrera","year":"2012","unstructured":"Herrera C, Chambon C, Michel BF, Paban V, Alescio-Lautier B. Positive effects of computer-based cognitive training in adults with mild cognitive impairment. Neuropsychologia. 2012;50(8):1871\u201381.","journal-title":"Neuropsychologia"},{"issue":"1","key":"1293_CR51","first-page":"44","volume":"23","author":"B Fern\u00e1ndez-Calvo","year":"2011","unstructured":"Fern\u00e1ndez-Calvo B, Rodr\u00edguez-P\u00e9rez R, Contador I, Rubio-Santorum A, Ramos F. Efficacy of cognitive training programs based on new software technologies in patients with Alzheimer-type dementia. Psicothema. 2011;23(1):44\u201350.","journal-title":"Psicothema."},{"issue":"3","key":"1293_CR52","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1375\/brim.12.3.187","volume":"12","author":"M Finn","year":"2012","unstructured":"Finn M, McDonald S. Computerised cognitive training for older persons with mild cognitive impairment: a pilot study using a randomised controlled trial design. Brain Impairment. 2012;12(3):187\u201399.","journal-title":"Brain Impairment"},{"issue":"3","key":"1293_CR53","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1177\/1533317509332624","volume":"24","author":"M Eckroth-Bucher","year":"2009","unstructured":"Eckroth-Bucher M, Siberski J. Preserving cognition through an integrated cognitive stimulation and training program. Am J Alzheimer\u2019s Dis Other Dement. 2009;24(3):234\u201345.","journal-title":"Am J Alzheimer\u2019s Dis Other Dement"},{"issue":"4","key":"1293_CR54","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3109\/09638288.2015.1096969","volume":"39","author":"A Alloni","year":"2017","unstructured":"Alloni A, Sinforiani E, Zucchella C, Sandrini G, Bernini S, Cattani B, et al. Computer-based cognitive rehabilitation: the CoRe system. Disabil Rehabil. 2017;39(4):407\u201317.","journal-title":"Disabil Rehabil"},{"issue":"1","key":"1293_CR55","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s12603-010-0006-0","volume":"14","author":"V Faucounau","year":"2010","unstructured":"Faucounau V, Wu YH, Boulay M, De Rotrou J, Rigaud AS. Cognitive intervention programmes on patients affected by mild cognitive impairment: a promising intervention tool for MCI? J Nutr Health Aging. 2010;14(1):31\u20135.","journal-title":"J Nutr Health Aging"},{"issue":"5","key":"1293_CR56","doi-asserted-by":"publisher","first-page":"421","DOI":"10.3109\/17483107.2014.900575","volume":"10","author":"G Burdea","year":"2015","unstructured":"Burdea G, Polistico K, Krishnamoorthy A, House G, Rethage D, Hundal J, et al. Feasibility study of the BrightBrainer integrative cognitive rehabilitation system for elderly with dementia. Disabil Rehabil Assist Technol. 2015;10(5):421\u201332.","journal-title":"Disabil Rehabil Assist Technol"},{"key":"1293_CR57","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.2147\/CIA.S93914","volume":"10","author":"J Chew","year":"2015","unstructured":"Chew J, Chong M-S, Fong Y-L, Tay L. Outcomes of a multimodal cognitive and physical rehabilitation program for persons with mild dementia and their caregivers: a goal-oriented approach. Clin Interv Aging. 2015;10:1687\u201394.","journal-title":"Clin Interv Aging"},{"issue":"1","key":"1293_CR58","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.regg.2009.10.005","volume":"45","author":"I Gonzalez-Abraldes","year":"2010","unstructured":"Gonzalez-Abraldes I, Millan-Calenti JC, Balo-Garcia A, Tubio J, Lorenzo T, Maseda A. Accesibility and usability of computer-based cognitive stimulation: Telecognitio. Rev Esp Geriatr Gerontol. 2010;45(1):26\u20139.","journal-title":"Rev Esp Geriatr Gerontol"},{"issue":"7","key":"1293_CR59","doi-asserted-by":"publisher","first-page":"e40588","DOI":"10.1371\/journal.pone.0040588","volume":"7","author":"AM Kueider","year":"2012","unstructured":"Kueider AM, Parisi JM, Gross AL, Rebok GW. Computerized cognitive training with older adults: a systematic review. PLoS ONE. 2012;7(7):e40588.","journal-title":"PLoS ONE"},{"issue":"8","key":"1293_CR60","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1017\/S1041610217000667","volume":"29","author":"C Tyack","year":"2017","unstructured":"Tyack C, Camic PM. Touchscreen interventions and the well-being of people with dementia and caregivers: a systematic review. Int Psychogeriatr. 2017;29(8):1261\u201380.","journal-title":"Int Psychogeriatr"},{"issue":"3","key":"1293_CR61","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1080\/13607863.2017.1423033","volume":"23","author":"JA Garcia-Casal","year":"2019","unstructured":"Garcia-Casal JA, Martinez-Abad F, Cid-Bartolome T, Smith SJ, Llano-Ordonez K, Perea-Bartolome MV, et al. Usability study and pilot validation of a computer-based emotion recognition test for older adults with Alzheimer\u2019s disease and amnestic mild cognitive impairment. Aging Mental Health. 2019;23(3):365\u201375.","journal-title":"Aging Mental Health"},{"issue":"9","key":"1293_CR62","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1162\/jocn_a_01080","volume":"29","author":"N Zokaei","year":"2017","unstructured":"Zokaei N, MacKellar C, \u010cepukaityt\u0117 G, Patai EZ, Nobre AC. Cognitive training in the elderly: bottlenecks and new avenues. J Cogn Neurosci. 2017;29(9):1473\u201382.","journal-title":"J Cogn Neurosci"},{"issue":"3","key":"1293_CR63","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.archger.2005.12.003","volume":"43","author":"G Cipriani","year":"2016","unstructured":"Cipriani G, Bianchetti A, Trabucchi M. Outcomes of a computer-based cognitive rehabilitation program on Alzheimer\u2019s disease patients compared with those on patients affected by mild cognitive impairment. Arch Gerontol Geriatr. 2016;43(3):327\u201335.","journal-title":"Arch Gerontol Geriatr"},{"issue":"4","key":"1293_CR64","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1176\/appi.ajp.2016.16030360","volume":"174","author":"NTM Hill","year":"2017","unstructured":"Hill NTM, Mowszowski L, Naismith SL, Chadwick VL, Valenzuela M, Lampit A. Computerized cognitive training in older adults with mild cognitive impairment or dementia: a systematic review and meta-analysis. Am J Psychiatry. 2017;174(4):329\u201340.","journal-title":"Am J Psychiatry"},{"key":"1293_CR65","unstructured":"Bueno Y. Estudio de la efectividad de un programa de entrenamiento en memoria denominado \u201cSistema estructurado de entrenamiento en memoria. M\u00e9todo Gradior\u201d [Doctoral]: Universidad Salamanca; 2013."},{"issue":"100","key":"1293_CR66","first-page":"1","volume":"19","author":"M Vanova","year":"2018","unstructured":"Vanova M, Irazoki E, Garc\u00eda-Casal A, Mart\u00ednez-Abad F, Botella C, Shiells KR, et al. The effectiveness of ICT-based neurocognitive and psychosocial rehabilitation programmes in people with mild dementia and mild cognitive impairment using GRADIOR and ehcoBUTLER: study protocol for a randomised controlled trial. Trial. 2018;19(100):1\u201315.","journal-title":"Trial"},{"issue":"5","key":"1293_CR67","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1080\/10400435.2017.1317675","volume":"30","author":"S Martin","year":"2018","unstructured":"Martin S, Armstrong E, Thomson E, Vargiu E, Sol\u00e0 M, Dauwalder S, et al. A qualitative study adopting a user-centered approach to design and validate a brain computer interface for cognitive rehabilitation for people with brain injury. Assist Technol. 2018;30(5):233\u201341.","journal-title":"Assist Technol"},{"issue":"7","key":"1293_CR68","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1080\/13607863.2014.899972","volume":"18","author":"F Gonz\u00e1lez-Palau","year":"2014","unstructured":"Gonz\u00e1lez-Palau F, Franco M, Bamidis P, Losada R, Parra E, Papageorgiou SG, et al. The effects of a computer-based cognitive and physical training program in a healthy and mildly cognitive impaired aging sample. Aging Mental Health. 2014;18(7):838\u201346.","journal-title":"Aging Mental Health"}],"container-title":["BMC Medical Informatics and Decision Making"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12911-020-01293-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12911-020-01293-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12911-020-01293-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T23:22:29Z","timestamp":1634858549000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedinformdecismak.biomedcentral.com\/articles\/10.1186\/s12911-020-01293-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,22]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1293"],"URL":"https:\/\/doi.org\/10.1186\/s12911-020-01293-w","relation":{},"ISSN":["1472-6947"],"issn-type":[{"value":"1472-6947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,22]]},"assertion":[{"value":"2 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"We confirm that we have written consent to reproduce Fig.\u00a0. Figures\u00a0 and  do not require consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"We declare the following interests: Angie A. Diaz-Baquero (AADB) is a paid member of the INTRAS Foundation responsible for the development and distribution of the GRADIOR software. Manuel A. Franco-Mart\u00edn (MAFM) was the initial designer of GRADIOR. Yolanda Bueno-Aguado (YBA), Mar\u00eda T. Cid-Bartolom\u00e9 (MTCB) and Esther Parra Vidales (EPV) are former members of the INTRAS Foundation. Mar\u00eda V. Perea Bartolom\u00e9 (MVPB), Isabel de la Torre D\u00edez (ITD) and Henri\u00ebtte van der Roest (HVDR) have not interests to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"274"}}