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The aim of the study was to evaluate the nature of individual diurnal, day-to-day and long-term variation in important prognostic markers of COPD exacerbations by employing a telehealth system developed in-house.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight women and five men with COPD performed measurements (spirometry, pulse oximetry and the COPD assessment test (CAT)) three times per week for 4\u20136\u2009months using the telehealth system. Short-term and long-term individual variations were assessed using the relative density and weekly means respectively. Quality of the spirometry measurements (forced expiratory volume in one second (FEV<jats:sub>1<\/jats:sub>) and inspiratory capacity (IC)) was assessed employing the criteria of American Thoracic Society (ATS)\/European Respiratory Society (ERS) guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Close to 1100 measurements of both FEV<jats:sub>1<\/jats:sub>and IC were performed during a total of 240 patient weeks. The two standard deviation ranges for intra-individual short-term variation were approximately \u00b1210\u2009mL and\u2009\u00b1\u2009350\u2009mL for FEV<jats:sub>1<\/jats:sub>and IC respectively. In long-term, spirometry values increased and decreased without notable changes in symptoms as reported by CAT, although it was unusual with a decrease of more than 50\u2009mL per measurement of FEV<jats:sub>1<\/jats:sub>between three consecutive measurement days. No exacerbation occurred. There was a moderate to strong positive correlation between FEV<jats:sub>1<\/jats:sub>and IC, but weak or absent correlation with the other prognostic markers in the majority of the participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although FEV<jats:sub>1<\/jats:sub>and IC varied within a noticeable range, no corresponding change in symptoms occurred. Therefore, this study reveals important and, to our knowledge, previously not reported information about short and long-term variability in prognostic markers in stable patients with COPD. The present data are of significance when defining criteria for detecting exacerbations using telehealth strategies.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12911-020-1103-6","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T19:03:26Z","timestamp":1589310206000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["How stable is lung function in patients with stable chronic obstructive pulmonary disease when monitored using a telehealth system? 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Each participant gave his\/her written informed consent before entering the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The participants did not sign a specific consent for publication. The plan for publication was included in the ethical application. Information about the participants\u2019 confidentiality was included in the consent to participate.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"87"}}