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Even more so since most of them will have a positive effect on society by returning to work. However, many cancer survivors have unmet needs, especially when it comes to improving their quality of life (QoL). Only few survivors are able to meet all of the recommendations regarding well-being and there is a body of evidence that cancer survivors\u2019 needs often remain neglected from health policy and national cancer control plans. This increases the impact of inequalities in cancer care and adds a dangerous component to it. The inequalities affect the individual survivor, their career, along with their relatives and society as a whole. The current study will evaluate the impact of the use of big data analytics and artificial intelligence on the self-efficacy of participants following intervention supported by digital tools. The secondary endpoints include evaluation of the impact of patient trajectories (from retrospective data) and patient gathered health data on prediction and improved intervention against possible secondary disease or negative outcomes (e.g. late toxicities, fatal events).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/design<\/jats:title><jats:p>The study is designed as a single-case experimental prospective study where each individual serves as its own control group with basal measurements obtained at the recruitment and subsequent measurements performed every 6\u00a0months during follow ups. The measurement will involve CASE-cancer, Patient Activation Measure and System Usability Scale. The study will involve 160 survivors (80 survivors of Breast Cancer and 80 survivors of Colorectal Cancer) from four countries, Belgium, Latvia, Slovenia, and Spain. The intervention will be implemented via a digital tool (mHealthApplication), collecting objective biomarkers (vital signs) and subjective biomarkers (PROs) with the support of a (embodied) conversational agent. Additionally, the Clinical Decision Support system (CDSS), including visualization of cohorts and trajectories will enable oncologists to personalize treatment for an efficient care plan and follow-up management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>We expect that cancer survivors will significantly increase their self-efficacy following the personalized intervention supported by the m-HealthApplication compared to control measurements at recruitment. We expect to observe improvement in healthy habits, disease self-management and self-perceived QoL.<\/jats:p><jats:p><jats:italic>Trial registration<\/jats:italic>ISRCTN97617326.<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1186\/ISRCTN97617326\">https:\/\/doi.org\/10.1186\/ISRCTN97617326<\/jats:ext-link>. Original Registration Date: 26\/03\/2021.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12911-021-01603-w","type":"journal-article","created":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T10:02:37Z","timestamp":1628935357000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Patients-centered SurvivorShIp care plan after Cancer treatments based on Big Data and Artificial Intelligence technologies (PERSIST): a multicenter study protocol to evaluate efficacy of digital tools supporting cancer survivors"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4910-1879","authenticated-orcid":false,"given":"Izidor","family":"Mlakar","sequence":"first","affiliation":[]},{"given":"Simon","family":"Lin","sequence":"additional","affiliation":[]},{"given":"Ilona","family":"Aleksandravi\u010da","sequence":"additional","affiliation":[]},{"given":"Krista","family":"Arcimovi\u010da","sequence":"additional","affiliation":[]},{"given":"J\u0101nis","family":"Egl\u012btis","sequence":"additional","affiliation":[]},{"given":"M\u0101rcis","family":"Leja","sequence":"additional","affiliation":[]},{"given":"\u00c1ngel","family":"Salgado Barreira","sequence":"additional","affiliation":[]},{"given":"Jes\u00fas G.","family":"G\u00f3mez","sequence":"additional","affiliation":[]},{"given":"Mercedes","family":"Salgado","sequence":"additional","affiliation":[]},{"given":"Jes\u00fas G.","family":"Mata","sequence":"additional","affiliation":[]},{"given":"Doroteja","family":"Batorek","sequence":"additional","affiliation":[]},{"given":"Matej","family":"Horvat","sequence":"additional","affiliation":[]},{"given":"Maja","family":"Molan","sequence":"additional","affiliation":[]},{"given":"Maja","family":"Ravnik","sequence":"additional","affiliation":[]},{"given":"Jean-Fran\u00e7ois","family":"Kaux","sequence":"additional","affiliation":[]},{"given":"Val\u00e9rie","family":"Bleret","sequence":"additional","affiliation":[]},{"given":"Catherine","family":"Loly","sequence":"additional","affiliation":[]},{"given":"Didier","family":"Maquet","sequence":"additional","affiliation":[]},{"given":"Elena","family":"Sartini","sequence":"additional","affiliation":[]},{"given":"Ur\u0161ka","family":"Smrke","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,8,14]]},"reference":[{"issue":"6","key":"1603_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. 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