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While post-hoc extraction using natural language processing on unstructured clinical notes continues to improve, there is a need to improve point-of-care collection of patient phenotypes. Therefore, we developed \u201cPheNominal\u201d, a point-of-care web application, embedded within Epic electronic health record (EHR) workflows, to permit capture of standardized phenotype data.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Using bi-directional web services available within commercial EHRs, we developed a lightweight web application that allows users to rapidly browse and identify relevant terms from the Human Phenotype Ontology (HPO). Selected terms are saved discretely within the patient\u2019s EHR, permitting reuse both in clinical notes as well as in downstream diagnostic and research pipelines.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the 16\u00a0months since implementation, PheNominal was used to capture discrete phenotype data for over 1500 individuals and 11,000 HPO terms during clinic and inpatient encounters for a genetic diagnostic consultation service within a quaternary-care pediatric academic medical center. An average of 7 HPO terms were captured per patient. Compared to a manual workflow, the average time to enter terms for a patient was reduced from 15 to 5\u00a0min per patient, and there were fewer annotation errors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Modern EHRs support integration of external applications using application programming interfaces. We describe a practical application of these interfaces to facilitate deep phenotype capture in a discrete, structured format within a busy clinical workflow. Future versions will include a vendor-agnostic implementation using FHIR. We describe pilot efforts to integrate structured phenotyping through controlled dictionaries into diagnostic and research pipelines, reducing manual effort for phenotype documentation and reducing errors in data entry.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12911-022-01927-1","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T22:09:45Z","timestamp":1659046185000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["PheNominal: an EHR-integrated web application for structured deep phenotyping at the point of care"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8388-1362","authenticated-orcid":false,"given":"James M.","family":"Havrilla","sequence":"first","affiliation":[]},{"given":"Anbumalar","family":"Singaravelu","sequence":"additional","affiliation":[]},{"given":"Dennis M.","family":"Driscoll","sequence":"additional","affiliation":[]},{"given":"Leonard","family":"Minkovsky","sequence":"additional","affiliation":[]},{"given":"Ingo","family":"Helbig","sequence":"additional","affiliation":[]},{"given":"Livija","family":"Medne","sequence":"additional","affiliation":[]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Ian","family":"Krantz","sequence":"additional","affiliation":[]},{"given":"Bimal R.","family":"Desai","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"key":"1927_CR1","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jbi.2015.10.001","volume":"58","author":"R Pivovarov","year":"2015","unstructured":"Pivovarov R, Perotte AJ, Grave E, Angiolillo J, Wiggins CH, Elhadad N. 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