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Venous thromboembolism clinical decision support system was proved to have a positive influence on the prevention and management of venous thromboembolism. As the direct users, nurses' acceptance of this system is of great importance to support the successful implementation of it. However, there are few relevant studies to investigate nurses' acceptance and the associated factors are still unclear.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To investigate the determinant factors of nurses' acceptance of venous thromboembolism clinical decision support system with the modified Unified Theory of Acceptance and Use of Technology.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We designed a questionnaire based on the modified Unified Theory of Acceptance and Use of Technology and then a cross-sectional survey was conducted among nurses in a tertiary hospital in Nanjing, China. Statistically, a Structural Equation Modeling -Partial Least Squares path modeling approach was applied to examine the research model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 1100 valid questionnaires were recycled. The modified model explained 74.7%, 83.0% and 86% of the variance in user satisfaction, behavioral intention and user behavior, respectively. The results showed that performance expectancy (\u03b2\u2009=\u20090.254, <jats:italic>p<\/jats:italic>\u2009=\u20090.000), social influence (\u03b2\u2009=\u20090.136, <jats:italic>p<\/jats:italic>\u2009=\u20090.047), facilitating conditions (\u03b2\u2009=\u20090.245, <jats:italic>p<\/jats:italic>\u2009=\u20090.000), self-efficacy (\u03b2\u2009=\u20090.121, <jats:italic>p<\/jats:italic>\u2009=\u20090.048) and user satisfaction (\u03b2\u2009=\u20090.193, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) all had significant effects on nurses' intention. Although effort expectancy (\u03b2\u2009=\u20090.010, <jats:italic>p<\/jats:italic>\u2009=\u20090.785) did not have a direct effect on nurses' intention, it could indirectly influence nurses' intention with user satisfaction as the mediator (\u03b2\u2009=\u20090.296, <jats:italic>p<\/jats:italic>\u2009=\u20090.000). User behavior was significantly predicted by facilitating conditions (\u03b2\u2009=\u20090.298, <jats:italic>p<\/jats:italic>\u2009=\u20090.000) and user intention (\u03b2\u2009=\u20090.654, <jats:italic>p<\/jats:italic>\u2009=\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The research enhances our understanding of the determinants of nurses' acceptance of venous thromboembolism clinical decision support system. Among these factors, performance expectancy was considered as the top priority. It highlights the importance of optimizing system performance to fit the users' needs. Generally, the findings in our research provide clinical technology designers and administrators with valuable information to better meet users' requirements and promote the implementation of venous thromboembolism clinical decision support system.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12911-022-01958-8","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T12:03:22Z","timestamp":1660910602000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Acceptance of clinical decision support system to prevent venous thromboembolism among nurses: an extension of the UTAUT model"],"prefix":"10.1186","volume":"22","author":[{"given":"Huixian","family":"Zha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Heng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyue","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"issue":"7","key":"1958_CR1","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1160\/TH16-10-0823","volume":"117","author":"S Schulman","year":"2017","unstructured":"Schulman S, Ageno W, Konstantinides SV. 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