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This protocol will be implemented for a study to evaluate the effects of an Android-based self-care application on patients with stroke.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The first stage will include the development of an android-based application using JAVA programming language for developing the user interface and ASP.NET Core for developing Web server. The second stage will be conducted using triple blinded randomized clinical trial (RCT). The sample size will include 60 patients with recent stroke and partial paralysis of limbs, who will be divided into two groups of intervention and control through permuted block randomization method. Patients in both groups will receive usual medical care, but those in the intervention group will also use an Android-based application for a period of two months. Outcomes will be assessed using valid and reliable questionnaires.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>The assessed outcomes will include stroke severity using National Institute of Health Stroke Scale (NIHSS) score, ability to perform activities of daily living using Barthel Index (BI) score, depression rate using Beck Depression Inventory (BDI-II) score, quality of life using EQ-5D-3L score, medication adherence using Modified Morisky Medication Adherence Scale (MMAS-8) score, patient satisfaction using Patient Satisfaction Questionnaire (PSQ) score and the number and type of complications in patients in two groups. These outcomes will be assessed at baseline, after two months and after three months from the beginning of the intervention. Intervention effects on the measured variables will also be evaluated using appropriate statistical tests based on the type of variable distribution. Potential consequences of the study might be the improvement of the measured variables in the intervention group compared to that of the control group. The expected results are that the intervention may significantly improve the status of the measured variables in the intervention group compared to that of the control group. If the outcomes of the intervention group do not change significantly compared to those of the control group, it can be due to different reasons. However, this can most likely be attributed to incorrect or insufficient use of the application by patients.<\/jats:p>\n                <jats:p><jats:italic>Trial registration<\/jats:italic>: This protocol is registered in the Iranian registration of clinical trial (IRCT) on November 7, 2020 with the code IRCT20201015049037N1. URL: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/irct.ir\/trial\/51674\">https:\/\/irct.ir\/trial\/51674<\/jats:ext-link><\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12911-022-02033-y","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T22:02:44Z","timestamp":1668204164000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of mobile-based self-management application on stroke outcomes: a study protocol for triple blinded randomized controlled trial"],"prefix":"10.1186","volume":"22","clinical-trial-number":[{"clinical-trial-number":"irct20201015049037n1","registry":"10.18810\/irct"}],"author":[{"given":"Hamidreza","family":"Tadayon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrdad","family":"Farzandipour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehsan","family":"Nabovati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Akbari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9038-9838","authenticated-orcid":false,"given":"Seyed Ali","family":"Masoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"issue":"2","key":"2033_CR1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1159\/000506396","volume":"54","author":"RV Krishnamurthi","year":"2020","unstructured":"Krishnamurthi RV, Ikeda T, Feigin VL. 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PLoS ONE. 2019;14(4): e0214241.","journal-title":"PLoS ONE"}],"container-title":["BMC Medical Informatics and Decision Making"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12911-022-02033-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12911-022-02033-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12911-022-02033-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T05:04:34Z","timestamp":1668315874000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedinformdecismak.biomedcentral.com\/articles\/10.1186\/s12911-022-02033-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,11]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["2033"],"URL":"https:\/\/doi.org\/10.1186\/s12911-022-02033-y","relation":{},"ISSN":["1472-6947"],"issn-type":[{"value":"1472-6947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,11]]},"assertion":[{"value":"28 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved in Kashan University of Medical Sciences with the ethics code of IR.KAUMS.NUHEPM.REC.1399.055 and its protocol was registered and approved in the Iranian Registration of Clinical Trial (IRCT) with the code of IRCT20201015049037N1. In all stages of conducting research on patients, the neurologist will continuously monitor the method of conducting the study. All usual care, which is performed for patients in the control group, will also be performed for patients in the intervention group, based on the opinion of neurologists. Implicit and verbal informed consent will be obtained from all patients by one of the researchers and all patients will have the right for informed and free consent to participate in the study. There will be no biological specimens in this study. Patients' identities will not be disclosed and data will be provided anonymously to others, if necessary. Written informed consent will not be obtained due to the possibility of unnecessary sensitivities in patients. If a patient decides to stop the intervention in the middle of the research, the researchers will consider themselves obliged to respect this request and without changing the treatment, they will exclude the patient from the study and replace this individual with another patient with similar conditions. Doing this research will not harm the environment or vulnerable groups. Researchers will be committed to the principle of privacy and confidentiality and no identity information about patients will be disclosed in the results of the study. Researchers will be obliged to publish the results of the research honestly, accurately and completely and to provide it to research participants and other stakeholders. The method of conducting this study will not contradict any social, cultural and religious values. Expected recruitment start date is April 2022. Results of this study have not already been published or submitted to any journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"292"}}