{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:01:10Z","timestamp":1785265270006,"version":"3.55.0"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Inform Decis Mak"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background and objectives<\/jats:title>\n                <jats:p>Sepsis is accompanied by a considerably high risk of mortality in the short term, despite the availability of recommended mortality risk assessment tools. However, these risk assessment tools seem to have limited predictive value. With the gradual integration of machine learning into clinical practice, some researchers have attempted to employ machine learning for early mortality risk prediction in sepsis patients. Nevertheless, there is a lack of comprehensive understanding regarding the construction of predictive variables using machine learning and the value of various machine learning methods. Thus, we carried out this systematic review and meta-analysis to explore the predictive value of machine learning for sepsis-related death at different time points.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>PubMed, Embase, Cochrane, and Web of Science databases were searched until August 9th, 2022. The risk of bias in predictive models was assessed using the Prediction model Risk of Bias Assessment Tool (PROBAST). We also performed subgroup analysis according to time of death and type of model and summarized current predictive variables used to construct models for sepsis death prediction.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Fifty original studies were included, covering 104 models. The combined Concordance index (C-index), sensitivity, and specificity of machine learning models were 0.799, 0.81, and 0.80 in the training set, and 0.774, 0.71, and 0.68 in the validation set, respectively. Machine learning outperformed conventional clinical scoring tools and showed excellent C-index, sensitivity, and specificity in different subgroups. Random Forest (RF) and eXtreme Gradient Boosting (XGBoost) are the preferred machine learning models because they showed more favorable accuracy with similar modeling variables. This study found that lactate was the most frequent predictor but was seriously ignored by current clinical scoring tools.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Machine learning methods demonstrate relatively favorable accuracy in predicting the mortality risk in sepsis patients. Given the limitations in accuracy and applicability of existing prediction scoring systems, there is an opportunity to explore updates based on existing machine learning approaches. Specifically, it is essential to develop or update more suitable mortality risk assessment tools based on the specific contexts of use, such as emergency departments, general wards, and intensive care units.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12911-023-02383-1","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T11:02:22Z","timestamp":1702292542000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Machine learning for the prediction of sepsis-related death: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"23","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"issue":"8","key":"2383_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, et al. The third international consensus definitions for Sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801\u201310.","journal-title":"JAMA"},{"issue":"5","key":"2383_CR2","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1056\/NEJMp1707170","volume":"377","author":"K Reinhart","year":"2017","unstructured":"Reinhart K, Daniels R, Kissoon N, Machado FR, Schachter RD, Finfer S. Recognizing sepsis as a global health priority - A WHO resolution. N Engl J Med. 2017;377(5):414\u20137.","journal-title":"N Engl J Med"},{"issue":"3","key":"2383_CR3","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","volume":"193","author":"C Fleischmann","year":"2016","unstructured":"Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, Angus DC, Reinhart K. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med. 2016;193(3):259\u201372.","journal-title":"Am J Respir Crit Care Med"},{"issue":"10219","key":"2383_CR4","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","volume":"395","author":"KE Rudd","year":"2020","unstructured":"Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, Colombara DV, Ikuta KS, Kissoon N, Finfer S, et al. Global, regional, and national sepsis incidence and mortality, 1990\u20132017: analysis for the global burden of disease study. Lancet (London England). 2020;395(10219):200\u201311.","journal-title":"Lancet (London England)"},{"issue":"5","key":"2383_CR5","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/S2213-2600(14)70061-X","volume":"2","author":"JL Vincent","year":"2014","unstructured":"Vincent JL, Marshall JC, Namendys-Silva SA, Fran\u00e7ois B, Martin-Loeches I, Lipman J, Reinhart K, Antonelli M, Pickkers P, Njimi H, et al. Assessment of the worldwide burden of critical Illness: the intensive care over nations (ICON) audit. The Lancet Respiratory Medicine. 2014;2(5):380\u20136.","journal-title":"The Lancet Respiratory Medicine"},{"issue":"8","key":"2383_CR6","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1007\/s00134-020-06151-x","volume":"46","author":"C Fleischmann-Struzek","year":"2020","unstructured":"Fleischmann-Struzek C, Mellhammar L, Rose N, Cassini A, Rudd KE, Schlattmann P, Allegranzi B, Reinhart K. Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis. Intensive Care Med. 2020;46(8):1552\u201362.","journal-title":"Intensive Care Med"},{"issue":"24","key":"2383_CR7","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1001\/jama.1993.03510240069035","volume":"270","author":"JR Le Gall","year":"1993","unstructured":"Le Gall JR, Lemeshow S, Saulnier F. A new simplified acute physiology score (SAPS II) based on a European\/North American multicenter study. JAMA. 1993;270(24):2957\u201363.","journal-title":"JAMA"},{"issue":"10","key":"2383_CR8","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","volume":"13","author":"WA Knaus","year":"1985","unstructured":"Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13(10):818\u201329.","journal-title":"Crit Care Med"},{"issue":"7","key":"2383_CR9","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/BF01709751","volume":"22","author":"JL Vincent","year":"1996","unstructured":"Vincent JL, Moreno R, Takala J, Willatts S, De Mendon\u00e7a A, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsis-related Organ failure Assessment) score to describe organ dysfunction\/failure. On behalf of the Working Group on Sepsis-related problems of the European society of intensive care medicine. Intensive Care Med. 1996;22(7):707\u201310.","journal-title":"Intensive Care Med"},{"issue":"3","key":"2383_CR10","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1007\/BF03016068","volume":"52","author":"DA Zygun","year":"2005","unstructured":"Zygun DA, Laupland KB, Fick GH, Sandham JD, Doig CJ. Limited ability of SOFA and MOD scores to discriminate outcome: a prospective evaluation in 1,436 patients. Can J Anaesth = J Canadien D\u2019anesthesie. 2005;52(3):302\u20138.","journal-title":"Can J Anaesth = J Canadien D\u2019anesthesie"},{"issue":"6","key":"2383_CR11","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1097\/SHK.0000000000000818","volume":"47","author":"B Khwannimit","year":"2017","unstructured":"Khwannimit B, Bhurayanontachai R, Vattanavanit V. Validation of the sepsis severity score compared with updated severity scores in predicting hospital mortality in sepsis patients. Shock (Augusta Ga). 2017;47(6):720\u20135.","journal-title":"Shock (Augusta Ga)"},{"issue":"1","key":"2383_CR12","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s13049-019-0609-3","volume":"27","author":"Z Liu","year":"2019","unstructured":"Liu Z, Meng Z, Li Y, Zhao J, Wu S, Gou S, Wu H. Prognostic accuracy of the serum lactate level, the SOFA score and the qSOFA score for mortality among adults with Sepsis. Scand J Trauma Resusc Emerg Med. 2019;27(1):51.","journal-title":"Scand J Trauma Resusc Emerg Med"},{"issue":"4","key":"2383_CR13","doi-asserted-by":"publisher","first-page":"266","DOI":"10.7326\/M17-2820","volume":"168","author":"SM Fernando","year":"2018","unstructured":"Fernando SM, Tran A, Taljaard M, Cheng W, Rochwerg B, Seely AJE, Perry JJ. Prognostic accuracy of the Quick Sequential Organ failure Assessment for Mortality in patients with suspected Infection: a systematic review and Meta-analysis. Ann Intern Med. 2018;168(4):266\u201375.","journal-title":"Ann Intern Med"},{"issue":"8","key":"2383_CR14","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41576-020-0224-1","volume":"21","author":"R Li","year":"2020","unstructured":"Li R, Chen Y, Ritchie MD, Moore JH. Electronic health records and polygenic risk scores for predicting Disease risk. Nat Rev Genet. 2020;21(8):493\u2013502.","journal-title":"Nat Rev Genet"},{"issue":"9","key":"2383_CR15","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.amjcard.2017.01.026","volume":"119","author":"KT Leong","year":"2017","unstructured":"Leong KT, Wong LY, Aung KC, Macdonald M, Cao Y, Lee S, Chow WL, Doddamani S, Richards AM. Risk stratification model for 30-Day Heart Failure readmission in a multiethnic South East Asian Community. Am J Cardiol. 2017;119(9):1428\u201332.","journal-title":"Am J Cardiol"},{"issue":"5","key":"2383_CR16","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1161\/STROKEAHA.118.024293","volume":"50","author":"J Heo","year":"2019","unstructured":"Heo J, Yoon JG, Park H, Kim YD, Nam HS, Heo JH. Machine learning-based model for prediction of outcomes in Acute Stroke. Stroke. 2019;50(5):1263\u20135.","journal-title":"Stroke"},{"issue":"20","key":"2383_CR17","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1161\/CIRCULATIONAHA.115.001593","volume":"132","author":"RC Deo","year":"2015","unstructured":"Deo RC. Machine learning in Medicine. Circulation. 2015;132(20):1920\u201330.","journal-title":"Circulation"},{"issue":"2","key":"2383_CR18","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1136\/amiajnl-2013-001815","volume":"21","author":"E Gultepe","year":"2014","unstructured":"Gultepe E, Green JP, Nguyen H, Adams J, Albertson T, Tagkopoulos I. From vital signs to clinical outcomes for patients with sepsis: a machine learning basis for a clinical decision support system. J Am Med Inf Association: JAMIA. 2014;21(2):315\u201325.","journal-title":"J Am Med Inf Association: JAMIA"},{"issue":"1","key":"2383_CR19","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/S2213-2600(14)70239-5","volume":"3","author":"R Pirracchio","year":"2015","unstructured":"Pirracchio R, Petersen ML, Carone M, Rigon MR, Chevret S, van der Laan MJ. Mortality prediction in intensive care units with the Super ICU Learner Algorithm (SICULA): a population-based study. The Lancet Respiratory Medicine. 2015;3(1):42\u201352.","journal-title":"The Lancet Respiratory Medicine"},{"issue":"1","key":"2383_CR20","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/jamiaopen\/ooy011","volume":"1","author":"F Tang","year":"2018","unstructured":"Tang F, Xiao C, Wang F, Zhou J. Predictive modeling in urgent care: a comparative study of machine learning approaches. JAMIA open. 2018;1(1):87\u201398.","journal-title":"JAMIA open"},{"key":"2383_CR21","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41746-018-0029-1","volume":"1","author":"A Rajkomar","year":"2018","unstructured":"Rajkomar A, Oren E, Chen K, Dai AM, Hajaj N, Hardt M, Liu PJ, Liu X, Marcus J, Sun M, et al. Scalable and accurate deep learning with electronic health records. NPJ Digit Med. 2018;1:18.","journal-title":"NPJ Digit Med"},{"issue":"3","key":"2383_CR22","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/acem.12876","volume":"23","author":"RA Taylor","year":"2016","unstructured":"Taylor RA, Pare JR, Venkatesh AK, Mowafi H, Melnick ER, Fleischman W, Hall MK. Prediction of In-hospital mortality in Emergency Department patients with Sepsis: a local Big Data-Driven, Machine Learning Approach. Acad Emerg Medicine: Official J Soc Acad Emerg Med. 2016;23(3):269\u201378.","journal-title":"Acad Emerg Medicine: Official J Soc Acad Emerg Med"},{"issue":"3","key":"2383_CR23","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s00134-019-05872-y","volume":"46","author":"LM Fleuren","year":"2020","unstructured":"Fleuren LM, Klausch TLT, Zwager CL, Schoonmade LJ, Guo T, Roggeveen LF, Swart EL, Girbes ARJ, Thoral P, Ercole A, et al. Machine learning for the prediction of sepsis: a systematic review and meta-analysis of diagnostic test accuracy. Intensive Care Med. 2020;46(3):383\u2013400.","journal-title":"Intensive Care Med"},{"key":"2383_CR24","first-page":"n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ (Clinical Research ed). 2021;372:n71.","journal-title":"BMJ (Clinical Research ed)"},{"key":"2383_CR25","first-page":"m689","volume":"368","author":"M Nagendran","year":"2020","unstructured":"Nagendran M, Chen Y, Lovejoy CA, Gordon AC, Komorowski M, Harvey H, Topol EJ, Ioannidis JPA, Collins GS, Maruthappu M. Artificial intelligence versus clinicians: systematic review of design, reporting standards, and claims of deep learning studies. BMJ (Clinical Research ed). 2020;368:m689.","journal-title":"BMJ (Clinical Research ed)"},{"issue":"9","key":"2383_CR26","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1177\/0962280218785504","volume":"28","author":"TP Debray","year":"2019","unstructured":"Debray TP, Damen JA, Riley RD, Snell K, Reitsma JB, Hooft L, Collins GS, Moons KG. A framework for meta-analysis of prediction model studies with binary and time-to-event outcomes. Stat Methods Med Res. 2019;28(9):2768\u201386.","journal-title":"Stat Methods Med Res"},{"issue":"12","key":"2383_CR27","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1016\/j.ajic.2021.07.010","volume":"49","author":"D Zhi","year":"2021","unstructured":"Zhi D, Zhang M, Lin J, Liu P, Wang Y, Duan M. Establishment and validation of the predictive model for the in-hospital death in patients with sepsis. Am J Infect Control. 2021;49(12):1515\u201321.","journal-title":"Am J Infect Control"},{"key":"2383_CR28","doi-asserted-by":"publisher","first-page":"106145","DOI":"10.1016\/j.intimp.2019.106145","volume":"80","author":"C Zhao","year":"2020","unstructured":"Zhao C, Wei Y, Chen D, Jin J, Chen H. Prognostic value of an inflammatory biomarker-based clinical algorithm in septic patients in the emergency department: an observational study. Int Immunopharmacol. 2020;80:106145.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"2383_CR29","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s12873-022-00582-z","volume":"22","author":"L Zhang","year":"2022","unstructured":"Zhang L, Huang T, Xu F, Li S, Zheng S, Lyu J, Yin H. Prediction of prognosis in elderly patients with sepsis based on machine learning (random survival forest). BMC Emerg Med. 2022;22(1):26.","journal-title":"BMC Emerg Med"},{"key":"2383_CR30","doi-asserted-by":"publisher","first-page":"609769","DOI":"10.3389\/fmed.2020.609769","volume":"7","author":"K Zhang","year":"2020","unstructured":"Zhang K, Zhang S, Cui W, Hong Y, Zhang G, Zhang Z. Development and validation of a Sepsis mortality risk score for Sepsis-3 patients in Intensive Care Unit. Front Med. 2020;7:609769.","journal-title":"Front Med"},{"issue":"1","key":"2383_CR31","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13040-021-00276-5","volume":"14","author":"Z Zeng","year":"2021","unstructured":"Zeng Z, Yao S, Zheng J, Gong X. Development and validation of a novel blending machine learning model for hospital mortality prediction in ICU patients with Sepsis. BioData Min. 2021;14(1):40.","journal-title":"BioData Min"},{"key":"2383_CR32","doi-asserted-by":"crossref","unstructured":"Zeng Q, He L, Zhang N, Lin Q, Zhong L, Song J. Prediction of 90-Day Mortality among Sepsis Patients Based on a Nomogram Integrating Diverse Clinical Indices. BioMed research international 2021, 2021:1023513.","DOI":"10.21203\/rs.3.rs-596906\/v1"},{"key":"2383_CR33","doi-asserted-by":"publisher","first-page":"445","DOI":"10.3389\/fmed.2020.00445","volume":"7","author":"RQ Yao","year":"2020","unstructured":"Yao RQ, Jin X, Wang GW, Yu Y, Wu GS, Zhu YB, Li L, Li YX, Zhao PY, Zhu SY, et al. A machine learning-based prediction of hospital mortality in patients with postoperative Sepsis. Front Med. 2020;7:445.","journal-title":"Front Med"},{"issue":"4","key":"2383_CR34","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1097\/CCM.0000000000000106","volume":"42","author":"HR Wong","year":"2014","unstructured":"Wong HR, Lindsell CJ, Pettil\u00e4 V, Meyer NJ, Thair SA, Karlsson S, Russell JA, Fjell CD, Boyd JH, Ruokonen E, et al. A multibiomarker-based outcome risk stratification model for adult septic shock*. Crit Care Med. 2014;42(4):781\u20139.","journal-title":"Crit Care Med"},{"key":"2383_CR35","doi-asserted-by":"publisher","first-page":"104312","DOI":"10.1016\/j.ijmedinf.2020.104312","volume":"145","author":"B Wernly","year":"2021","unstructured":"Wernly B, Mamandipoor B, Baldia P, Jung C, Osmani V. Machine learning predicts mortality in septic patients using only routinely available ABG variables: a multi-centre evaluation. Int J Med Informatics. 2021;145:104312.","journal-title":"Int J Med Informatics"},{"issue":"Suppl 2","key":"2383_CR36","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s12911-022-01871-0","volume":"22","author":"H Wang","year":"2022","unstructured":"Wang H, Li Y, Naidech A, Luo Y. Comparison between machine learning methods for mortality prediction for sepsis patients with different social determinants. BMC Med Inf Decis Mak. 2022;22(Suppl 2):156.","journal-title":"BMC Med Inf Decis Mak"},{"issue":"5","key":"2383_CR37","doi-asserted-by":"publisher","first-page":"e0252009","DOI":"10.1371\/journal.pone.0252009","volume":"16","author":"B Wang","year":"2021","unstructured":"Wang B, Chen J. Establishment and validation of a predictive model for mortality within 30 days in patients with sepsis-induced blood pressure drop: a retrospective analysis. PLoS ONE. 2021;16(5):e0252009.","journal-title":"PLoS ONE"},{"issue":"1","key":"2383_CR38","doi-asserted-by":"publisher","first-page":"e0245157","DOI":"10.1371\/journal.pone.0245157","volume":"16","author":"W van Doorn","year":"2021","unstructured":"van Doorn W, Stassen PM, Borggreve HF, Schalkwijk MJ, Stoffers J, Bekers O, Meex SJR. A comparison of machine learning models versus clinical evaluation for mortality prediction in patients with sepsis. PLoS ONE. 2021;16(1):e0245157.","journal-title":"PLoS ONE"},{"issue":"1","key":"2383_CR39","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s13613-018-0459-6","volume":"8","author":"S Vallabhajosyula","year":"2018","unstructured":"Vallabhajosyula S, Jentzer JC, Kotecha AA, Murphree DH Jr., Barreto EF, Khanna AK, Iyer VN. Development and performance of a novel vasopressor-driven mortality prediction model in septic shock. Ann Intensiv Care. 2018;8(1):112.","journal-title":"Ann Intensiv Care"},{"issue":"1","key":"2383_CR40","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.2196\/medinform.3445","volume":"3","author":"A Tsoukalas","year":"2015","unstructured":"Tsoukalas A, Albertson T, Tagkopoulos I. From data to optimal decision making: a data-driven, probabilistic machine learning approach to decision support for patients with sepsis. JMIR Med Inf. 2015;3(1):e11.","journal-title":"JMIR Med Inf"},{"issue":"4","key":"2383_CR41","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1111\/cts.13030","volume":"14","author":"I Taneja","year":"2021","unstructured":"Taneja I, Damhorst GL, Lopez-Espina C, Zhao SD, Zhu R, Khan S, White K, Kumar J, Vincent A, Yeh L, et al. Diagnostic and prognostic capabilities of a biomarker and EMR-based machine learning algorithm for sepsis. Clin Transl Sci. 2021;14(4):1578\u201389.","journal-title":"Clin Transl Sci"},{"key":"2383_CR42","doi-asserted-by":"publisher","first-page":"664966","DOI":"10.3389\/fmed.2021.664966","volume":"8","author":"L Su","year":"2021","unstructured":"Su L, Xu Z, Chang F, Ma Y, Liu S, Jiang H, Wang H, Li D, Chen H, Zhou X, et al. Early Prediction of Mortality, Severity, and length of stay in the Intensive Care Unit of Sepsis patients based on Sepsis 3.0 by machine learning models. Front Med. 2021;8:664966.","journal-title":"Front Med"},{"key":"2383_CR43","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s40560-018-0335-3","volume":"6","author":"JL Speiser","year":"2018","unstructured":"Speiser JL, Karvellas CJ, Shumilak G, Sligl WI, Mirzanejad Y, Gurka D, Kumar A, Kumar A. Predicting in-hospital mortality in pneumonia-associated septic shock patients using a classification and regression tree: a nested cohort study. J Intensive care. 2018;6:66.","journal-title":"J Intensive care"},{"issue":"23","key":"2383_CR44","doi-asserted-by":"publisher","first-page":"e10866","DOI":"10.1097\/MD.0000000000010866","volume":"97","author":"MI Samsudin","year":"2018","unstructured":"Samsudin MI, Liu N, Prabhakar SM, Chong SL, Kit Lye W, Koh ZX, Guo D, Rajesh R, Ho AFW, Ong MEH. A novel heart rate variability based risk prediction model for septic patients presenting to the emergency department. Medicine. 2018;97(23):e10866.","journal-title":"Medicine"},{"key":"2383_CR45","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.ajem.2020.09.013","volume":"45","author":"A Rodr\u00edguez","year":"2021","unstructured":"Rodr\u00edguez A, Mendoza D, Ascuntar J, Jaimes F. Supervised classification techniques for prediction of mortality in adult patients with sepsis. Am J Emerg Med. 2021;45:392\u20137.","journal-title":"Am J Emerg Med"},{"issue":"1","key":"2383_CR46","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12890-021-01809-8","volume":"22","author":"Y Ren","year":"2022","unstructured":"Ren Y, Zhang L, Xu F, Han D, Zheng S, Zhang F, Li L, Wang Z, Lyu J, Yin H. Risk factor analysis and nomogram for predicting in-hospital mortality in ICU patients with sepsis and lung Infection. BMC Pulm Med. 2022;22(1):17.","journal-title":"BMC Pulm Med"},{"issue":"3","key":"2383_CR47","doi-asserted-by":"publisher","first-page":"e0213445","DOI":"10.1371\/journal.pone.0213445","volume":"14","author":"SM Prabhakar","year":"2019","unstructured":"Prabhakar SM, Tagami T, Liu N, Samsudin MI, Ng JCJ, Koh ZX, Ong MEH. Combining quick sequential organ failure assessment score with heart rate variability may improve predictive ability for mortality in septic patients at the emergency department. PLoS ONE. 2019;14(3):e0213445.","journal-title":"PLoS ONE"},{"key":"2383_CR48","doi-asserted-by":"crossref","unstructured":"Perng JW, Kao IH, Kung CT, Hung SC, Lai YH, Su CM. Mortality prediction of septic patients in the Emergency Department based on machine learning. J Clin Med 2019, 8(11).","DOI":"10.3390\/jcm8111906"},{"issue":"4","key":"2383_CR49","doi-asserted-by":"publisher","first-page":"e29982","DOI":"10.2196\/29982","volume":"24","author":"JY Park","year":"2022","unstructured":"Park JY, Hsu TC, Hu JR, Chen CY, Hsu WT, Lee M, Ho J, Lee CC. Predicting Sepsis Mortality in a Population-Based National Database: Machine Learning Approach. J Med Internet Res. 2022;24(4):e29982.","journal-title":"J Med Internet Res"},{"issue":"8","key":"2383_CR50","doi-asserted-by":"publisher","first-page":"e0249868","DOI":"10.1371\/journal.pone.0249868","volume":"16","author":"N Liu","year":"2021","unstructured":"Liu N, Chee ML, Foo MZQ, Pong JZ, Guo D, Koh ZX, Ho AFW, Niu C, Chong SL, Ong MEH. Heart rate n-variability (HRnV) measures for prediction of mortality in sepsis patients presenting at the emergency department. PLoS ONE. 2021;16(8):e0249868.","journal-title":"PLoS ONE"},{"issue":"9","key":"2383_CR51","doi-asserted-by":"publisher","first-page":"300060521104489","DOI":"10.1177\/03000605211044892","volume":"49","author":"H Liu","year":"2021","unstructured":"Liu H, Zhang L, Xu F, Li S, Wang Z, Han D, Zhang F, Lyu J, Yin H. Establishment of a prognostic model for patients with sepsis based on SOFA: a retrospective cohort study. J Int Med Res. 2021;49(9):3000605211044892.","journal-title":"J Int Med Res"},{"issue":"19","key":"2383_CR52","doi-asserted-by":"publisher","first-page":"e25813","DOI":"10.1097\/MD.0000000000025813","volume":"100","author":"K Li","year":"2021","unstructured":"Li K, Shi Q, Liu S, Xie Y, Liu J. Predicting in-hospital mortality in ICU patients with sepsis using gradient boosting decision tree. Medicine. 2021;100(19):e25813.","journal-title":"Medicine"},{"issue":"11","key":"2383_CR53","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1097\/CCM.0b013e31822572e3","volume":"39","author":"T Lagu","year":"2011","unstructured":"Lagu T, Lindenauer PK, Rothberg MB, Nathanson BH, Pekow PS, Steingrub JS, Higgins TL. Development and validation of a model that uses enhanced administrative data to predict mortality in patients with sepsis. Crit Care Med. 2011;39(11):2425\u201330.","journal-title":"Crit Care Med"},{"issue":"1","key":"2383_CR54","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1186\/s12911-020-01271-2","volume":"20","author":"G Kong","year":"2020","unstructured":"Kong G, Lin K, Hu Y. Using machine learning methods to predict in-hospital mortality of sepsis patients in the ICU. BMC Med Inf Decis Mak. 2020;20(1):251.","journal-title":"BMC Med Inf Decis Mak"},{"issue":"1","key":"2383_CR55","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s12873-021-00475-7","volume":"21","author":"A Karlsson","year":"2021","unstructured":"Karlsson A, Stassen W, Loutfi A, Wallgren U, Larsson E, Kurland L. Predicting mortality among septic patients presenting to the emergency department-a cross sectional analysis using machine learning. BMC Emerg Med. 2021;21(1):84.","journal-title":"BMC Emerg Med"},{"issue":"2","key":"2383_CR56","doi-asserted-by":"publisher","first-page":"R150","DOI":"10.1186\/cc3054","volume":"9","author":"F Jaimes","year":"2005","unstructured":"Jaimes F, Farbiarz J, Alvarez D, Mart\u00ednez C. Comparison between logistic regression and neural networks to predict death in patients with suspected sepsis in the emergency room. Crit Care (London England). 2005;9(2):R150\u2013156.","journal-title":"Crit Care (London England)"},{"issue":"3","key":"2383_CR57","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1007\/s40121-022-00628-6","volume":"11","author":"C Hu","year":"2022","unstructured":"Hu C, Li L, Huang W, Wu T, Xu Q, Liu J, Hu B. Interpretable Machine Learning for early prediction of prognosis in Sepsis: A Discovery and Validation Study. Infect Dis Therapy. 2022;11(3):1117\u201332.","journal-title":"Infect Dis Therapy"},{"key":"2383_CR58","doi-asserted-by":"crossref","unstructured":"Hsu JF, Chang YF, Cheng HJ, Yang C, Lin CY, Chu SM, Huang HR, Chiang MC, Wang HC, Tsai MH. Machine learning approaches to Predict In-Hospital mortality among neonates with clinically suspected Sepsis in the neonatal Intensive Care Unit. J Personalized Med 2021, 11(8).","DOI":"10.3390\/jpm11080695"},{"issue":"1","key":"2383_CR59","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1186\/s12967-020-02620-5","volume":"18","author":"N Hou","year":"2020","unstructured":"Hou N, Li M, He L, Xie B, Wang L, Zhang R, Yu Y, Sun X, Pan Z, Wang K. Predicting 30-days mortality for MIMIC-III patients with sepsis-3: a machine learning approach using XGboost. J Translational Med. 2020;18(1):462.","journal-title":"J Translational Med"},{"issue":"6","key":"2383_CR60","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.aucc.2020.12.007","volume":"34","author":"S Hargovan","year":"2021","unstructured":"Hargovan S, Gunnarsson R, Carter A, De Costa A, Brooks J, Groch T, Sivalingam S. The 4-Hour Cairns Sepsis Model: a novel approach to predicting sepsis mortality at intensive care unit admission. Australian Crit care: Official J Confederation Australian Crit Care Nurses. 2021;34(6):552\u201360.","journal-title":"Australian Crit care: Official J Confederation Australian Crit Care Nurses"},{"key":"2383_CR61","doi-asserted-by":"crossref","unstructured":"Ghiasi S, Zhu T, Lu P, Hagenah J, Khanh PNQ, Hao NV, Vital C, Thwaites L, Clifton DA. Sepsis mortality prediction using Wearable Monitoring in Low-Middle Income Countries. Sensors 2022, 22(10).","DOI":"10.3390\/s22103866"},{"issue":"3","key":"2383_CR62","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.medin.2018.07.016","volume":"44","author":"JE Garc\u00eda-Gallo","year":"2020","unstructured":"Garc\u00eda-Gallo JE, Fonseca-Ruiz NJ, Celi LA, Duitama-Mu\u00f1oz JF. A machine learning-based model for 1-year mortality prediction in patients admitted to an intensive care unit with a diagnosis of sepsis. Med Intensiva. 2020;44(3):160\u201370.","journal-title":"Med Intensiva"},{"issue":"2","key":"2383_CR63","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1097\/CCM.0000000000001392","volume":"44","author":"DW Ford","year":"2016","unstructured":"Ford DW, Goodwin AJ, Simpson AN, Johnson E, Nadig N, Simpson KN. A severe Sepsis mortality prediction model and score for Use with Administrative Data. Crit Care Med. 2016;44(2):319\u201327.","journal-title":"Crit Care Med"},{"issue":"20","key":"2383_CR64","doi-asserted-by":"publisher","first-page":"e6923","DOI":"10.1097\/MD.0000000000006923","volume":"96","author":"M Chen","year":"2017","unstructured":"Chen M, Lu X, Hu L, Liu P, Zhao W, Yan H, Tang L, Zhu Y, Xiao Z, Chen L, et al. Development and validation of a mortality risk model for pediatric sepsis. Medicine. 2017;96(20):e6923.","journal-title":"Medicine"},{"key":"2383_CR65","doi-asserted-by":"crossref","unstructured":"Chao HY, Wu CC, Singh A, Shedd A, Wolfshohl J, Chou EH, Huang YC, Chen KF. Using machine learning to develop and validate an In-Hospital mortality prediction model for patients with suspected Sepsis. Biomedicines 2022, 10(4).","DOI":"10.3390\/biomedicines10040802"},{"issue":"5","key":"2383_CR66","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1097\/CCM.0000000000002824","volume":"46","author":"GS Phillips","year":"2018","unstructured":"Phillips GS, Osborn TM, Terry KM, Gesten F, Levy MM, Lemeshow S. The New York Sepsis Severity score: development of a risk-adjusted severity model for Sepsis. Crit Care Med. 2018;46(5):674\u201383.","journal-title":"Crit Care Med"},{"issue":"1","key":"2383_CR67","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.artmed.2014.03.004","volume":"61","author":"VJ Ribas Ripoll","year":"2014","unstructured":"Ribas Ripoll VJ, Vellido A, Romero E, Ruiz-Rodr\u00edguez JC. Sepsis mortality prediction with the quotient basis Kernel. Artif Intell Med. 2014;61(1):45\u201352.","journal-title":"Artif Intell Med"},{"key":"2383_CR68","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.cca.2022.04.994","volume":"531","author":"X Guo","year":"2022","unstructured":"Guo X, Shuai XY, Cai TT, Wu ZY, Wu DW, Ding SF. The thrombodynamic ratio as a predictor of 28-day mortality in sepsis patients. Clin Chim Acta. 2022;531:399\u2013405.","journal-title":"Clin Chim Acta"},{"issue":"3","key":"2383_CR69","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1007\/s11517-022-02521-3","volume":"60","author":"M Gong","year":"2022","unstructured":"Gong M, Liu J, Li C, Guo W, Wang R, Chen Z. Early warning model for death of sepsis via length insensitive temporal convolutional network. Med Biol Eng Comput. 2022;60(3):875\u201385.","journal-title":"Med Biol Eng Comput"},{"key":"2383_CR70","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Gallo JE, Fonseca-Ruiz NJ, Duitama-Mu\u00f1oz JF. Development of a Model that uses Data obtained in the admission to Predict one-year mortality in patients with Sepsis in the Intensive Care Unit. Int J Pharma Med Biol Sci 2019.","DOI":"10.18178\/ijpmbs.8.1.12-16"},{"key":"2383_CR71","doi-asserted-by":"publisher","first-page":"108841","DOI":"10.1016\/j.intimp.2022.108841","volume":"108","author":"X Ding","year":"2022","unstructured":"Ding X, Tong R, Song H, Sun G, Wang D, Liang H, Sun J, Cui Y, Zhang X, Liu S, et al. Identification of metabolomics-based prognostic prediction models for ICU septic patients. Int Immunopharmacol. 2022;108:108841.","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"2383_CR72","doi-asserted-by":"publisher","first-page":"395","DOI":"10.2478\/rrlm-2021-0034","volume":"29","author":"W Wang","year":"2021","unstructured":"Wang W, Jie Y, Zhou J. Values of serum PCT, suPAR combined with severity scores for evaluating prognosis of septic shock patients. Revista Romana De Medicina De Laborator. 2021;29(4):395\u2013402.","journal-title":"Revista Romana De Medicina De Laborator"},{"key":"2383_CR73","doi-asserted-by":"crossref","unstructured":"Wang L, Tang C, He S, Chen Y, Xie C. Combined suPAR and qSOFA for the prediction of 28-day mortality in sepsis patients. Signa Vitae 2022, 18(3).","DOI":"10.21203\/rs.3.rs-195966\/v1"},{"key":"2383_CR74","doi-asserted-by":"publisher","first-page":"100861","DOI":"10.1016\/j.imu.2022.100861","volume":"28","author":"M Selcuk","year":"2022","unstructured":"Selcuk M, Koc O, Kestel AS. The prediction power of machine learning on estimating the sepsis mortality in the intensive care unit. Inf Med Unlocked. 2022;28:100861.","journal-title":"Inf Med Unlocked"},{"key":"2383_CR75","doi-asserted-by":"crossref","unstructured":"Ribas VJ, L\u00f3pez JC, Ruiz-Sanmartin A, Ruiz-Rodr\u00edguez JC, Rello J, Wojdel A, Vellido A. Severe sepsis mortality prediction with relevance vector machines. Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual International Conference 2011, 2011:100\u2013103.","DOI":"10.1109\/IEMBS.2011.6089906"},{"issue":"3","key":"2383_CR76","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1001\/jama.2016.20328","volume":"317","author":"EP Raith","year":"2017","unstructured":"Raith EP, Udy AA, Bailey M, McGloughlin S, MacIsaac C, Bellomo R, Pilcher DV. Prognostic accuracy of the SOFA score, SIRS Criteria, and qSOFA score for In-Hospital mortality among adults with suspected Infection admitted to the Intensive Care Unit. JAMA. 2017;317(3):290\u2013300.","journal-title":"JAMA"},{"key":"2383_CR77","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s13054-016-1243-3","volume":"20","author":"AP Houwink","year":"2016","unstructured":"Houwink AP, Rijkenberg S, Bosman RJ, van der Voort PH. The association between lactate, mean arterial pressure, central venous oxygen saturation and peripheral temperature and mortality in severe sepsis: a retrospective cohort analysis. Crit Care (London England). 2016;20:56.","journal-title":"Crit Care (London England)"},{"issue":"6","key":"2383_CR78","doi-asserted-by":"publisher","first-page":"e489","DOI":"10.1097\/CCM.0000000000003030","volume":"46","author":"SM Ryoo","year":"2018","unstructured":"Ryoo SM, Lee J, Lee YS, Lee JH, Lim KS, Huh JW, Hong SB, Lim CM, Koh Y, Kim WY. Lactate Level Versus Lactate Clearance for Predicting Mortality in patients with septic shock defined by Sepsis-3. Crit Care Med. 2018;46(6):e489\u201395.","journal-title":"Crit Care Med"},{"issue":"8","key":"2383_CR79","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1097\/CCM.0000000000003208","volume":"46","author":"E Estenssoro","year":"2018","unstructured":"Estenssoro E, Kanoore Edul VS, Loudet CI, Osatnik J, R\u00edos FG, V\u00e1zquez DN, Pozo MO, Lattanzio B, P\u00e1lizas F, Klein F, et al. Predictive validity of Sepsis-3 definitions and Sepsis outcomes in critically Ill patients: a Cohort Study in 49 ICUs in Argentina. Crit Care Med. 2018;46(8):1276\u201383.","journal-title":"Crit Care Med"},{"issue":"5","key":"2383_CR80","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1097\/CCM.0b013e31819fcf68","volume":"37","author":"ME Mikkelsen","year":"2009","unstructured":"Mikkelsen ME, Miltiades AN, Gaieski DF, Goyal M, Fuchs BD, Shah CV, Bellamy SL, Christie JD. Serum lactate is associated with mortality in severe sepsis Independent of organ failure and shock. Crit Care Med. 2009;37(5):1670\u20137.","journal-title":"Crit Care Med"},{"issue":"8","key":"2383_CR81","doi-asserted-by":"publisher","first-page":"e14453","DOI":"10.1097\/MD.0000000000014453","volume":"98","author":"J Pan","year":"2019","unstructured":"Pan J, Peng M, Liao C, Hu X, Wang A, Li X. Relative efficacy and safety of early lactate clearance-guided therapy resuscitation in patients with sepsis: a meta-analysis. Medicine. 2019;98(8):e14453.","journal-title":"Medicine"},{"issue":"8","key":"2383_CR82","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1001\/jama.2010.158","volume":"303","author":"AE Jones","year":"2010","unstructured":"Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA. 2010;303(8):739\u201346.","journal-title":"JAMA"},{"issue":"6","key":"2383_CR83","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/ki.2009.517","volume":"77","author":"P Muntner","year":"2010","unstructured":"Muntner P, Warnock DG. Acute kidney injury in sepsis: questions answered, but others remain. Kidney Int. 2010;77(6):485\u20137.","journal-title":"Kidney Int"},{"issue":"2","key":"2383_CR84","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ccc.2020.11.010","volume":"37","author":"CL Manrique-Caballero","year":"2021","unstructured":"Manrique-Caballero CL, Del Rio-Pertuz G, Gomez H. Sepsis-Associated Acute kidney Injury. Crit Care Clin. 2021;37(2):279\u2013301.","journal-title":"Crit Care Clin"},{"issue":"13","key":"2383_CR85","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1001\/jama.2017.10913","volume":"318","author":"B Andrews","year":"2017","unstructured":"Andrews B, Semler MW, Muchemwa L, Kelly P, Lakhi S, Heimburger DC, Mabula C, Bwalya M, Bernard GR. Effect of an early resuscitation protocol on In-hospital mortality among adults with Sepsis and hypotension: a Randomized Clinical Trial. JAMA. 2017;318(13):1233\u201340.","journal-title":"JAMA"}],"container-title":["BMC Medical Informatics and Decision Making"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12911-023-02383-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12911-023-02383-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12911-023-02383-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T03:04:10Z","timestamp":1702350250000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedinformdecismak.biomedcentral.com\/articles\/10.1186\/s12911-023-02383-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,11]]},"references-count":85,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["2383"],"URL":"https:\/\/doi.org\/10.1186\/s12911-023-02383-1","relation":{},"ISSN":["1472-6947"],"issn-type":[{"value":"1472-6947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,11]]},"assertion":[{"value":"1 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"283"}}