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Shared decision-making (SDM) models help to understand considerations that influence patients\u2019 decision. Discussion of patient values is essential to SDM, but such communication is often limited in this context and may require new interventions. The OnVaCT intervention, consisting of a preparatory online value clarification tool (OnVaCT) for patients and communication training for oncologists, was previously developed to support SDM. This study aimed to qualitatively explore associations between patient values that are discussed between patients and oncologists during consultations about potential participation in early phase clinical trials before and after implementation of the OnVaCT intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study is part of a prospective multicentre nonrandomized controlled clinical trial and had a between-subjects design: pre-intervention patients received usual care, while post-intervention patients additionally received the OnVaCT. Oncologists participated in the communication training between study phases. Patients\u2019 initial consultation on potential early phase clinical trial participation was recorded and transcribed verbatim. Applying a directed approach, two independent coders analysed the transcripts using an initial codebook based on previous studies. Steps of continuous evaluation and revision were repeated until data saturation was reached.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data saturation was reached after 32 patient-oncologist consultations (i.e. 17 pre-intervention and 15 post-intervention). The analysis revealed the values: hope, perseverance, quality or quantity of life, risk tolerance, trust in the healthcare system\/professionals, autonomy, social adherence, altruism, corporeality, acceptance of one\u2019s fate, and humanity. Patients in the pre-intervention phase tended to express values briefly and spontaneously. Oncologists acknowledged the importance of patients\u2019 values, but generally only gave \u2018contrasting\u2019 examples of why some accept and others refuse to participate in trials. In the post-intervention phase, many oncologists referred to the OnVaCT and\/or asked follow-up questions, while patients used longer phrases that combined multiple values, sometimes clearly indicating their weighing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While all values were recognized in both study phases, our results have highlighted the different communication patterns around patient values in SDM for potential early phase clinical trial participation before and after implementation of the OnVaCT intervention. This study therefore provides a first (qualitative) indication that the OnVaCT intervention may support patients and oncologists in discussing their values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>Netherlands Trial Registry: NL7335, registered on July 17, 2018.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12911-024-02434-1","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T01:02:24Z","timestamp":1706835744000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Patient values in patient-provider communication about participation in early phase clinical cancer trials: a qualitative analysis before and after implementation of an online value clarification tool intervention"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4979-3051","authenticated-orcid":false,"given":"Liza G. 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The Medical Ethics Committee of the Erasmus MC (Rotterdam, The Netherlands), has reviewed the research proposal for the entire project (of which the study reported here is a part) and assessed that the rules laid down in the Medical Research Involving Human Subjects Act, do not apply (MEC-2018\u2013151). Research governance approval was received from all participating hospitals. Patients provided written informed consent before their consultation was recorded. Additionally, all (fellow) medical oncologists whose consultations were recorded provided written informed consent before their first consultation was recorded.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"CR has received the grant from Dutch Cancer Society for the conduct of the study; and a personal fee from Kyowa Kirin BV and Ipsen Pharmaceutica BV (both outside the submitted work). The other authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"32"}}