{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T15:59:28Z","timestamp":1768579168909,"version":"3.49.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001652","name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001652","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Inform Decis Mak"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Molecular tumor boards (MTBs) play a pivotal role in personalized oncology, leveraging complex data sets to tailor therapy for cancer patients. The integration of digital support and visualization tools is essential in this rapidly evolving field facing fast-growing data and changing clinical processes. This study addresses the gap in understanding the evolution of software and visualization needs within MTBs and evaluates the current state of digital support. Alignment between user requirements and software development is crucial to avoid waste of resources and maintain trust.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>In two consecutive nationwide medical informatics projects in Germany, surveys and expert interviews were conducted as stage 1 (<jats:italic>n<\/jats:italic>\u2009=\u200914), stage 2 (<jats:italic>n<\/jats:italic>\u2009=\u200930), and stage 3 (<jats:italic>n<\/jats:italic>\u2009=\u20099). Surveys, via the SoSci Survey tool, covered participants' roles, working methods, and support needs. The second survey additionally addressed requirements for visualization solutions in molecular tumor boards. These aimed to understand diverse requirements for preparation, implementation, and documentation. Nine semi-structured expert interviews complemented quantitative findings through open discussion.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Using quantitative and qualitative analyses, we show that existing digital tools may improve therapy recommendations and streamline MTB case preparation, while continuous training and system improvements are needed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our study contributes to the field by highlighting the importance of developing user-centric, customizable software solutions that can adapt to the fast-paced environment of MTBs to advance personalized oncology. In doing so, it lays the foundation for further advances in personalized medicine in oncology and points to a shift towards more efficient, technology-driven clinical decision-making processes. This research not only enriches our understanding of the integration of digital tools into MTBs, but also signals a broader shift towards technological innovation in healthcare.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12911-024-02821-8","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T10:01:08Z","timestamp":1737021668000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Empowering personalized oncology: evolution of digital support and visualization tools for molecular tumor boards"],"prefix":"10.1186","volume":"25","author":[{"given":"Cosima","family":"Strantz","sequence":"first","affiliation":[]},{"given":"Dominik","family":"B\u00f6hm","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"Ganslandt","sequence":"additional","affiliation":[]},{"given":"Melanie","family":"B\u00f6rries","sequence":"additional","affiliation":[]},{"given":"Patrick","family":"Metzger","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"Pauli","sequence":"additional","affiliation":[]},{"given":"Andreas","family":"Blaumeiser","sequence":"additional","affiliation":[]},{"given":"Alexander","family":"Scheiter","sequence":"additional","affiliation":[]},{"given":"Ian-Christopher","family":"Jung","sequence":"additional","affiliation":[]},{"given":"Jan","family":"Christoph","sequence":"additional","affiliation":[]},{"given":"Iryna","family":"Manuilova","sequence":"additional","affiliation":[]},{"given":"Konstantin","family":"Strauch","sequence":"additional","affiliation":[]},{"given":"Arsenij","family":"Ustjanzew","sequence":"additional","affiliation":[]},{"given":"Niklas","family":"Reimer","sequence":"additional","affiliation":[]},{"given":"Hauke","family":"Busch","sequence":"additional","affiliation":[]},{"given":"Philipp","family":"Unberath","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"issue":"4","key":"2821_CR1","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s00292-021-00938-5","volume":"42","author":"P Horak","year":"2021","unstructured":"Horak P, Leichsenring J, Kreutzfeldt S, Kazdal D, Teleanu V, Endris V, et al. Varianteninterpretation in der molekularen Pathologie und Onkologie: Eine Einf\u00fchrung. Pathologe. 2021;42(4):369\u201379.","journal-title":"Pathologe"},{"issue":"5","key":"2821_CR2","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.3390\/cancers13051151","volume":"13","author":"R Hoefflin","year":"2021","unstructured":"Hoefflin R, Lazarou A, Hess ME, Reiser M, Wehrle J, Metzger P, et al. Transitioning the molecular tumor board from proof of concept to clinical routine: A German single-center analysis. Cancers. 2021;13(5):1151.","journal-title":"Cancers"},{"issue":"24","key":"2821_CR3","doi-asserted-by":"publisher","first-page":"5892","DOI":"10.3390\/cancers15245892","volume":"15","author":"L T\u00f6gel","year":"2023","unstructured":"T\u00f6gel L, Schubart C, Lettmaier S, Neufert C, Hoyer J, Wolff K, et al. Determinants affecting the clinical implementation of a molecularly informed molecular tumor board recommendation: experience from a tertiary cancer center. Cancers. 2023;15(24):5892.","journal-title":"Cancers"},{"issue":"6","key":"2821_CR4","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1038\/s41591-023-02354-z","volume":"29","author":"AL Illert","year":"2023","unstructured":"Illert AL, Stenzinger A, Bitzer M, Horak P, Gaidzik VI, M\u00f6ller Y, et al. The German network for personalized medicine to enhance patient care and translational research. Nat Med. 2023;29(6):1298\u2013301.","journal-title":"Nat Med"},{"issue":"11","key":"2821_CR5","doi-asserted-by":"publisher","first-page":"e50017","DOI":"10.2196\/50017","volume":"11","author":"C Renner","year":"2023","unstructured":"Renner C, Reimer N, Christoph J, Busch H, Metzger P, Boerries M, et al. Extending cBioPortal for therapy recommendation documentation in molecular tumor boards: development and usability study. JMIR Med Inform. 2023;11(11):e50017.","journal-title":"JMIR Med Inform"},{"issue":"10","key":"2821_CR6","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/s41580-023-00615-w","volume":"24","author":"A Baysoy","year":"2023","unstructured":"Baysoy A, Bai Z, Satija R, Fan R. The technological landscape and applications of single-cell multi-omics. Nat Rev Mol Cell Biol. 2023;24(10):695\u2013713.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"2821_CR7","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.trecan.2020.05.008","volume":"6","author":"C Luchini","year":"2020","unstructured":"Luchini C, Lawlor RT, Milella M, Scarpa A. Molecular tumor boards in clinical practice. Trends Cancer. 2020;6(9):738\u201344.","journal-title":"Trends Cancer"},{"key":"2821_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1200\/PO.18.00105","volume":"2","author":"R Hoefflin","year":"2018","unstructured":"Hoefflin R, Gei\u00dfler AL, Fritsch R, Claus R, Wehrle J, Metzger P, et al. Personalized clinical decision making through implementation of a molecular tumor board: a German single-center experience. JCO Precis Oncol. 2018;2:1\u201316.","journal-title":"JCO Precis Oncol"},{"issue":"20","key":"2821_CR9","doi-asserted-by":"publisher","first-page":"5040","DOI":"10.3390\/cancers14205040","volume":"14","author":"F L\u00fcke","year":"2022","unstructured":"L\u00fcke F, Haller F, Utpatel K, Krebs M, Meidenbauer N, Scheiter A, et al. Identification of disparities in personalized cancer care\u2014a joint approach of the German WERA Consortium. Cancers. 2022;14(20):5040.","journal-title":"Cancers"},{"issue":"6","key":"2821_CR10","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1038\/s41416-022-02120-x","volume":"128","author":"A Scheiter","year":"2023","unstructured":"Scheiter A, Hierl F, L\u00fcke F, Keil F, Heudobler D, Einhell S, et al. Critical evaluation of molecular tumour board outcomes following 2 years of clinical practice in a Comprehensive Cancer Centre. Br J Cancer. 2023;128(6):1134\u201347.","journal-title":"Br J Cancer"},{"issue":"8","key":"2821_CR11","doi-asserted-by":"publisher","first-page":"e1347","DOI":"10.1002\/onco.13580","volume":"26","author":"B Koopman","year":"2021","unstructured":"Koopman B, Groen HJM, Ligtenberg MJL, Gr\u00fcnberg K, Monkhorst K, Langen AJ, et al. Multicenter comparison of molecular tumor boards in The Netherlands: definition, composition, methods, and targeted therapy recommendations. Oncologist. 2021;26(8):e1347\u201358.","journal-title":"Oncologist"},{"issue":"3","key":"2821_CR12","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s00104-013-2481-4","volume":"84","author":"J Haier","year":"2013","unstructured":"Haier J, Bergmann KO. Medizinrechtliche Aspekte von Tumorboards. Chirurg. 2013;84(3):225\u201330.","journal-title":"Chirurg"},{"issue":"7","key":"2821_CR13","doi-asserted-by":"publisher","first-page":"3485","DOI":"10.3390\/app12073485","volume":"12","author":"K Lauk","year":"2022","unstructured":"Lauk K, Peters MC, Velthaus JL, N\u00fcrnberg S, Ueckert F. Use of process modelling for optimization of molecular tumor boards. Appl Sci. 2022;12(7):3485.","journal-title":"Appl Sci"},{"issue":"1","key":"2821_CR14","doi-asserted-by":"publisher","first-page":"4965","DOI":"10.1038\/s41467-020-18613-3","volume":"11","author":"S Kato","year":"2020","unstructured":"Kato S, Kim KH, Lim HJ, Boichard A, Nikanjam M, Weihe E, et al. Real-world data from a molecular tumor board demonstrates improved outcomes with a precision N-of-One strategy. Nat Commun. 2020;11(1):4965.","journal-title":"Nat Commun"},{"key":"2821_CR15","first-page":"48","volume":"236","author":"M Hinderer","year":"2017","unstructured":"Hinderer M, Boerries M, Haller F, Wagner S, Sollfrank S, Acker T, et al. Supporting molecular tumor boards in molecular-guided decision-making - the current status of five German University Hospitals. Stud Health Technol Inform. 2017;236:48\u201354.","journal-title":"Stud Health Technol Inform"},{"issue":"2","key":"2821_CR16","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3390\/diagnostics10020093","volume":"10","author":"P Buechner","year":"2020","unstructured":"Buechner P, Hinderer M, Unberath P, Metzger P, Boeker M, Acker T, et al. Requirements analysis and specification for a molecular tumor board platform based on cBioPortal. Diagnostics. 2020;10(2):93.","journal-title":"Diagnostics"},{"issue":"S 01","key":"2821_CR17","doi-asserted-by":"publisher","first-page":"e82","DOI":"10.3414\/ME17-02-0025","volume":"57","author":"HU Prokosch","year":"2018","unstructured":"Prokosch HU, Acker T, Bernarding J, Binder H, Boeker M, Boerries M, et al. MIRACUM: Medical Informatics in Research and Care in University Medicine. Methods Inf Med. 2018;57(S 01):e82\u201391.","journal-title":"Methods Inf Med."},{"issue":"13","key":"2821_CR18","doi-asserted-by":"publisher","first-page":"3456","DOI":"10.3390\/cancers15133456","volume":"15","author":"P Metzger","year":"2023","unstructured":"Metzger P, Hess ME, Blaumeiser A, Pauli T, Schipperges V, Mertes R, et al. MIRACUM-Pipe: an adaptable pipeline for next-generation sequencing analysis, reporting, and visualization for clinical decision making. Cancers. 2023;15(13):3456.","journal-title":"Cancers"},{"issue":"2","key":"2821_CR19","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/s43018-022-00332-x","volume":"3","author":"D Tamborero","year":"2022","unstructured":"Tamborero D, Dienstmann R, Rachid MH, Boekel J, Lopez-Fernandez A, Jonsson M, et al. The molecular tumor board portal supports clinical decisions and automated reporting for precision oncology. Nat Cancer. 2022;3(2):251\u201361.","journal-title":"Nat Cancer"},{"issue":"02","key":"2821_CR20","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1055\/s-0042-1743560","volume":"13","author":"P Unberath","year":"2022","unstructured":"Unberath P, Mahlmeister L, Reimer N, Busch H, Boerries M, Christoph J. Searching of clinical trials made easier in cBioPortal using patients\u2019 genetic and clinical profiles. Appl Clin Inform. 2022;13(02):363\u20139.","journal-title":"Appl Clin Inform"},{"issue":"1","key":"2821_CR21","doi-asserted-by":"publisher","first-page":"e53627","DOI":"10.2196\/53627","volume":"13","author":"D Boehm","year":"2024","unstructured":"Boehm D, Strantz C, Christoph J, Busch H, Ganslandt T, Unberath P. Data visualization support for tumor boards and clinical oncology: protocol for a scoping review. JMIR Res Prot. 2024;13(1):e53627.","journal-title":"JMIR Res Prot"},{"issue":"5","key":"2821_CR22","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","volume":"2","author":"E Cerami","year":"2012","unstructured":"Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012;2(5):401\u20134.","journal-title":"Cancer Discov"},{"issue":"6","key":"2821_CR23","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1136\/jamia.2001.0080527","volume":"8","author":"I Sim","year":"2001","unstructured":"Sim I, Gorman P, Greenes RA, Haynes RB, Kaplan B, Lehmann H, et al. Clinical decision support systems for the practice of evidence-based medicine. J Am Med Inform Assoc. 2001;8(6):527\u201334.","journal-title":"J Am Med Inform Assoc"},{"issue":"16","key":"2821_CR24","doi-asserted-by":"publisher","first-page":"8435","DOI":"10.3390\/ijerph18168435","volume":"18","author":"T Harada","year":"2021","unstructured":"Harada T, Miyagami T, Kunitomo K, Shimizu T. Clinical decision support systems for diagnosis in primary care: a scoping review. Int J Environ Res Public Health. 2021;18(16):8435.","journal-title":"Int J Environ Res Public Health"},{"issue":"2","key":"2821_CR25","doi-asserted-by":"publisher","first-page":"e24","DOI":"10.2196\/medinform.8912","volume":"6","author":"S Khairat","year":"2018","unstructured":"Khairat S, Marc D, Crosby W, Al SA. Reasons for physicians not adopting clinical decision support systems: critical analysis. JMIR Med Inform. 2018;6(2):e24.","journal-title":"JMIR Med Inform"},{"issue":"1","key":"2821_CR26","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41746-020-0221-y","volume":"3","author":"RT Sutton","year":"2020","unstructured":"Sutton RT, Pincock D, Baumgart DC, Sadowski DC, Fedorak RN, Kroeker KI. An overview of clinical decision support systems: benefits, risks, and strategies for success. npj Digit Med. 2020;3(1):17.","journal-title":"npj Digit Med."},{"issue":"2","key":"2821_CR27","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3758\/BF03204742","volume":"27","author":"E Colet","year":"1995","unstructured":"Colet E, Aaronson D. Visualization of multivariate data: Human-factors considerations. Behav Res Methods Instrum Comput. 1995;27(2):257\u201363.","journal-title":"Behav Res Methods Instrum Comput"},{"issue":"6","key":"2821_CR28","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1007\/s00103-024-03886-6","volume":"67","author":"P Metzger","year":"2024","unstructured":"Metzger P, Boerries M. Das Verbundprojekt \u201ePersonalisierte Medizin f\u00fcr die Onkologie\u201c (PM4Onco) als Teil der Medizininformatik-Initiative (MII). Bundesgesundheitsbl. 2024;67(6):668\u201375.","journal-title":"Bundesgesundheitsbl"},{"issue":"2","key":"2821_CR29","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1080\/17538157.2021.1982949","volume":"47","author":"S Park","year":"2022","unstructured":"Park S, Bekemeier B, Flaxman A, Schultz M. Impact of data visualization on decision-making and its implications for public health practice: a systematic literature review. Inform Health Soc Care. 2022;47(2):175\u201393.","journal-title":"Inform Health Soc Care"},{"issue":"5","key":"2821_CR30","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s00761-020-00725-6","volume":"26","author":"C Schickhardt","year":"2020","unstructured":"Schickhardt C, Horak P, Fr\u00f6hling S, Winkler EC. Das Molekulare Tumorboard: Ethische Herausforderungen und Empfehlungen f\u00fcr die Praxis. Onkologe. 2020;26(5):431\u20137.","journal-title":"Onkologe"},{"key":"2821_CR31","unstructured":"SoSci Survey \u2023 the Professional Solution for Your Online Survey. Available from: https:\/\/www.soscisurvey.de\/. Cited 2024 Feb 28"},{"key":"2821_CR32","doi-asserted-by":"crossref","unstructured":"Mayring P. Qualitative Inhaltsanalyse: Grundlagen und Techniken. 13. Auflage. Weinheim Basel: Beltz; 2022.","DOI":"10.1007\/978-3-658-37985-8_43"},{"key":"2821_CR33","doi-asserted-by":"crossref","unstructured":"Herrmann A. Grundlagen der Anforderungsanalyse: Standardkonformes Requirements Engineering. Wiesbaden: Springer Fachmedien Wiesbaden; 2022. Available from:\u00a0https:\/\/link.springer.com\/10.1007\/978-3-658-35460-2. Cited 2024 Feb 28","DOI":"10.1007\/978-3-658-35460-2"},{"key":"2821_CR34","doi-asserted-by":"crossref","unstructured":"Maguire M, Bevan N. User Requirements Analysis. In: Hammond J, Gross T, Wesson J, editors. Usability. Boston, MA: Springer US; 2002. p. 133\u201348. (IFIP Advances in Information and Communication Technology; vol. 99). Available from:\u00a0http:\/\/link.springer.com\/10.1007\/978-0-387-35610-5_9. Cited 2024 Feb 27","DOI":"10.1007\/978-0-387-35610-5_9"},{"key":"2821_CR35","doi-asserted-by":"crossref","unstructured":"McKinney W. Data Structures for Statistical Computing in Python. In Austin, Texas; 2010. p. 56\u201361. Available from: https:\/\/doi.curvenote.com\/10.25080\/Majora-92bf1922-00a. Cited 2024 Oct 27","DOI":"10.25080\/Majora-92bf1922-00a"},{"key":"2821_CR36","unstructured":"Understanding Your Users. Elsevier; 2005. Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/B9781558609358X50295. Cited 2024 Feb 27"},{"key":"2821_CR37","doi-asserted-by":"crossref","unstructured":"Kuckartz U, R\u00e4diker S. Vom Leitfaden zum Kategoriensystem. In: Fokussierte Interviewanalyse mit MAXQDA. Wiesbaden: Springer Fachmedien Wiesbaden; 2020. p. 23\u201341. Available from:\u00a0http:\/\/link.springer.com\/10.1007\/978-3-658-31468-2_2. Cited 2024 Feb 27","DOI":"10.1007\/978-3-658-31468-2_2"},{"key":"2821_CR38","doi-asserted-by":"crossref","unstructured":"R\u00e4diker S, Kuckartz U. Analyse qualitativer Daten mit MAXQDA: Text, Audio und Video. Wiesbaden: Springer Fachmedien Wiesbaden; 2019. Available from:\u00a0http:\/\/link.springer.com\/10.1007\/978-3-658-22095-2. Cited 2024 Feb 27","DOI":"10.1007\/978-3-658-22095-2"},{"issue":"6","key":"2821_CR39","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1093\/intqhc\/mzm042","volume":"19","author":"A Tong","year":"2007","unstructured":"Tong A, Sainsbury P, Craig J. Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Int J Qual Health Care. 2007;19(6):349\u201357.","journal-title":"Int J Qual Health Care"},{"key":"2821_CR40","doi-asserted-by":"crossref","unstructured":"Reimer N, Unberath P, Busch H, B\u00f6rries M, Metzger P, Ustjanzew A, et al. Challenges and Experiences Extending the cBioPortal for Cancer Genomics to a Molecular Tumor Board Platform. In: Delgado J, Benis A, De Toledo P, Gallos P, Giacomini M, Mart\u00ednez-Garc\u00eda A, et al., editors. Studies in Health Technology and Informatics. IOS Press; 2021. Available from:\u00a0https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI210833. Cited 2024 Feb 27","DOI":"10.3233\/SHTI210833"},{"issue":"3","key":"2821_CR41","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1177\/1535370217750088","volume":"243","author":"RM Califf","year":"2018","unstructured":"Califf RM. Biomarker definitions and their applications. Exp Biol Med (Maywood). 2018;243(3):213\u201321.","journal-title":"Exp Biol Med (Maywood)"},{"key":"2821_CR42","doi-asserted-by":"crossref","unstructured":"Reimer N, Unberath P, Busch H, Ingenerf J. FhirSpark \u2013 Implementing a Mediation Layer to Bring FHIR to the cBioPortal for Cancer Genomics. In: Mantas J, Stoicu-Tivadar L, Chronaki C, Hasman A, Weber P, Gallos P, et al., editors. Studies in Health Technology and Informatics. IOS Press; 2021. Available from:\u00a0https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI210169. Cited 2024 Oct 28","DOI":"10.3233\/SHTI210169"},{"issue":"13","key":"2821_CR43","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1111\/1471-0528.15199","volume":"125","author":"E Hariton","year":"2018","unstructured":"Hariton E, Locascio JJ. Randomised controlled trials - the gold standard for effectiveness research: Study design: randomised controlled trials. BJOG. 2018;125(13):1716.","journal-title":"BJOG"},{"key":"2821_CR44","doi-asserted-by":"crossref","unstructured":"Damasceno B. Fundamentals of Statistical Analysis. In: Research on Cognition Disorders. Cham: Springer International Publishing; 2020. p. 149\u201355. Available from:\u00a0http:\/\/link.springer.com\/10.1007\/978-3-030-57267-9_15. Cited 2024 Apr 20","DOI":"10.1007\/978-3-030-57267-9_15"},{"issue":"49","key":"2821_CR45","doi-asserted-by":"publisher","first-page":"44772","DOI":"10.1021\/acsomega.2c04782","volume":"7","author":"SA Barua","year":"2022","unstructured":"Barua SA, Goswami N, Mishra N, Sawant UU, Varma AK. In Silico and structure-based assessment of similar variants discovered in tandem repeats of BRCT domains of BRCA1 and BARD1 to characterize the folding pattern. ACS Omega. 2022;7(49):44772\u201385.","journal-title":"ACS Omega"},{"issue":"4","key":"2821_CR46","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1007\/s42979-023-01771-8","volume":"4","author":"MP Schapranow","year":"2023","unstructured":"Schapranow MP, Borchert F, Bougatf N, Hund H, Eils R. Software-tool support for collaborative, virtual, multi-site molecular tumor boards. SN Comput Sci. 2023;4(4):358.","journal-title":"SN Comput Sci"},{"key":"2821_CR47","doi-asserted-by":"publisher","first-page":"e2200032","DOI":"10.1200\/CCI.22.00032","volume":"6","author":"A Kahraman","year":"2022","unstructured":"Kahraman A, Arnold FM, Hanimann J, Nowak M, Pauli C, Britschgi C, et al. MTPpilot: an interactive software for visualization of next-generation sequencing results in molecular tumor boards. JCO Clin Cancer Inform. 2022;6:e2200032.","journal-title":"JCO Clin Cancer Inform"},{"issue":"9","key":"2821_CR48","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1074\/mcp.TIR119.001673","volume":"18","author":"P Wu","year":"2019","unstructured":"Wu P, Heins ZJ, Muller JT, Katsnelson L, De Bruijn I, Abeshouse AA, et al. Integration and analysis of CPTAC proteomics data in the context of cancer genomics in the cBioPortal. Mol Cell Proteomics. 2019;18(9):1893\u20138.","journal-title":"Mol Cell Proteomics"},{"issue":"sup1","key":"2821_CR49","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3109\/13814788.2015.1043123","volume":"21","author":"M Nurek","year":"2015","unstructured":"Nurek M, Kostopoulou O, Delaney BC, Esmail A. Reducing diagnostic errors in primary care. A systematic meta-review of computerized diagnostic decision support systems by the LINNEAUS collaboration on patient safety in primary care. Eur J Gen Pract. 2015;21(sup1):8\u201313.","journal-title":"Eur J Gen Pract"},{"key":"2821_CR50","doi-asserted-by":"crossref","unstructured":"Halfmann M, Stenzhorn H, Gerjets P, Kohlbacher O, Oestermeier U. User-Driven Development of a Novel Molecular Tumor Board Support Tool. In: Auer S, Vidal ME, editors. Data Integration in the Life Sciences. Cham: Springer International Publishing; 2019. p. 195\u20139. (Lecture Notes in Computer Science; vol. 11371). Available from:\u00a0http:\/\/link.springer.com\/10.1007\/978-3-030-06016-9_18. Cited 2024 Feb 27","DOI":"10.1007\/978-3-030-06016-9_18"},{"key":"2821_CR51","doi-asserted-by":"publisher","first-page":"107697","DOI":"10.1016\/j.cmpb.2023.107697","volume":"240","author":"A F\u00fcrstberger","year":"2023","unstructured":"F\u00fcrstberger A, Ikonomi N, Kestler AMR, Marienfeld R, Schwab JD, Kuhn P, et al. AMBAR - Interactive Alteration annotations for molecular tumor boards. Comput Methods Programs Biomed. 2023;240: 107697.","journal-title":"Comput Methods Programs Biomed"},{"key":"2821_CR52","unstructured":"Precision Medicine Online. 2019. \u2018Virtual\u2019 Molecular Tumor Board Cuts Turnaround Time, Boosts Trial Enrollment Rate. Available from: https:\/\/www.precisionmedicineonline.com\/informatics\/virtual-molecular-tumor-board-cuts-turnaround-time-boosts-trial-enrollment-rate. Cited 2024 Mar 5"},{"issue":"15","key":"2821_CR53","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1093\/bioinformatics\/btr330","volume":"27","author":"P Danecek","year":"2011","unstructured":"Danecek P, Auton A, Abecasis G, Albers CA, Banks E, DePristo MA, et al. The variant call format and VCFtools. Bioinformatics. 2011;27(15):2156\u20138.","journal-title":"Bioinformatics"},{"key":"2821_CR54","unstructured":"MAF. Available from: https:\/\/docs.gdc.cancer.gov\/Data\/File_Formats\/MAF_Format\/"},{"key":"2821_CR55","doi-asserted-by":"crossref","unstructured":"Kurz NS, Perera-Bel J, H\u00f6ltermann C, Tucholski T, Yang J, Beissbarth T, et al. Identifying Actionable Variants in Cancer \u2013 The Dual Web and Batch Processing Tool MTB-Report. In: R\u00f6hrig R, Grabe N, Hoffmann VS, H\u00fcbner U, K\u00f6nig J, Sax U, et al., editors. Studies in Health Technology and Informatics. IOS Press; 2022. Available from:\u00a0https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI220806. Cited 2024 Mar 5","DOI":"10.3233\/SHTI220806"},{"issue":"1","key":"2821_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12911-021-01719-z","volume":"21","author":"A Ustjanzew","year":"2021","unstructured":"Ustjanzew A, Desuki A, Ritzel C, Dolezilek AC, Wagner DC, Christoph J, et al. cbpManager: a web application to streamline the integration of clinical and genomic data in cBioPortal to support the molecular tumor board. BMC Med Inform Decis Mak. 2021;21(1):1\u201313.","journal-title":"BMC Med Inform Decis Mak"},{"key":"2821_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1200\/PO.17.00011","volume":"1","author":"D Chakravarty","year":"2017","unstructured":"Chakravarty D, Gao J, Phillips S, Kundra R, Zhang H, Wang J, et al. OncoKB: a precision oncology knowledge base. JCO Precis Oncol. 2017;1:1\u201316.","journal-title":"JCO Precis Oncol"},{"issue":"2","key":"2821_CR58","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/ng.3774","volume":"49","author":"M Griffith","year":"2017","unstructured":"Griffith M, Spies NC, Krysiak K, McMichael JF, Coffman AC, Danos AM, et al. CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer. Nat Genet. 2017;49(2):170\u20134.","journal-title":"Nat Genet"},{"issue":"6","key":"2821_CR59","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1093\/jamia\/ocad061","volume":"30","author":"C Stellmach","year":"2023","unstructured":"Stellmach C, Sass J, Auber B, Boeker M, Wienker T, Heidel AJ, et al. Creation of a structured molecular genomics report for Germany as a local adaption of HL7\u2019s genomic reporting implementation guide. J Am Med Inform Assoc. 2023;30(6):1179\u201389.","journal-title":"J Am Med Inform Assoc"}],"container-title":["BMC Medical Informatics and Decision Making"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12911-024-02821-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12911-024-02821-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12911-024-02821-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T10:46:10Z","timestamp":1737024370000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedinformdecismak.biomedcentral.com\/articles\/10.1186\/s12911-024-02821-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,16]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2821"],"URL":"https:\/\/doi.org\/10.1186\/s12911-024-02821-8","relation":{},"ISSN":["1472-6947"],"issn-type":[{"value":"1472-6947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,16]]},"assertion":[{"value":"16 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The ethics committee of Friedrich-Alexander-University Erlangen-N\u00fcrnberg approved stage 1 of the study on January 24, 2022 (approval number: 22\u201324-ANF) and stage 2 and 3 (including small subsequent survey) on December 22, 2023 (approval number: 23\u2013391-B). All participants provided written informed consent to participate in the study. All methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"29"}}