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This study aimed to identify the most effective approach for detecting and classifying reliable information versus misinformation health content shared on Twitter\/X related to COVID-19.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We have used 7 different machine learning\/deep learning models. Tweets were collected, processed, labeled, and analyzed using relevant keywords and hashtags, then classified into two distinct datasets: \u201cTrustworthy information\u201d versus \u201cMisinformation\u201d, through a labeling process. The cosine similarity metric was employed to address oversampling the minority of the Trustworthy information class, ensuring a more balanced representation of both classes for training and testing purposes. Finally, the performance of the various fact-checking models was analyzed and compared using accuracy, precision, recall, and F1-score ROC curve, and AUC.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>For measures of accuracy, precision, F1 score, and recall, the average values of TextConvoNet were found to be 90.28, 90.28, 90.29, and 0.9030, respectively. ROC AUC was 0.901.\u201cTrustworthy information\u201d class achieved an accuracy of 85%, precision of 93%, recall of 86%, and F1 score of 89%. These values were higher than other models. Moreover, its performance in the misinformation category was even more impressive, with an accuracy of 94%, precision of 88%, recall of 94%, and F1 score of 91%.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This study showed that TextConvoNet was the most effective in detecting and classifying trustworthy information V.S misinformation related to health issues that have been shared on Twitter\/X.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12911-025-02895-y","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T18:17:12Z","timestamp":1739297832000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Classifying and fact-checking health-related information about COVID-19 on Twitter\/X using machine learning and deep learning models"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9902-4245","authenticated-orcid":false,"given":"Elham","family":"Sharifpoor","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0070-289X","authenticated-orcid":false,"given":"Maryam","family":"Okhovati","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3482-7642","authenticated-orcid":false,"given":"Mostafa","family":"Ghazizadeh-Ahsaee","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6047-5962","authenticated-orcid":false,"given":"Mina","family":"Avaz Beigi","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"2895_CR1","doi-asserted-by":"publisher","first-page":"102679","DOI":"10.1016\/j.ipm.2021.102679","volume":"58","author":"C Zhou","year":"2021","unstructured":"Zhou C, Li K, Lu Y. 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