{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:48:40Z","timestamp":1783115320147,"version":"3.54.6"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003032","name":"Association Nationale de la Recherche et de la Technologie","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003032","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Inform Decis Mak"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Chronic Obstructive Pulmonary Disease (COPD) is one of the main causes of morbidity and mortality worldwide. Its management represents real economic and public health burdens, accentuated by periods of acute disease deterioration, called exacerbations. Some researchers have studied the interest of monitoring patients\u2019 breathing rate as an indicator of exacerbation, although achieving limited sensitivity and\/or specificity. In this study, we look to improve the previously described method, by combining breathing variables, using multiple daily measures, and using an artificial intelligence-based novelty detection approach.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Patients with COPD were monitored with a telemedicine device during their stay in a rehabilitation care center. Daily measures are compared to individually trained reference models based on: i. oxygen therapy duration ii. mean breathing rate, iii. mean inspiratory amplitude, iv. mean breathing rate and mean inspiratory amplitude, v. average distribution of breathing rate and inspiratory amplitude, vi. hidden Markov model (HMM) from a time series of breathing rate and inspiratory amplitude.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A set of 16 recordings with exacerbation and 23 recordings without exacerbation was obtained. When using a daily measure of breathing rate, pre-exacerbation periods were identified with a specificity of 50% and a sensitivity of 55.6%. The method based on daily oxygen therapy usage and the method based on time series obtain a sensitivity of 76.8% and 73.2%, respectively, for a fixed specificity of 50%.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>A single daily measure of breathing rate alone is not sufficient for the detection of pre-exacerbation periods. More complete models also achieve limited performance, equivalent to models based on changes in the duration of therapy usage.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12911-025-02939-3","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T14:58:02Z","timestamp":1740495482000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Detection of COPD exacerbations with continuous monitoring of breathing rate and inspiratory amplitude under oxygen therapy"],"prefix":"10.1186","volume":"25","author":[{"given":"Juliana","family":"Alves Pegoraro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Guerder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Similowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Salamitou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Gonzalez-Bermejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Birmel\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"2939_CR1","unstructured":"GOLD. 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Patients provided written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"JAP was employed by Srett during the development of the study and is employed by L\u00f6wenstein Medical Technology. PS is the founder and CEO of Srett. JAP, TS, PS, JG-B, and EB are inventors of the patent EP20315396.0, in which a respiration monitoring system combining breathing rate and signal amplitude measures is covered. All other authors declare that they do not have any competing interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"101"}}