{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:58:12Z","timestamp":1762113492544},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T00:00:00Z","timestamp":1411776000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/s12918-014-0112-4","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T15:51:06Z","timestamp":1411746666000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Autocrine FGF feedback can establish distinct states of Nanog expression in pluripotent stem cells: a computational analysis"],"prefix":"10.1186","volume":"8","author":[{"given":"Dora","family":"Lakatos","sequence":"first","affiliation":[]},{"given":"Emily D","family":"Travis","sequence":"additional","affiliation":[]},{"given":"Kelsey E","family":"Pierson","sequence":"additional","affiliation":[]},{"given":"Jay L","family":"Vivian","sequence":"additional","affiliation":[]},{"given":"Andras","family":"Czirok","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,9,27]]},"reference":[{"issue":"5819","key":"112_CR1","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/292154a0","volume":"292","author":"MJ Evans","year":"1981","unstructured":"Evans MJ, Kaufman MH: Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981, 292 (5819): 154-156. 10.1038\/292154a0.","journal-title":"Nature"},{"key":"112_CR2","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1146\/annurev.cellbio.17.1.435","volume":"17","author":"AG Smith","year":"2001","unstructured":"Smith AG: Embryo-derived stem cells: of mice and men. Annu Rev Cell Dev Biol. 2001, 17: 435-462. 10.1146\/annurev.cellbio.17.1.435.","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"2","key":"112_CR3","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/sj.gt.3303065","volume":"15","author":"S Ohtsuka","year":"2008","unstructured":"Ohtsuka S, Dalton S: Molecular and biological properties of pluripotent embryonic stem cells. Gene Ther. 2008, 15 (2): 74-81. 10.1038\/sj.gt.3303065.","journal-title":"Gene Ther"},{"issue":"5","key":"112_CR4","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.gde.2006.08.009","volume":"16","author":"LA Boyer","year":"2006","unstructured":"Boyer LA, Mathur D, Jaenisch R: Molecular control of pluripotency. Curr Opin Genet Dev. 2006, 16 (5): 455-462. 10.1016\/j.gde.2006.08.009.","journal-title":"Curr Opin Genet Dev"},{"issue":"1","key":"112_CR5","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/sj.cr.7310125","volume":"17","author":"G Pan","year":"2007","unstructured":"Pan G, Thomson JA: Nanog and transcriptional networks in embryonic stem cell pluripotency. Cell Res. 2007, 17 (1): 42-49. 10.1038\/sj.cr.7310125.","journal-title":"Cell Res"},{"issue":"5","key":"112_CR6","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/S0092-8674(03)00393-3","volume":"113","author":"K Mitsui","year":"2003","unstructured":"Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, Maruyama M, Maeda M, Yamanaka S: The homeoprotein nanog is required for maintenance of pluripotency in mouse epiblast and es cells. Cell. 2003, 113 (5): 631-642. 10.1016\/S0092-8674(03)00393-3.","journal-title":"Cell"},{"issue":"7173","key":"112_CR7","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1038\/nature06403","volume":"450","author":"I Chambers","year":"2007","unstructured":"Chambers I, Silva J, Colby D, Nichols J, Nijmeijer B, Robertson M, Vrana J, Jones K, Grotewold L, Smith A: Nanog safeguards pluripotency and mediates germline development. Nature. 2007, 450 (7173): 1230-1234. 10.1038\/nature06403.","journal-title":"Nature"},{"issue":"9","key":"112_CR8","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1371\/journal.pcbi.0020123","volume":"2","author":"V Chickarmane","year":"2006","unstructured":"Chickarmane V, Troein C, Nuber UA, Sauro HM, Peterson C: Transcriptional dynamics of the embryonic stem cell switch. PLoS Comput Biol. 2006, 2 (9): 123-10.1371\/journal.pcbi.0020123.","journal-title":"PLoS Comput Biol"},{"issue":"7","key":"112_CR9","doi-asserted-by":"publisher","first-page":"1000149","DOI":"10.1371\/journal.pbio.1000149","volume":"7","author":"T Kalmar","year":"2009","unstructured":"Kalmar T, Lim C, Hayward P, Mu\u00f1oz-Descalzo S, Nichols J, Garcia-Ojalvo J, Arias AM: Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells. PLoS Biol. 2009, 7 (7): 1000149-10.1371\/journal.pbio.1000149.","journal-title":"PLoS Biol"},{"issue":"24","key":"112_CR10","doi-asserted-by":"publisher","first-page":"4547","DOI":"10.1038\/emboj.2012.321","volume":"31","author":"P Navarro","year":"2012","unstructured":"Navarro P, Festuccia N, Colby D, Gagliardi A, Mullin NP, Zhang W, Karwacki-Neisius V, Osorno R, Kelly D, Robertson M, Chambers I: Oct4\/sox2-independent nanog autorepression modulates heterogeneous nanog gene expression in mouse es cells. EMBO J. 2012, 31 (24): 4547-4562. 10.1038\/emboj.2012.321.","journal-title":"EMBO J"},{"issue":"4","key":"112_CR11","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.stem.2008.07.027","volume":"3","author":"K Hayashi","year":"2008","unstructured":"Hayashi K, de Sousa Lopes SMC, Tang F, Surani MA: Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. Cell Stem Cell. 2008, 3 (4): 391-401. 10.1016\/j.stem.2008.07.027.","journal-title":"Cell Stem Cell"},{"issue":"2","key":"112_CR12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/stem.265","volume":"28","author":"F Lanner","year":"2010","unstructured":"Lanner F, Lee KL, Sohl M, Holmborn K, Yang H, Wilbertz J, Poellinger L, Rossant J, Farnebo F: Heparan sulfation-dependent fibroblast growth factor signaling maintains embryonic stem cells primed for differentiation in a heterogeneous state. Stem Cells. 2010, 28 (2): 191-200.","journal-title":"Stem Cells"},{"issue":"1","key":"112_CR13","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1002\/stem.1252","volume":"31","author":"KE Galvin-Burgess","year":"2013","unstructured":"Galvin-Burgess KE, Travis ED, Pierson KE, Vivian JL: Tgf-\u03b2-superfamily signaling regulates embryonic stem cell heterogeneity: self-renewal as a dynamic and regulated equilibrium. Stem Cells. 2013, 31 (1): 48-58. 10.1002\/stem.1252.","journal-title":"Stem Cells"},{"issue":"78","key":"112_CR14","doi-asserted-by":"publisher","first-page":"20120525","DOI":"10.1098\/rsif.2012.0525","volume":"10","author":"Y Luo","year":"2012","unstructured":"Luo Y, Lim CL, Nichols J, Martinez-Arias A, Wernisch L: Cell signalling regulates dynamics of nanog distribution in embryonic stem cell populations. J R Soc Interface. 2012, 10 (78): 20120525-10.1098\/rsif.2012.0525.","journal-title":"J R Soc Interface"},{"issue":"2","key":"112_CR15","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.cell.2006.02.041","volume":"125","author":"BE Bernstein","year":"2006","unstructured":"Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, Fry B, Meissner A, Wernig M, Plath K, Jaenisch R, Wagschal A, Feil R, Schreiber SL, Lander ES: A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell. 2006, 125 (2): 315-326. 10.1016\/j.cell.2006.02.041.","journal-title":"Cell"},{"issue":"9","key":"112_CR16","doi-asserted-by":"publisher","first-page":"5136","DOI":"10.1073\/pnas.0930314100","volume":"100","author":"NE Buchler","year":"2003","unstructured":"Buchler NE, Gerland U, Hwa T: On schemes of combinatorial transcription logic. Proc Natl Acad Sci U S A. 2003, 100 (9): 5136-5141. 10.1073\/pnas.0930314100.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"112_CR17","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/1752-0509-6-98","volume":"6","author":"V Chickarmane","year":"2012","unstructured":"Chickarmane V, Olariu V, Peterson C: Probing the role of stochasticity in a model of the embryonic stem cell: heterogeneous gene expression and reprogramming efficiency. BMC Syst Biol. 2012, 6: 98-10.1186\/1752-0509-6-98.","journal-title":"BMC Syst Biol"},{"issue":"20","key":"112_CR18","doi-asserted-by":"publisher","first-page":"3351","DOI":"10.1242\/dev.050146","volume":"137","author":"F Lanner","year":"2010","unstructured":"Lanner F, Rossant J: The role of fgf\/erk signaling in pluripotent cells. Development. 2010, 137 (20): 3351-3360. 10.1242\/dev.050146.","journal-title":"Development"},{"issue":"Database issue","key":"112_CR19","first-page":"48","volume":"41","author":"P Flicek","year":"2003","unstructured":"Flicek P, Ahmed I, Amode MR, Barrell D, Beal K, Brent S, Carvalho-Silva D, Clapham P, Coates G, Fairley S, Fitzgerald S, Gil L, Garc\u00eda-Gir\u00f3n C, Gordon L, Hourlier T, Hunt S, Juettemann T, K\u00e4h\u00e4ri AK, Keenan S, Komorowska M, Kulesha E, Longden I, Maurel T, McLaren WM, Muffato M, Nag R, Overduin B, Pignatelli M, Pritchard B, Pritchard E, et al: Ensembl 2013. Nucleic Acids Res 2013. 2003, 41 (Database issue): 48-55.","journal-title":"Nucleic Acids Res 2013"},{"issue":"16","key":"112_CR20","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1242\/dev.02880","volume":"134","author":"T Kunath","year":"2007","unstructured":"Kunath T, Saba-El-Leil MK, Almousailleakh M, Wray J, Meloche S, Smith A: Fgf stimulation of the erk1\/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development. 2007, 134 (16): 2895-2902. 10.1242\/dev.02880.","journal-title":"Development"},{"issue":"4","key":"112_CR21","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.stem.2012.08.002","volume":"11","author":"N Festuccia","year":"2012","unstructured":"Festuccia N, Osorno R, Halbritter F, Karwacki-Neisius V, Navarro P, Colby D, Wong F, Yates A, Tomlinson SR, Chambers I: Esrrb is a direct nanog target gene that can substitute for nanog function in pluripotent cells. Cell Stem Cell. 2012, 11 (4): 477-490. 10.1016\/j.stem.2012.08.002.","journal-title":"Cell Stem Cell"},{"issue":"3","key":"112_CR22","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/ncb1698","volume":"10","author":"J Jiang","year":"2008","unstructured":"Jiang J, Chan Y-S, Loh Y-H, Cai J, Tong G-Q, Lim C-A, Robson P, Zhong S, Ng H-H: A core klf circuitry regulates self-renewal of embryonic stem cells. Nat Cell Biol. 2008, 10 (3): 353-360. 10.1038\/ncb1698.","journal-title":"Nat Cell Biol"},{"issue":"6","key":"112_CR23","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/j.cell.2008.04.043","volume":"133","author":"X Chen","year":"2008","unstructured":"Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB, Wong E, Orlov YL, Zhang W, Jiang J, Loh Y-H, Yeo HC, Yeo ZX, Narang V, Govindarajan KR, Leong B, Shahab A, Ruan Y, Bourque G, Sung W-K, Clarke ND, Wei C-L, Ng H-H: Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell. 2008, 133 (6): 1106-1117. 10.1016\/j.cell.2008.04.043.","journal-title":"Cell"},{"issue":"3","key":"112_CR24","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.cell.2008.07.020","volume":"134","author":"A Marson","year":"2008","unstructured":"Marson A, Levine SS, Cole MF, Frampton GM, Brambrink T, Johnstone S, Guenther MG, Johnston WK, Wernig M, Newman J, Calabrese JM, Dennis LM, Volkert TL, Gupta S, Love J, Hannett N, Sharp PA, Bartel DP, Jaenisch R, Young RA: Connecting microrna genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell. 2008, 134 (3): 521-533. 10.1016\/j.cell.2008.07.020.","journal-title":"Cell"},{"issue":"26","key":"112_CR25","doi-asserted-by":"publisher","first-page":"19747","DOI":"10.1074\/jbc.M109.077347","volume":"285","author":"KE Galvin","year":"2010","unstructured":"Galvin KE, Travis ED, Yee D, Magnuson T, Vivian JL: Nodal signaling regulates the bone morphogenic protein pluripotency pathway in mouse embryonic stem cells. J Biol Chem. 2010, 285 (26): 19747-19756. 10.1074\/jbc.M109.077347.","journal-title":"J Biol Chem"},{"issue":"Pt 12","key":"112_CR26","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1242\/jcs.114.12.2301","volume":"114","author":"AE DeWitt","year":"2001","unstructured":"DeWitt AE, Dong JY, Wiley HS, Lauffenburger DA: Quantitative analysis of the egf receptor autocrine system reveals cryptic regulation of cell response by ligand capture. J Cell Sci. 2001, 114 (Pt 12): 2301-2313.","journal-title":"J Cell Sci"},{"issue":"19","key":"112_CR27","doi-asserted-by":"publisher","first-page":"10078","DOI":"10.1073\/pnas.93.19.10078","volume":"93","author":"CY Huang","year":"1996","unstructured":"Huang CY, Ferrell JE: Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc Natl Acad Sci U S A. 1996, 93 (19): 10078-10083. 10.1073\/pnas.93.19.10078.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"38","key":"112_CR28","doi-asserted-by":"publisher","first-page":"27119","DOI":"10.1074\/jbc.274.38.27119","volume":"274","author":"AR Asthagiri","year":"1999","unstructured":"Asthagiri AR, Nelson CM, Horwitz AF, Lauffenburger DA: Quantitative relationship among integrin-ligand binding, adhesion, and signaling via focal adhesion kinase and extracellular signal-regulated kinase 2. J Biol Chem. 1999, 274 (38): 27119-27127. 10.1074\/jbc.274.38.27119.","journal-title":"J Biol Chem"},{"issue":"2","key":"112_CR29","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1021\/bp010009k","volume":"17","author":"AR Asthagiri","year":"2001","unstructured":"Asthagiri AR, Lauffenburger DA: A computational study of feedback effects on signal dynamics in a mitogen-activated protein kinase (mapk) pathway model. Biotechnol Prog. 2001, 17 (2): 227-239. 10.1021\/bp010009k.","journal-title":"Biotechnol Prog"},{"issue":"4","key":"112_CR30","doi-asserted-by":"publisher","first-page":"4901","DOI":"10.1371\/journal.pone.0004901","volume":"4","author":"AA Cohen","year":"2009","unstructured":"Cohen AA, Kalisky T, Mayo A, Geva-Zatorsky N, Danon T, Issaeva I, Kopito RB, Perzov N, Milo R, Sigal A, Alon U: Protein dynamics in individual human cells: experiment and theory. PLoS One. 2009, 4 (4): 4901-10.1371\/journal.pone.0004901.","journal-title":"PLoS One"},{"issue":"4","key":"112_CR31","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/74199","volume":"24","author":"H Niwa","year":"2000","unstructured":"Niwa H, Miyazaki J, Smith AG: Quantitative expression of oct-3\/4 defines differentiation, dedifferentiation or self-renewal of es cells. Nat Genet. 2000, 24 (4): 372-376. 10.1038\/74199.","journal-title":"Nat Genet"},{"issue":"4","key":"112_CR32","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/ng1760","volume":"38","author":"Y-H Loh","year":"2006","unstructured":"Loh Y-H, Wu Q, Chew J-L, Vega VB, Zhang W, Chen X, Bourque G, George J, Leong B, Liu J, Wong K-Y, Sung KW, Lee CWH, Zhao X-D, Chiu K-P, Lipovich L, Kuznetsov VA, Robson P, Stanton LW, Wei C-L, Ruan Y, Lim B, Ng H-H: The oct4 and nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet. 2006, 38 (4): 431-440. 10.1038\/ng1760.","journal-title":"Nat Genet"},{"issue":"6","key":"112_CR33","doi-asserted-by":"publisher","first-page":"11238","DOI":"10.1371\/journal.pone.0011238","volume":"5","author":"I Glauche","year":"2010","unstructured":"Glauche I, Herberg M, Roeder I: Nanog variability and pluripotency regulation of embryonic stem cells-insights from a mathematical model analysis. PLoS One. 2010, 5 (6): 11238-10.1371\/journal.pone.0011238.","journal-title":"PLoS One"},{"issue":"10","key":"112_CR34","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1096\/fj.05-5543fje","volume":"20","author":"G Pan","year":"2006","unstructured":"Pan G, Li J, Zhou Y, Zheng H, Pei D: A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. FASEB J. 2006, 20 (10): 1730-1732. 10.1096\/fj.05-5543fje.","journal-title":"FASEB J"},{"issue":"12","key":"112_CR35","doi-asserted-by":"publisher","first-page":"9180","DOI":"10.1074\/jbc.M109.077958","volume":"285","author":"P Zhang","year":"2010","unstructured":"Zhang P, Andrianakos R, Yang Y, Liu C, Lu W: Kruppel-like factor 4 (klf4) prevents embryonic stem (es) cell differentiation by regulating nanog gene expression. J Biol Chem. 2010, 285 (12): 9180-9189. 10.1074\/jbc.M109.077958.","journal-title":"J Biol Chem"},{"issue":"3","key":"112_CR36","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/nsmb.2217","volume":"19","author":"MO Kim","year":"2012","unstructured":"Kim MO, Kim S-H, Cho Y-Y, Nadas J, Jeong C-H, Yao K, Kim DJ, Yu D-H, Keum Y-S, Lee K-Y, Huang Z, Bode AM, Dong Z: Erk1 and erk2 regulate embryonic stem cell self-renewal through phosphorylation of klf4. Nat Struct Mol Biol. 2012, 19 (3): 283-290. 10.1038\/nsmb.2217.","journal-title":"Nat Struct Mol Biol"},{"issue":"19","key":"112_CR37","doi-asserted-by":"publisher","first-page":"5986","DOI":"10.1128\/MCB.00301-08","volume":"28","author":"DLC van den Berg","year":"2008","unstructured":"van den Berg DLC, Zhang W, Yates A, Engelen E, Takacs K, Bezstarosti K, Demmers J, Chambers I, Poot RA: Estrogen-related receptor beta interacts with oct4 to positively regulate nanog gene expression. Mol Cell Biol. 2008, 28 (19): 5986-5995. 10.1128\/MCB.00301-08.","journal-title":"Mol Cell Biol"},{"issue":"4","key":"112_CR38","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1016\/S0006-3495(01)75837-7","volume":"81","author":"SY Shvartsman","year":"2001","unstructured":"Shvartsman SY, Wiley HS, Deen WM, Lauffenburger DA: Spatial range of autocrine signaling: modeling and computational analysis. Biophys J. 2001, 81 (4): 1854-1867. 10.1016\/S0006-3495(01)75837-7.","journal-title":"Biophys J"},{"issue":"5400","key":"112_CR39","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1126\/science.283.5400.381","volume":"283","author":"US Bhalla","year":"1999","unstructured":"Bhalla US, Iyengar R: Emergent properties of networks of biological signaling pathways. Science. 1999, 283 (5400): 381-387. 10.1126\/science.283.5400.381.","journal-title":"Science"},{"issue":"4","key":"112_CR40","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/ncb1233","volume":"7","author":"S Sasagawa","year":"2005","unstructured":"Sasagawa S, Ozaki Y-I, Fujita K, Kuroda S: Prediction and validation of the distinct dynamics of transient and sustained erk activation. Nat Cell Biol. 2005, 7 (4): 365-373. 10.1038\/ncb1233.","journal-title":"Nat Cell Biol"},{"issue":"31","key":"112_CR41","doi-asserted-by":"publisher","first-page":"12675","DOI":"10.1073\/pnas.1104030108","volume":"108","author":"K Aoki","year":"2011","unstructured":"Aoki K, Yamada M, Kunida K, Yasuda S, Matsuda M: Processive phosphorylation of erk map kinase in mammalian cells. Proc Natl Acad Sci U S A. 2011, 108 (31): 12675-12680. 10.1073\/pnas.1104030108.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"112_CR42","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/0022-2836(85)90086-5","volume":"181","author":"MA Shea","year":"1985","unstructured":"Shea MA, Ackers GK: The or control system of bacteriophage lambda. A physical-chemical model for gene regulation. J Mol Biol. 1985, 181 (2): 211-230. 10.1016\/0022-2836(85)90086-5.","journal-title":"J Mol Biol"},{"issue":"2","key":"112_CR43","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.cell.2010.09.010","volume":"143","author":"J Kim","year":"2010","unstructured":"Kim J, Woo AJ, Chu J, Snow JW, Fujiwara Y, Kim CG, Cantor AB, Orkin SH: A myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell. 2010, 143 (2): 313-324. 10.1016\/j.cell.2010.09.010.","journal-title":"Cell"},{"issue":"7","key":"112_CR44","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/ncb2267","volume":"13","author":"J Wray","year":"2011","unstructured":"Wray J, Kalkan T, Gomez-Lopez S, Eckardt D, Cook A, Kemler R, Smith A: Inhibition of glycogen synthase kinase-3 alleviates tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation. Nat Cell Biol. 2011, 13 (7): 838-845. 10.1038\/ncb2267.","journal-title":"Nat Cell Biol"},{"issue":"4","key":"112_CR45","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.stem.2012.06.008","volume":"11","author":"G Martello","year":"2012","unstructured":"Martello G, Sugimoto T, Diamanti E, Joshi A, Hannah R, Ohtsuka S, G\u00f6ttgens B, Niwa H, Smith A: Esrrb is a pivotal target of the gsk3\/tcf3 axis regulating embryonic stem cell self-renewal. Cell Stem Cell. 2012, 11 (4): 491-504. 10.1016\/j.stem.2012.06.008.","journal-title":"Cell Stem Cell"},{"issue":"7","key":"112_CR46","doi-asserted-by":"publisher","first-page":"1003140","DOI":"10.1371\/journal.pcbi.1003140","volume":"9","author":"J Wu","year":"2013","unstructured":"Wu J, Tzanakakis ES: Distinct allelic patterns of nanog expression impart embryonic stem cell population heterogeneity. PLoS Comput Biol. 2013, 9 (7): 1003140-10.1371\/journal.pcbi.1003140.","journal-title":"PLoS Comput Biol"},{"issue":"1","key":"112_CR47","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.stem.2013.04.019","volume":"13","author":"DA Faddah","year":"2013","unstructured":"Faddah DA, Wang H, Cheng AW, Katz Y, Buganim Y, Jaenisch R: Single-cell analysis reveals that expression of nanog is biallelic and equally variable as that of other pluripotency factors in mouse escs. Cell Stem Cell. 2013, 13 (1): 23-29. 10.1016\/j.stem.2013.04.019.","journal-title":"Cell Stem Cell"},{"issue":"5","key":"112_CR48","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nmeth0506-397","volume":"3","author":"C Schaniel","year":"2006","unstructured":"Schaniel C, Li F, Schafer XL, Moore T, Lemischka IR, Paddison PJ: Delivery of short hairpin rnas-triggers of gene silencing-into mouse embryonic stem cells. Nat Methods. 2006, 3 (5): 397-400. 10.1038\/nmeth0506-397.","journal-title":"Nat Methods"},{"issue":"1","key":"112_CR49","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0092-8674(02)00680-3","volume":"109","author":"M Kyba","year":"2002","unstructured":"Kyba M, Perlingeiro RCR, Daley GQ: Hoxb4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell. 2002, 109 (1): 29-37. 10.1016\/S0092-8674(02)00680-3.","journal-title":"Cell"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12918-014-0112-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12918-014-0112-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12918-014-0112-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12918-014-0112-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T01:11:45Z","timestamp":1650244305000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/s12918-014-0112-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,27]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["112"],"URL":"https:\/\/doi.org\/10.1186\/s12918-014-0112-4","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,27]]},"assertion":[{"value":"12 March 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"112"}}