{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:54:44Z","timestamp":1770414884158,"version":"3.49.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/s12918-014-0127-x","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T15:05:23Z","timestamp":1416236723000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Parameter estimation of dynamic biological network models using integrated fluxes"],"prefix":"10.1186","volume":"8","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[]},{"given":"Rudiyanto","family":"Gunawan","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,11,18]]},"reference":[{"issue":"2","key":"127_CR1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mbs.2009.03.002","volume":"219","author":"IC Chou","year":"2009","unstructured":"Chou IC, Voit EO: Recent developments in parameter estimation and structure identification of biochemical and genomic systems . Math Biosci. 2009, 219 (2): 57-83. 10.1016\/j.mbs.2009.03.002.","journal-title":"Math Biosci"},{"issue":"13","key":"127_CR2","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/j.ces.2004.03.023","volume":"59","author":"A Bardow","year":"2004","unstructured":"Bardow A, Marquardt W: Incremental and simultaneous identification of reaction kinetics: methods and comparison . Chem Eng Sci. 2004, 59 (13): 2673-2684. 10.1016\/j.ces.2004.03.023.","journal-title":"Chem Eng Sci"},{"issue":"3","key":"127_CR3","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jbiotec.2010.02.019","volume":"149","author":"S Srinath","year":"2010","unstructured":"Srinath S, Gunawan R: Parameter identifiability of power-law biochemical system models . J Biotechnol. 2010, 149 (3): 132-140. 10.1016\/j.jbiotec.2010.02.019.","journal-title":"J Biotechnol"},{"issue":"1","key":"127_CR4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/1752-0509-5-177","volume":"5","author":"G Szederkenyi","year":"2011","unstructured":"Szederkenyi G, Banga J, Alonso A: Inference of complex biological networks: distinguishability issues and optimization-based solutions . BMC Syst Biol. 2011, 5 (1): 177-10.1186\/1752-0509-5-177.","journal-title":"BMC Syst Biol"},{"issue":"4","key":"127_CR5","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1049\/ip-syb:20050087","volume":"153","author":"EO Voit","year":"2006","unstructured":"Voit EO, Almeida J, Marino S, Lall R, Goel G, Neves AR, Santos H: Regulation of glycolysis in lactococcus lactis: an unfinished systems biological case study . Syst Biol. 2006, 153 (4): 286-298. 10.1049\/ip-syb:20050087.","journal-title":"Syst Biol"},{"issue":"11","key":"127_CR6","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1093\/bioinformatics\/bth140","volume":"20","author":"EO Voit","year":"2004","unstructured":"Voit EO, Almeida J: Decoupling dynamical systems for pathway identification from metabolic profiles . Bioinformatics. 2004, 20 (11): 1670-1681. 10.1093\/bioinformatics\/bth140.","journal-title":"Bioinformatics"},{"issue":"21","key":"127_CR7","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1093\/bioinformatics\/btn470","volume":"24","author":"G Goel","year":"2008","unstructured":"Goel G, Chou IC, Voit EO: System estimation from metabolic time-series data . Bioinformatics. 2008, 24 (21): 2505-2511. 10.1093\/bioinformatics\/btn470.","journal-title":"Bioinformatics"},{"issue":"14","key":"127_CR8","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1093\/bioinformatics\/btr293","volume":"27","author":"G Jia","year":"2011","unstructured":"Jia G, Stephanopoulos GN, Gunawan R: Parameter estimation of kinetic models from metabolic profiles: two-phase dynamic decoupling method . Bioinformatics. 2011, 27 (14): 1964-1970. 10.1093\/bioinformatics\/btr293.","journal-title":"Bioinformatics"},{"issue":"8","key":"127_CR9","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1093\/bioinformatics\/btt083","volume":"29","author":"TH Nim","year":"2013","unstructured":"Nim TH, Luo L, Cl\u00e9ment M-V, White JK, Tucker-Kellogg L: Systematic parameter estimation in data-rich environments for cell signalling dynamics . Bioinformatics. 2013, 29 (8): 1044-1051. 10.1093\/bioinformatics\/btt083.","journal-title":"Bioinformatics"},{"key":"127_CR10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1752-0509-6-142","volume":"6","author":"G Jia","year":"2012","unstructured":"Jia G, Stephanopoulos G, Gunawan R: Incremental parameter estimation of kinetic metabolic network models . BMC Syst Biol. 2012, 6: 142-10.1186\/1752-0509-6-142.","journal-title":"BMC Syst Biol"},{"issue":"11","key":"127_CR11","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1002\/aic.12125","volume":"56","author":"M Amrhein","year":"2010","unstructured":"Amrhein M, Bhatt N, Srinivasan B, Bonvin D: Extents of reaction and flow for homogeneous reaction systems with inlet and outlet streams . AIChE J. 2010, 56 (11): 2873-2886. 10.1002\/aic.12125.","journal-title":"AIChE J"},{"issue":"23","key":"127_CR12","doi-asserted-by":"crossref","first-page":"12960","DOI":"10.1021\/ie2007196","volume":"50","author":"N Bhatt","year":"2011","unstructured":"Bhatt N, Amrhein M, Bonvin D: Incremental identification of reaction and mass-transfer kinetics using the concept of extents . Ind Eng Chem Res. 2011, 50 (23): 12960-12974. 10.1021\/ie2007196.","journal-title":"Ind Eng Chem Res"},{"key":"127_CR13","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ces.2012.05.040","volume":"83","author":"N Bhatt","year":"2012","unstructured":"Bhatt N, Kerimoglu N, Amrhein M, Marquardt W, Bonvin D: Incremental identification of reaction systems-a comparison between rate-based and extent-based approaches . Chem Eng Sci. 2012, 83: 24-38. 10.1016\/j.ces.2012.05.040.","journal-title":"Chem Eng Sci"},{"issue":"3","key":"127_CR14","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1049\/iet-syb:20070030","volume":"2","author":"RC del Rosario","year":"2008","unstructured":"del Rosario RC, Mendoza E, Voit EO: Challenges in lin-log modelling of glycolysis in lactococcus lactis . IET Syst Biol. 2008, 2 (3): 136-149. 10.1049\/iet-syb:20070030.","journal-title":"IET Syst Biol"},{"issue":"3","key":"127_CR15","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1145\/1089014.1089020","volume":"31","author":"AC Hindmarsh","year":"2005","unstructured":"Hindmarsh AC, Brown PN, Grant KE, Lee SL, Serban R, Shumaker DE, Woodward CS: Sundials: Suite of nonlinear and differential\/algebraic equation solvers . ACM Trans Math Software. 2005, 31 (3): 363-396. 10.1145\/1089014.1089020.","journal-title":"ACM Trans Math Software"},{"issue":"3","key":"127_CR16","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s10898-006-9075-3","volume":"37","author":"JA Egea","year":"2007","unstructured":"Egea JA, Rodr\u00edguez-Fern\u00e1ndez M, Banga JR: Scatter search for chemical and bio-process optimization . J Global Optim. 2007, 37 (3): 481-503. 10.1007\/s10898-006-9075-3.","journal-title":"J Global Optim"},{"key":"127_CR17","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1186\/1471-2105-7-483","volume":"7","author":"M Rodr\u00edguez-Fern\u00e1ndez","year":"2006","unstructured":"Rodr\u00edguez-Fern\u00e1ndez M, Egea JA, Banga JR: Novel metaheuristic for parameter estimation in nonlinear dynamic biological systems . BMC Bioinformatics. 2006, 7: 483-10.1186\/1471-2105-7-483.","journal-title":"BMC Bioinformatics"},{"issue":"2","key":"127_CR18","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cor.2009.05.003","volume":"37","author":"JA Egea","year":"2010","unstructured":"Egea JA, Mart\u00ed R, Banga JR: An evolutionary method for complex-process optimization . Comput Oper Res. 2010, 37 (2): 315-324. 10.1016\/j.cor.2009.05.003.","journal-title":"Comput Oper Res"},{"issue":"0","key":"127_CR19","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mbs.2014.03.001","volume":"251","author":"J Leander","year":"2014","unstructured":"Leander J, Lundh T, Jirstrand M: Stochastic differential equations as a tool to regularize the parameter estimation problem for continuous time dynamical systems given discrete time measurements . Math Biosci. 2014, 251 (0): 54-62. 10.1016\/j.mbs.2014.03.001.","journal-title":"Math Biosci"},{"issue":"3","key":"127_CR20","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S1096-7176(03)00025-9","volume":"5","author":"D Visser","year":"2003","unstructured":"Visser D, Heijnen JJ: Dynamic simulation and metabolic re-design of a branched pathway using linlog kinetics . Metab Eng. 2003, 5 (3): 164-176. 10.1016\/S1096-7176(03)00025-9.","journal-title":"Metab Eng"},{"issue":"2","key":"127_CR21","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/(SICI)1097-0290(19990720)64:2<200::AID-BIT9>3.0.CO;2-K","volume":"64","author":"AR Neves","year":"1999","unstructured":"Neves AR, Ramos A, Nunes MC, Kleerebezem M, Hugenholtz J, de Vos WM, Almeida J: In vivo nuclear magnetic resonance studies of glycolytic kinetics in lactococcus lactis . Biotechnol Bioeng. 1999, 64 (2): 200-212. 10.1002\/(SICI)1097-0290(19990720)64:2<200::AID-BIT9>3.0.CO;2-K.","journal-title":"Biotechnol Bioeng"},{"key":"127_CR22","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/978-1-4757-5362-2_15","volume-title":"Handbook of Global Optimization. Volume 2","author":"JD Pint\u00e9r","year":"2002","unstructured":"Pint\u00e9r JD: Global optimization: software, test problems, and applications . Handbook of Global Optimization. Volume 2 . Edited by: Pardalos PM, Romeijn HE. 2002, Kluwer Academic Publishers, Dordrecht, 515-569."}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12918-014-0127-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12918-014-0127-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12918-014-0127-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T07:39:34Z","timestamp":1551166774000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/s12918-014-0127-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,18]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["127"],"URL":"https:\/\/doi.org\/10.1186\/s12918-014-0127-x","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,18]]},"article-number":"127"}}