{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:44:43Z","timestamp":1758476683714},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"S2","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1186\/s12918-016-0296-x","type":"journal-article","created":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T08:42:34Z","timestamp":1470040954000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Protein-protein interaction prediction based on multiple kernels and partial network with linear programming"],"prefix":"10.1186","volume":"10","author":[{"given":"Lei","family":"Huang","sequence":"first","affiliation":[]},{"given":"Li","family":"Liao","sequence":"additional","affiliation":[]},{"given":"Cathy H.","family":"Wu","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,8,1]]},"reference":[{"issue":"8","key":"296_CR1","doi-asserted-by":"crossref","first-page":"1000454","DOI":"10.1371\/journal.pcbi.1000454","volume":"5","author":"O Kuchaiev","year":"2009","unstructured":"Kuchaiev O, Ra\u0161ajski M, Higham DJ, Pr\u017eulj N. Geometric de-noising of protein-protein interaction networks. PLoS Comput Biol. 2009; 5(8):1000454.","journal-title":"PLoS Comput Biol"},{"issue":"1","key":"296_CR2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/1471-2105-15-213","volume":"15","author":"Y Murakami","year":"2014","unstructured":"Murakami Y, Mizuguchi K. Homology-based prediction of interactions between proteins using averaged one-dependence estimators. BMC Bioinformatics. 2014; 15(1):213.","journal-title":"BMC Bioinformatics"},{"issue":"3","key":"296_CR3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0959-440X(03)00070-8","volume":"13","author":"L Salwinski","year":"2003","unstructured":"Salwinski L, Eisenberg D. Computational methods of analysis of protein\u2013protein interactions. Curr Opin Struct Biol. 2003; 13(3):377\u201382.","journal-title":"Curr Opin Struct Biol"},{"issue":"1","key":"296_CR4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2105-8-6","volume":"8","author":"R Craig","year":"2007","unstructured":"Craig R, Liao L. Phylogenetic tree information aids supervised learning for predicting protein-protein interaction based on distance matrices. BMC Bioinformatics. 2007; 8(1):6.","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"296_CR5","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1186\/1471-2105-11-537","volume":"11","author":"A Gonzalez","year":"2010","unstructured":"Gonzalez A, Liao L. Predicting domain-domain interaction based on domain profiles with feature selection and support vector machines. BMC Bioinformatics. 2010; 11(1):537.","journal-title":"BMC Bioinformatics"},{"issue":"7421","key":"296_CR6","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature11503","volume":"490","author":"QC Zhang","year":"2012","unstructured":"Zhang QC, Petrey D, Deng L, Qiang L, Shi Y, Thu CA, Bisikirska B, Lefebvre C, Accili D, Hunter T, Maniatis T, Califano A, Honig B. Structure-based prediction of protein-protein interactions on a genome-wide scale. Nature. 2012; 490(7421):556\u201360.","journal-title":"Nature"},{"issue":"suppl 2","key":"296_CR7","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/nar\/gkq481","volume":"38","author":"R Singh","year":"2010","unstructured":"Singh R, Park D, Xu J, Hosur R, Berger B. Struct2net: a web service to predict protein\u2013protein interactions using a structure-based approach. Nucleic Acids Res. 2010; 38(suppl 2):508\u201315.","journal-title":"Nucleic Acids Res"},{"issue":"Suppl 2","key":"296_CR8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1752-0509-7-S2-S8","volume":"7","author":"Y Deng","year":"2013","unstructured":"Deng Y, Gao L, Wang B. ppipre: predicting protein-protein interactions by combining heterogeneous features. BMC Syst Biol. 2013; 7(Suppl 2):8.","journal-title":"BMC Syst Biol"},{"issue":"1","key":"296_CR9","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1186\/1471-2105-8-414","volume":"8","author":"J Sun","year":"2007","unstructured":"Sun J, Sun Y, Ding G, Liu Q, Wang C, He Y, Shi T, Li Y, Zhao Z. Inpreppi: an integrated evaluation method based on genomic context for predicting protein-protein interactions in prokaryotic genomes. BMC Bioinformatics. 2007; 8(1):414.","journal-title":"BMC Bioinformatics"},{"issue":"Suppl 1","key":"296_CR10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1477-5956-11-S1-S3","volume":"11","author":"YR Cho","year":"2013","unstructured":"Cho YR, Mina M, Lu Y, Kwon N, Guzzi P. M-finder: Uncovering functionally associated proteins from interactome data integrated with go annotations. Proteome Sci. 2013; 11(Suppl 1):3.","journal-title":"Proteome Sci"},{"issue":"4","key":"296_CR11","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1109\/TCBB.2012.55","volume":"9","author":"SH Jung","year":"2012","unstructured":"Jung SH, Jang WH, Han DS. A computational model for predicting protein interactions based on multidomain collaboration. IEEE\/ACM Trans Comput Biol Bioinformatics. 2012; 9(4):1081\u201390.","journal-title":"IEEE\/ACM Trans Comput Biol Bioinformatics"},{"key":"296_CR12","volume-title":"Proceedings of the 27th Annual ACM Symposium on Applied Computing. SAC \u201912","author":"HH Chen","year":"2012","unstructured":"Chen HH, Gou L, Zhang XL, Giles CL. Discovering missing links in networks using vertex similarity measures. In: Proceedings of the 27th Annual ACM Symposium on Applied Computing. SAC \u201912. New York, NY, USA: ACM: 2012. p. 138\u201343."},{"issue":"6","key":"296_CR13","first-page":"11501170","volume":"390","author":"L L\u00fc","year":"2011","unstructured":"L\u00fc L, Zhou T. Link prediction in complex networks: A survey. Physica A. 2011; 390(6):11501170.","journal-title":"Physica A"},{"key":"296_CR14","doi-asserted-by":"publisher","unstructured":"Lei C, Ruan J. A novel link prediction algorithm for reconstructing protein-protein interaction networks by topological similarity. Bioinformatics. 2012. doi: 10.1093\/bioinformatics\/bts688 . http:\/\/bioinformatics.oxfordjournals.org\/content\/early\/2012\/12\/11\/bioinformatics.bts688.full.pdf+html .","DOI":"10.1093\/bioinformatics\/bts688"},{"issue":"2","key":"296_CR15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/bies.201000044","volume":"33","author":"N Pr\u017eulj","year":"2011","unstructured":"Pr\u017eulj N. Protein-protein interactions: Making sense of networks via graph-theoretic modeling. BioEssays. 2011; 33(2):115\u201323.","journal-title":"BioEssays"},{"key":"296_CR16","unstructured":"Page L, Brin S, Motwani R, Winograd T. The pagerank citation ranking: Bringing order to the web. Technical Report 1999-66, Stanford InfoLab (November 1999). Previous number = SIDL-WP-1999-0120. http:\/\/ilpubs.stanford.edu:8090\/422\/ ."},{"issue":"3","key":"296_CR17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s10115-007-0094-2","volume":"14","author":"H Tong","year":"2008","unstructured":"Tong H, Faloutsos C, Pan JY. Random walk with restart: fast solutions and applications. Knowl Inform Syst. 2008; 14(3):327\u201346.","journal-title":"Knowl Inform Syst"},{"key":"296_CR18","doi-asserted-by":"publisher","DOI":"10.1145\/2063576.2063741","volume-title":"Proceedings of the 20th ACM International Conference on Information and Knowledge Management. CIKM \u201911","author":"RH Li","year":"2011","unstructured":"Li RH, Yu JX, Liu J. Link prediction: The power of maximal entropy random walk. In: Proceedings of the 20th ACM International Conference on Information and Knowledge Management. CIKM \u201911. New York, NY, USA: ACM: 2011. p. 1147\u20131156, doi: 10.1145\/2063576.2063741 ."},{"key":"296_CR19","volume-title":"Proceedings of the Fourth ACM International Conference on Web Search and Data Mining. WSDM \u201911","author":"L Backstrom","year":"2011","unstructured":"Backstrom L, Leskovec J. Supervised random walks: Predicting and recommending links in social networks. In: Proceedings of the Fourth ACM International Conference on Web Search and Data Mining. WSDM \u201911. New York, NY, USA: ACM: 2011. p. 635\u201344."},{"issue":"0","key":"296_CR20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neunet.2012.03.001","volume":"31","author":"F Fouss","year":"2012","unstructured":"Fouss F, Francoisse K, Yen L, Pirotte A, Saerens M. An experimental investigation of kernels on graphs for collaborative recommendation and semisupervised classification. Neural Netw. 2012; 31(0):53\u201372.","journal-title":"Neural Netw"},{"issue":"13","key":"296_CR21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/bioinformatics\/btt208","volume":"29","author":"CV Cannistraci","year":"2013","unstructured":"Cannistraci CV, Alanis-Lobato G, Ravasi T. Minimum curvilinearity to enhance topological prediction of protein interactions by network embedding. Bioinformatics. 2013; 29(13):199\u2013209.","journal-title":"Bioinformatics"},{"issue":"0","key":"296_CR22","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.datak.2013.05.008","volume":"87","author":"P Symeonidis","year":"2013","unstructured":"Symeonidis P, Iakovidou N, Mantas N, Manolopoulos Y. From biological to social networks: Link prediction based on multi-way spectral clustering. Data Knowl Eng. 2013; 87(0):226\u201342.","journal-title":"Data Knowl Eng"},{"issue":"4","key":"296_CR23","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1089\/cmb.2012.0273","volume":"20","author":"H Wang","year":"2013","unstructured":"Wang H, Huang H, Ding C, Nie F. Predicting protein\u2013protein interactions from multimodal biological data sources via nonnegative matrix tri-factorization. J Comput Biol. 2013; 20(4):344\u201358. doi: 10.1089\/cmb.2012.0273 .","journal-title":"J Comput Biol"},{"key":"296_CR24","volume-title":"Proceedings of the 2011 European Conference on Machine Learning and Knowledge Discovery in Databases - Volume Part II. ECML PKDD\u201911","author":"AK Menon","year":"2011","unstructured":"Menon AK, Elkan C. Link prediction via matrix factorization. In: Proceedings of the 2011 European Conference on Machine Learning and Knowledge Discovery in Databases - Volume Part II. ECML PKDD\u201911. Berlin, Heidelberg: Springer: 2011. p. 437\u201352."},{"issue":"suppl 1","key":"296_CR25","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/bioinformatics\/bth910","volume":"20","author":"Y Yamanishi","year":"2004","unstructured":"Yamanishi Y, Vert JP, Kanehisa M. Protein network inference from multiple genomic data: a supervised approach. Bioinformatics. 2004; 20(suppl 1):363\u201370.","journal-title":"Bioinformatics"},{"issue":"1","key":"296_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13637-016-0040-2","volume":"2016","author":"L Huang","year":"2016","unstructured":"Huang L, Liao L, Wu CH. Inference of protein-protein interaction networks from multiple heterogeneous data. EURASIP J Bioinformatics Syst Biol. 2016; 2016(1):1\u20139. doi: 10.1186\/s13637-016-0040-2 .","journal-title":"EURASIP J Bioinformatics Syst Biol"},{"key":"296_CR27","volume-title":"Proceedings of 2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","author":"L Huang","year":"2015","unstructured":"Huang L, Liao L, Wu CH. Protein-protein interaction network inference from multiple kernels with optimization based on random walk by linear programming. In: Proceedings of 2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). Washington DC, USA: IEEE computer society: 2015. p. 201\u20137."},{"key":"296_CR28","volume-title":"Proceedings of the Eleventh ACM SIGKDD International Conference on Knowledge Discovery in Data Mining. KDD \u201905","author":"T Ito","year":"2005","unstructured":"Ito T, Shimbo M, Kudo T, Matsumoto Y. Application of kernels to link analysis. In: Proceedings of the Eleventh ACM SIGKDD International Conference on Knowledge Discovery in Data Mining. KDD \u201905. New York, NY, USA: ACM: 2005. p. 586\u201392."},{"key":"296_CR29","volume-title":"Learning Theory and Kernel Machines: 16th Annual Conference on Learning Theory and 7th Kernel Workshop, COLT\/Kernel 2003, Washington, DC, USA, August 24\u201327, 2003. Proceedings","author":"AJ Smola","year":"2003","unstructured":"Smola AJ, Kondor R. Kernels and Regularization on Graphs In: Sch\u00f6lkopf B, Warmuth MK, editors. Learning Theory and Kernel Machines: 16th Annual Conference on Learning Theory and 7th Kernel Workshop, COLT\/Kernel 2003, Washington, DC, USA, August 24\u201327, 2003. Proceedings. Berlin, Heidelberg: Springer: 2003. p. 144\u201358."},{"issue":"6","key":"296_CR30","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.patcog.2010.11.019","volume":"44","author":"A Mantrach","year":"2011","unstructured":"Mantrach A, van Zeebroeck N, Francq P, Shimbo M, Bersini H, Saerens M. Semi-supervised classification and betweenness computation on large, sparse, directed graphs. Pattern Recognit. 2011; 44(6):1212\u201324.","journal-title":"Pattern Recognit"},{"key":"296_CR31","volume-title":"Proceedings of the Tenth ACM SIGKDD International Conference on Knowledge Discovery and Data Mining. KDD \u201904","author":"JY Pan","year":"2004","unstructured":"Pan JY, Yang HJ, Faloutsos C, Duygulu P. Automatic multimedia cross-modal correlation discovery. In: Proceedings of the Tenth ACM SIGKDD International Conference on Knowledge Discovery and Data Mining. KDD \u201904. New York, NY, USA: ACM: 2004. p. 653\u20138."},{"issue":"4","key":"296_CR32","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1002\/jcc.540070402","volume":"7","author":"J Baker","year":"1986","unstructured":"Baker J. An algorithm for the location of transition states. J Comput Chem. 1986; 7(4):385\u201395. doi: 10.1002\/jcc.540070402 .","journal-title":"J Comput Chem"},{"issue":"1","key":"296_CR33","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1145\/355984.355989","volume":"8","author":"CC Paige","year":"1982","unstructured":"Paige CC, Saunders MA. Lsqr: An algorithm for sparse linear equations and sparse least squares. ACM Trans Math Softw. 1982; 8(1):43\u201371.","journal-title":"ACM Trans Math Softw"},{"issue":"5","key":"296_CR34","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1137\/10079687X","volume":"33","author":"DC-L Fong","year":"2011","unstructured":"Fong DC-L, Saunders M. Lsmr: An iterative algorithm for sparse least-squares problems. SIAM J Sci Comput. 2011; 33(5):2950\u201371.","journal-title":"SIAM J Sci Comput"},{"issue":"5939","key":"296_CR35","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1126\/science.1173299","volume":"325","author":"AL Barab\u00e1si","year":"2009","unstructured":"Barab\u00e1si AL. Scale-free networks: A decade and beyond. Science. 2009; 325(5939):412\u20133. doi: 10.1126\/science.1173299 . http:\/\/science.sciencemag.org\/content\/325\/5939\/412.full.pdf .","journal-title":"Science"},{"key":"296_CR36","volume-title":"Proceedings of the 41st Annual Symposium on Foundations of Computer Science. FOCS \u201900","author":"R Kumar","year":"2000","unstructured":"Kumar R, Raghavan P, Rajagopalan S, Sivakumar D, Tomkins A, Upfal E. Stochastic models for the web graph. In: Proceedings of the 41st Annual Symposium on Foundations of Computer Science. FOCS \u201900. Washington, DC, USA: IEEE Computer Society: 2000. p. 57."},{"issue":"90001","key":"296_CR37","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/nar\/gkh086","volume":"32","author":"L Salwinski","year":"2004","unstructured":"Salwinski L, Miller CS, Smith AJ, Pettit FK, Bowie JU, Eisenberg D. The database of interacting proteins: 2004 update. Nucleic Acids Res. 2004; 32(90001):449\u201351.","journal-title":"Nucleic Acids Res"},{"key":"296_CR38","volume-title":"Prabhakar Raghavan: Introduction to Information Retrieval","author":"D Christopher","year":"2008","unstructured":"Christopher D, Manning HS. Prabhakar Raghavan: Introduction to Information Retrieval. New York, USA: Cambridge University Press; 2008."},{"issue":"D1","key":"296_CR39","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1093\/nar\/gks1231","volume":"41","author":"QC Zhang","year":"2013","unstructured":"Zhang QC, Petrey D, Garz\u00f3n JI, Deng L, Honig B. Preppi: a structure-informed database of protein\u2013protein interactions. Nucleic Acids Res. 2013; 41(D1):828\u201333. doi: 10.1093\/nar\/gks1231 . http:\/\/nar.oxfordjournals.org\/content\/41\/D1\/D828.full.pdf+html .","journal-title":"Nucleic Acids Res"},{"issue":"16","key":"296_CR40","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1093\/bioinformatics\/bth294","volume":"20","author":"GRG Lanckriet","year":"2004","unstructured":"Lanckriet GRG, De Bie T, Cristianini N, Jordan MI, Noble WS. A statistical framework for genomic data fusion. Bioinformatics. 2004; 20(16):2626\u2013635.","journal-title":"Bioinformatics"},{"key":"296_CR41","first-page":"547","volume":"37","author":"P Jaccard","year":"1901","unstructured":"Jaccard P. \u00c9tude comparative de la distribution florale dans une portion des Alpes et des Jura. Bulletin del la Soci\u00e9t\u00e9 Vaudoise des Sciences Naturelles. 1901; 37:547\u201379.","journal-title":"Bulletin del la Soci\u00e9t\u00e9 Vaudoise des Sciences Naturelles"},{"issue":"3","key":"296_CR42","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"SF Altschul","year":"1990","unstructured":"Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. Basic local alignment search tool. J Mol Biol. 1990; 215(3):403\u201310.","journal-title":"J Mol Biol"},{"issue":"3","key":"296_CR43","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/(SICI)1097-0134(199707)28:3<405::AID-PROT10>3.0.CO;2-L","volume":"28","author":"ELL Sonnhammer","year":"1997","unstructured":"Sonnhammer ELL, Eddy SR, Durbin R. Pfam: A comprehensive database of protein domain families based on seed alignments. Proteins: Struct Funct Bioinformatics. 1997; 28(3):405\u201320.","journal-title":"Proteins: Struct Funct Bioinformatics"},{"issue":"5","key":"296_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pcbi.1000063","volume":"4","author":"N Song","year":"2008","unstructured":"Song N, Joseph JM, Davis GB, Durand D. Sequence similarity network reveals common ancestry of multidomain proteins. PLoS Comput Biol. 2008; 4(5):1\u201319. doi: 10.1371\/journal.pcbi.1000063 .","journal-title":"PLoS Comput Biol"},{"key":"296_CR45","volume-title":"Proceedings of the 14th International Joint Conference on Artificial Intelligence - Volume 1. IJCAI\u201995","author":"P Resnik","year":"1995","unstructured":"Resnik P. Using information content to evaluate semantic similarity in a taxonomy. In: Proceedings of the 14th International Joint Conference on Artificial Intelligence - Volume 1. IJCAI\u201995. San Francisco, CA, USA: Morgan Kaufmann Publishers Inc: 1995. p. 448\u201353. http:\/\/dl.acm.org\/citation.cfm?id=1625855.1625914 ."},{"issue":"3","key":"296_CR46","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1109\/TCBB.2014.2366748","volume":"12","author":"L Huang","year":"2015","unstructured":"Huang L, Liao L, Wu CH. Evolutionary model selection and parameter estimation for protein-protein interaction network based on differential evolution algorithm. Comput Biol Bioinformatics, IEEE\/ACM Trans. 2015; 12(3):622\u201331.","journal-title":"Comput Biol Bioinformatics, IEEE\/ACM Trans"},{"issue":"10","key":"296_CR47","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1101\/gr.153002","volume":"12","author":"M Deng","year":"2002","unstructured":"Deng M, Mehta S, Sun F, Chen T. Inferring domain\u2013domain interactions from protein\u2013protein interactions. Genome Res. 2002; 12(10):1540\u20138.","journal-title":"Genome Res"},{"issue":"12","key":"296_CR48","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/gb-2006-7-12-r125","volume":"7","author":"Z Itzhaki","year":"2006","unstructured":"Itzhaki Z, Akiva E, Altuvia Y, Margalit H. Evolutionary conservation of domain-domain interactions. Genome Biol. 2006; 7(12):125.","journal-title":"Genome Biol"},{"issue":"3","key":"296_CR49","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1006\/jmbi.2001.4526","volume":"307","author":"J Park","year":"2001","unstructured":"Park J, Lappe M, Teichmann SA. Mapping protein family interactions: intramolecular and intermolecular protein family interaction repertoires in the {PDB} and yeast1. J Mol Biol. 2001; 307(3):929\u201338.","journal-title":"J Mol Biol"},{"issue":"suppl 1","key":"296_CR50","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/bioinformatics\/bth903","volume":"20","author":"D Betel","year":"2004","unstructured":"Betel D, Isserlin R, Hogue CWV. Analysis of domain correlations in yeast protein complexes. Bioinformatics. 2004; 20(suppl 1):55\u201362.","journal-title":"Bioinformatics"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12918-016-0296-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T19:37:37Z","timestamp":1498333057000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/s12918-016-0296-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":50,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["296"],"URL":"https:\/\/doi.org\/10.1186\/s12918-016-0296-x","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8]]},"article-number":"45"}}