{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T01:08:20Z","timestamp":1773623300166,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T00:00:00Z","timestamp":1471564800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T00:00:00Z","timestamp":1471564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL007567"],"award-info":[{"award-number":["T32HL007567"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Translational Science Collaborative Case Western Reserve University"},{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Global Alliance to Prevent Prematurity and Stillbirth"},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD069819"],"award-info":[{"award-number":["HD069819"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12918-016-0320-1","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T12:30:06Z","timestamp":1471609806000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A dynamical systems model of progesterone receptor interactions with inflammation in human parturition"],"prefix":"10.1186","volume":"10","author":[{"given":"Douglas","family":"Brubaker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alethea","family":"Barbaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"R. Chance","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Mesiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,8,19]]},"reference":[{"issue":"12","key":"320_CR1","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1080\/14767050600965882","volume":"19","author":"CV Ananth","year":"2006","unstructured":"Ananth CV, et al.Epidemiology of preterm birth and its clinical subtypes. J Mat Fet Neonat Med. 2006; 19(12):773\u201382.","journal-title":"J Mat Fet Neonat Med"},{"issue":"1","key":"320_CR2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2471\/BLT.08.062554","volume":"88","author":"S Beck","year":"2010","unstructured":"Beck S, Wojdyla D, Say L, et al.The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bull World Health Organ. 2010; 88(1):31\u201338. PMC2802437.","journal-title":"Bull World Health Organ"},{"issue":"2","key":"320_CR3","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/aja.1000980206","volume":"98","author":"A Csapo","year":"1956","unstructured":"Csapo A. Progesterone block. Am J Anat. 1956; 98(2):273\u201391.","journal-title":"Am J Anat"},{"key":"320_CR4","unstructured":"Corner GW. The hormones in human reproduction: Princeton University Press; 1946."},{"issue":"4812","key":"320_CR5","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1136\/bmj.1.4812.687","volume":"1","author":"GW Corner","year":"1953","unstructured":"Corner GW, Csapo A. Action of the ovarian hormones on uterine muscle. Br Med J. 1953; 1(4812):687\u201393.","journal-title":"Br Med J"},{"issue":"5","key":"320_CR6","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.siny.2006.05.001","volume":"11","author":"R Romero","year":"2006","unstructured":"Romero R, Espinoza J, Goncalves LF, Kusanovic JP, Friel LA, Nien JK. Inflammation in preterm and term labour and delivery. Semin Fetal Neonatal Med. 2006; 11(5):317\u2013326.","journal-title":"Semin Fetal Neonatal Med"},{"key":"320_CR7","doi-asserted-by":"crossref","unstructured":"Norman JE, et al.Inflammatory pathways in the mechanism of parturition. BMC Pregnancy Childbirth. 2007;7(1)1.","DOI":"10.1186\/1471-2393-7-S1-S7"},{"key":"320_CR8","doi-asserted-by":"publisher","first-page":"2924","DOI":"10.1210\/jcem.87.6.8609","volume":"87","author":"S Mesiano","year":"2002","unstructured":"Mesiano S, et al.Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium. J Clin Endocrinol Metab. 2002; 87:2924\u201330.","journal-title":"J Clin Endocrinol Metab"},{"key":"320_CR9","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/1471-2164-13-115","volume":"13","author":"J Kim","year":"2012","unstructured":"Kim J, et al.Transcriptome landscape of the human placenta. BMC Genomics. 2012; 13:115.","journal-title":"BMC Genomics"},{"key":"320_CR10","doi-asserted-by":"crossref","unstructured":"Larsen B, et al.Progesterone interactions with the cervix: translational implications for term and preterm birth; 2011.","DOI":"10.1155\/2011\/353297"},{"issue":"5","key":"320_CR11","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1002\/j.1460-2075.1990.tb08280.x","volume":"9","author":"P Kastner","year":"1990","unstructured":"Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H, et al.Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J. 1990; 9(5):1603\u201314.","journal-title":"EMBO J"},{"issue":"9","key":"320_CR12","doi-asserted-by":"publisher","first-page":"3102","DOI":"10.1128\/MCB.20.9.3102-3115.2000","volume":"20","author":"PH Giangrande","year":"2000","unstructured":"Giangrande PH, Kimbrel EA, Edwards DP, McDonnell DP. The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. Mol Cell Biol. 2000; 20(9):3102\u201315.","journal-title":"Mol Cell Biol"},{"issue":"10","key":"320_CR13","first-page":"1244","volume":"7","author":"E Vegeto","year":"1993","unstructured":"Vegeto E, Shahbaz MM, Wen DX, Goldman ME, O\u2019Malley BW, McDonnell DP. Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. Mol Endocrinol. 1993; 7(10):1244\u201355.","journal-title":"Mol Endocrinol"},{"issue":"6","key":"320_CR14","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/0002-9378(72)90556-X","volume":"113","author":"D Tulchinsky","year":"1972","unstructured":"Tulchinsky D, Hobel CJ, Yeager E, Marshall JR. Plasma estradiol, estriol, and progesterone in human pregnancy. II. Clinical applications in Rh-isoimmunization disease. Am J Obstet Gynecol. 1972; 113(6):766\u2013770.","journal-title":"Am J Obstet Gynecol"},{"issue":"8","key":"320_CR15","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/0002-9378(72)90185-8","volume":"112","author":"D Tulchinsky","year":"1972","unstructured":"Tulchinsky D, Hobel CJ, Yeager E, Marshall JR. Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy. Am J Obstet Gynecol. 1972; 112(8):1095\u20131100.","journal-title":"Am J Obstet Gynecol"},{"key":"320_CR16","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0002-9378(75)90001-0","volume":"121","author":"D Tulchinsky","year":"1975","unstructured":"Tulchinsky D, Okada D. Hormones in human pregnancy: IV. Plasma progesterone. Am J Obstet Gynecol. 1975; 121:293\u2013299.","journal-title":"Am J Obstet Gynecol"},{"key":"320_CR17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0002-9378(79)80013-7","volume":"135","author":"S Walsh","year":"1979","unstructured":"Walsh S, Kittinger G, Novy M. Maternal peripheral concentrations of estradiol, estrone, cortisol, and progesterone during late pregnancy in rhesus monkeys (Macaca mulatta) and after experimental fetal anencephaly and fetal death. Am J Obstet Gynecol. 1979; 135:37\u201342.","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"320_CR18","first-page":"686","volume":"51","author":"RS Boroditsky","year":"1978","unstructured":"Boroditsky RS, Reyes FI, Winter JS, Faiman C. Maternal serum estrogen and progesterone concentrations preceding normal labor. Obstet Gynecol. 1978; 51(6):686\u2013691.","journal-title":"Obstet Gynecol"},{"issue":"5","key":"320_CR19","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1210\/jc.2007-0077","volume":"92","author":"AA Merlino","year":"2007","unstructured":"Merlino AA, et al.Nuclear progesterone receptors in the human pregnancy myometrium: evidence that parturition involves functional progesterone withdrawal mediated by increased expression of progesterone receptor-A. J Clin Endocrinol Metab. 2007; 92(5):1927\u201333.","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"320_CR20","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1210\/jc.2011-3251","volume":"97","author":"H Tan","year":"2012","unstructured":"Tan H, et al.Progesterone receptor-A and -B have opposite effects on pro inflammatory gene expression in human myometrial cells: implications for progesterone actions in human pregnancy and parturition. J Clin Endocrinol Metab. 2012; 97(5):19\u201330.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"320_CR21","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1210\/jc.2003-031037","volume":"89","author":"G Madsen","year":"2004","unstructured":"Madsen G, et al.Prostaglandins differentially modulate progesterone receptor-A and -B expression in human myometrial cells: evidence for prostaglandin-induced functional progesterone withdrawal. J Clin Endocrinol Metab. 2004; 89(2):1010\u20133.","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"320_CR22","doi-asserted-by":"publisher","first-page":"2724","DOI":"10.1210\/me.2006-0112","volume":"20","author":"DB Hardy","year":"2006","unstructured":"Hardy DB, et al.Progesterone receptor plays a major antiinflammatory role in human myometrial cells by antagonism of nuclear factor-kappaB activation of cyclooxygenase 2 expression. Mol Endocrinol. 2006; 20(11):2724\u201333.","journal-title":"Mol Endocrinol"},{"key":"320_CR23","unstructured":"Britton NF. Essential Mathematical Biology: Springer; 2005."},{"key":"320_CR24","unstructured":"Calvetti D, Erkki S. Computational Mathematical Modeling: SIAM; 2013."},{"key":"320_CR25","doi-asserted-by":"crossref","unstructured":"Iber D, Fengos G. Predictive models for cellular signaling networks: Springer; 2012. Chapter 1.","DOI":"10.1007\/978-1-61779-833-7_1"},{"key":"320_CR26","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1042\/bse0450083","volume":"45","author":"P Rangamani","year":"2008","unstructured":"Rangamani P, Iyengar R. Modelling cellular signalling systems. Essays Biochem. 2008; 45:83\u201394.","journal-title":"Essays Biochem"},{"issue":"1","key":"320_CR27","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1177\/1933719110382922","volume":"18","author":"S Mesiano","year":"2011","unstructured":"Mesiano S, et al.Progesterone receptors in the human pregnancy uterus: do they hold the key to birth timing?Reprod Sci. 2011; 18(1):6\u201319.","journal-title":"Reprod Sci"},{"issue":"8","key":"320_CR28","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1210\/me.2003-0007","volume":"17","author":"KE Bethin","year":"2003","unstructured":"Bethin KE, et al.Microarray analysis of uterine gene expression in mouse and human pregnancy. J Mol Endocrinol. 2003; 17(8):1454\u201369.","journal-title":"J Mol Endocrinol"},{"issue":"3","key":"320_CR29","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1113\/expphysiol.2013.072868","volume":"99","author":"YW Chan","year":"2014","unstructured":"Chan YW, et al.Assessment of myometrial transcriptome changes associated with spontaneous human labour by high-throughput RNA-seq. J Exp Physiol. 2014; 99(3):510\u201324.","journal-title":"J Exp Physiol"},{"key":"320_CR30","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.4161\/cc.25070","volume":"12","author":"JJ Brosens","year":"2013","unstructured":"Brosens JJ, et al.Progesterone and FOXO1 signaling. Cell Cycle. 2013; 12:1660.","journal-title":"Cell Cycle"},{"key":"320_CR31","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.mce.2010.08.005","volume":"335","author":"E Golightly","year":"2011","unstructured":"Golightly E, et al.Endocrine immune interactions in human parturition. Mol Cell Endocrinol. 2011; 335:52\u20139.","journal-title":"Mol Cell Endocrinol"},{"issue":"4","key":"320_CR32","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.ajog.2006.07.002","volume":"195","author":"JL Gotkin","year":"2006","unstructured":"Gotkin JL, et al.Progesterone reduces lipopolysaccharide induced interleukin-6 secretion in fetoplacental chorionic arteries, fractionated cord blood, and maternal mononuclear cells. Am J Obstet Gynecol. 2006; 195(4):1015\u20139.","journal-title":"Am J Obstet Gynecol"},{"issue":"11","key":"320_CR33","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.tcb.2008.08.008","volume":"18","author":"W Li","year":"2008","unstructured":"Li W. Canonical and non-canonical JAK?STAT signaling. Trends Cell Biol. 2008; 18(11):545\u2013551.","journal-title":"Trends Cell Biol"},{"key":"320_CR34","first-page":"900","volume":"3","author":"K Shuai","year":"2003","unstructured":"Shuai K, Liu B. Regulation of JAK-STAT Signaling in the Immune System. Nat Rev. 2003; 3:900\u2013911.","journal-title":"Nat Rev"},{"key":"320_CR35","doi-asserted-by":"publisher","first-page":"68.e1","DOI":"10.1016\/j.ajog.2014.07.050","volume":"212","author":"J Neal","year":"2015","unstructured":"Neal J, et al. Differences in inflammatory markers between nulliparous women admitted to hospitals in preactive vs active labor. Am J Obstet Gynecol. 2015; 212:68.e1\u20138.","journal-title":"Am J Obstet Gynecol"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12918-016-0320-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12918-016-0320-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12918-016-0320-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12918-016-0320-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T19:01:58Z","timestamp":1657134118000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/s12918-016-0320-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,19]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["320"],"URL":"https:\/\/doi.org\/10.1186\/s12918-016-0320-1","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,19]]},"assertion":[{"value":"14 July 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"79"}}