{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:23:13Z","timestamp":1760170993688},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"S4","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12918-016-0361-5","type":"journal-article","created":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T11:37:42Z","timestamp":1482493062000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Interspecies gene function prediction using semantic similarity"],"prefix":"10.1186","volume":"10","author":[{"given":"Guoxian","family":"Yu","sequence":"first","affiliation":[]},{"given":"Wei","family":"Luo","sequence":"additional","affiliation":[]},{"given":"Guangyuan","family":"Fu","sequence":"additional","affiliation":[]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,12,23]]},"reference":[{"issue":"3","key":"361_CR1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1371\/journal.pbio.0020042","volume":"2","author":"RJ Roberts","year":"2004","unstructured":"Roberts RJ. Identifying protein function-a call for community action. PLoS Biol. 2004; 2(3):293\u20134.","journal-title":"PLoS Biol"},{"issue":"3","key":"361_CR2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nmeth.2340","volume":"10","author":"P Radivojac","year":"2013","unstructured":"Radivojac P, Clark WT, Oron TR, Schnoes AM, Wittkop T, Sokolov A, Graim K, Funk C, Verspoor K, Ben-Hur A. A large-scale evaluation of computational protein function prediction. Nat Methods. 2013; 10(3):221\u20137.","journal-title":"Nat Methods"},{"issue":"10","key":"361_CR3","first-page":"1","volume":"2015","author":"Q Zou","year":"2014","unstructured":"Zou Q, Li J, Hong Q, Lin Z, Wu Y, Shi H, Ying J. Prediction of microrna-disease associations based on social network analysis methods. Biomed Res Int. 2014; 2015(10):1\u20139.","journal-title":"Biomed Res Int"},{"issue":"5013","key":"361_CR4","first-page":"416323","volume":"2014","author":"Q Zou","year":"2014","unstructured":"Zou Q, Li J, Wang C, Zeng X. Approaches for recognizing disease genes based on network. Biomed Res Int. 2014; 2014(5013):416323\u201316323.","journal-title":"Biomed Res Int"},{"issue":"2","key":"361_CR5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/bib\/bbv033","volume":"17","author":"X Zeng","year":"2015","unstructured":"Zeng X, Zhang X, Zou Q. Integrative approaches for predicting microrna function and prioritizing disease-related microrna using biological interaction networks. Brief Bioinform. 2015; 17(2):193\u2013203.","journal-title":"Brief Bioinform"},{"issue":"5","key":"361_CR6","doi-asserted-by":"crossref","first-page":"1003063","DOI":"10.1371\/journal.pcbi.1003063","volume":"9","author":"MS Alexandra","year":"2013","unstructured":"Alexandra MS, David CR, Alexander WT, Patricia CB, Iddo F. Biases in the experimental annotations of protein function and their effect on our understanding of protein function space. PLoS Comput Biol. 2013; 9(5):1003063.","journal-title":"PLoS Comput Biol"},{"issue":"7","key":"361_CR7","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrg2363","volume":"9","author":"SY Rhee","year":"2008","unstructured":"Rhee SY, Wood V, Dolinski K, Draghici S. Use and misuse of the gene ontology annotations. Nat Rev Genet. 2008; 9(7):509\u201315.","journal-title":"Nat Rev Genet"},{"issue":"7","key":"361_CR8","doi-asserted-by":"crossref","first-page":"1000431","DOI":"10.1371\/journal.pcbi.1000431","volume":"5","author":"GO Consortium","year":"2009","unstructured":"Consortium GO. The gene ontology\u2019s reference genome project: A unified framework for functional annotation across species. PLoS Comput Biol. 2009; 5(7):1000431.","journal-title":"PLoS Comput Biol"},{"issue":"2","key":"361_CR9","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1371\/journal.pcbi.1002386","volume":"8","author":"PD Thomas","year":"2012","unstructured":"Thomas PD, Wood V, Mungall CJ, Lewis SE, Blake JA, Consortium GO. On the use of gene ontology annotations to assess functional similarity among orthologs and paralogs: A short report. PLoS Comput Biol. 2012; 8(2):1454\u20131459.","journal-title":"PLoS Comput Biol"},{"issue":"12","key":"361_CR10","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/nrm2281","volume":"8","author":"D Lee","year":"2007","unstructured":"Lee D, Redfern O, Orengo C. Predicting protein function from sequence and structure. Nat Rev Mol Cell Biol. 2007; 8(12):995\u20131005.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"361_CR11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/msb4100129","volume":"3","author":"R Sharan","year":"2007","unstructured":"Sharan R, Igor U, Shamir R. Network-based prediction of protein function. Molecular Systems Biology. 2007; 3(1):88.","journal-title":"Molecular Systems Biology"},{"issue":"12","key":"361_CR12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/bioinformatics\/btu263","volume":"30","author":"M Cao","year":"2014","unstructured":"Cao M, Pietras CM, Feng X, Doroschak KJ, Schaffner T, Park J, Zhang H, Cowen LJ, Hescott BJ. New directions for diffusion-based network prediction of protein function: incorporating pathways with confidence. Bioinformatics. 2014; 30(12):219\u201327.","journal-title":"Bioinformatics"},{"issue":"5","key":"361_CR13","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1109\/TCBB.2014.2323058","volume":"11","author":"J Wu","year":"2014","unstructured":"Wu J, Huang SJ, Zhou Z. Genome-wide protein function prediction through multi-instance multi-label learning. IEEE\/ACM Trans Comput Biol Bioinforma. 2014; 11(5):891\u2013902.","journal-title":"IEEE\/ACM Trans Comput Biol Bioinforma"},{"issue":"14","key":"361_CR14","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/bioinformatics\/btq262","volume":"26","author":"S Mostafavi","year":"2010","unstructured":"Mostafavi S, Morris Q. Fast integration of heterogeneous data sources for predicting gene function with limited annotation. Bioinformatics. 2010; 26(14):1759\u20131765.","journal-title":"Bioinformatics"},{"issue":"1","key":"361_CR15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1752-0509-9-S1-S3","volume":"9","author":"G Yu","year":"2015","unstructured":"Yu G, Zhu H, Domeniconi C, Guo M. Integrating multiple networks for protein function prediction. BMC Syst Biol. 2015; 9(1):3.","journal-title":"BMC Syst Biol"},{"issue":"1","key":"361_CR16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1109\/TCBB.2014.2351821","volume":"12","author":"G Yu","year":"2015","unstructured":"Yu G, Rangwala H, Domeniconi C, Zhang G, Zhang Z. Predicting protein function using multiple kernels. IEEE\/ACM Trans Comput Biol Bioinforma. 2015; 12(1):219\u201333.","journal-title":"IEEE\/ACM Trans Comput Biol Bioinforma"},{"issue":"1","key":"361_CR17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10994-011-5271-6","volume":"88","author":"N Cesa-Bianchi","year":"2012","unstructured":"Cesa-Bianchi N, Re M, Valentini G. Synergy of multi-label hierarchical ensembles, data fusion, and cost-sensitive methods for gene functional inference. Mach Learn. 2012; 88(1):209\u201341.","journal-title":"Mach Learn"},{"issue":"1","key":"361_CR18","first-page":"1045","volume":"10","author":"G Yu","year":"2013","unstructured":"Yu G, Rangwala H, Domeniconi C, Zhang G, Yu Z. Protein function prediction using multilabel ensemble classification. IEEE\/ACM Trans Comput Biol Bioinforma. 2013; 10(1):1045\u20131057.","journal-title":"IEEE\/ACM Trans Comput Biol Bioinforma"},{"issue":"1","key":"361_CR19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al. Gene ontology: tool for the unification of biology. Nat Genet. 2000; 25(1):25\u20139.","journal-title":"Nat Genet"},{"issue":"3","key":"361_CR20","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1109\/TCBB.2010.38","volume":"8","author":"G Valentini","year":"2011","unstructured":"Valentini G. True path rule hierarchical ensembles for genome-wide gene function prediction. IEEE\/ACM Trans Comput Biol Bioinforma. 2011; 8(3):832\u201347.","journal-title":"IEEE\/ACM Trans Comput Biol Bioinforma"},{"issue":"8","key":"361_CR21","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1109\/TKDE.2013.39","volume":"26","author":"ML Zhang","year":"2014","unstructured":"Zhang ML, Zhou ZH. A review on multi-label learning algorithms. IEEE Trans Knowl Data Eng. 2014; 26(8):1819\u20131837.","journal-title":"IEEE Trans Knowl Data Eng"},{"issue":"7","key":"361_CR22","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1093\/bioinformatics\/btk048","volume":"22","author":"Z Barutcuoglu","year":"2006","unstructured":"Barutcuoglu Z, Schapire RE, Troyanskaya OG. Hierarchical multi-label prediction of gene function. Bioinformatics. 2006; 22(7):830\u20136.","journal-title":"Bioinformatics"},{"issue":"7","key":"361_CR23","first-page":"111","volume":"10","author":"P Legrain","year":"2011","unstructured":"Legrain P, Aebersold R, Archakov A, Bairoch A, Bala K, Beretta L, Bergeron J, Borchers C, Corthals GL, Costello CE. The human proteome project: Current state and future direction. Mol Cell Proteome. 2011; 10(7):111\u2013009993.","journal-title":"Mol Cell Proteome"},{"issue":"13","key":"361_CR24","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/bioinformatics\/btm195","volume":"23","author":"Y Tao","year":"2007","unstructured":"Tao Y, Sam L, Li J, Friedman C, Lussier YA. Information theory applied to the sparse gene ontology annotation network to predict novel gene function. Bioinformatics. 2007; 23(13):529\u201338.","journal-title":"Bioinformatics"},{"issue":"16","key":"361_CR25","first-page":"1","volume":"16","author":"G Yu","year":"2015","unstructured":"Yu G, Zhu H, Domeniconi C. Predicting protein functions using incomplete hierarchical labels. BMC Bioinforma. 2015; 16(16):1.","journal-title":"BMC Bioinforma"},{"issue":"1","key":"361_CR26","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s12859-015-0641-x","volume":"16","author":"G Yu","year":"2015","unstructured":"Yu G, Zhu H, Domeniconi C, Liu J. Predicting protein function via downward random walks on a gene ontology. BMC Bioinforma. 2015; 16(1):217.","journal-title":"BMC Bioinforma"},{"issue":"2","key":"361_CR27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/gb-2009-10-2-207","volume":"10","author":"Y Loewenstein","year":"2009","unstructured":"Loewenstein Y, Raimondo D, Redfern OC, Watson J, Frishman D, Linial M, Orengo C, Thornton J, Tramontano A. Protein function annotation by homology-based inference. Genome Biol. 2009; 10(2):207.","journal-title":"Genome Biol"},{"issue":"3","key":"361_CR28","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1109\/TCBB.2010.15","volume":"8","author":"A Mitrofanova","year":"2011","unstructured":"Mitrofanova A, Pavlovic V, Mishra B. Prediction of protein functions with gene ontology and interspecies protein homology data. IEEE\/ACM Trans Comput Biol Bioinforma. 2011; 8(3):775\u201384.","journal-title":"IEEE\/ACM Trans Comput Biol Bioinforma"},{"issue":"1","key":"361_CR29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-5956-11-S1-S1","volume":"11","author":"A Benso","year":"2013","unstructured":"Benso A, Carlo SD, Rehman HU, Politano G, Savino A, Suravajhala P. A combined approach for genome wide protein function annotation\/prediction. Proteome Sci. 2013; 11(1):1.","journal-title":"Proteome Sci"},{"issue":"5","key":"361_CR30","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1101\/gr.440803","volume":"13","author":"OD King","year":"2003","unstructured":"King OD, Foulger RE, Dwight SS, White JV, Roth FP. Predicting gene function from patterns of annotation. Genome Res. 2003; 13(5):896\u2013904.","journal-title":"Genome Res"},{"issue":"10","key":"361_CR31","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/bioinformatics\/btg153","volume":"19","author":"PW Lord","year":"2003","unstructured":"Lord PW, Stevens RD, Brass A, Goble CA. Investigating semantic similarity measures across the gene ontology: the relationship between sequence and annotation. Bioinformatics. 2003; 19(10):1275\u20131283.","journal-title":"Bioinformatics"},{"issue":"7","key":"361_CR32","doi-asserted-by":"crossref","first-page":"1000443","DOI":"10.1371\/journal.pcbi.1000443","volume":"5","author":"C Pesquita","year":"2009","unstructured":"Pesquita C, Faria D, Falcao AO, Lord P, Couto FM. Semantic similarity in biomedical ontologies. PLoS Comput Biol. 2009; 5(7):1000443.","journal-title":"PLoS Comput Biol"},{"issue":"5","key":"361_CR33","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/bib\/bbr066","volume":"13","author":"PH Guzzi","year":"2012","unstructured":"Guzzi PH, Mina M, Guerra C, Cannataro M. Semantic similarity analysis of protein data: assessment with biological features and issues. Brief Bioinforma. 2012; 13(5):569\u201385.","journal-title":"Brief Bioinforma"},{"issue":"15","key":"361_CR34","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/1471-2105-9-327","volume":"9","author":"M Mistry","year":"2008","unstructured":"Mistry M, Pavlidis P. Gene ontology term overlap as a measure of gene functional similarity. BMC Bioinforma. 2008; 9(15):327.","journal-title":"BMC Bioinforma"},{"issue":"1","key":"361_CR35","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/1471-2105-7-302","volume":"7","author":"A Schlicker","year":"2006","unstructured":"Schlicker A, Domingues FS, Rahnenfuhrer J, Lengauer T. A new measure for functional similarity of gene products based on gene ontology. BMC Bioinforma. 2006; 7(1):302.","journal-title":"BMC Bioinforma"},{"issue":"4","key":"361_CR36","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1109\/TCBB.2005.50","volume":"2","author":"JL Sevilla","year":"2005","unstructured":"Sevilla JL, Segura V, Podhorski A, Guruceaga E, Mato JM, Martinezcruz LA, Corrales FJ, Rubio A. Correlation between gene expression and go semantic similarity. IEEE\/ACM Trans Comput Biol Bioinforma. 2005; 2(4):330\u20138.","journal-title":"IEEE\/ACM Trans Comput Biol Bioinforma"},{"key":"361_CR37","unstructured":"Jiang JJ, Conrath DW. Semantic similarity based on corpus statistics and lexical taxonomy. In: Proceedings of International Conference on Research in Computational Linguistics. Taiwan: 1997. p. 11512\u201311520."},{"issue":"1","key":"361_CR38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1109\/21.24528","volume":"19","author":"R Rada","year":"1989","unstructured":"Rada R, Mili H, Bicknell E, Blettner M. Development and application of a metric on semantic nets. IEEE Trans Syst Man Cybern. 1989; 19(1):17\u201330.","journal-title":"IEEE Trans Syst Man Cybern"},{"key":"361_CR39","volume-title":"Proceedings of Annual Meeting on Association for Computational Linguistics","author":"Z Wu","year":"1994","unstructured":"Wu Z, Palmer M. Verb semantics and lexical selection. In: Proceedings of Annual Meeting on Association for Computational Linguistics. New Mexico: Las Cruces: 1994. p. 133\u20138."},{"key":"361_CR40","doi-asserted-by":"crossref","unstructured":"Pekar V, Staab S. Taxonomy learning: factoring the structure of a taxonomy into a semantic classification decision. In: International Conference on Computational Linguistics. Taiwan: 2002.","DOI":"10.3115\/1072228.1072318"},{"issue":"10","key":"361_CR41","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1093\/bioinformatics\/btm087","volume":"23","author":"JZ Wang","year":"2007","unstructured":"Wang JZ, Du Z, Payattakool R, Philip SY, Chen CF. A new method to measure the semantic similarity of go terms. Bioinformatics. 2007; 23(10):1274\u20131281.","journal-title":"Bioinformatics"},{"issue":"S5","key":"361_CR42","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2105-9-S5-S4","volume":"9","author":"C Pesquita","year":"2008","unstructured":"Pesquita C, Faria D, Bastos H, Ferreira AE, Falcao AO, Couto FM. Metrics for go based protein semantic similarity: a systematic evaluation. BMC Bioinforma. 2008; 9(S5):4.","journal-title":"BMC Bioinforma"},{"key":"361_CR43","unstructured":"Lin D. An information-theoretic definition of similarity. In: In Proceedings of 15th International Conference on Machine Learning. Madison: 1998. p. 296\u2013304."},{"issue":"11","key":"361_CR44","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1093\/bioinformatics\/btt160","volume":"29","author":"Z Teng","year":"2013","unstructured":"Teng Z, Guo M, Liu X, Dai Q, Wang C, Xuan P. Measuring gene functional similarity based on group-wise comparison of go terms. Bioinformatics. 2013; 29(11):1424\u20131432.","journal-title":"Bioinformatics"},{"issue":"10","key":"361_CR45","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1093\/bioinformatics\/bts129","volume":"28","author":"H Yang","year":"2012","unstructured":"Yang H, Nepusz T, Paccanaro A. Improving go semantic similarity measures by exploring the ontology beneath the terms and modelling uncertainty. Bioinformatics. 2012; 28(10):1383\u20131389.","journal-title":"Bioinformatics"},{"issue":"5","key":"361_CR46","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/jhered\/esp047","volume":"100","author":"MW Hahn","year":"2009","unstructured":"Hahn MW. Distinguishing among evolutionary models for the maintenance of gene duplicates. J Hered. 2009; 100(5):605\u201317.","journal-title":"J Hered"},{"key":"361_CR47","unstructured":"The gene ontology database. http:\/\/geneontology.org\/page\/download-ontology . Accessed 4 Jan 2016."},{"key":"361_CR48","unstructured":"The gene ontology annotation files. http:\/\/geneontology.org\/page\/download-annotations . Accessed 20 Jan 2014."},{"issue":"10","key":"361_CR49","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/1471-2164-7-187","volume":"7","author":"CL Myers","year":"2006","unstructured":"Myers CL, Barrett DR, Hibbs MA, Huttenhower C, Troyanskaya OG. Finding function: evaluation methods for functional genomic data. BMC Genomics. 2006; 7(10):187.","journal-title":"BMC Genomics"},{"key":"361_CR50","doi-asserted-by":"crossref","unstructured":"Yu G, Domeniconi C, Rangwala H, Zhang G. Protein function prediction using dependence maximization. In: European Conference on Machine Learning and Knowledge Discovery in Databases: 2013. p. 574\u201389.","DOI":"10.1007\/978-3-642-40988-2_37"},{"issue":"6","key":"361_CR51","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2307\/3001968","volume":"1","author":"L Wilcoxon","year":"1945","unstructured":"Wilcoxon L. Individual comparison by ranking methods. Biometrics. 1945; 1(6):80\u20133.","journal-title":"Biometrics"},{"issue":"1","key":"361_CR52","first-page":"1","volume":"7","author":"J Demsar","year":"2006","unstructured":"Demsar J. Statistical comparisons of classifiers over multiple data sets. J Mach Learn Res. 2006; 7(1):1\u201330.","journal-title":"J Mach Learn Res"},{"key":"361_CR53","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-662-43968-5","volume-title":"Interactive Knowledge Discovery and Data Mining in Biomedical Informatics","author":"A Holzinger","year":"2014","unstructured":"Holzinger A, Schantl J, Schroettner M, Seifert S, Verspoor K. Biomedical text mining: state-of-the-art, open problems and future challenges. In: Interactive Knowledge Discovery and Data Mining in Biomedical Informatics. Berlin: Springer: 2014. p. 271\u2013300."},{"issue":"19","key":"361_CR54","first-page":"1","volume":"1","author":"FM Couto","year":"2006","unstructured":"Couto FM, Silva MJ, Lee V, Dimmer E, Camon E, Apweiler R, Harald K, Dietrich RS. Goannotator: linking protein go annotations to evidence text. J Biomed Discov Collab. 2006; 1(19):1\u20136.","journal-title":"J Biomed Discov Collab"},{"issue":"1","key":"361_CR55","first-page":"1255","volume":"40","author":"BM Good","year":"2011","unstructured":"Good BM, Clarke EL, Alfaro LD, Su AI. The gene wiki in 2011: Community intelligence applied to human gene annotation. Nucleic Acids Res. 2011; 40(1):1255\u20131261.","journal-title":"Nucleic Acids Res"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12918-016-0361-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T21:42:23Z","timestamp":1568670143000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/s12918-016-0361-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":55,"journal-issue":{"issue":"S4","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["361"],"URL":"https:\/\/doi.org\/10.1186\/s12918-016-0361-5","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]},"article-number":"121"}}