{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:18:24Z","timestamp":1767374304488},"reference-count":122,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"BMBF","award":["01ZX1407A","FKZ01ZX1508","FKZ031L0024A","FKZ01ZX1408A"],"award-info":[{"award-number":["01ZX1407A","FKZ01ZX1508","FKZ031L0024A","FKZ01ZX1408A"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12918-018-0579-5","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T12:20:10Z","timestamp":1524658810000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["New perspectives: systems medicine in cardiovascular disease"],"prefix":"10.1186","volume":"12","author":[{"given":"Frank","family":"Kramer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Just","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Zeller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"issue":"6","key":"579_CR1","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1161\/CIRCRESAHA.117.308903","volume":"121","author":"P Joseph","year":"2017","unstructured":"Joseph P, Leong D, McKee M, Anand SS, Schwalm JD, Teo K, et al. Reducing the Global Burden of Cardiovascular Disease, Part 1: the epidemiology and risk factors. Circulation Res. 2017;121(6):677\u201394. Epub 2017\/09\/02.","journal-title":"Circulation Res"},{"issue":"1","key":"579_CR2","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1161\/CIRCRESAHA.116.309955","volume":"120","author":"MR Thomas","year":"2017","unstructured":"Thomas MR, Lip GY. Novel risk markers and risk assessments for cardiovascular disease. Circ Res. 2017;120(1):133\u201349. Epub 2017\/01\/07.","journal-title":"Circ Res"},{"issue":"9","key":"579_CR3","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1038\/ng.3913","volume":"49","author":"CP Nelson","year":"2017","unstructured":"Nelson CP, Goel A, Butterworth AS, Kanoni S, Webb TR, Marouli E, et al. Association analyses based on false discovery rate implicate new loci for coronary artery disease. Nat Genet. 2017;49(9):1385\u201391. Epub 2017\/07\/18.","journal-title":"Nat Genet"},{"issue":"7","key":"579_CR4","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1038\/ng.3874","volume":"49","author":"JMM Howson","year":"2017","unstructured":"Howson JMM, Zhao W, Barnes DR, Ho WK, Young R, Paul DS, et al. Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms. Nature Genet. 2017;49(7):1113\u20139. Epub 2017\/05\/23.","journal-title":"Nature Genet"},{"issue":"6","key":"579_CR5","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.tcm.2017.03.005","volume":"27","author":"PL Auer","year":"2017","unstructured":"Auer PL, Stitziel NO. Genetic association studies in cardiovascular diseases: do we have enough power? Trends Cardiovasc Med. 2017;27(6):397\u2013404. Epub 2017\/05\/01.","journal-title":"Trends Cardiovasc Med"},{"issue":"10","key":"579_CR6","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1038\/ng.3396","volume":"47","author":"M Nikpay","year":"2015","unstructured":"Nikpay M, Goel A, Won HH, Hall LM, Willenborg C, Kanoni S, et al. A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet. 2015;47(10):1121\u201330. Epub 2015\/09\/08.","journal-title":"Nat Genet"},{"issue":"7480","key":"579_CR7","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/nature12722","volume":"504","author":"J Erdmann","year":"2013","unstructured":"Erdmann J, Stark K, Esslinger UB, Rumpf PM, Koesling D, de Wit C, et al. Dysfunctional nitric oxide signalling increases risk of myocardial infarction. Nature. 2013;504(7480):432\u20136. Epub 2013\/11\/12.","journal-title":"Nature"},{"issue":"6","key":"579_CR8","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1002\/wsbm.144","volume":"3","author":"J Loscalzo","year":"2011","unstructured":"Loscalzo J, Barabasi AL. Systems biology and the future of medicine. Wiley Interdiscip Rev Syst Biol Med. 2011;3(6):619\u201327. Epub 2011\/09\/20.","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"key":"579_CR9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fcvm.2016.00027","volume":"3","author":"T Haase","year":"2016","unstructured":"Haase T, Bornigen D, Muller C, Zeller T. Systems medicine as an emerging tool for cardiovascular genetics. Front Cardiovasc Med. 2016;3:27. Epub 2016\/09\/15.","journal-title":"Front Cardiovasc Med"},{"issue":"25","key":"579_CR10","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.1161\/CIRCULATIONAHA.116.023528","volume":"133","author":"RS Vasan","year":"2016","unstructured":"Vasan RS, Benjamin EJ. The future of cardiovascular epidemiology. Circulation. 2016;133(25):2626\u201333. Epub 2016\/06\/22.","journal-title":"Circulation"},{"issue":"4 Pt 2","key":"579_CR11","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/pr.2013.4","volume":"73","author":"O Wolkenhauer","year":"2013","unstructured":"Wolkenhauer O, Auffray C, Jaster R, Steinhoff G, Dammann O. The road from systems biology to systems medicine. Pediatr Res. 2013;73(4 Pt 2):502\u20137. Epub 2013\/01\/15.","journal-title":"Pediatr Res"},{"issue":"1","key":"579_CR12","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12910-016-0113-5","volume":"17","author":"T Fischer","year":"2016","unstructured":"Fischer T, Brothers KB, Erdmann P, Langanke M. Clinical decision-making and secondary findings in systems medicine. BMC Med ethics. 2016;17(1):32. Epub 2016\/05\/23.","journal-title":"BMC Med ethics"},{"issue":"10","key":"579_CR13","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s13073-014-0082-6","volume":"6","author":"M Gustafsson","year":"2014","unstructured":"Gustafsson M, Nestor CE, Zhang H, Barabasi AL, Baranzini S, Brunak S, et al. Modules, networks and systems medicine for understanding disease and aiding diagnosis. Genome Med. 2014;6(10):82. Epub 2014\/12\/05.","journal-title":"Genome Med"},{"key":"579_CR14","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/msb4100163","volume":"3","author":"J Loscalzo","year":"2007","unstructured":"Loscalzo J, Kohane I, Barabasi AL. Human disease classification in the postgenomic era: a complex systems approach to human pathobiology. Mol Syst Biol. 2007;3:124. Epub 2007\/07\/13.","journal-title":"Mol Syst Biol"},{"issue":"4","key":"579_CR15","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1002\/wsbm.1297","volume":"7","author":"RS Wang","year":"2015","unstructured":"Wang RS, Maron BA, Loscalzo J. Systems medicine: evolution of systems biology from bench to bedside. Wiley Interdiscip Rev Syst Biol Med. 2015;7(4):141\u201361. Epub 2015\/04\/22.","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"issue":"3","key":"579_CR16","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/nrcardio.2011.208","volume":"9","author":"WR MacLellan","year":"2012","unstructured":"MacLellan WR, Wang Y, Lusis AJ. Systems-based approaches to cardiovascular disease. Nat Rev Cardiol. 2012;9(3):172\u201384. Epub 2012\/01\/11.","journal-title":"Nat Rev Cardiol"},{"issue":"14","key":"579_CR17","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1091\/mbc.e16-01-0038","volume":"27","author":"AK Peter","year":"2016","unstructured":"Peter AK, Bjerke MA, Leinwand LA. Biology of the cardiac myocyte in heart disease. Mol Biol Cell. 2016;27(14):2149\u201360. Epub 2016\/07\/16.","journal-title":"Mol Biol Cell"},{"issue":"12","key":"579_CR18","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1161\/CIRCRESAHA.117.311080","volume":"120","author":"Y Yoshida","year":"2017","unstructured":"Yoshida Y, Yamanaka S. Induced pluripotent stem cells 10 years later: for cardiac applications. Circ Res. 2017;120(12):1958\u201368. Epub 2017\/06\/10.","journal-title":"Circ Res"},{"issue":"9","key":"579_CR19","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1242\/dmm.030320","volume":"10","author":"KO Brandao","year":"2017","unstructured":"Brandao KO, Tabel VA, Atsma DE, Mummery CL, Davis RP. Human pluripotent stem cell models of cardiac disease: from mechanisms to therapies. Dis Model Mech. 2017;10(9):1039\u201359. Epub 2017\/09\/09.","journal-title":"Dis Model Mech"},{"key":"579_CR20","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.addr.2015.05.010","volume":"96","author":"A Eder","year":"2016","unstructured":"Eder A, Vollert I, Hansen A, Eschenhagen T. Human engineered heart tissue as a model system for drug testing. Adv Drug Deliv Rev. 2016;96:214\u201324. Epub 2015\/06\/01.","journal-title":"Adv Drug Deliv Rev"},{"issue":"6","key":"579_CR21","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1242\/dev.143966","volume":"144","author":"HK Voges","year":"2017","unstructured":"Voges HK, Mills RJ, Elliott DA, Parton RG, Porrello ER, Hudson JE. Development of a human cardiac organoid injury model reveals innate regenerative potential. Development. 2017;144(6):1118\u201327. Epub 2017\/02\/09.","journal-title":"Development"},{"key":"579_CR22","first-page":"81","volume":"8","author":"MT Alrefai","year":"2015","unstructured":"Alrefai MT, Murali D, Paul A, Ridwan KM, Connell JM, Shum-Tim D. Cardiac tissue engineering and regeneration using cell-based therapy. Stem Cells Cloning. 2015;8:81\u2013101. Epub 2015\/05\/23.","journal-title":"Stem Cells Cloning"},{"issue":"3","key":"579_CR23","first-page":"70","volume":"6","author":"P Camacho","year":"2016","unstructured":"Camacho P, Fan H, Liu Z, He JQ. Small mammalian animal models of heart disease. Am J Cardiovasc Dis. 2016;6(3):70\u201380. Epub 2016\/09\/30.","journal-title":"Am J Cardiovasc Dis"},{"issue":"6020","key":"579_CR24","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1126\/science.1200708","volume":"331","author":"ER Porrello","year":"2011","unstructured":"Porrello ER, Mahmoud AI, Simpson E, Hill JA, Richardson JA, Olson EN, et al. Transient regenerative potential of the neonatal mouse heart. Science. 2011;331(6020):1078\u201380. Epub 2011\/02\/26.","journal-title":"Science"},{"issue":"2","key":"579_CR25","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/nprot.2014.021","volume":"9","author":"AI Mahmoud","year":"2014","unstructured":"Mahmoud AI, Porrello ER, Kimura W, Olson EN, Sadek HA. Surgical models for cardiac regeneration in neonatal mice. Nat Protoc. 2014;9(2):305\u201311. Epub 2014\/01\/18.","journal-title":"Nat Protoc"},{"issue":"3","key":"579_CR26","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1161\/CIRCRESAHA.117.308428","volume":"121","author":"X Yuan","year":"2017","unstructured":"Yuan X, Braun T. Multimodal regulation of cardiac myocyte proliferation. Circ Res. 2017;121(3):293\u2013309. Epub 2017\/07\/22.","journal-title":"Circ Res"},{"issue":"1\u20132","key":"579_CR27","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1242\/dmm.000687","volume":"2","author":"T Dahme","year":"2009","unstructured":"Dahme T, Katus HA, Rottbauer W. Fishing for the genetic basis of cardiovascular disease. Dis Models Mech. 2009;2(1\u20132):18\u201322. Epub 2009\/01\/10.","journal-title":"Dis Models Mech"},{"key":"579_CR28","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1146\/annurev-genet-110711-155646","volume":"46","author":"D Staudt","year":"2012","unstructured":"Staudt D, Stainier D. Uncovering the molecular and cellular mechanisms of heart development using the zebrafish. Annu Rev Genet. 2012;46:397\u2013418. Epub 2012\/09\/15.","journal-title":"Annu Rev Genet"},{"issue":"11","key":"579_CR29","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1517\/17460441.2015.1078788","volume":"10","author":"M Kessler","year":"2015","unstructured":"Kessler M, Rottbauer W, Just S. Recent progress in the use of zebrafish for novel cardiac drug discovery. Expert Opin Drug Discovery. 2015;10(11):1231\u201341. Epub 2015\/08\/22.","journal-title":"Expert Opin Drug Discovery"},{"issue":"11","key":"579_CR30","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.2174\/0929867321666131227130218","volume":"21","author":"A Pott","year":"2014","unstructured":"Pott A, Rottbauer W, Just S. Functional genomics in zebrafish as a tool to identify novel antiarrhythmic targets. Curr Med Chem. 2014;21(11):1320\u20139. Epub 2014\/01\/01.","journal-title":"Curr Med Chem"},{"key":"579_CR31","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1242\/dev.123.1.285","volume":"123","author":"DY Stainier","year":"1996","unstructured":"Stainier DY, Fouquet B, Chen JN, Warren KS, Weinstein BM, Meiler SE, et al. Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development. 1996;123:285\u201392. Epub 1996\/12\/01.","journal-title":"Development"},{"issue":"17","key":"579_CR32","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1101\/gad.1448306","volume":"20","author":"G Bendig","year":"2006","unstructured":"Bendig G, Grimmler M, Huttner IG, Wessels G, Dahme T, Just S, et al. Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart. Genes Dev. 2006;20(17):2361\u201372. Epub 2006\/08\/22.","journal-title":"Genes Dev"},{"issue":"5","key":"579_CR33","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1161\/CIRCULATIONAHA.107.689984","volume":"116","author":"R Knoll","year":"2007","unstructured":"Knoll R, Postel R, Wang J, Kratzner R, Hennecke G, Vacaru AM, et al. Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation. 2007;116(5):515\u201325. Epub 2007\/07\/25.","journal-title":"Circulation"},{"issue":"11","key":"579_CR34","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1038\/nm.2037","volume":"15","author":"D Hassel","year":"2009","unstructured":"Hassel D, Dahme T, Erdmann J, Meder B, Huge A, Stoll M, et al. Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy. Nat Med. 2009;15(11):1281\u20138. Epub 2009\/11\/03.","journal-title":"Nat Med"},{"key":"579_CR35","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1146\/annurev-cellbio-101011-155739","volume":"28","author":"K Kikuchi","year":"2012","unstructured":"Kikuchi K, Poss KD. Cardiac regenerative capacity and mechanisms. Annu Rev Cell Dev Biol. 2012;28:719\u201341. Epub 2012\/10\/13.","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"4","key":"579_CR36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018503","volume":"6","author":"K Schnabel","year":"2011","unstructured":"Schnabel K, Wu CC, Kurth T, Weidinger G. Regeneration of cryoinjury induced necrotic heart lesions in zebrafish is associated with epicardial activation and cardiomyocyte proliferation. PLoS One. 2011;6(4):e18503. Epub 2011\/05\/03.","journal-title":"PLoS One"},{"issue":"3","key":"579_CR37","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/cbf.3173","volume":"34","author":"HG Tsang","year":"2016","unstructured":"Tsang HG, Rashdan NA, Whitelaw CB, Corcoran BM, Summers KM, MacRae VE. Large animal models of cardiovascular disease. Cell Biochem Funct. 2016;34(3):113\u201332. Epub 2016\/02\/26.","journal-title":"Cell Biochem Funct"},{"issue":"7","key":"579_CR38","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.tibtech.2013.04.004","volume":"31","author":"T Gaj","year":"2013","unstructured":"Gaj T, Gersbach CA, Barbas CF 3rd. ZFN, TALEN, and CRISPR\/Cas-based methods for genome engineering. Trends Biotechnol. 2013;31(7):397\u2013405. Epub 2013\/05\/15.","journal-title":"Trends Biotechnol"},{"issue":"3","key":"579_CR39","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s11886-017-0830-5","volume":"19","author":"AC Chadwick","year":"2017","unstructured":"Chadwick AC, Musunuru K. Genome editing for the study of cardiovascular diseases. Curr Cardiol Rep. 2017;19(3):22. Epub 2017\/02\/22.","journal-title":"Curr Cardiol Rep"},{"issue":"6","key":"579_CR40","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1097\/PRS.0b013e3181f44abc","volume":"126","author":"JW Song","year":"2010","unstructured":"Song JW, Chung KC. Observational studies: cohort and case-control studies. Plast Reconstr Surg. 2010;126(6):2234\u201342. Epub 2010\/08\/11.","journal-title":"Plast Reconstr Surg"},{"issue":"3","key":"579_CR41","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nrendo.2015.226","volume":"12","author":"MT Long","year":"2016","unstructured":"Long MT, Fox CS. The Framingham heart study--67 years of discovery in metabolic disease. Nat Rev Endocrinol. 2016;12(3):177\u201383. Epub 2016\/01\/19.","journal-title":"Nat Rev Endocrinol"},{"issue":"7","key":"579_CR42","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1001\/jamacardio.2016.2050","volume":"1","author":"G Chen","year":"2016","unstructured":"Chen G, Levy D. Contributions of the Framingham heart study to the epidemiology of coronary heart disease. JAMA Cardiol. 2016;1(7):825\u201330. Epub 2016\/10\/21.","journal-title":"JAMA Cardiol"},{"issue":"6\u20137","key":"579_CR43","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1007\/s00103-012-1502-7","volume":"55","author":"PS Wild","year":"2012","unstructured":"Wild PS, Zeller T, Beutel M, Blettner M, Dugi KA, Lackner KJ, et al. The Gutenberg Health Study. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012;55(6\u20137):824\u20139. Epub 2012\/06\/28. Die Gutenberg Gesundheitsstudie.","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz"},{"issue":"46","key":"579_CR44","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1055\/s-0029-1242688","volume":"134","author":"B Koch","year":"2009","unstructured":"Koch B, Schaper C, Ittermann T, Volzke H, Felix SB, Ewert R, et al. Reference values for lung function testing in adults--results from the study of health in Pomerania (SHIP). Dtsch Med Wochenschr. 2009;134(46):2327\u201332. Epub 2009\/11\/07. Referenzwerte fur die Spirometrie bei Erwachsenen.","journal-title":"Dtsch Med Wochenschr"},{"issue":"3","key":"579_CR45","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/0895-4356(91)90036-9","volume":"44","author":"H Lowel","year":"1991","unstructured":"Lowel H, Lewis M, Hormann A, Keil U. Case finding, data quality aspects and comparability of myocardial infarction registers: results of a south German register study. J Clin Epidemiol. 1991;44(3):249\u201360. Epub 1991\/01\/01.","journal-title":"J Clin Epidemiol"},{"issue":"10","key":"579_CR46","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s10654-014-9952-x","volume":"29","author":"T Zeller","year":"2014","unstructured":"Zeller T, Hughes M, Tuovinen T, Schillert A, Conrads-Frank A, Ruijter H, et al. BiomarCaRE: rationale and design of the European BiomarCaRE project including 300,000 participants from 13 European countries. Eur J Epidemiol. 2014;29(10):777\u201390. Epub 2014\/09\/23.","journal-title":"Eur J Epidemiol"},{"key":"579_CR47","doi-asserted-by":"crossref","unstructured":"The ARIC investigators. The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. Am J Epidemiol. 1989;129(4):687\u2013702. Epub 1989\/04\/01.","DOI":"10.1093\/oxfordjournals.aje.a115184"},{"issue":"5","key":"579_CR48","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1159\/000448254","volume":"43","author":"D Simeon-Dubach","year":"2016","unstructured":"Simeon-Dubach D, Zeisberger SM, Hoerstrup SP. Quality assurance in biobanking for pre-clinical research. Transfus Med Hemother. 2016;43(5):353\u20137. Epub 2016\/10\/27.","journal-title":"Transfus Med Hemother"},{"issue":"3","key":"579_CR49","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s00103-015-2301-8","volume":"59","author":"MT Mayrhofer","year":"2016","unstructured":"Mayrhofer MT, Holub P, Wutte A, Litton JE. BBMRI-ERIC: the novel gateway to biobanks. From humans to humans. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2016;59(3):379\u201384. Epub 2016\/02\/11.","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz"},{"issue":"1","key":"579_CR50","doi-asserted-by":"publisher","first-page":"799","DOI":"10.15252\/msb.20145399","volume":"11","author":"T Huan","year":"2015","unstructured":"Huan T, Meng Q, Saleh MA, Norlander AE, Joehanes R, Zhu J, et al. Integrative network analysis reveals molecular mechanisms of blood pressure regulation. Mol Syst Biol. 2015;11(1):799. Epub 2015\/04\/18.","journal-title":"Mol Syst Biol"},{"issue":"3","key":"579_CR51","doi-asserted-by":"publisher","first-page":"e1005035","DOI":"10.1371\/journal.pgen.1005035","volume":"11","author":"T Huan","year":"2015","unstructured":"Huan T, Esko T, Peters MJ, Pilling LC, Schramm K, Schurmann C, et al. A meta-analysis of gene expression signatures of blood pressure and hypertension. PLoS Gen. 2015;11(3):e1005035. Epub 2015\/03\/19.","journal-title":"PLoS Gen"},{"issue":"9","key":"579_CR52","doi-asserted-by":"publisher","first-page":"e1005487","DOI":"10.1371\/journal.pgen.1005487","volume":"11","author":"J Raffler","year":"2015","unstructured":"Raffler J, Friedrich N, Arnold M, Kacprowski T, Rueedi R, Altmaier E, et al. Genome-wide association study with targeted and non-targeted NMR metabolomics identifies 15 novel loci of urinary human metabolic individuality. PLoS Genet. 2015;11(9):e1005487. Epub 2015\/09\/10.","journal-title":"PLoS Genet"},{"key":"579_CR53","doi-asserted-by":"crossref","unstructured":"Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008;455(7216):1061\u20138. Epub 2008\/09\/06.","DOI":"10.1038\/nature07385"},{"issue":"1","key":"579_CR54","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","volume":"30","author":"R Edgar","year":"2002","unstructured":"Edgar R, Domrachev M, Lash AE. Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 2002;30(1):207\u201310. Epub 2001\/12\/26.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"579_CR55","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1093\/nar\/gkg091","volume":"31","author":"A Brazma","year":"2003","unstructured":"Brazma A, Parkinson H, Sarkans U, Shojatalab M, Vilo J, Abeygunawardena N, et al. ArrayExpress--a public repository for microarray gene expression data at the EBI. Nucleic Acids Res. 2003;31(1):68\u201371. Epub 2003\/01\/10.","journal-title":"Nucleic Acids Res"},{"issue":"7391","key":"579_CR56","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/nature11003","volume":"483","author":"J Barretina","year":"2012","unstructured":"Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, et al. The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2012;483(7391):603\u20137. Epub 2012\/03\/31.","journal-title":"Nature"},{"issue":"Web Server issu","key":"579_CR57","doi-asserted-by":"publisher","first-page":"W449","DOI":"10.1093\/nar\/gku476","volume":"42","author":"Q Duan","year":"2014","unstructured":"Duan Q, Flynn C, Niepel M, Hafner M, Muhlich JL, Fernandez NF, et al. LINCS canvas browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures. Nucleic Acids Res. 2014;42(Web Server issue):W449\u201360. Epub 2014\/06\/08.","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"579_CR58","first-page":"D36","volume":"41","author":"DA Benson","year":"2013","unstructured":"Benson DA, Cavanaugh M, Clark K, Karsch-Mizrachi I, Lipman DJ, Ostell J, et al. GenBank. Nucleic Acids Res. 2013;41(Database issue):D36\u201342. Epub 2012\/11\/30.","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"579_CR59","doi-asserted-by":"publisher","first-page":"D154","DOI":"10.1093\/nar\/gki070","volume":"33","author":"A Bairoch","year":"2005","unstructured":"Bairoch A, Apweiler R, Wu CH, Barker WC, Boeckmann B, Ferro S, et al. The Universal Protein Resource (UniProt). Nucleic Acids Res. 2005;33(Database issue):D154\u20139. Epub 2004\/12\/21.","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"579_CR60","doi-asserted-by":"publisher","first-page":"D504","DOI":"10.1093\/nar\/gkj126","volume":"34","author":"GD Bader","year":"2006","unstructured":"Bader GD, Cary MP, Sander C. Pathguide: a pathway resource list. Nucleic Acids Res. 2006;34(Database issue):D504\u20136. Epub 2005\/12\/31.","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"579_CR61","doi-asserted-by":"publisher","first-page":"D691","DOI":"10.1093\/nar\/gkq1018","volume":"39","author":"D Croft","year":"2011","unstructured":"Croft D, O'Kelly G, Wu G, Haw R, Gillespie M, Matthews L, et al. Reactome: a database of reactions, pathways and biological processes. Nucleic Acids Res. 2011;39(Database issue):D691\u20137. Epub 2010\/11\/12.","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"579_CR62","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.cels.2015.10.001","volume":"1","author":"D Pratt","year":"2015","unstructured":"Pratt D, Chen J, Welker D, Rivas R, Pillich R, Rynkov V, et al. NDEx, the Network Data Exchange. Cell Syst. 2015;1(4):302\u20135. Epub 2015\/11\/26.","journal-title":"Cell Syst"},{"issue":"1","key":"579_CR63","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/nar\/27.1.29","volume":"27","author":"H Ogata","year":"1999","unstructured":"Ogata H, Goto S, Sato K, Fujibuchi W, Bono H, Kanehisa M. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 1999;27(1):29\u201334. Epub 1998\/12\/10","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"579_CR64","doi-asserted-by":"publisher","first-page":"e184","DOI":"10.1371\/journal.pbio.0060184","volume":"6","author":"AR Pico","year":"2008","unstructured":"Pico AR, Kelder T, van Iersel MP, Hanspers K, Conklin BR, Evelo C. WikiPathways: pathway editing for the people. PLoS Biol. 2008;6(7):e184. Epub 2008\/07\/25.","journal-title":"PLoS Biol"},{"issue":"1","key":"579_CR65","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1093\/nar\/30.1.52","volume":"30","author":"A Hamosh","year":"2002","unstructured":"Hamosh A, Scott AF, Amberger J, Bocchini C, Valle D, McKusick VA. Online Mendelian inheritance in man (OMIM), a knowledgebase of human genes and genetic disorders. Nucleic Acids Res. 2002;30(1):52\u20135. Epub 2001\/12\/26.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"579_CR66","doi-asserted-by":"publisher","first-page":"D369","DOI":"10.1093\/nar\/gkw1102","volume":"45","author":"A Chatr-Aryamontri","year":"2017","unstructured":"Chatr-Aryamontri A, Oughtred R, Boucher L, Rust J, Chang C, Kolas NK, et al. The BioGRID interaction database: 2017 update. Nucleic Acids Res. 2017;45(D1):D369\u2013D79. Epub 2016\/12\/17.","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"579_CR67","doi-asserted-by":"publisher","first-page":"D452","DOI":"10.1093\/nar\/gkh052","volume":"32","author":"H Hermjakob","year":"2004","unstructured":"Hermjakob H, Montecchi-Palazzi L, Lewington C, Mudali S, Kerrien S, Orchard S, et al. IntAct: an open source molecular interaction database. Nucleic Acids Res. 2004;32(Database issue):D452\u20135. Epub 2003\/12\/19.","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"579_CR68","doi-asserted-by":"publisher","first-page":"D447","DOI":"10.1093\/nar\/gku1003","volume":"43","author":"D Szklarczyk","year":"2015","unstructured":"Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, et al. STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 2015;43(Database issue):D447\u201352. Epub 2014\/10\/30.","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"579_CR69","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1038\/nbt.1666","volume":"28","author":"E Demir","year":"2010","unstructured":"Demir E, Cary MP, Paley S, Fukuda K, Lemer C, Vastrik I, et al. The BioPAX community standard for pathway data sharing. Nat Biotechnol. 2010;28(9):935\u201342. Epub 2010\/09\/11.","journal-title":"Nat Biotechnol"},{"issue":"4","key":"579_CR70","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1093\/bioinformatics\/btg015","volume":"19","author":"M Hucka","year":"2003","unstructured":"Hucka M, Finney A, Sauro HM, Bolouri H, Doyle JC, Kitano H, et al. The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics. 2003;19(4):524\u201331. Epub 2003\/03\/04.","journal-title":"Bioinformatics"},{"issue":"2","key":"579_CR71","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nbt926","volume":"22","author":"H Hermjakob","year":"2004","unstructured":"Hermjakob H, Montecchi-Palazzi L, Bader G, Wojcik J, Salwinski L, Ceol A, et al. The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data. Nat Biotechnol. 2004;22(2):177\u201383. Epub 2004\/02\/03.","journal-title":"Nat Biotechnol"},{"key":"579_CR72","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/978-1-4939-6783-4_13","volume":"1558","author":"RT Pillich","year":"2017","unstructured":"Pillich RT, Chen J, Rynkov V, Welker D, Pratt D. NDEx: a community resource for sharing and publishing of biological networks. Methods Mol Biol. 2017;1558:271\u2013301. Epub 2017\/02\/06.","journal-title":"Methods Mol Biol"},{"issue":"16","key":"579_CR73","doi-asserted-by":"publisher","first-page":"3439","DOI":"10.1093\/bioinformatics\/bti525","volume":"21","author":"S Durinck","year":"2005","unstructured":"Durinck S, Moreau Y, Kasprzyk A, Davis S, De Moor B, Brazma A, et al. BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis. Bioinformatics. 2005;21(16):3439\u201340. Epub 2005\/08\/06.","journal-title":"Bioinformatics"},{"key":"579_CR74","volume-title":"Some rapid approximate statistical procedures leaderless laboratories","author":"F Wilcoxon","year":"1964","unstructured":"Wilcoxon F, Wilcox, RA.. Some rapid approximate statistical procedures leaderless laboratories. 1964."},{"key":"579_CR75","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1080\/01621459.1967.10482916","volume":"62","author":"HW Lilliefors","year":"1967","unstructured":"Lilliefors HW. On the Kolmogorov-Smirnov test for normality with mean and variance unknown. J Am Stat Assoc. 1967;62:399\u2013402.","journal-title":"J Am Stat Assoc"},{"key":"579_CR76","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1080\/01621459.1989.10478874","volume":"84","author":"DY Lin","year":"1989","unstructured":"Lin DY, Wei LJ. The robust inference for the cox proportional hazards model. J Am Stat Assoc. 1989;84:1074\u20138.","journal-title":"J Am Stat Assoc"},{"key":"579_CR77","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/BF02289588","volume":"32","author":"SC Johnson","year":"1967","unstructured":"Johnson SC. Hierarchical clustering schemes. Psychometrika. 1967;32:241\u201354.","journal-title":"Psychometrika"},{"key":"579_CR78","first-page":"273","volume":"20","author":"C Cortes","year":"1995","unstructured":"Cortes C, Vapnik V. Support-vector networks. Mach Learn. 1995;20:273\u201397.","journal-title":"Mach Learn"},{"key":"579_CR79","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1109\/101.8118","volume":"4","author":"JJ Hopfield","year":"1988","unstructured":"Hopfield JJ. Artificial neural networks. IEEE Circuits and Devices Magazine. 1988;4:3\u201310.","journal-title":"IEEE Circuits and Devices Magazine"},{"key":"579_CR80","first-page":"407","volume":"5","author":"DJ Spiegelhalter","year":"1996","unstructured":"Spiegelhalter DJ. Computation on Bayesian graphical models. Bayesian. Statistics. 1996;5:407\u201325.","journal-title":"Statistics"},{"issue":"25","key":"579_CR81","doi-asserted-by":"publisher","first-page":"14796","DOI":"10.1073\/pnas.2036429100","volume":"100","author":"S Kauffman","year":"2003","unstructured":"Kauffman S, Peterson C, Samuelsson B, Troein C. Random Boolean network models and the yeast transcriptional network. Proc Natl Acad Sci U S A. 2003;100(25):14796\u20139. Epub 2003\/12\/06.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"579_CR82","doi-asserted-by":"publisher","first-page":"e1002367","DOI":"10.1371\/journal.pgen.1002367","volume":"7","author":"M Rotival","year":"2011","unstructured":"Rotival M, Zeller T, Wild PS, Maouche S, Szymczak S, Schillert A, et al. Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans. PLoS Genet. 2011;7(12):e1002367. Epub 2011\/12\/07.","journal-title":"PLoS Genet"},{"issue":"3","key":"579_CR83","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1172\/JCI76327","volume":"125","author":"MA Saleh","year":"2015","unstructured":"Saleh MA, McMaster WG, Wu J, Norlander AE, Funt SA, Thabet SR, et al. Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation. Eur J Clin Investig. 2015;125(3):1189\u2013202. Epub 2015\/02\/11.","journal-title":"Eur J Clin Investig"},{"issue":"4","key":"579_CR84","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1161\/HYPERTENSIONAHA.117.09458","volume":"70","author":"T Zeller","year":"2017","unstructured":"Zeller T, Schurmann C, Schramm K, Muller C, Kwon S, Wild PS, et al. Transcriptome-wide analysis identifies novel associations with blood pressure. Hypertension. 2017;70(4):743\u201350. Epub 2017\/08\/09.","journal-title":"Hypertension"},{"issue":"3","key":"579_CR85","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.pharmthera.2013.10.007","volume":"141","author":"N Milani-Nejad","year":"2014","unstructured":"Milani-Nejad N, Janssen PM. Small and large animal models in cardiac contraction research: advantages and disadvantages. Pharmacol Ther. 2014;141(3):235\u201349. Epub 2013\/10\/22.","journal-title":"Pharmacol Ther"},{"key":"579_CR86","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.atherosclerosis.2016.03.013","volume":"248","author":"CA Gleissner","year":"2016","unstructured":"Gleissner CA. Translational atherosclerosis research: from experimental models to coronary artery disease in humans. Atherosclerosis. 2016;248:110\u20136. Epub 2016\/03\/22.","journal-title":"Atherosclerosis"},{"key":"579_CR87","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-319-20579-3_1","volume":"864","author":"F Karimi-Busheri","year":"2015","unstructured":"Karimi-Busheri F, Rasouli-Nia A. Integration, networking, and global biobanking in the age of new biology. Adv Exp Med Biol. 2015;864:1\u20139. Epub 2015\/10\/01.","journal-title":"Adv Exp Med Biol"},{"issue":"7469","key":"579_CR88","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/502038d","volume":"502","author":"H Gijzen","year":"2013","unstructured":"Gijzen H. Development: big data for a sustainable future. Nature. 2013;502(7469):38. Epub 2013\/10\/05.","journal-title":"Nature"},{"issue":"10","key":"579_CR89","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1007\/s00384-017-2871-z","volume":"32","author":"M Lowes","year":"2017","unstructured":"Lowes M, Kleiss M, Lueck R, Detken S, Koenig A, Nietert M, et al. The utilization of multidisciplinary tumor boards (MDT) in clinical routine: results of a health care research study focusing on patients with metastasized colorectal cancer. Int J Colorectal Dis. 2017;32(10):1463\u20139. Epub 2017\/08\/06.","journal-title":"Int J Colorectal Dis"},{"issue":"6","key":"579_CR90","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1056\/NEJMp1114866","volume":"366","author":"R Mirnezami","year":"2012","unstructured":"Mirnezami R, Nicholson J, Darzi A. Preparing for precision medicine. N Engl J Med. 2012;366(6):489\u201391. Epub 2012\/01\/20.","journal-title":"N Engl J Med"},{"issue":"6","key":"579_CR91","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.trsl.2009.09.005","volume":"154","author":"GS Ginsburg","year":"2009","unstructured":"Ginsburg GS, Willard HF. Genomic and personalized medicine: foundations and applications. Transl Res. 2009;154(6):277\u201387. Epub 2009\/11\/26.","journal-title":"Transl Res"},{"key":"579_CR92","first-page":"100","volume":"243","author":"S Mate","year":"2017","unstructured":"Mate S, Kadioglu D, Majeed RW, Stohr MR, Folz M, Vormstein P, et al. Proof-of-concept integration of heterogeneous biobank IT infrastructures into a Hybrid Biobanking Network. Stud Health Technol Inform. 2017;243:100\u20134. Epub 2017\/09\/09.","journal-title":"Stud Health Technol Inform"},{"issue":"1","key":"579_CR93","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s12911-017-0513-6","volume":"17","author":"A Boussadi","year":"2017","unstructured":"Boussadi A, Zapletal E. A fast healthcare interoperability resources (FHIR) layer implemented over i2b2. BMC Med Inform Decis Mak. 2017;17(1):120. Epub 2017\/08\/16.","journal-title":"BMC Med Inform Decis Mak"},{"key":"579_CR94","first-page":"70","volume":"236","author":"J Christoph","year":"2017","unstructured":"Christoph J, Knell C, Naschberger E, Sturzl M, Maier C, Prokosch HU, et al. Two Years of tranSMART in a University Hospital for Translational Research and Education. Stud Health Technol Inform. 2017;236:70\u20139. Epub 2017\/05\/17.","journal-title":"Stud Health Technol Inform"},{"issue":"269","key":"579_CR95","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1126\/scisignal.2004088","volume":"6","author":"J Gao","year":"2013","unstructured":"Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 2013;6(269):11. Epub 2013\/04\/04.","journal-title":"Sci Signal"},{"issue":"7","key":"579_CR96","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2002654","volume":"15","author":"T Caulfield","year":"2017","unstructured":"Caulfield T, Murdoch B. Genes, cells, and biobanks: yes, there's still a consent problem. PLoS Biol. 2017;15(7):e2002654. Epub 2017\/07\/26.","journal-title":"PLoS Biol"},{"key":"579_CR97","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/1479-5876-12-144","volume":"12","author":"HJ Grabe","year":"2014","unstructured":"Grabe HJ, Assel H, Bahls T, Dorr M, Endlich K, Endlich N, et al. Cohort profile: Greifswald approach to individualized medicine (GANI_MED). J Transl Med. 2014;12:144. Epub 2014\/06\/03.","journal-title":"J Transl Med"},{"key":"579_CR98","first-page":"719","volume":"210","author":"E Lamas","year":"2015","unstructured":"Lamas E, Barh A, Brown D, Jaulent MC. Ethical, legal and social issues related to the health data-warehouses: re-using health data in the research and public health research. Stud Health Technol Inform. 2015;210:719\u201323. Epub 2015\/05\/21.","journal-title":"Stud Health Technol Inform"},{"issue":"10","key":"579_CR99","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1038\/gim.2013.117","volume":"15","author":"R Hazin","year":"2013","unstructured":"Hazin R, Brothers KB, Malin BA, Koenig BA, Sanderson SC, Rothstein MA, et al. Ethical, legal, and social implications of incorporating genomic information into electronic health records. Genet Med. 2013;15(10):810\u20136. Epub 2013\/09\/14.","journal-title":"Genet Med"},{"issue":"1","key":"579_CR100","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s13073-016-0323-y","volume":"8","author":"C Auffray","year":"2016","unstructured":"Auffray C, Balling R, Barroso I, Bencze L, Benson M, Bergeron J, et al. Making sense of big data in health research: Towards an EU action plan. Genome Med. 2016;8(1):71. Epub 2016\/06\/25.","journal-title":"Genome Med"},{"issue":"2","key":"579_CR101","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/pbc.26201","volume":"64","author":"A Thenappan","year":"2017","unstructured":"Thenappan A, Halaweish I, Mody RJ, Smith EA, Geiger JD, Ehrlich PF, et al. Review at a multidisciplinary tumor board impacts critical management decisions of pediatric patients with cancer. Pediatr Blood Cancer. 2017;64(2):254\u20138. Epub 2016\/09\/01.","journal-title":"Pediatr Blood Cancer"},{"key":"579_CR102","doi-asserted-by":"publisher","first-page":"698169","DOI":"10.1155\/2015\/698169","volume":"2015","author":"D Ayers","year":"2015","unstructured":"Ayers D, Day PJ. Systems medicine: the application of systems biology approaches for modern medical research and drug development. Mol Biol Int. 2015;2015:698169. Epub 2015\/09\/12.","journal-title":"Mol Biol Int"},{"issue":"D1","key":"579_CR103","doi-asserted-by":"publisher","first-page":"D746","DOI":"10.1093\/nar\/gkv1045","volume":"44","author":"R Petryszak","year":"2016","unstructured":"Petryszak R, Keays M, Tang YA, Fonseca NA, Barrera E, Burdett T, et al. Expression Atlas update--an integrated database of gene and protein expression in humans, animals and plants. Nucleic Acids Res. 2016;44(D1):D746\u201352. Epub 2015\/10\/21.","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"579_CR104","doi-asserted-by":"publisher","first-page":"D568","DOI":"10.1093\/nar\/gkh069","volume":"32","author":"DP Hill","year":"2004","unstructured":"Hill DP, Begley DA, Finger JH, Hayamizu TF, McCright IJ, Smith CM, et al. The mouse Gene Expression Database (GXD): updates and enhancements. Nucleic Acids Res. 2004;32(Database issue):D568\u201371. Epub 2003\/12\/19.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"579_CR105","doi-asserted-by":"publisher","first-page":"D447","DOI":"10.1093\/nar\/gkv1145","volume":"44","author":"JA Vizcaino","year":"2016","unstructured":"Vizcaino JA, Csordas A, del-Toro N, Dianes JA, Griss J, Lavidas I, et al. 2016 update of the PRIDE database and its related tools. Nucleic Acids Res. 2016;44(D1):D447\u201356. Epub 2015\/11\/04.","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"579_CR106","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1161\/CIRCRESAHA.113.301151","volume":"113","author":"NC Zong","year":"2013","unstructured":"Zong NC, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, et al. Integration of cardiac proteome biology and medicine by a specialized knowledgebase. Circ Res. 2013;113(9):1043\u201353. Epub 2013\/08\/24.","journal-title":"Circ Res"},{"issue":"1","key":"579_CR107","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1093\/nar\/30.1.38","volume":"30","author":"T Hubbard","year":"2002","unstructured":"Hubbard T, Barker D, Birney E, Cameron G, Chen Y, Clark L, et al. The Ensembl genome database project. Nucleic acids Res. 2002;30(1):38\u201341. Epub 2001\/12\/26.","journal-title":"Nucleic acids Res"},{"issue":"1","key":"579_CR108","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1093\/nar\/30.1.59","volume":"30","author":"PD Karp","year":"2002","unstructured":"Karp PD, Riley M, Paley SM, Pellegrini-Toole A. The MetaCyc database. Nucleic Acids Res. 2002;30(1):59\u201361. Epub 2001\/12\/26.","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"579_CR109","doi-asserted-by":"publisher","first-page":"D535","DOI":"10.1093\/nar\/gkj109","volume":"34","author":"C Stark","year":"2006","unstructured":"Stark C, Breitkreutz BJ, Reguly T, Boucher L, Breitkreutz A, Tyers M. BioGRID: a general repository for interaction datasets. Nucleic Acids Res. 2006;34(Database issue):D535\u20139. Epub 2005\/12\/31.","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"579_CR110","doi-asserted-by":"publisher","first-page":"D901","DOI":"10.1093\/nar\/gkm958","volume":"36","author":"DS Wishart","year":"2008","unstructured":"Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, et al. DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008;36(Database issue):D901\u20136. Epub 2007\/12\/01.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"579_CR111","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1093\/nar\/30.1.163","volume":"30","author":"M Hewett","year":"2002","unstructured":"Hewett M, Oliver DE, Rubin DL, Easton KL, Stuart JM, Altman RB, et al. PharmGKB: the pharmacogenetics knowledge base. Nucleic Acids Res. 2002;30(1):163\u20135. Epub 2001\/12\/26.","journal-title":"Nucleic Acids Res"},{"issue":"Web Server issu","key":"579_CR112","doi-asserted-by":"publisher","first-page":"W137","DOI":"10.1093\/nar\/gku412","volume":"42","author":"CC Liu","year":"2014","unstructured":"Liu CC, Tseng YT, Li W, Wu CY, Mayzus I, Rzhetsky A, et al. DiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections. Nucleic Acids Res. 2014;42(Web Server issue):W137\u201346. Epub 2014\/06\/05.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"579_CR113","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.toxlet.2008.08.009","volume":"186","author":"H Toyoshiba","year":"2009","unstructured":"Toyoshiba H, Sawada H, Naeshiro I, Horinouchi A. Similar compounds searching system by using the gene expression microarray database. Toxicol Lett. 2009;186(1):52\u20137. Epub 2008\/09\/20.","journal-title":"Toxicol Lett"},{"issue":"Database issue","key":"579_CR114","doi-asserted-by":"publisher","first-page":"D514","DOI":"10.1093\/nar\/gki033","volume":"33","author":"A Hamosh","year":"2005","unstructured":"Hamosh A, Scott AF, Amberger JS, Bocchini CA, McKusick VA. Online Mendelian inheritance in man (OMIM), a knowledgebase of human genes and genetic disorders. Nucleic Acids Res. 2005;33(Database issue):D514\u20137. Epub 2004\/12\/21.","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"579_CR115","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1093\/bioinformatics\/bts710","volume":"29","author":"F Kramer","year":"2013","unstructured":"Kramer F, Bayerlova M, Klemm F, Bleckmann A, Beissbarth T. rBiopaxParser--an R package to parse, modify and visualize BioPAX data. Bioinformatics. 2013;29(4):520\u20132. Epub 2013\/01\/01.","journal-title":"Bioinformatics"},{"issue":"9","key":"579_CR116","doi-asserted-by":"publisher","first-page":"e1003194","DOI":"10.1371\/journal.pcbi.1003194","volume":"9","author":"E Demir","year":"2013","unstructured":"Demir E, Babur O, Rodchenkov I, Aksoy BA, Fukuda KI, Gross B, et al. Using biological pathway data with paxtools. PLoS Comput Biol. 2013;9(9):e1003194. Epub 2013\/09\/27.","journal-title":"PLoS Comput Biol"},{"issue":"6","key":"579_CR117","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1093\/bioinformatics\/btn051","volume":"24","author":"BJ Bornstein","year":"2008","unstructured":"Bornstein BJ, Keating SM, Jouraku A, Hucka M. LibSBML: an API library for SBML. Bioinformatics. 2008;24(6):880\u20131. Epub 2008\/02\/07.","journal-title":"Bioinformatics"},{"issue":"8","key":"579_CR118","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1038\/nbt.1558","volume":"27","author":"N Le Novere","year":"2009","unstructured":"Le Novere N, Hucka M, Mi H, Moodie S, Schreiber F, Sorokin A, et al. The systems biology graphical notation. Nature Biotechnol. 2009;27(8):735\u201341. Epub 2009\/08\/12.","journal-title":"Nature Biotechnol"},{"issue":"15","key":"579_CR119","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1093\/bioinformatics\/bts270","volume":"28","author":"MP van Iersel","year":"2012","unstructured":"van Iersel MP, Villeger AC, Czauderna T, Boyd SE, Bergmann FT, Luna A, et al. Software support for SBGN maps: SBGN-ML and LibSBGN. Bioinformatics. 2012;28(15):2016\u201321. Epub 2012\/05\/15.","journal-title":"Bioinformatics"},{"issue":"7","key":"579_CR120","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/nmeth.1637","volume":"8","author":"B Aranda","year":"2011","unstructured":"Aranda B, Blankenburg H, Kerrien S, Brinkman FS, Ceol A, Chautard E, et al. PSICQUIC and PSISCORE: accessing and scoring molecular interactions. Nat Methods. 2011;8(7):528\u20139. Epub 2011\/07\/01.","journal-title":"Nat Methods"},{"key":"579_CR121","first-page":"271","volume-title":"NDEx: A Community Resource for Sharing and Publishing of Biological Networks. Protein Bioinformatics. Methods in Molecular Biology","author":"RT Pillich","year":"2017","unstructured":"Pillich RT. NDEx: A Community Resource for Sharing and Publishing of Biological Networks. Protein Bioinformatics. Methods in Molecular Biology. New York: Humana Press; 2017. p. 271\u2013301."},{"key":"579_CR122","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1093\/bioinformatics\/btx683","volume":"34","author":"F Auer","year":"2017","unstructured":"Auer F, Hammoud Z, Ishkin A, Dexter P, Ideker T, Kramer F. Ndexr\u2014an R package to interface with the network data exchange. Bioinformatics. 2017;34:716\u20137. in press.","journal-title":"Bioinformatics"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12918-018-0579-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12918-018-0579-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12918-018-0579-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T23:43:50Z","timestamp":1661039030000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/s12918-018-0579-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,25]]},"references-count":122,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["579"],"URL":"https:\/\/doi.org\/10.1186\/s12918-018-0579-5","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,25]]},"assertion":[{"value":"19 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"57"}}