{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T11:49:01Z","timestamp":1781264941205,"version":"3.54.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"S7","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12918-018-0634-2","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T09:21:43Z","timestamp":1544779303000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Increased AURKA promotes cell proliferation and predicts poor prognosis in bladder cancer"],"prefix":"10.1186","volume":"12","author":[{"given":"Mengjie","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaohui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Q.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youping","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,14]]},"reference":[{"key":"634_CR1","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1074\/mcp.M900294-MCP200","volume":"9","author":"JM Moreira","year":"2010","unstructured":"Moreira JM, Ohlsson G, Gromov P, Simon R, Sauter G, Celis JE, Gromova I. Bladder cancer-associated protein, a potential prognostic biomarker in human bladder cancer. Mol Cell Proteomics. 2010;9:161\u201377.","journal-title":"Mol Cell Proteomics"},{"key":"634_CR2","doi-asserted-by":"crossref","first-page":"25856","DOI":"10.18632\/oncotarget.4624","volume":"6","author":"Y Gong","year":"2015","unstructured":"Gong Y, Qiu W, Ning X, Yang X, Liu L, Wang Z, Lin J, Li X, Guo Y. CCDC34 is up-regulated in bladder cancer and regulates bladder cancer cell proliferation, apoptosis and migration. Oncotarget. 2015;6:25856\u201367.","journal-title":"Oncotarget"},{"key":"634_CR3","doi-asserted-by":"crossref","first-page":"37782","DOI":"10.18632\/oncotarget.5622","volume":"6","author":"T Zhang","year":"2015","unstructured":"Zhang T, Wu K, Ding C, Sun K, Guan Z, Wang X, Hsieh JT, He D, Fan J. Inhibiting bladder tumor growth with a cell penetrating R11 peptide derived from the p53 C-terminus. Oncotarget. 2015;6:37782\u201391.","journal-title":"Oncotarget"},{"key":"634_CR4","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1111\/bju.12403","volume":"113","author":"RH Breau","year":"2014","unstructured":"Breau RH, Karnes RJ, Farmer SA, Thapa P, Cagiannos I, Morash C, Frank I. Progression to detrusor muscle invasion during urothelial carcinoma surveillance is associated with poor prognosis. BJU Int. 2014;113:900\u20136.","journal-title":"BJU Int"},{"key":"634_CR5","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1158\/1078-0432.CCR-12-2383","volume":"19","author":"N Zhou","year":"2013","unstructured":"Zhou N, Singh K, Mir MC, Parker Y, Lindner D, Dreicer R, Ecsedy JA, Zhang Z, Teh BT, Almasan A, Hansel DE. The investigational Aurora kinase a inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo. Clin Cancer Res. 2013;19:1717\u201328.","journal-title":"Clin Cancer Res"},{"key":"634_CR6","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1158\/1078-0432.CCR-11-2271","volume":"18","author":"M Riester","year":"2012","unstructured":"Riester M, Taylor JM, Feifer A, Koppie T, Rosenberg JE, Downey RJ, Bochner BH, Michor F. Combination of a novel gene expression signature with a clinical nomogram improves the prediction of survival in high-risk bladder cancer. Clin Cancer Res. 2012;18:1323\u201333.","journal-title":"Clin Cancer Res"},{"key":"634_CR7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1476-4598-9-3","volume":"9","author":"WJ Kim","year":"2010","unstructured":"Kim WJ, Kim EJ, Kim SK, Kim YJ, Ha YS, Jeong P, Kim MJ, Yun SJ, Lee KM, Moon SK, Lee SC, Cha EJ, Bae SC. Predictive value of progression-related gene classifier in primary non-muscle invasive bladder cancer. Mol Cancer. 2010;9:3.","journal-title":"Mol Cancer"},{"key":"634_CR8","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1038\/bjc.2013.608","volume":"109","author":"JA Goos","year":"2013","unstructured":"Goos JA, Coupe VM, Diosdado B, Delis-Van Diemen PM, Karga C, Belien JA, Carvalho B, van den Tol MP, Verheul HM, Geldof AA, Meijer GA, Hoekstra OS, Fijneman RJ. Aurora kinase a (AURKA) expression in colorectal cancer liver metastasis is associated with poor prognosis. Br J Cancer. 2013;109:2445\u201352.","journal-title":"Br J Cancer"},{"key":"634_CR9","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3233\/CBM-160427","volume":"19","author":"Q Yuan","year":"2017","unstructured":"Yuan Q, Sun T, Ye F, Kong W, Jin H. MicroRNA-124-3p affects proliferation, migration and apoptosis of bladder cancer cells through targeting AURKA. Cancer Biomark. 2017;19:93\u2013101.","journal-title":"Cancer Biomark"},{"key":"634_CR10","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1158\/1541-7786.MCR-17-0063","volume":"15","author":"A Mathison","year":"2017","unstructured":"Mathison A, Salmonson A, Missfeldt M, Bintz J, Williams M, Kossak S, Nair A, de Assuncao TM, Christensen T, Buttar N, Iovanna J, Huebert R, Lomberk G. Combined AURKA and H3K9 methyltransferase targeting inhibits cell growth by inducing mitotic catastrophe. Mol Cancer Res. 2017;15:984\u201397.","journal-title":"Mol Cancer Res"},{"key":"634_CR11","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s10549-013-2649-0","volume":"140","author":"D Fanale","year":"2013","unstructured":"Fanale D, Bazan V, Corsini LR, Caruso S, Insalaco L, Castiglia M, Cicero G, Bronte G, Russo A. HIF-1 is involved in the negative regulation of AURKA expression in breast cancer cell lines under hypoxic conditions. Breast Cancer Res Treat. 2013;140:505\u201317.","journal-title":"Breast Cancer Res Treat"},{"key":"634_CR12","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1002\/ijc.28434","volume":"134","author":"J Yang","year":"2014","unstructured":"Yang J, Ikezoe T, Nishioka C, Udaka K, Yokoyama A. Bcr-Abl activates AURKA and AURKB in chronic myeloid leukemia cells via AKT signaling. Int J Cancer. 2014;134:1183\u201394.","journal-title":"Int J Cancer"},{"key":"634_CR13","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.bbrc.2017.03.075","volume":"486","author":"C Chen","year":"2017","unstructured":"Chen C, Song G, Xiang J, Zhang H, Zhao S, Zhan Y. AURKA promotes cancer metastasis by regulating epithelial-mesenchymal transition and cancer stem cell properties in hepatocellular carcinoma. Biochem Biophys Res Commun. 2017;486:514\u201320.","journal-title":"Biochem Biophys Res Commun"},{"key":"634_CR14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.cancergencyto.2004.09.008","volume":"159","author":"J Zhu","year":"2005","unstructured":"Zhu J, Abbruzzese JL, Izzo J, Hittelman WN, Li D. AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells. Cancer Genet Cytogenet. 2005;159:10\u20137.","journal-title":"Cancer Genet Cytogenet"},{"key":"634_CR15","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1093\/jnci\/djn304","volume":"100","author":"HS Park","year":"2008","unstructured":"Park HS, Park WS, Bondaruk J, Tanaka N, Katayama H, Lee S, Spiess PE, Steinberg JR, Wang Z, Katz RL, Dinney C, Elias KJ, Lotan Y, et al. Quantitation of Aurora kinase a gene copy number in urine sediments and bladder cancer detection. J Natl Cancer Inst. 2008;100:1401\u201311.","journal-title":"J Natl Cancer Inst"},{"key":"634_CR16","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13046-014-0067-8","volume":"33","author":"Y Feng","year":"2014","unstructured":"Feng Y, Liu J, Kang Y, He Y, Liang B, Yang P, Yu Z. miR-19a acts as an oncogenic microRNA and is up-regulated in bladder cancer. J Exp Clin Cancer Res. 2014;33:67.","journal-title":"J Exp Clin Cancer Res"},{"key":"634_CR17","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s10147-008-0812-0","volume":"13","author":"MA Knowles","year":"2008","unstructured":"Knowles MA. Molecular pathogenesis of bladder cancer. Int J Clin Oncol. 2008;13:287\u201397.","journal-title":"Int J Clin Oncol"},{"key":"634_CR18","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/414865a","volume":"414","author":"P Deloukas","year":"2001","unstructured":"Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, et al. The DNA sequence and comparative analysis of human chromosome 20. Nature. 2001;414:865\u201371.","journal-title":"Nature"},{"key":"634_CR19","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1136\/gutjnl-2011-301153","volume":"61","author":"AH Sillars-Hardebol","year":"2012","unstructured":"Sillars-Hardebol AH, Carvalho B, Tijssen M, Belien JA, de Wit M, Delis-van Diemen PM, Ponten F, van de Wiel MA, Fijneman RJ, Meijer GA. TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression. Gut. 2012;61:1568\u201375.","journal-title":"Gut"},{"key":"634_CR20","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/sj.onc.1200868","volume":"14","author":"E Savelieva","year":"1997","unstructured":"Savelieva E, Belair CD, Newton MA, DeVries S, Gray JW, Waldman F, Reznikoff CA. 20q gain associates with immortalization: 20q13.2 amplification correlates with genome instability in human papillomavirus 16 E7 transformed human uroepithelial cells. Oncogene. 1997;14:551\u201360.","journal-title":"Oncogene"},{"key":"634_CR21","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12935-014-0091-y","volume":"14","author":"ZJ Dai","year":"2014","unstructured":"Dai ZJ, Kang HF, Wang XJ, Shao YP, Lin S, Zhao Y, Ren HT, Min WL, Wang M, Liu XX. Association between genetic polymorphisms in AURKA (rs2273535 and rs1047972) and breast cancer risk: a meta-analysis involving 37,221 subjects. Cancer Cell Int. 2014;14:91.","journal-title":"Cancer Cell Int"},{"key":"634_CR22","doi-asserted-by":"crossref","first-page":"33152","DOI":"10.18632\/oncotarget.8888","volume":"7","author":"X Liu","year":"2016","unstructured":"Liu X, Li Z, Song Y, Wang R, Han L, Wang Q, Jiang K, Kang C, Zhang Q. AURKA induces EMT by regulating histone modification through Wnt\/beta-catenin and PI3K\/Akt signaling pathway in gastric cancer. Oncotarget. 2016;7:33152\u201364.","journal-title":"Oncotarget"},{"key":"634_CR23","doi-asserted-by":"crossref","first-page":"45803","DOI":"10.18632\/oncotarget.9960","volume":"7","author":"TP Chuang","year":"2016","unstructured":"Chuang TP, Wang JY, Jao SW, Wu CC, Chen JH, Hsiao KH, Lin CY, Chen SH, Su SY, Chen YJ, Chen YT, Wu DC, Li LH. Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression. Oncotarget. 2016;7:45803\u201318.","journal-title":"Oncotarget"},{"key":"634_CR24","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s00345-014-1267-8","volume":"33","author":"M de Martino","year":"2015","unstructured":"de Martino M, Shariat SF, Hofbauer SL, Lucca I, Taus C, Wiener HG, Haitel A, Susani M, Klatte T. Aurora a kinase as a diagnostic urinary marker for urothelial bladder cancer. World J Urol. 2015;33:105\u201310.","journal-title":"World J Urol"},{"key":"634_CR25","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1007\/s00345-012-0967-1","volume":"30","author":"OR Faba","year":"2012","unstructured":"Faba OR, Palou J, Breda A, Villavicencio H. High-risk non-muscle-invasive bladder cancer: update for a better identification and treatment. World J Urol. 2012;30:833\u201340.","journal-title":"World J Urol"},{"key":"634_CR26","first-page":"1371","volume":"25","author":"P Bufo","year":"2010","unstructured":"Bufo P, Sanguedolce F, Tortorella S, Cormio L, Carrieri G, Pannone G. Expression of mitotic kinases phospho-aurora a and aurora B correlates with clinical and pathological parameters in bladder neoplasms. Histol Histopathol. 2010;25:1371\u20137.","journal-title":"Histol Histopathol"},{"key":"634_CR27","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.urology.2007.12.026","volume":"72","author":"E Comperat","year":"2008","unstructured":"Comperat E, Bieche I, Dargere D, Laurendeau I, Vieillefond A, Benoit G, Vidaud M, Camparo P, Capron F, Verret C, Cussenot O, Bedossa P, Paradis V. Gene expression study of Aurora-a reveals implication during bladder carcinogenesis and increasing values in invasive urothelial cancer. Urology. 2008;72:873\u20137.","journal-title":"Urology"},{"key":"634_CR28","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nrc1560","volume":"5","author":"JM Brown","year":"2005","unstructured":"Brown JM, Attardi LD. The role of apoptosis in cancer development and treatment response. Nat Rev Cancer. 2005;5:231\u20137.","journal-title":"Nat Rev Cancer"},{"key":"634_CR29","doi-asserted-by":"publisher","first-page":"22932","DOI":"10.1074\/jbc.274.33.22932","volume":"274","author":"AH Boulares","year":"1999","unstructured":"Boulares AH, Yakovlev AG, Ivanova V, Stoica BA, Wang G, Iyer S, Smulson M. Role of poly (ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J Biol Chem. 1999;274:22932\u201340.","journal-title":"J Biol Chem"},{"key":"634_CR30","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1002\/cncr.27801","volume":"119","author":"V Sehdev","year":"2013","unstructured":"Sehdev V, Katsha A, Ecsedy J, Zaika A, Belkhiri A, El-Rifai W. The combination of alisertib, an investigational Aurora kinase a inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas. Cancer. 2013;119:904\u201314.","journal-title":"Cancer"},{"key":"634_CR31","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1158\/1535-7163.MCT-11-0623","volume":"11","author":"V Sehdev","year":"2012","unstructured":"Sehdev V, Peng D, Soutto M, Washington MK, Revetta F, Ecsedy J, Zaika A, Rau TT, Schneider-Stock R, Belkhiri A, El-Rifai W. The aurora kinase a inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells. Mol Cancer Ther. 2012;11:763\u201374.","journal-title":"Mol Cancer Ther"},{"key":"634_CR32","doi-asserted-by":"publisher","first-page":"5202","DOI":"10.1182\/blood-2009-12-259523","volume":"115","author":"G Gorgun","year":"2010","unstructured":"Gorgun G, Calabrese E, Hideshima T, Ecsedy J, Perrone G, Mani M, Ikeda H, Bianchi G, Hu Y, Cirstea D, Santo L, Tai YT, Nahar S, et al. A novel Aurora-a kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma. Blood. 2010;115:5202\u201313.","journal-title":"Blood"},{"key":"634_CR33","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.3892\/or.2015.3764","volume":"33","author":"J Chen","year":"2015","unstructured":"Chen J, Lu H, Zhou W, Yin H, Zhu L, Liu C, Zhang P, Hu H, Yang Y, Han H. AURKA upregulation plays a role in fibroblast-reduced gefitinib sensitivity in the NSCLC cell line HCC827. Oncol Rep. 2015;33:1860\u20136.","journal-title":"Oncol Rep"},{"key":"634_CR34","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.18632\/oncotarget.6610","volume":"7","author":"C Gu","year":"2016","unstructured":"Gu C, Feng L, Peng H, Yang H, Feng Z, Yang Y. MTDH is an oncogene in multiple myeloma, which is suppressed by Bortezomib treatment. Oncotarget. 2016;7:4559\u201369.","journal-title":"Oncotarget"},{"key":"634_CR35","doi-asserted-by":"crossref","first-page":"78918","DOI":"10.18632\/oncotarget.12912","volume":"7","author":"MC Tsai","year":"2016","unstructured":"Tsai MC, Li WM, Huang CN, Ke HL, Li CC, Yeh HC, Chan TC, Liang PI, Yeh BW, Wu WJ, Lim SW, Li CF. DDR2 overexpression in urothelial carcinoma indicates an unfavorable prognosis: a large cohort study. Oncotarget. 2016;7:78918\u201331.","journal-title":"Oncotarget"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12918-018-0634-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12918-018-0634-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12918-018-0634-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T18:54:35Z","timestamp":1605639275000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/s12918-018-0634-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":35,"journal-issue":{"issue":"S7","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["634"],"URL":"https:\/\/doi.org\/10.1186\/s12918-018-0634-2","relation":{},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"14 December 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"None of the authors above has disclosed a conflicts of interest with this submission.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"118"}}