{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T14:53:50Z","timestamp":1763564030870,"version":"3.37.3"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201708060077"],"award-info":[{"award-number":["201708060077"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12918-018-0677-4","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T08:16:54Z","timestamp":1547108214000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Modelling overflow metabolism in Escherichia coli with flux balance analysis incorporating differential proteomic efficiencies of energy pathways"],"prefix":"10.1186","volume":"13","author":[{"given":"Hong","family":"Zeng","sequence":"first","affiliation":[]},{"given":"Aidong","family":"Yang","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,1,10]]},"reference":[{"key":"677_CR1","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.tibtech.2006.09.001","volume":"24","author":"MA Eiteman","year":"2006","unstructured":"Eiteman MA, Altman E. Overcoming acetate in Escherichia coli recombinant protein fermentations. Trends Biotechnol. 2006;24:530\u20136.","journal-title":"Trends Biotechnol"},{"key":"677_CR2","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1128\/AEM.63.8.3205-3210.1997","volume":"63","author":"WR Farmer","year":"1997","unstructured":"Farmer WR, Liao JC. Reduction of aerobic acetate production by Escherichia coli. Appl Environ Microbiol. 1997;63:3205\u201310.","journal-title":"Appl Environ Microbiol"},{"key":"677_CR3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1574-6976.1996.tb00255.x","volume":"19","author":"H Holms","year":"1996","unstructured":"Holms H. Flux analysis and control of the central metabolic pathways in Escherichia coli. FEMS Microbiol Rev. 1996;19:85\u2013116.","journal-title":"FEMS Microbiol Rev"},{"key":"677_CR4","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/BF01032744","volume":"9","author":"JG Pan","year":"1987","unstructured":"Pan JG, Rhee JS, Lebeault JM. Physiological constraints in increasing biomass concentration of Escherichiacoli B in fed-batch culture. Biotechnol Lett. 1987;9:89\u201394.","journal-title":"Biotechnol Lett"},{"key":"677_CR5","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1021\/bp9801087","volume":"15","author":"B Xu","year":"1999","unstructured":"Xu B, Jahic M, Enfors SO. Modeling of overflow metabolism in batch and fed-batch cultures of Escherichia coli. Biotechnol Prog. 1999;15:81\u201390.","journal-title":"Biotechnol Prog"},{"key":"677_CR6","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/0167-7799(96)80930-9","volume":"14","author":"SY Lee","year":"1996","unstructured":"Lee SY. High cell-density culture of Escherichia coli. Trends Biotechnol. 1996;14:98\u2013105.","journal-title":"Trends Biotechnol"},{"key":"677_CR7","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/B978-0-12-152828-7.50004-4","volume":"28","author":"WH Holmes","year":"1986","unstructured":"Holmes WH. The central metabolic pathways of Escherichia coli: relationship between flux and control at a branch point, efficiency of conversion to biomass, and excretion of acetate. Curr Top Cell Regul. 1986;28:69\u2013105.","journal-title":"Curr Top Cell Regul"},{"key":"677_CR8","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1128\/AEM.56.4.1004-1011.1990","volume":"56","author":"GW Luli","year":"1990","unstructured":"Luli GW, Strohl WR. Comparison of growth, acetate production, and acetate inhibition of Escherichia coli strains in batch and fed-batch fermentations. Appl Environ Microbiol. 1990;56:1004\u201311.","journal-title":"Appl Environ Microbiol"},{"key":"677_CR9","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/nbt.3095","volume":"33","author":"K Zhou","year":"2015","unstructured":"Zhou K, Qiao K, Edgar S, Stephanopoulos G. Distributing a metabolic pathway among a microbial consortium enhances production of natural products. Nat Biotechnol. 2015;33:377\u201383. \n                    https:\/\/doi.org\/10.1038\/nbt.3095\n                    \n                  .","journal-title":"Nat Biotechnol"},{"key":"677_CR10","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1074\/jbc.M511064200","volume":"281","author":"TJ Schulz","year":"2006","unstructured":"Schulz TJ, Thierbach R, Voigt A, Drewes G, Mietzner B, Steinberg P, et al. Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth Otto Warburg revisited. J Biol Chem. 2006;281:977\u201381.","journal-title":"J Biol Chem"},{"key":"677_CR11","doi-asserted-by":"publisher","unstructured":"Shlomi T, Benyamini T, Gottlieb E, Sharan R, Ruppin E. Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect. PLoS Comput Biol. 2011;7. \n                    https:\/\/doi.org\/10.1371\/journal.pcbi.1002018\n                    \n                  .","DOI":"10.1371\/journal.pcbi.1002018"},{"key":"677_CR12","doi-asserted-by":"publisher","unstructured":"Vazquez A, Liu J, Zhou Y, Oltvai ZN. Catabolic efficiency of aerobic glycolysis: the Warburg effect revisited. BMC Syst Biol. 2010;4. \n                    https:\/\/doi.org\/10.1186\/1752-0509-4-58\n                    \n                  .","DOI":"10.1186\/1752-0509-4-58"},{"key":"677_CR13","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1042\/BST20150153","volume":"43","author":"S Schuster","year":"2015","unstructured":"Schuster S, Boley D, M\u00f6ller P, Stark H, Kaleta C. Mathematical models for explaining the Warburg effect: a review focussed on ATP and biomass production. Biochem Soc Trans. 2015;43:1187\u201394. \n                    https:\/\/doi.org\/10.1042\/BST20150153\n                    \n                  .","journal-title":"Biochem Soc Trans"},{"key":"677_CR14","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1128\/MMBR.69.1.12-50.2005","volume":"69","author":"AJ Wolfe","year":"2005","unstructured":"Wolfe AJ. The acetate switch. Microbiol Mol Biol Rev. 2005;69:12\u201350. \n                    https:\/\/doi.org\/10.1128\/MMBR.69.1.12-50.2005\n                    \n                  .","journal-title":"Microbiol Mol Biol Rev"},{"key":"677_CR15","doi-asserted-by":"publisher","unstructured":"Molenaar D, van Berlo R, de Ridder D, Teusink B. Shifts in growth strategies reflect tradeoffs in cellular economics. Mol Syst Biol. 2009;5. \n                    https:\/\/doi.org\/10.1038\/msb.2009.82\n                    \n                  .","DOI":"10.1038\/msb.2009.82"},{"key":"677_CR16","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature15765","volume":"528","author":"M Basan","year":"2015","unstructured":"Basan M, Hui S, Okano H, Zhang Z, Shen Y, Williamson JR, et al. Overflow metabolism in Escherichia coli results from efficient proteome allocation. Nature. 2015;528:99\u2013104. \n                    https:\/\/doi.org\/10.1038\/nature15765\n                    \n                  .","journal-title":"Nature"},{"key":"677_CR17","doi-asserted-by":"publisher","first-page":"42135","DOI":"10.1038\/srep42135","volume":"7","author":"B Enjalbert","year":"2017","unstructured":"Enjalbert B, Millard P, Dinclaux M, Portais JC, L\u00e9tisse F. Acetate fluxes in Escherichia coli are determined by the thermodynamic control of the Pta-AckA pathway. Sci Rep. 2017;7:42135. \n                    https:\/\/doi.org\/10.1038\/srep42135\n                    \n                  .","journal-title":"Sci Rep"},{"key":"677_CR18","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.bej.2017.05.013","volume":"125","author":"E Anane","year":"2017","unstructured":"Anane E, L\u00f3pez CDC, Neubauer P, Cruz Bournazou MN. Modelling overflow metabolism in Escherichia coli by acetate cycling. Biochem Eng J. 2017;125:23\u201330. \n                    https:\/\/doi.org\/10.1016\/j.bej.2017.05.013\n                    \n                  .","journal-title":"Biochem Eng J"},{"key":"677_CR19","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1007\/s10529-012-1038-9","volume":"34","author":"A Goel","year":"2012","unstructured":"Goel A, Wortel MT, Molenaar D, Teusink B. Metabolic shifts: a fitness perspective for microbial cell factories. Biotechnol Lett. 2012;34:2147\u201360.","journal-title":"Biotechnol Lett"},{"key":"677_CR20","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/nbt.1614","volume":"28","author":"JD Orth","year":"2010","unstructured":"Orth JD, Thiele I, Palsson B\u00d8. What is flux balance analysis? Nat Biotechnol. 2010;28:245\u20138. \n                    https:\/\/doi.org\/10.1038\/nbt.1614\n                    \n                  .","journal-title":"Nat Biotechnol"},{"key":"677_CR21","doi-asserted-by":"publisher","unstructured":"Beg QK, Vazquez A, Ernst J, de Menezes MA, Bar-Joseph Z, Barabasi AL, et al. Intracellular crowding defines the mode and sequence of substrate uptake by Escherichia coli and constrains its metabolic activity. P Natl Acad Sci USA. 2007;104. \n                    https:\/\/doi.org\/10.1073\/pnas.0609845104\n                    \n                  .","DOI":"10.1073\/pnas.0609845104"},{"key":"677_CR22","doi-asserted-by":"publisher","unstructured":"Vazquez A, Beg QK, Demenezes MA, Ernst J, Bar-Joseph Z, Barabasi AL, et al. Impact of the solvent capacity constraint on E. coli metabolism. BMC Syst Biol. 2008;2. \n                    https:\/\/doi.org\/10.1186\/1752-0509-2-7\n                    \n                  .","DOI":"10.1186\/1752-0509-2-7"},{"key":"677_CR23","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1016\/j.automatica.2011.02.038","volume":"47","author":"A Goelzer","year":"2011","unstructured":"Goelzer A, Fromion V, Scorletti G. Cell design in bacteria as a convex optimization problem. Automatica. 2011;47:1210\u20138.","journal-title":"Automatica"},{"key":"677_CR24","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.bbagen.2011.05.014","volume":"1810","author":"A Goelzer","year":"2011","unstructured":"Goelzer A, Fromion V. Bacterial growth rate reflects a bottleneck in resource allocation. Biochim Biophys Acta (BBA)-General Subj. 2011;1810:978\u201388.","journal-title":"Biochim Biophys Acta (BBA)-General Subj"},{"key":"677_CR25","doi-asserted-by":"publisher","unstructured":"Goelzer A, Fromion V. Resource allocation in living organisms. Biochem Soc Trans. 2017. \n                    https:\/\/doi.org\/10.1042\/BST20160436\n                    \n                  .","DOI":"10.1042\/BST20160436"},{"key":"677_CR26","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/msb.2013.52","volume":"9","author":"EJ O\u2019Brien","year":"2014","unstructured":"O\u2019Brien EJ, Lerman JA, Chang RL, Hyduke DR, Palsson BO. Genome-scale models of metabolism and gene expression extend and refine growth phenotype prediction. Mol Syst Biol. 2014;9:693. \n                    https:\/\/doi.org\/10.1038\/msb.2013.52\n                    \n                  .","journal-title":"Mol Syst Biol"},{"key":"677_CR27","doi-asserted-by":"publisher","unstructured":"Zhuang K, Vemuri GN, Mahadevan R. Economics of membrane occupancy and respiro-fermentation. Mol Syst Biol. 2011;7. \n                    https:\/\/doi.org\/10.1038\/msb.2011.34\n                    \n                  .","DOI":"10.1038\/msb.2011.34"},{"issue":"6","key":"677_CR28","doi-asserted-by":"publisher","first-page":"e1004913","DOI":"10.1371\/journal.pcbi.1004913","volume":"12","author":"M Mori","year":"2016","unstructured":"Mori M, Hwa T, Martin OC, De Martino A, Marinari E. Constrained allocation flux balance analysis. PLoS Comput Biol. 2016;12(6):e1004913.","journal-title":"PLoS Comput Biol"},{"key":"677_CR29","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1128\/JB.148.1.58-63.1981","volume":"148","author":"CL Woldringh","year":"1981","unstructured":"Woldringh CL, Binnerts JS, Mans A. Variation in Escherichia coli buoyant density measured in Percoll gradients. J Bacteriol. 1981;148:58\u201363.","journal-title":"J Bacteriol"},{"key":"677_CR30","doi-asserted-by":"publisher","unstructured":"Hui S, Silverman JM, Chen SS, Erickson DW, Basan M, Wang J, et al. Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria. Mol Syst Biol. 2015;11. \n                    https:\/\/doi.org\/10.15252\/msb.20145697.","DOI":"10.15252\/msb.20145697."},{"key":"677_CR31","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1126\/science.1192588","volume":"330","author":"M Scott","year":"2010","unstructured":"Scott M, Gunderson CW, Mateescu EM, Zhang Z, Hwa T. Interdependence of cell growth and gene expression: origins and consequences. Science (80- ). 2010;330:1099\u2013102. \n                    https:\/\/doi.org\/10.1126\/science.1192588\n                    \n                  .","journal-title":"Science (80- )"},{"key":"677_CR32","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/nature12446","volume":"500","author":"C You","year":"2013","unstructured":"You C, Okano H, Hui S, Zhang Z, Kim M, Gunderson CW, et al. Coordination of bacterial proteome with metabolism by cyclic AMP signalling. Nature. 2013;500:301\u20136. \n                    https:\/\/doi.org\/10.1038\/nature12446\n                    \n                  .","journal-title":"Nature"},{"key":"677_CR33","doi-asserted-by":"publisher","first-page":"31007","DOI":"10.1038\/srep31007","volume":"6","author":"A Vazquez","year":"2016","unstructured":"Vazquez A, Oltvai ZN. Macromolecular crowding explains overflow metabolism in cells. Sci Rep. 2016;6:31007. \n                    https:\/\/doi.org\/10.1038\/srep31007\n                    \n                  .","journal-title":"Sci Rep"},{"key":"677_CR34","doi-asserted-by":"publisher","unstructured":"Orth JD, Palsson B\u00d8, Fleming RMT. Reconstruction and use of microbial metabolic networks: the Core Escherichia coli metabolic model as an educational guide. EcoSal Plus. 2010;4. \n                    https:\/\/doi.org\/10.1128\/ecosalplus.10.2.1\n                    \n                  .","DOI":"10.1128\/ecosalplus.10.2.1"},{"key":"677_CR35","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1038\/nprot.2011.308","volume":"6","author":"J Schellenberger","year":"2011","unstructured":"Schellenberger J, Que R, Fleming RMT, Thiele I, Orth JD, Feist AM, et al. Quantitative prediction of cellular metabolism with constraint-based models: the COBRA toolbox v2. 0. Nat Protoc. 2011;6:1290.","journal-title":"Nat Protoc"},{"key":"677_CR36","doi-asserted-by":"publisher","unstructured":"Feist AM, Henry CS, Reed JL, Krummenacker M, Joyce AR, Karp PD, et al. A genome-scale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information. Mol Syst Biol. 2007;3. \n                    https:\/\/doi.org\/10.1038\/msb4100155\n                    \n                  .","DOI":"10.1038\/msb4100155"},{"key":"677_CR37","doi-asserted-by":"publisher","first-page":"46446","DOI":"10.1074\/jbc.M307968200","volume":"278","author":"E Fischer","year":"2003","unstructured":"Fischer E, Sauer U. A novel metabolic cycle catalyzes glucose oxidation and anaplerosis in hungry Escherichia coli. J Biol Chem. 2003;278:46446\u201351.","journal-title":"J Biol Chem"},{"key":"677_CR38","doi-asserted-by":"publisher","first-page":"10039","DOI":"10.1073\/pnas.1215283110","volume":"110","author":"A Flamholz","year":"2013","unstructured":"Flamholz A, Noor E, Bar-Even A, Liebermeister W, Milo R. Glycolytic strategy as a tradeoff between energy yield and protein cost. Proc Natl Acad Sci. 2013;110:10039\u201344.","journal-title":"Proc Natl Acad Sci"},{"key":"677_CR39","doi-asserted-by":"publisher","unstructured":"Fuhrer T, Fischer E, Sauer U. Experimental identification and quantification of glucose metabolism in seven bacterial species. J Bacteriol. 2005;187. \n                    https:\/\/doi.org\/10.1128\/JB.187.5.1581-1590.2005\n                    \n                  .","DOI":"10.1128\/JB.187.5.1581-1590.2005"},{"key":"677_CR40","doi-asserted-by":"publisher","first-page":"6613","DOI":"10.1074\/jbc.M311657200","volume":"279","author":"U Sauer","year":"2004","unstructured":"Sauer U, Canonaco F, Heri S, Perrenoud A, Fischer E. The soluble and membrane-bound transhydrogenases UdhA and PntAB have divergent functions in NADPH metabolism of Escherichia coli. J Biol Chem. 2004;279:6613\u20139.","journal-title":"J Biol Chem"},{"key":"677_CR41","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1128\/AEM.72.2.1164-1172.2006","volume":"72","author":"A Nanchen","year":"2006","unstructured":"Nanchen A, Schicker A, Sauer U. Nonlinear dependency of intracellular fluxes on growth rate in miniaturized continuous cultures of Escherichia coli. Appl Environ Microbiol. 2006;72:1164\u201372.","journal-title":"Appl Environ Microbiol"},{"key":"677_CR42","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1099\/mic.0.000118","volume":"161","author":"JP Folsom","year":"2015","unstructured":"Folsom JP, Carlson RP. Physiological, biomass elemental composition and proteomic analyses of Escherichia coli ammonium-limited chemostat growth, and comparison with iron-and glucose-limited chemostat growth. Microbiology. 2015;161:1659\u201370.","journal-title":"Microbiology"},{"key":"677_CR43","doi-asserted-by":"publisher","unstructured":"Becker SA, Feist AM, Mo ML, Hannum G, Palsson B\u00d8, Herrgard MJ. Quantitative prediction of cellular metabolism with constraint-based models: the COBRA toolbox. Nat Protoc. 2007;2. \n                    https:\/\/doi.org\/10.1038\/nprot.2007.99\n                    \n                  .","DOI":"10.1038\/nprot.2007.99"},{"key":"677_CR44","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1099\/mic.0.27481-0","volume":"151","author":"A Kayser","year":"2005","unstructured":"Kayser A, Weber J, Hecht V, Rinas U. Metabolic flux analysis of Escherichia coli in glucose-limited continuous culture. I. Growth-rate-dependent metabolic efficiency at steady state. Microbiology. 2005;151:693\u2013706 \n                    http:\/\/mic.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/mic.0.27481-0\n                    \n                  .","journal-title":"Microbiology"},{"key":"677_CR45","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1752-0509-6-22","volume":"6","author":"MJ Hoek van","year":"2012","unstructured":"van Hoek MJ, Merks RM. Redox balance is key to explaining full vs. partial switching to low-yield metabolism. BMC Syst Biol. 2012;6:22. \n                    https:\/\/doi.org\/10.1186\/1752-0509-6-22\n                    \n                  .","journal-title":"BMC Syst Biol"},{"key":"677_CR46","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/mmi.13012","volume":"97","author":"A Goel","year":"2015","unstructured":"Goel A, Eckhardt TH, Puri P, Jong A, dos Santos F, Giera M, et al. Protein costs do not explain evolution of metabolic strategies and regulation of ribosomal content: does protein investment explain an anaerobic bacterial Crabtree effect? Mol Microbiol. 2015;97:77\u201392.","journal-title":"Mol Microbiol"},{"key":"677_CR47","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/msb.2010.11","volume":"6","author":"S-M Fendt","year":"2010","unstructured":"Fendt S-M, Buescher JM, Rudroff F, Picotti P, Zamboni N, Sauer U. Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity. Mol Syst Biol. 2010;6:356.","journal-title":"Mol Syst Biol"},{"key":"677_CR48","doi-asserted-by":"publisher","first-page":"aaf2786","DOI":"10.1126\/science.aaf2786","volume":"354","author":"SR Hackett","year":"2016","unstructured":"Hackett SR, Zanotelli VRT, Xu W, Goya J, Park JO, Perlman DH, et al. Systems-level analysis of mechanisms regulating yeast metabolic flux. Science (80- ). 2016;354:aaf2786.","journal-title":"Science (80- )"}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12918-018-0677-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12918-018-0677-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12918-018-0677-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T19:08:46Z","timestamp":1578596926000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/s12918-018-0677-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,10]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["677"],"URL":"https:\/\/doi.org\/10.1186\/s12918-018-0677-4","relation":{},"ISSN":["1752-0509"],"issn-type":[{"type":"electronic","value":"1752-0509"}],"subject":[],"published":{"date-parts":[[2019,1,10]]},"assertion":[{"value":"18 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"3"}}