{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:03:15Z","timestamp":1777161795369,"version":"3.51.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31300897"],"award-info":[{"award-number":["31300897"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundation of Hebei Educational Committee","award":["ZD2015012"],"award-info":[{"award-number":["ZD2015012"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Syst Biol"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12918-019-0680-4","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T09:02:51Z","timestamp":1548061371000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["miRNAs and target genes in the blood as biomarkers for the early diagnosis of Parkinson\u2019s disease"],"prefix":"10.1186","volume":"13","author":[{"given":"Xiaoting","family":"Liu","sequence":"first","affiliation":[]},{"given":"Jinhu","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Tianyuan","family":"Guan","sequence":"additional","affiliation":[]},{"given":"Hui","family":"Yao","sequence":"additional","affiliation":[]},{"given":"Wenpei","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Zhenlong","family":"Guan","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5056-1963","authenticated-orcid":false,"given":"Yanqin","family":"Wang","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,1,21]]},"reference":[{"issue":"9996","key":"680_CR1","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","volume":"386","author":"LV Kalia","year":"2015","unstructured":"Kalia LV, Lang AE. Parkinson's disease. Lancet. 2015;386(9996):896\u2013912.","journal-title":"Lancet"},{"issue":"Suppl 1","key":"680_CR2","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1007\/s10654-011-9581-6","volume":"26","author":"K Wirdefeldt","year":"2011","unstructured":"Wirdefeldt K, Adami HO, Cole P, Trichopoulos D, Mandel J. Epidemiology and etiology of Parkinson's disease: a review of the evidence. Eur J Epidemiol. 2011;26(Suppl 1):S1\u201358.","journal-title":"Eur J Epidemiol"},{"key":"680_CR3","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.freeradbiomed.2013.01.018","volume":"62","author":"DT Dexter","year":"2013","unstructured":"Dexter DT, Jenner P. Parkinson disease: from pathology to molecular disease mechanisms. Free Radic Biol Med. 2013;62:132\u201344.","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"680_CR4","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1136\/jnnp.2007.131045","volume":"79","author":"J Jankovic","year":"2008","unstructured":"Jankovic J. Parkinson's disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry. 2008;79(4):368\u201376.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"680_CR5","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/S1474-4422(16)00057-0","volume":"15","author":"A Iranzo","year":"2016","unstructured":"Iranzo A, Santamaria J, Tolosa E. Idiopathic rapid eye movement sleep behaviour disorder: diagnosis, management, and the need for neuroprotective interventions. Lancet Neurol. 2016;15(4):405\u201319.","journal-title":"Lancet Neurol"},{"issue":"6163","key":"680_CR6","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1126\/science.1244193","volume":"342","author":"CL Tan","year":"2013","unstructured":"Tan CL, Plotkin JL, Ven\u00f8 MT, et al. MicroRNA-128 governs neuronal excitability and motor behavior in mice. Science. 2013;342(6163):1254\u20138.","journal-title":"Science"},{"issue":"6152","key":"680_CR7","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1126\/science.1242528","volume":"341","author":"ME Pedersen","year":"2013","unstructured":"Pedersen ME, Snieckute G, Kagias K, et al. An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state. Science. 2013;341(6152):1404\u20138.","journal-title":"Science"},{"issue":"5","key":"680_CR8","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1158\/0008-5472.CAN-13-2117","volume":"74","author":"GG Gomez","year":"2014","unstructured":"Gomez GG, Volinia S, Croce CM, et al. Suppression of microRNA-9 by mutant EGFR signaling upregulates FOXP1 to enhance glioblastoma tumorigenicity. Cancer Res. 2014;74(5):1429\u201339.","journal-title":"Cancer Res"},{"issue":"4","key":"680_CR9","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1001\/jama.2013.284665","volume":"311","author":"DJ Buchsbaum","year":"2014","unstructured":"Buchsbaum DJ, Croce CM. Will detection of microRNA biomarkers in blood improve the diagnosis and survival of patients with pancreatic cancer. JAMA. 2014;311(4):363\u20135.","journal-title":"JAMA"},{"issue":"1","key":"680_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086856","volume":"9","author":"IZ Ben-Dov","year":"2014","unstructured":"Ben-Dov IZ, Tan YC, Morozov P, et al. Urine microRNA as potential biomarkers of autosomal dominant polycystic kidney disease progression: description of miRNA profiles at baseline. PLoS One. 2014;9(1):e86856.","journal-title":"PLoS One"},{"issue":"5","key":"680_CR11","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1158\/0008-5472.CAN-13-1449","volume":"74","author":"J Kim","year":"2014","unstructured":"Kim J, Zhang Y, Skalski M, et al. microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastoma. Cancer Res. 2014;74(5):1541\u201353.","journal-title":"Cancer Res"},{"issue":"1","key":"680_CR12","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"dW Huang","year":"2009","unstructured":"Huang dW, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44\u201357.","journal-title":"Nat Protoc"},{"issue":"1\u20132","key":"680_CR13","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jns.2014.01.002","volume":"338","author":"PJ Garcia-Ruiz","year":"2014","unstructured":"Garcia-Ruiz PJ, Chaudhuri KR, Martinez-Martin P. Non-motor symptoms of Parkinson's disease a review\u2026from the past. J Neurol Sci. 2014;338(1\u20132):30\u20133.","journal-title":"J Neurol Sci"},{"issue":"5","key":"680_CR14","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1586\/14737175.2015.1038244","volume":"15","author":"AQ Rana","year":"2015","unstructured":"Rana AQ, Ahmed US, Chaudry ZM, Vasan S. Parkinson's disease: a review of non-motor symptoms. Expert Rev Neurother. 2015;15(5):549\u201362.","journal-title":"Expert Rev Neurother"},{"issue":"2","key":"680_CR15","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.ymgme.2015.09.005","volume":"117","author":"H Kobo","year":"2016","unstructured":"Kobo H, Bar-Shira A, Dahary D, et al. Down-regulation of B cell-related genes in peripheral blood leukocytes of Parkinson's disease patients with and without GBA mutations. Mol Genet Metab. 2016;117(2):179\u201385.","journal-title":"Mol Genet Metab"},{"issue":"1","key":"680_CR16","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1093\/toxsci\/kfx117","volume":"159","author":"EM Martinez","year":"2017","unstructured":"Martinez EM, Young AL, Patankar YR, et al. Editor's highlight: Nlrp3 is required for inflammatory changes and Nigral cell loss resulting from chronic Intragastric rotenone exposure in mice. Toxicol Sci. 2017;159(1):64\u201375.","journal-title":"Toxicol Sci"},{"key":"680_CR17","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s13024-016-0094-3","volume":"11","author":"Y Zhou","year":"2016","unstructured":"Zhou Y, Lu M, Du RH, et al. MicroRNA-7 targets nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson's disease. Mol Neurodegener. 2016;11:28.","journal-title":"Mol Neurodegener"},{"issue":"4","key":"680_CR18","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.941","volume":"8","author":"L Chen","year":"2018","unstructured":"Chen L, Yang J, L\u00fc J, Cao S, Zhao Q, Yu Z. Identification of aberrant circulating miRNAs in Parkinson's disease plasma samples. Brain Behav. 2018;8(4):e00941.","journal-title":"Brain Behav"},{"key":"680_CR19","doi-asserted-by":"crossref","unstructured":"Xie N, Qi J, Li S, Deng J, Chen Y, Lian Y. Upregulated lncRNA small nucleolar RNA host gene 1 promotes 1-methyl-4-phenylpyridinium ion-induced cytotoxicity and reactive oxygen species production through miR-15b-5p\/GSK3\u03b2 axis in human dopaminergic SH-SY5Y cells. J Cell Biochem. 2018:1\u201312.","DOI":"10.1002\/jcb.27865"},{"key":"680_CR20","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.neuro.2017.12.001","volume":"68","author":"Y Chen","year":"2018","unstructured":"Chen Y, Lian YJ, Ma YQ, Wu CJ, Zheng YK, Xie NC. LncRNA SNHG1 promotes \u03b1-synuclein aggregation and toxicity by targeting miR-15b-5p to activate SIAH1 in human neuroblastoma SH-SY5Y cells. Neurotoxicology. 2018;68:212\u201321.","journal-title":"Neurotoxicology"},{"key":"680_CR21","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.parkreldis.2015.11.014","volume":"22","author":"H Ding","year":"2016","unstructured":"Ding H, Huang Z, Chen M, et al. Identification of a panel of five serum miRNAs as a biomarker for Parkinson's disease. Parkinsonism Relat Disord. 2016;22:68\u201373.","journal-title":"Parkinsonism Relat Disord"},{"issue":"3","key":"680_CR22","first-page":"39","volume":"62","author":"J Wang","year":"2016","unstructured":"Wang J, Le T, Wei R, Jiao Y. Knockdown of JMJD1C, a target gene of hsa-miR-590-3p, inhibits mitochondrial dysfunction and oxidative stress in MPP+\u2212treated MES23.5 and SH-SY5Y cells. Cell Mol Biol (Noisy-le-grand). 2016;62(3):39\u201345.","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"680_CR23","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.dci.2017.08.001","volume":"77","author":"S Sharma","year":"2017","unstructured":"Sharma S. Immunomodulation: a definitive role of microRNA-142. Dev Comp Immunol. 2017;77:150\u20136.","journal-title":"Dev Comp Immunol"},{"issue":"4","key":"680_CR24","doi-asserted-by":"publisher","first-page":"432","DOI":"10.4149\/neo_2013_056","volume":"60","author":"M Dahlhaus","year":"2013","unstructured":"Dahlhaus M, Roolf C, Ruck S, Lange S, Freund M, Junghanss C. Expression and prognostic significance of hsa-miR-142-3p in acute leukemias. Neoplasma. 2013;60(4):432\u20138.","journal-title":"Neoplasma"},{"issue":"12","key":"680_CR25","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1038\/cr.2013.145","volume":"23","author":"X Lu","year":"2013","unstructured":"Lu X, Li X, He Q, et al. miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates. Cell Res. 2013;23(12):1356\u201368.","journal-title":"Cell Res"},{"issue":"7","key":"680_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069807","volume":"8","author":"P Kumar","year":"2013","unstructured":"Kumar P, Dezso Z, MacKenzie C, et al. Circulating miRNA biomarkers for Alzheimer's disease. PLoS One. 2013;8(7):e69807.","journal-title":"PLoS One"},{"issue":"1","key":"680_CR27","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/j.1365-2230.2011.04158.x","volume":"37","author":"K Makino","year":"2012","unstructured":"Makino K, Jinnin M, Kajihara I, et al. Circulating miR-142-3p levels in patients with systemic sclerosis. Clin Exp Dermatol. 2012;37(1):34\u20139.","journal-title":"Clin Exp Dermatol"},{"issue":"5","key":"680_CR28","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1016\/j.jaci.2016.02.018","volume":"137","author":"T Maes","year":"2016","unstructured":"Maes T, Cobos FA, Schleich F, et al. Asthma inflammatory phenotypes show differential microRNA expression in sputum. J Allergy Clin Immunol. 2016;137(5):1433\u201346.","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"680_CR29","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1523\/JNEUROSCI.0851-16.2016","volume":"37","author":"G Mandolesi","year":"2017","unstructured":"Mandolesi G, De Vito F, Musella A, et al. miR-142-3p is a key regulator of IL-1\u03b2-dependent Synaptopathy in Neuroinflammation. J Neurosci. 2017;37(3):546\u201361.","journal-title":"J Neurosci"},{"issue":"10","key":"680_CR30","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/cgt.2015.44","volume":"22","author":"X Zhang","year":"2015","unstructured":"Zhang X, Zhang Y, Yang J, Li S, Chen J. Upregulation of miR-582-5p inhibits cell proliferation, cell cycle progression and invasion by targeting Rab27a in human colorectal carcinoma. Cancer Gene Ther. 2015;22(10):475\u201380.","journal-title":"Cancer Gene Ther"},{"issue":"10","key":"680_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078381","volume":"8","author":"Y Liu","year":"2013","unstructured":"Liu Y, Jiang J, Wang X, Zhai F, Cheng X. miR-582-5p is upregulated in patients with active tuberculosis and inhibits apoptosis of monocytes by targeting FOXO1. PLoS One. 2013;8(10):e78381.","journal-title":"PLoS One"},{"key":"680_CR32","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.biochi.2014.08.003","volume":"106","author":"PP He","year":"2014","unstructured":"He PP, Ouyang XP, Tang YY, et al. MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages. Biochimie. 2014;106:81\u201390.","journal-title":"Biochimie"},{"issue":"1","key":"680_CR33","doi-asserted-by":"publisher","first-page":"867","DOI":"10.3892\/mmr.2015.4606","volume":"13","author":"MH Bao","year":"2016","unstructured":"Bao MH, Li JM, Zhou QL, et al. Effects of miR-590 on oxLDL-induced endothelial cell apoptosis: roles of p53 and NF-\u03baB. Mol Med Rep. 2016;13(1):867\u201373.","journal-title":"Mol Med Rep"},{"issue":"23","key":"680_CR34","doi-asserted-by":"publisher","first-page":"16085","DOI":"10.1074\/jbc.M114.554071","volume":"289","author":"JC Sunryd","year":"2014","unstructured":"Sunryd JC, Cheon B, Graham JB, Giorda KM, Fissore RA, Hebert DN. TMTC1 and TMTC2 are novel endoplasmic reticulum tetratricopeptide repeat-containing adapter proteins involved in calcium homeostasis. J Biol Chem. 2014;289(23):16085\u201399.","journal-title":"J Biol Chem"}],"updated-by":[{"DOI":"10.1186\/s12918-019-0701-3","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000}}],"container-title":["BMC Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12918-019-0680-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12918-019-0680-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12918-019-0680-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T19:08:58Z","timestamp":1579547338000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/s12918-019-0680-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,21]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["680"],"URL":"https:\/\/doi.org\/10.1186\/s12918-019-0680-4","relation":{"correction":[{"id-type":"doi","id":"10.1186\/s12918-019-0701-3","asserted-by":"object"}]},"ISSN":["1752-0509"],"issn-type":[{"value":"1752-0509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,21]]},"assertion":[{"value":"23 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2019","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"AbstractIt was highlighted that the original article [1] contained some typesetting mistakes in the first paragraph of the Background section.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study does not contain any studies with human participants or animals performed by any of the authors. Informed consent was obtained from all individual participants included in the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"10"}}