{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:57:17Z","timestamp":1778227037162,"version":"3.51.4"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T00:00:00Z","timestamp":1470096000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T00:00:00Z","timestamp":1470096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000153","name":"Division of Biological Infrastructure","doi-asserted-by":"publisher","award":["0850195"],"award-info":[{"award-number":["0850195"]}],"id":[{"id":"10.13039\/100000153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009227","name":"Iowa State University","doi-asserted-by":"publisher","award":["Plant Sciences Institute Scholar Award"],"award-info":[{"award-number":["Plant Sciences Institute Scholar Award"]}],"id":[{"id":"10.13039\/100009227","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BioData Mining"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s13040-016-0105-5","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T13:34:45Z","timestamp":1470144885000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mango: combining and analyzing heterogeneous biological networks"],"prefix":"10.1186","volume":"9","author":[{"given":"Jennifer","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyejin","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2029-8743","authenticated-orcid":false,"given":"Hui-Hsien","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,8,2]]},"reference":[{"issue":"D1","key":"105_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/nar\/gkt1282","volume":"42","author":"XM Fern\u00e1ndez-Su\u00e1rez","year":"2014","unstructured":"Fern\u00e1ndez-Su\u00e1rez XM, Rigden DJ, Galperin MY. The 2014 nucleic acids research database issue and an updated nar online molecular biology database collection. Nucleic Acids Res. 2014; 42(D1):1\u20136.","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"105_CR2","doi-asserted-by":"publisher","first-page":"1002375","DOI":"10.1371\/journal.pcbi.1002375","volume":"8","author":"P Khatri","year":"2012","unstructured":"Khatri P, Sirota M, Butte AJ. Ten years of pathway analysis: current approaches and outstanding challenges. PLoS Comput Biol. 2012; 8(2):1002375.","journal-title":"PLoS Comput Biol"},{"issue":"6833","key":"105_CR3","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/35075138","volume":"411","author":"H Jeong","year":"2001","unstructured":"Jeong H, Mason SP, Barab\u00e1si AL, Oltvai ZN. Lethality and centrality in protein networks. Nature. 2001; 411(6833):41\u20132.","journal-title":"Nature"},{"issue":"1","key":"105_CR4","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1103\/RevModPhys.74.47","volume":"74","author":"R Albert","year":"2002","unstructured":"Albert R, Barab\u00e1si AL. Statistical mechanics of complex networks. Rev Modern Phys. 2002; 74(1):47.","journal-title":"Rev Modern Phys"},{"issue":"1","key":"105_CR5","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1756-0381-4-10","volume":"4","author":"GA Pavlopoulos","year":"2011","unstructured":"Pavlopoulos GA, Secrier M, Moschopoulos CN, Soldatos TG, Kossida S, Aerts J, Schneider R, Bagos PG, et al.Using graph theory to analyze biological networks. BioData mining. 2011; 4(1):10.","journal-title":"BioData mining"},{"issue":"3","key":"105_CR6","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/bioinformatics\/btq675","volume":"27","author":"ME Smoot","year":"2011","unstructured":"Smoot ME, Ono K, Ruscheinski J, Wang PL, Ideker T. Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics. 2011; 27(3):431\u20132.","journal-title":"Bioinformatics"},{"issue":"4","key":"105_CR7","first-page":"944","volume":"8","author":"S Jarukasemratana","year":"2013","unstructured":"Jarukasemratana S, Murata T. Recent large graph visualization tools: a review. Inf Media Technol. 2013; 8(4):944\u201360.","journal-title":"Inf Media Technol"},{"key":"105_CR8","volume-title":"Proceedings of the SIGCHI Conference on Human Factors in Computing Systems","author":"E Adar","year":"2006","unstructured":"Adar E. Guess: a language and interface for graph exploration. In: Proceedings of the SIGCHI Conference on Human Factors in Computing Systems. Montreal, Quebec, Canada: ACM: 2006. p. 791\u2013800."},{"key":"105_CR9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1609\/icwsm.v3i1.13937","volume":"8","author":"M Bastian","year":"2009","unstructured":"Bastian M, Heymann S, Jacomy M, et al.Gephi: an open source software for exploring and manipulating networks. ICWSM. 2009; 8:361\u20132.","journal-title":"ICWSM"},{"key":"105_CR10","volume-title":"Graph Drawing Software","author":"D Auber","year":"2004","unstructured":"Auber D. Tulip-a huge graph visualization framework. In: Graph Drawing Software. Berlin Heidelberg: Springer: 2004. p. 105\u201326."},{"issue":"10","key":"105_CR11","doi-asserted-by":"publisher","first-page":"1003285","DOI":"10.1371\/journal.pcbi.1003285","volume":"9","author":"GK Sandve","year":"2013","unstructured":"Sandve GK, Nekrutenko A, Taylor J, Hovig E. Ten simple rules for reproducible computational research. PLoS Comput Biol. 2013; 9(10):1003285.","journal-title":"PLoS Comput Biol"},{"key":"105_CR12","volume-title":"The grammar of graphics","author":"L Wilkinson","year":"2006","unstructured":"Wilkinson L. The grammar of graphics. New York: Springer; 2006."},{"issue":"1","key":"105_CR13","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S. Wgcna: an r package for weighted correlation network analysis. BMC Bioinforma. 2008; 9(1):559.","journal-title":"BMC Bioinforma"},{"issue":"1","key":"105_CR14","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1186\/s13104-016-2113-4","volume":"9","author":"H Cho","year":"2016","unstructured":"Cho H, Chou HH. Thermodynamically optimal whole-genome tiling microarray design and validation. BMC Res Notes. 2016; 9(1):305.","journal-title":"BMC Res Notes"},{"issue":"3","key":"105_CR15","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nbt.2831","volume":"32","author":"SV Rajagopala","year":"2014","unstructured":"Rajagopala SV, Sikorski P, Kumar A, Mosca R, Vlasblom J, Arnold R, Franca-Koh J, Pakala SB, Phanse S, Ceol A, et al.The binary protein-protein interaction landscape of escherichia coli. Nat Biotechnol. 2014; 32(3):285\u201390.","journal-title":"Nat Biotechnol"}],"container-title":["BioData Mining"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13040-016-0105-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13040-016-0105-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13040-016-0105-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13040-016-0105-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T12:59:53Z","timestamp":1692449993000},"score":1,"resource":{"primary":{"URL":"https:\/\/biodatamining.biomedcentral.com\/articles\/10.1186\/s13040-016-0105-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,2]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["105"],"URL":"https:\/\/doi.org\/10.1186\/s13040-016-0105-5","relation":{},"ISSN":["1756-0381"],"issn-type":[{"value":"1756-0381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,2]]},"assertion":[{"value":"18 March 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"25"}}