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But the bioactive compounds and potential mechanisms of TJQW for COVID-19 prevention and treatment are unclear. This study aimed to explore the potential therapeutic mechanism of TJQW in coronavirus disease 2019 (COVID-19) based on an integrated network pharmacology approach.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>TCMSP were used to search and screen the active ingredients in TJQW. The Swiss TargetPrediction was used to predict the potential targets of active ingredients. Genes co-expressed with ACE2 were considered potential therapeutic targets on COVID-19. Venn diagram was created to show correlative targets of TJQW against COVID-19. Cytoscape was used to construct a \u201cdrug-active ingredient-potential target\u201d network, STRING were used to construct protein-protein interaction network, and cytoHubba performed network topology analysis. Enrichment of biological functions and signaling pathways of core targets was performed by using the clusterProfiler package in R software and ClueGO with CluePedia plugins in Cytoscape.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 156 active ingredients were obtained through oral bioavailability and drug-likeness screenings. Two hundred twenty-seven potential targets of TJQW were related to COVID-19. The top ten core targets are EGFR, CASP3, STAT3, ESR1, FPR2, F2, BCL2L1, BDKRB2, MPO, and ACE. Based on that, we obtained 19 key active ingredients: umbelliprenin, quercetin, kaempferol, luteolin, praeruptorin E, stigmasterol, and oroxylin A. And the enrichment analysis obtained multiple related gene ontology functions and signaling pathways. Lastly, we constructed a key network of \u201cdrug-component-target-biological process-signaling pathway\u201d. Our findings suggested that TJQW treatment for COVID-19 was associated with elevation of immunity and suppression of inflammatory stress, including regulation of inflammatory response, viral process, neutrophil mediated immunity, PI3K-Akt signaling pathway, MAPK signaling pathway, Jak-STAT signaling pathway, Complement and coagulation cascades, and HIF-1 signaling pathway.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Our study uncovered the pharmacological mechanism underlying TJQW treatment for COVID-19. These results should benefit efforts for people around the world to gain more knowledge about Chinese medicine TJQW in the treatment of this vicious epidemic COVID-19, and help to address this pressing problem currently facing the world.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s13040-020-00225-8","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T10:03:04Z","timestamp":1600941784000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Therapeutic mechanism of Toujie Quwen granules in COVID-19 based on network pharmacology"],"prefix":"10.1186","volume":"13","author":[{"given":"Ying","family":"Huang","sequence":"first","affiliation":[]},{"given":"Wen-jiang","family":"Zheng","sequence":"additional","affiliation":[]},{"given":"Yong-shi","family":"Ni","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3726-3720","authenticated-orcid":false,"given":"Mian-sha","family":"Li","sequence":"additional","affiliation":[]},{"given":"Jian-kun","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Xiao-hong","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Xing-hua","family":"Tan","sequence":"additional","affiliation":[]},{"given":"Ji-qiang","family":"Li","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"issue":"10223","key":"225_CR1","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/S0140-6736(20)30185-9","volume":"395","author":"C Wang","year":"2020","unstructured":"Wang C, Horby PW, Hayden FG, Gao GF. 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