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In consideration of the time-consuming and expensive of experimental methods. Therefore, it is a challenging task that how to develop efficient computational approaches for the accurate predicting potential associations between drug and target.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the paper, we proposed a novel computational method called WELM-SURF based on drug fingerprints and protein evolutionary information for identifying DTIs. More specifically, for exploiting protein sequence feature, Position Specific Scoring Matrix (PSSM) is applied to capturing protein evolutionary information and Speed up robot features (SURF) is employed to extract sequence key feature from PSSM. For drug fingerprints, the chemical structure of molecular substructure fingerprints was used to represent drug as feature vector. Take account of the advantage that the Weighted Extreme Learning Machine (WELM) has short training time, good generalization ability, and most importantly ability to efficiently execute classification by optimizing the loss function of weight matrix. Therefore, the WELM classifier is used to carry out classification based on extracted features for predicting DTIs. The performance of the WELM-SURF model was evaluated by experimental validations on\n                      <jats:italic>enzyme<\/jats:italic>\n                      ,\n                      <jats:italic>ion channel<\/jats:italic>\n                      ,\n                      <jats:italic>GPCRs<\/jats:italic>\n                      and\n                      <jats:italic>nuclear receptor<\/jats:italic>\n                      datasets by using fivefold cross-validation test. The WELM-SURF obtained average accuracies of 93.54, 90.58, 85.43 and 77.45% on\n                      <jats:italic>enzyme<\/jats:italic>\n                      ,\n                      <jats:italic>ion channels<\/jats:italic>\n                      ,\n                      <jats:italic>GPCRs<\/jats:italic>\n                      and\n                      <jats:italic>nuclear receptor<\/jats:italic>\n                      dataset respectively. We also compared our performance with the Extreme Learning Machine (ELM), the state-of-the-art Support Vector Machine (SVM) on\n                      <jats:italic>enzyme<\/jats:italic>\n                      and\n                      <jats:italic>ion channel<\/jats:italic>\n                      s dataset and other exiting methods on four datasets. By comparing with experimental results, the performance of WELM-SURF is significantly better than that of ELM, SVM and other previous methods in the domain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results demonstrated that the proposed WELM-SURF model is competent for predicting DTIs with high accuracy and robustness. It is anticipated that the WELM-SURF method is a useful computational tool to facilitate widely bioinformatics studies related to DTIs prediction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13040-021-00242-1","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T05:03:27Z","timestamp":1611119007000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["An efficient computational method for predicting drug-target interactions using weighted extreme learning machine and speed up robot features"],"prefix":"10.1186","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9546-3654","authenticated-orcid":false,"given":"Ji-Yong","family":"An","sequence":"first","affiliation":[]},{"given":"Fan-Rong","family":"Meng","sequence":"additional","affiliation":[]},{"given":"Zi-Ji","family":"Yan","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,1,20]]},"reference":[{"issue":"5","key":"242_CR1","doi-asserted-by":"publisher","first-page":"370","DOI":"10.2174\/157018010791163433","volume":"7","author":"YC Wang","year":"2010","unstructured":"Wang YC, et al. 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